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  1. AU="Rakow, Anastasia"
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  3. AU="Sharpley, A N"
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  1. Article ; Online: Noninfectious tissue interactions at periprosthetic interfaces.

    Schulze, Frank / Perino, Giorgio / Rakow, Anastasia / Wassilew, Georgi / Schoon, Janosch

    Orthopadie (Heidelberg, Germany)

    2023  Volume 52, Issue 3, Page(s) 186–195

    Abstract: The success of hip arthroplasty is based on modern materials in addition to the continuous development of surgical techniques and clinical experience gained over six decades. The biocompatible implant materials used in hip arthroplasty can be textured or ...

    Title translation Nichtinfektiöse Gewebsinteraktionen an den periprothetischen Interfaces.
    Abstract The success of hip arthroplasty is based on modern materials in addition to the continuous development of surgical techniques and clinical experience gained over six decades. The biocompatible implant materials used in hip arthroplasty can be textured or coated with biomimetic surfaces to ensure durable component ingrowth and moderate host response. Material integrity plays a critical role in the durability of the stable interface between implant components and periprosthetic tissues. Inflammation at the interfaces due to the release of degradation products from the implant materials is one of the causes of hip arthroplasty failure. This review summarizes the implant materials currently used in hip arthroplasty, their preclinical testing and the postoperative neogenesis of periprosthetic tissues, and the interactions of periprosthetic bone and the implant materials at the periprosthetic interfaces.
    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Biocompatible Materials ; Prostheses and Implants ; Joints
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-02-28
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2731-7153
    ISSN (online) 2731-7153
    DOI 10.1007/s00132-023-04352-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Outcome and Failure Analysis of 132 Episodes of Hematogenous Periprosthetic Joint Infections-A Cohort Study.

    Renz, Nora / Trampuz, Andrej / Perka, Carsten / Rakow, Anastasia

    Open forum infectious diseases

    2022  Volume 9, Issue 4, Page(s) ofac094

    Abstract: Background: The outcomes of hematogenous periprosthetic joint infection (PJI) and reasons for failure are largely unknown.: Methods: The outcomes of consecutive patients with hematogenous PJI treated at our institution between 2010 and 2019 were ... ...

    Abstract Background: The outcomes of hematogenous periprosthetic joint infection (PJI) and reasons for failure are largely unknown.
    Methods: The outcomes of consecutive patients with hematogenous PJI treated at our institution between 2010 and 2019 were evaluated. Failure was classified as persistence or relapse of infection or new infection. Failure-free survival was assessed using Kaplan-Meier analysis. Proportions between groups were compared with the Fisher exact test.
    Results: One hundred thirty-two hematogenous PJI episodes involving knee (n = 76), hip (n = 54), shoulder (n = 1), or elbow (n = 1) prostheses experienced by 110 patients were included. The median follow-up (range) was 20.7 (0.2-89.9) months. Hematogenous PJIs were caused by
    Conclusions: Persistence-/relapse-free survival after treatment of hematogenous PJI was high (84%). New hematogenous PJI due to the same or a new pathogen occurred frequently, reducing treatment success to 62% after 4 years of follow-up, suggesting an individual predisposition to hematogenous PJI. The outcome was similar for different pathogens but worse in episodes treated with prosthesis retention compared with multistage exchange.
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Systemic Effects of Metals Released from Arthroplasty Implants - a Brief Summary.

    Rakow, Anastasia / Schoon, Janosch

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2020  Volume 158, Issue 5, Page(s) 501–507

    Abstract: In recent years, increasing concern has been raised regarding potential systemic toxicity of metals released from arthroplasty implants. A lack of valid metal thresholds for human (organ) toxicity and the prospect of multi-decade survival of modern hip ... ...

    Title translation Systemische Effekte einer Metallbelastung durch Endoprothesen – ein Überblick.
    Abstract In recent years, increasing concern has been raised regarding potential systemic toxicity of metals released from arthroplasty implants. A lack of valid metal thresholds for human (organ) toxicity and the prospect of multi-decade survival of modern hip and knee replacements pose special challenges. Indeed, evidence of systemic effects of metals released from such implants is largely missing. Systemic cobalt exposure has repeatedly been associated with cardiotoxic and neurotoxic effects, and also with thyroid dysfunction. The toxic potential of chromium is considered less pronounced. Yet, in arthroplasty there is usually a co-exposure to chromium and cobalt which complicates evaluation of element-specific effects. Toxicity of titanium dioxide nanoparticles has been subject to debate among international regulatory authorities. Their wide use in a variety of products in everyday life, such as toothpaste, cosmetics and food colorants, hampers the assessment of an arthroplasty-induced systemic titanium exposure. To date there is no clear evidence for systemic complications due to titanium dioxide released from arthroplasty implants. Release of further metals such as tantalum, niobium, nickel, vanadium and zirconium from hip and knee replacement implants has been described occasionally, but systemic effects of respective long-term exposure scenarios are unknown. Generally, the characterization of all released metals regarding their chemical and physical specifications is critical for the evaluation of potential systemic risks. Systematic studies investigating the accumulation of metals relevant in arthroplasty in different organs/organ systems and the biological consequences of such accumulations are urgently needed.
    MeSH term(s) Arthroplasty, Replacement, Hip ; Arthroplasty, Replacement, Knee ; Chromium/toxicity ; Cobalt ; Hip Prosthesis ; Humans ; Zirconium
    Chemical Substances Chromium (0R0008Q3JB) ; Cobalt (3G0H8C9362) ; Zirconium (C6V6S92N3C)
    Language German
    Publishing date 2020-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-1187-1751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Conference proceedings: Sonication of paediatric orthopaedic implants

    Rakow, Anastasia / Lebek, Susanne / Renz, Nora / Funk, Julia

    2023  , Page(s) AB11–3446

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit ; implant removal ; paediatric orthopaedics ; sonication ; implant-associated infection ; bacterial colonization
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou006
    Database German Medical Science

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  5. Article: Clinical and Radiological Outcome of Disc Arthroplasty for the Treatment of Cervical Spondylotic Myelopathy.

    Obid, Peter / Rakow, Anastasia / Lang, Gernot Michael / Marx, Wolfgang / Niemeyer, Thomas / Rahim, Tamim

    Journal of personalized medicine

    2023  Volume 13, Issue 4

    Abstract: Introduction: The aim of this study is to evaluate the clinical and radiological results of cervical disc arthroplasty (CDA) in patients with cervical spondylotic myelopathy (CSM) using the CP ESP: Materials and methods: Prospectively collected data ... ...

    Abstract Introduction: The aim of this study is to evaluate the clinical and radiological results of cervical disc arthroplasty (CDA) in patients with cervical spondylotic myelopathy (CSM) using the CP ESP
    Materials and methods: Prospectively collected data of 56 patients with CSM have been analyzed. The mean age at surgery was 35.6 years (range: 25-43 years). The mean follow-up was 28.2 months (range: 13-42 months). The range of motion (ROM) of the index segments, as well as upper and lower adjacent segments, was measured before surgery and at final follow-up. The C2-C7 sagittal vertical axis (SVA), C2-C7 cervical lordosis (CL), and T1 slope minus cervical lordosis (T1s-CL) were analyzed as well. Pain intensity was measured preoperatively and during follow-up using an 11-point numeric rating scale (NRS). Modified Japanese Orthopaedic Association (mJOA) score was assessed preoperatively and during follow-up for the clinical assessment of myelopathy. Surgical and implant-associated complications were analyzed as well.
    Results: The NRS pain score improved from a mean of 7.4 (±1.1) preoperatively to a mean of 1.5 (±0.7) at last follow-up (
    Conclusions: CDA showed good clinical and radiological outcome in this cohort of young patients. The motion of index segments could be preserved. CDA may be a viable treatment option in selected patients with CSM.
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13040592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Letter to the Editor: Adverse Local Tissue Reactions are Common in Asymptomatic Individuals After Hip Resurfacing Arthroplasty: Interim Report from a Prospective Longitudinal Study.

    Rakow, Anastasia / Schoon, Janosch / Wassilew, Georgi I / Perino, Giorgio

    Clinical orthopaedics and related research

    2022  Volume 480, Issue 7, Page(s) 1425–1426

    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Hip Prosthesis/adverse effects ; Humans ; Longitudinal Studies ; Metal-on-Metal Joint Prostheses/adverse effects ; Prospective Studies
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings: Knochenmark von jungen, adulten Osteotomie-Patienten als neuartige Stammzellquelle

    Schoon, Janosch / Handke, Maximilian / Schulze, Frank / Rakow, Anastasia / Wassilew, Georgi

    2023  , Page(s) AB86–3075

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou491
    Database German Medical Science

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  8. Conference proceedings: Outcome and failure analysis of 132 episodes of haematogenous periprosthetic joint infections – a cohort study

    Renz, Nora / Perka, Carsten / Trampuz, Andrej / Rakow, Anastasia

    2022  , Page(s) AB41–660

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2022); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2022
    Keywords Medizin, Gesundheit ; haematogenous ; periprosthetic joint infection ; outcome ; treatment failure
    Publishing date 2022-10-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dkou290
    Database German Medical Science

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  9. Conference proceedings: Whole blood of patients undergoing revision total hip or knee arthroplasty reveals multi-element exposure

    Rakow, Anastasia / Perka, Carsten / Wittenberg, Silvan / Schoon, Janosch

    2022  , Page(s) AB12–829

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2022); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2022
    Keywords Medizin, Gesundheit ; metal ; multi-element analysis ; revision arthroplasty ; metal exposure
    Publishing date 2022-10-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dkou017
    Database German Medical Science

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  10. Article: Systemic Effects of Metals Released from Arthroplasty Implants – a Brief Summary

    Rakow, Anastasia / Schoon, Janosch

    Zeitschrift für Orthopädie und Unfallchirurgie

    2020  Volume 158, Issue 05, Page(s) 501–507

    Abstract: In recent years, increasing concern has been raised regarding potential systemic toxicity of metals released from arthroplasty implants. A lack of valid metal thresholds for human (organ) toxicity and the prospect of multi-decade survival of modern hip ... ...

    Abstract In recent years, increasing concern has been raised regarding potential systemic toxicity of metals released from arthroplasty implants. A lack of valid metal thresholds for human (organ) toxicity and the prospect of multi-decade survival of modern hip and knee replacements pose special challenges. Indeed, evidence of systemic effects of metals released from such implants is largely missing. Systemic cobalt exposure has repeatedly been associated with cardiotoxic and neurotoxic effects, and also with thyroid dysfunction. The toxic potential of chromium is considered less pronounced. Yet, in arthroplasty there is usually a co-exposure to chromium and cobalt which complicates evaluation of element-specific effects. Toxicity of titanium dioxide nanoparticles has been subject to debate among international regulatory authorities. Their wide use in a variety of products in everyday life, such as toothpaste, cosmetics and food colorants, hampers the assessment of an

    arthroplasty-induced systemic titanium exposure. To date there is no clear evidence for systemic complications due to titanium dioxide released from arthroplasty implants. Release of further metals such as tantalum, niobium, nickel, vanadium and zirconium from hip and knee replacement implants has been described occasionally, but systemic effects of respective long-term exposure scenarios are unknown. Generally, the characterization of all released metals regarding their chemical and physical specifications is critical for the evaluation of potential systemic risks. Systematic studies investigating the accumulation of metals relevant in arthroplasty in different organs/organ systems and the biological consequences of such accumulations are urgently needed.

    Systemische Effekte von aus Endoprothesen freigesetzten Metallen rücken zunehmend in den Fokus des Interesses von Patienten, Ärzten, Wissenschaftlern und Legislative. Besondere Herausforderungen stellen das Fehlen valider Schwellenwerte für (Organ-)Toxizität und die zunehmend langen Standzeiten moderner Hüft- und Knietotalendoprothesen dar. Tatsächlich ist die Evidenz für systemische Komplikationen einer Metallbelastung durch solche Implantate jedoch sehr schwach. Eine systemische Exposition gegenüber Cobalt wurde wiederholt vor allem mit kardio- und neurotoxischen Effekten, aber auch mit thyreoidalen Funktionsstörungen in Verbindung gebracht. Das toxische Potenzial von freigesetztem Chrom gilt als weitaus weniger ausgeprägt, ist allerdings im Kontext der Endoprothetik schwer zu evaluieren, da hier quasi regelhaft eine simultane Exposition gegenüber Chrom und Cobalt erfolgt. Die Toxizität nanopartikulären Titandioxids ist Gegenstand internationaler regulatorischer

    Debatten, sein vielfältiges Vorkommen in unserem Alltag, etwa als Weißmacher in Zahnpasta, Kosmetika oder Lebensmitteln, erschwert die Einschätzung einer möglichen zusätzlichen Belastung durch Endoprothesen. Bislang gibt es keine eineindeutige Evidenz für systemische Komplikationen durch die Freisetzung von Titandioxid aus Endoprothesen. Die Freisetzung von weiteren Metallen wie Tantal, Niob, Nickel, Vanadium und Zirkonium aus Endoprothesen wurde in einzelnen Fällen beschrieben, systemische Effekte entsprechender Langzeitexpositionen sind noch nicht bekannt. Generell ist die Charakterisierung freigesetzter Metalle hinsichtlich ihrer chemischen und physikalischen Spezifikationen für die Bewertung eines möglichen systemischen Risikos entscheidend. Systematische Studien, die die Akkumulation von in der Endoprothetik relevanten Metallen in verschiedenen Organen bzw. Organsystemen und deren biologische Konsequenzen untersuchen, sind dringend erforderlich.
    Keywords metal ions ; wear ; corrosion ; metal toxicity ; systemic effects ; Metallionen ; Korrosion ; Endoprothesen ; Metalltoxizität ; systemische Effekte
    Language English
    Publishing date 2020-09-17
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-1187-1751
    Database Thieme publisher's database

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