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  1. Book ; Online ; E-Book: Artificial Intelligence for Bone Disorder

    Malviya, Rishabha / Rajput, Shivam / Vaidya, Makarand

    Diagnosis and Treatment

    2024  

    Language English
    Size 1 online resource (262 pages)
    Edition 1st ed.
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-394-23091-5 ; 1-394-23090-7 ; 9781394230884 ; 978-1-394-23091-4 ; 978-1-394-23090-7 ; 1394230885
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Advances in the Treatment of Kidney Disorders using Mesenchymal Stem Cells.

    Rajput, Shivam / Malviya, Rishabha / Uniyal, Prerna

    Current pharmaceutical design

    2024  

    Abstract: Renal disease is a medical condition that poses a potential threat to the life of an individual and is related to substantial morbidity and mortality rates in clinical environments. The aetiology of this condition is influenced by multiple factors, and ... ...

    Abstract Renal disease is a medical condition that poses a potential threat to the life of an individual and is related to substantial morbidity and mortality rates in clinical environments. The aetiology of this condition is influenced by multiple factors, and its incidence tends to increase with progressive aging. Although supportive therapy and kidney transplantation have potential advantages, they also have limitations in terms of mitigating the progression of KD. Despite significant advancements in the domain of supportive therapy, mortality rates in patients continue to increase. Due to their ability to self-renew and multidirectionally differentiate, stem cell therapy has been shown to have tremendous potential in the repair of the diseased kidney. MSCs (Mesenchymal stem cells) are a cell population that is extensively distributed and can be located in various niches throughout an individual's lifespan. The cells in question are characterised by their potential for indefinite replication and their aptitude for undergoing differentiation into fully developed cells of mesodermal origin under laboratory conditions. It is essential to emphasize that MSCs have demonstrated a favorable safety profile and efficacy as a therapeutic intervention for renal diseases in both preclinical as well as clinical investigations. MSCs have been found to slow the advancement of kidney disease, and this impact is thought to be due to their control over a number of physiological processes, including immunological response, tubular epithelial- mesenchymal transition, oxidative stress, renal tubular cell death, and angiogenesis. In addition, MSCs demonstrate recognised effectiveness in managing both acute and chronic kidney diseases via paracrine pathways. The proposal to utilise a therapy that is based on stem-cells as an effective treatment has been put forward in search of discovering novel therapies to promote renal regeneration. Preclinical researchers have demonstrated that various types of stem cells can provide advantages in acute and chronic kidney disease. Moreover, preliminary results from clinical trials have suggested that these interventions are both safe and well-tolerated. This manuscript provides a brief overview of the potential renoprotective effects of stem cell-based treatments in acute as well as chronic renal dysfunction. Furthermore, the mechanisms that govern the process of kidney regeneration induced by stem cells are investigated. This article will examine the therapeutic approaches that make use of stem cells for the treatment of kidney disorders. The analysis will cover various cellular sources that have been utilised, potential mechanisms involved, and the outcomes that have been achieved so far.
    Language English
    Publishing date 2024-03-13
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128296105240305110312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
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  3. Article ; Online: Advancements in the diagnosis, prognosis, and treatment of retinoblastoma.

    Rajput, Shivam / Malviya, Rishabha / Uniyal, Prerna

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2024  

    Abstract: Retinoblastoma (RB) is a prevalent primitive intraocular malignancy in children, particularly in those younger than age 3 years. RB is caused by mutations in the RB1 gene. In developing countries, mortality rates for this type of cancer are still high, ... ...

    Abstract Retinoblastoma (RB) is a prevalent primitive intraocular malignancy in children, particularly in those younger than age 3 years. RB is caused by mutations in the RB1 gene. In developing countries, mortality rates for this type of cancer are still high, whereas industrialized countries have achieved a survival rate of >95%-98%. Untreated, the condition can be fatal, underscoring the importance of early diagnosis. The existing treatments primarily consist of surgery, radiotherapy, and chemotherapy. The detrimental effects of radiation and chemotherapeutic drugs have been documented as factors that contribute to increased mortality rates and negatively affect the quality of life for patients. MicroRNA (miRNA), a type of noncoding RNA, exerts a substantial influence on RB development and the emergence of treatment resistance by regulating diverse cellular processes. This review highlights recent developments in the involvement of miRNAs in RB. This encompasses the clinical significance of miRNAs in the diagnosis, prognosis, and treatment of RB. Additionally, this paper examines the regulatory mechanisms of miRNAs in RB and explores potential therapeutic interventions. This paper provides an overview of the current and emerging treatment options for RB, focusing on recent studies investigating the application of different types of nanoparticles for the diagnosis and treatment of this condition.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2024.01.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Utilization of Herbal Components as Insecticidal and Repellent Effects.

    Rajput, Shivam / Sharma, Pramod / Malviya, Rishabha

    Recent advances in food, nutrition & agriculture

    2023  Volume 14, Issue 3, Page(s) 144–154

    Abstract: Humans and many other creatures depend on agriculture for survival, but it is impossible to cultivate without the use of pesticides. Different types of harmful organism or pest exists in every agricultural crop. Synthetic pesticides are widely utilised ... ...

    Abstract Humans and many other creatures depend on agriculture for survival, but it is impossible to cultivate without the use of pesticides. Different types of harmful organism or pest exists in every agricultural crop. Synthetic pesticides are widely utilised around the world as a solution to this problem, but there are drawbacks associated with their application, the most significant of which are the severe negative impacts on ecosystems and human health. Organically made pesticides should be used instead of synthetic pesticides to reduce their harmful effects. Unlike chemical pesticides, natural pesticides do not cause any harm to non-target creatures and are inexpensive. Most botanical pesticides degrade rapidly, usually in only a few days but sometimes may even take hour. One of the most promising approaches to reducing pesticide pollution and protecting crops, food, and the environment is to use botanical insecticides. Beneficial insects such as earthworms are much less likely to be killed by biopesticides. The source of herbal insecticides is herbal plants. Each plant has distinct effect since every plant have their own chemical constituent. This review explains about numerous herbs and shrubs that feature distinct insecticidal, pesticidal and repelling effect. Insecticidal activity is discovered in a broad variety of herbal plants, and this review analyses those plants in detail, defining the major active ingredient responsible for these effects.
    MeSH term(s) Animals ; Humans ; Insecticides/pharmacology ; Ecosystem ; Pesticides/pharmacology ; Insecta ; Crops, Agricultural ; Insect Repellents/pharmacology
    Chemical Substances Insecticides ; Pesticides ; Insect Repellents
    Language English
    Publishing date 2023-08-03
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ISSN 2772-5758
    ISSN (online) 2772-5758
    DOI 10.2174/2772574X14666230804102104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Herbal Drugs Inducing Autophagy for the Management of Cancer: Mechanism and Utilization.

    Rajput, Shivam / Sharma, Pramod Kumar / Malviya, Rishabha

    Current pharmaceutical biotechnology

    2023  

    Abstract: When compared to chemical medicines, herbal medicines have the greatest therapeutic benefit while having fewer harmful side effects. Many different components in herbs have an anticancer impact, but the exact mechanism of how they work is unknown. Some ... ...

    Abstract When compared to chemical medicines, herbal medicines have the greatest therapeutic benefit while having fewer harmful side effects. Many different components in herbs have an anticancer impact, but the exact mechanism of how they work is unknown. Some herbal medicines have even been shown to trigger autophagy, a process that has shown promise as a potential cancer treatment. In the past ten years, autophagy has come to be recognised as a crucial mechanism in the maintenance of cellular homeostasis, which has led to the discovery of its implications in the pathology of the majority of cellular environments as well as human disorders. Autophagy is a catabolic process that is used by cells to maintain their homeostasis. This process involves the degradation of misfolded, damaged, and excessive proteins, as well as nonfunctional organelles, foreign pathogens, and other cellular components. Autophagy is a highly conserved process. In this review article, several naturally occurring chemicals are discussed. These compounds offer excellent prospects for autophagy inducers, which are substances that can hasten the death of cells when used as a complementary or alternative treatment for cancer. It requires additional exploration in preclinical and clinical investigations, notwithstanding recent advances in therapeutic medications or agents of natural products in numerous cancers. These advancements have been made despite the need for further investigation.
    Language English
    Publishing date 2023-04-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201024666230428114740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  6. Article ; Online: Biomarkers and Treatment Strategies for Breast Cancer Recurrence.

    Rajput, Shivam / Sharma, Pramod Kumar / Malviya, Rishabha

    Current drug targets

    2023  Volume 24, Issue 15, Page(s) 1209–1220

    Abstract: Despite recent treatment advancements, breast cancer remains a life-threatening disease. Although treatment is successful in the early stages, a significant proportion of individuals with breast cancer eventually experience a recurrence of the disease. ... ...

    Abstract Despite recent treatment advancements, breast cancer remains a life-threatening disease. Although treatment is successful in the early stages, a significant proportion of individuals with breast cancer eventually experience a recurrence of the disease. Breast tumour recurrence poses a significant medical issue. Despite tumours being a primary cause of mortality, there remains a limited understanding of the fundamental mechanisms underlying tumour recurrence. The majority of the time, after surgery or medical treatment, this metastatic disease manifests itself after the disease is undiagnosed for a considerable amount of time. This phenomenon is commonly referred to as a relapse or recurrence. Metastatic breast cancer has the potential to recur at varying intervals, ranging from a few months to several decades following the initial diagnosis and treatment. This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Breast Neoplasms/drug therapy ; Neoplasm Recurrence, Local/prevention & control ; Biomarkers ; Recurrence
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-12-12
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/0113894501258059231103072025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Recent Updates on the Development of Therapeutics for the Targeted Treatment of Alzheimer's Disease.

    Rajput, Shivam / Malviya, Rishabha / Bahadur, Shiv / Puri, Dinesh

    Current pharmaceutical design

    2023  Volume 29, Issue 35, Page(s) 2802–2813

    Abstract: Alzheimer's disease (AD) is a complicated, multifaceted, irreversible, and incurable neurotoxic old age illness. Although NMDA (N-methyl D-aspartate)-receptor antagonists, cholinesterase repressors, and their pairings have been approved for the treatment, ...

    Abstract Alzheimer's disease (AD) is a complicated, multifaceted, irreversible, and incurable neurotoxic old age illness. Although NMDA (N-methyl D-aspartate)-receptor antagonists, cholinesterase repressors, and their pairings have been approved for the treatment, they are useful for short symptomatic relief. Researchers throughout the globe have been constantly working to uncover the therapy of Alzheimer's disease as new candidates must be determined, and newer treatment medicines must be developed. The aim of this review is to address recent advances in medication research along with new Alzheimer's disease therapy for diverse targets. Information was gathered utilizing a variety of internet resources as well as websites, such as ALZFORUM (alzforum.org) and clinicaltrials.gov. In contrast to other domains, the proposed medicines target amyloids (secretases, A42 generation, neuroinflammation, amyloid precipitation, and immunization), tau proteins (tau phosphorylation/aggregation and immunotherapy), and amyloid deposition. Despite tremendous advancement in our understanding of the underlying pathophysiology of Alzheimer's disease, the FDA (Food and Drug Administration) only approved aducanumab for diagnosis and treatment in 2003. Hence, novel treatment tactics are needed to find and develop therapeutic medicines to combat Alzheimer's disease.
    MeSH term(s) Humans ; Alzheimer Disease/therapy ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Immunotherapy
    Chemical Substances tau Proteins ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-11-28
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128274618231105173031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: PVG at WASSA 2021

    Kulkarni, Atharva / Somwase, Sunanda / Rajput, Shivam / Marathe, Manisha

    A Multi-Input, Multi-Task, Transformer-Based Architecture for Empathy and Distress Prediction

    2021  

    Abstract: Active research pertaining to the affective phenomenon of empathy and distress is invaluable for improving human-machine interaction. Predicting intensities of such complex emotions from textual data is difficult, as these constructs are deeply rooted in ...

    Abstract Active research pertaining to the affective phenomenon of empathy and distress is invaluable for improving human-machine interaction. Predicting intensities of such complex emotions from textual data is difficult, as these constructs are deeply rooted in the psychological theory. Consequently, for better prediction, it becomes imperative to take into account ancillary factors such as the psychological test scores, demographic features, underlying latent primitive emotions, along with the text's undertone and its psychological complexity. This paper proffers team PVG's solution to the WASSA 2021 Shared Task on Predicting Empathy and Emotion in Reaction to News Stories. Leveraging the textual data, demographic features, psychological test score, and the intrinsic interdependencies of primitive emotions and empathy, we propose a multi-input, multi-task framework for the task of empathy score prediction. Here, the empathy score prediction is considered the primary task, while emotion and empathy classification are considered secondary auxiliary tasks. For the distress score prediction task, the system is further boosted by the addition of lexical features. Our submission ranked 1$^{st}$ based on the average correlation (0.545) as well as the distress correlation (0.574), and 2$^{nd}$ for the empathy Pearson correlation (0.517).

    Comment: Accepted at the 11th Workshop on Computational Approaches to Subjectivity, Sentiment and Social Media Analysis (WASSA 2021), co-located with EACL 2021
    Keywords Computer Science - Computation and Language ; Computer Science - Human-Computer Interaction ; Computer Science - Machine Learning
    Subject code 004
    Publishing date 2021-03-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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