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  1. Article ; Online: Multitasking functions of bacterial extracellular DNA in biofilms.

    Sharma, Dhirendra Kumar / Rajpurohit, Yogendra Singh

    Journal of bacteriology

    2024  Volume 206, Issue 4, Page(s) e0000624

    Abstract: Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) ... ...

    Abstract Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) originates from cell lysis or is actively secreted, where it exerts a significant influence on the formation, stability, and resistance of biofilms to environmental stressors. The exploration of eDNA within bacterial biofilms holds paramount importance in research, with far-reaching implications for both human health and the environment. An enhanced understanding of the functions of eDNA in biofilm formation and antibiotic resistance could inspire the development of strategies to combat biofilm-related infections and improve the management of antibiotic resistance. This comprehensive review encapsulates the latest discoveries concerning eDNA, encompassing its origins, functions within bacterial biofilms, and significance in bacterial pathogenesis.
    MeSH term(s) Humans ; DNA, Bacterial/genetics ; Ecosystem ; Biofilms ; Bacteria/genetics ; Extracellular Matrix
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00006-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm.

    Misra, Hari Sharan / Rajpurohit, Yogendra Singh

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1389074

    Abstract: The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control. This process is called the SOS response, and genes that are expressed in response to DNA ... ...

    Abstract The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control. This process is called the SOS response, and genes that are expressed in response to DNA damage are called SOS genes. The proteins encoded by the SOS genes are involved in both DNA repair and maintaining the functions of crucial cell division proteins (e.g., FtsZ) under check until the damaged DNA is presumably repaired. This mechanism of SOS response is the only known mechanism of DNA damage response and cell cycle regulation in bacteria. However, there are bacteria that do not obey this rule of DNA damage response and cell cycle regulation, yet they respond to DNA damage, repair it, and survive. That means such bacteria would have some alternate mechanism(s) of DNA damage response and cell cycle regulation beyond the canonical pathway of the SOS response. In this study, we present the perspectives that bacteria may have other mechanisms of DNA damage response and cell cycle regulation mediated by bacterial eukaryotic type Ser/Thr protein kinases as an alternate to the canonical SOS response and herewith elaborate on them with a well-studied example in the radioresistant bacterium
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1389074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Natural transformation-specific DprA coordinate DNA double-strand break repair pathways in heavily irradiated

    Sharma, Dhirendra Kumar / Soni, Ishu / Misra, Hari S / Rajpurohit, Yogendra Singh

    Applied and environmental microbiology

    2024  Volume 90, Issue 2, Page(s) e0194823

    Abstract: Deinococcus ... ...

    Abstract Deinococcus radiodurans
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA Repair ; DNA Breaks, Double-Stranded ; DNA/metabolism ; DNA Damage ; Deinococcus/genetics ; Deinococcus/metabolism ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism
    Chemical Substances Bacterial Proteins ; DNA (9007-49-2) ; DNA, Bacterial
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01948-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: PprA Protein Inhibits DNA Strand Exchange and ATP Hydrolysis of

    Rajpurohit, Yogendra Singh / Sharma, Dhirendra Kumar / Misra, Hari S

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 636178

    Abstract: DrRecA and PprA proteins function are crucial for the extraordinary resistance to γ-radiation and DNA strand break repair ... ...

    Abstract DrRecA and PprA proteins function are crucial for the extraordinary resistance to γ-radiation and DNA strand break repair in
    Language English
    Publishing date 2021-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.636178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Phosphorylation of deinococcal RecA affects its structural and functional dynamics implicated for its roles in radioresistance of

    Sharma, Dhirendra Kumar / Siddiqui, Mohammad Quadir / Gadewal, Nikhil / Choudhary, Rajan Kumar / Varma, Ashok Kumar / Misra, Hari Sharan / Rajpurohit, Yogendra Singh

    Journal of biomolecular structure & dynamics

    2019  Volume 38, Issue 1, Page(s) 114–123

    Abstract: Deinococcus RecA (DrRecA) protein is a key repair enzyme and contributes to efficient DNA repair ... ...

    Abstract Deinococcus RecA (DrRecA) protein is a key repair enzyme and contributes to efficient DNA repair of
    MeSH term(s) Amino Acids/chemistry ; Amino Acids/metabolism ; DNA Damage ; DNA Repair ; DNA, Single-Stranded ; Deinococcus/enzymology ; Deinococcus/radiation effects ; Models, Molecular ; Phosphorylation ; Radiation Tolerance ; Rec A Recombinases/chemistry ; Rec A Recombinases/metabolism ; Structure-Activity Relationship
    Chemical Substances Amino Acids ; DNA, Single-Stranded ; Rec A Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 2019-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2019.1568916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pyrroloquinoline quinone and a quinoprotein kinase support γ-radiation resistance in Deinococcus radiodurans and regulate gene expression.

    Rajpurohit, Yogendra Singh / Desai, Shruti Sumeet / Misra, Hari Sharan

    Journal of basic microbiology

    2013  Volume 53, Issue 6, Page(s) 518–531

    Abstract: Deinococcus radiodurans is known for its extraordinary resistance to various DNA damaging agents including γ-radiation and desiccation. The pqqE:cat and Δdr2518 mutants making these cells devoid of pyrroloquinoline quinone (PQQ) and a PQQ inducible Ser/ ... ...

    Abstract Deinococcus radiodurans is known for its extraordinary resistance to various DNA damaging agents including γ-radiation and desiccation. The pqqE:cat and Δdr2518 mutants making these cells devoid of pyrroloquinoline quinone (PQQ) and a PQQ inducible Ser/Thr protein kinase, respectively, became sensitive to γ-radiation. Transcriptome analysis of these mutants showed differential expression of the genes including those play roles in oxidative stress tolerance and (DSB) repair in D. radiodurans and in genome maintenance and stress response in other bacteria. Escherichia coli cells expressing DR2518 and PQQ showed improved resistance to γ-radiation, which increased further when both DR2518 and PQQ were present together. Although, profiles of genes getting affected in these mutants were different, there were still a few common genes showing similar expression trends in both the mutants and some others as reported earlier in oxyR and pprI mutant of this bacterium. These results suggested that PQQ and DR2518 have independent roles in γ-radiation resistance of D. radiodurans but their co-existence improves radioresistance further, possibly by regulating differential expression of the genes important for bacterial response to oxidative stress and DNA damage.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA Damage ; DNA Repair ; DNA, Bacterial/genetics ; DNA, Bacterial/radiation effects ; Deinococcus/genetics ; Deinococcus/metabolism ; Deinococcus/physiology ; Deinococcus/radiation effects ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gamma Rays ; Gene Expression ; Gene Expression Profiling/methods ; Gene Expression Regulation, Bacterial ; Mutation ; Oxidative Stress/genetics ; PQQ Cofactor/genetics ; PQQ Cofactor/metabolism ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Radiation Tolerance/physiology
    Chemical Substances Bacterial Proteins ; DNA, Bacterial ; PQQ Cofactor (72909-34-3) ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2013-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.201100650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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