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  1. AU="Ramírez, Cecilia de la Luna"
  2. AU="Cloquell, Ana"
  3. AU="William P. Cawthorn"
  4. AU="Graham-Brown, M P M"
  5. AU="Smedholen, Madelen Foss"
  6. AU="Waldner, Andreas"
  7. AU="Awni Alshurafa"
  8. AU="Qiqi Xin"
  9. AU="Jamal, Bilal"
  10. AU="Andeol, Guillaume"
  11. AU=Binz Thomas
  12. AU=Yorlets Rachel R.
  13. AU="Klawitter, Sandra"
  14. AU="Wheeler, Jeanna M"
  15. AU="Kavishe, Bazil Baltazar"
  16. AU=Muench Ricardo AU=Muench Ricardo
  17. AU="Guler, Emrah"
  18. AU="Kim, Kyeong Bae"
  19. AU="Birindelli, S"
  20. AU="Monguió-Tortajada, Marta"
  21. AU="Kumta, Nikhil A"
  22. AU="Wu, Wenli"
  23. AU="Curland, Nele"
  24. AU="Redish, A David"
  25. AU="Patterson, Bradley"
  26. AU="Lombardi, Gianmarco"
  27. AU="Rassl, Doris"
  28. AU="Román, Pablo"

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  1. Artikel ; Online: Rapid detection of KPC-producing Enterobacterales by using a modified Carba NP test with imipenem/relebactam.

    Oviaño, Marina / Ramírez, Cecilia de la Luna / González-Bardanca, Mónica / Candela, Ana / Bou, Germán

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Band 40, Heft 10, Seite(n) 568–571

    Abstract: Introduction: Here, we propose a novel modified Carba NP test for detecting KPC-producing Enterobacterales using imipenem/relebactam.: Material and methods: The test performance was evaluated in a random selection of 160 previously molecularly ... ...

    Abstract Introduction: Here, we propose a novel modified Carba NP test for detecting KPC-producing Enterobacterales using imipenem/relebactam.
    Material and methods: The test performance was evaluated in a random selection of 160 previously molecularly characterized clinical isolates carrying the 110 bla
    Results: All class A producing Enterobacterales (111/111) were detected using imipenem/relebactam as no visual appreciation of color change was perceived due to a nule hydrolysis of imipenem in the antibiotic solution. Overall, the assay showed 100% sensitivity (111/111) and specificity (69/69) for detecting class A KPC-producing Enterobacterales.
    Discussion: The biochemical assay provides very reliable results for detecting KPC-producing Enterobacterales, with a turnaround time of less than 1 hour, minimum handling and no specialized equipment required.
    Mesh-Begriff(e) Gammaproteobacteria ; Imipenem/pharmacology ; Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds
    Chemische Substanzen relebactam (Y1MYA2UHFL) ; Imipenem (71OTZ9ZE0A) ; Anti-Bacterial Agents ; Azabicyclo Compounds
    Sprache Englisch
    Erscheinungsdatum 2022-11-01
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.03.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Rapid detection of KPC-producing Enterobacterales by using a modified Carba NP test with imipenem/relebactam.

    Oviaño, Marina / Ramírez, Cecilia de la Luna / González-Bardanca, Mónica / Candela, Ana / Bou, Germán

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2021  

    Abstract: Introduction: Here, we propose a novel modified Carba NP test for detecting KPC-producing Enterobacterales using imipenem/relebactam.: Material and methods: The test performance was evaluated in a random selection of 160 previously molecularly ... ...

    Abstract Introduction: Here, we propose a novel modified Carba NP test for detecting KPC-producing Enterobacterales using imipenem/relebactam.
    Material and methods: The test performance was evaluated in a random selection of 160 previously molecularly characterized clinical isolates carrying the 110 bla
    Results: All class A producing Enterobacterales (111/111) were detected using imipenem/relebactam as no visual appreciation of color change was perceived due to a nule hydrolysis of imipenem in the antibiotic solution. Overall, the assay showed 100% sensitivity (111/111) and specificity (69/69) for detecting class A KPC-producing Enterobacterales.
    Discussion: The biochemical assay provides very reliable results for detecting KPC-producing Enterobacterales, with a turnaround time of less than 1 hour, minimum handling and no specialized equipment required.
    Sprache Spanisch
    Erscheinungsdatum 2021-04-15
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimc.2021.03.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: Rapid direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples by MALDI-TOF MS analysis.

    Oviaño, Marina / Ramírez, Cecilia de la Luna / Barbeyto, Luis Pedro / Bou, Germán

    The Journal of antimicrobial chemotherapy

    2017  Band 72, Heft 5, Seite(n) 1350–1354

    Abstract: Objectives: Development of an automated MALDI-TOF MS-based method for the rapid, direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples within 90 min of sample reception.: Methods: A total of 3041 urine samples were ... ...

    Abstract Objectives: Development of an automated MALDI-TOF MS-based method for the rapid, direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples within 90 min of sample reception.
    Methods: A total of 3041 urine samples were processed by flow cytometry, and a cut-off value of ≥1.5 × 10 5 bacteria/mL was used to select samples for the study. Following these criteria, 608 samples were selected for direct bacterial identification. Detection of carbapenemase activity by MALDI-TOF MS analysis was only performed after reliable direct identification of Gram-negative bacilli. A novel protocol was developed for extracting bacteria from urine samples by using the Sepsityper Kit (Bruker Daltonik, Germany). Carbapenem resistance was detected with imipenem as an antibiotic marker and the results were automatically interpreted using the STAR-BL module of MALDI-TOF Biotyper Compass software (Bruker Daltonik, Germany).
    Results: The MALDI-TOF MS-based assay yielded direct reliable identification of 91% (503/553) of the samples. The assay showed 100% sensitivity (30/30) and specificity (454/454) for detecting carbapenemase activity within 90 min of sample reception. Isolates included in the study were further characterized by PCR and sequencing, and bla OXA-48 was detected from all isolates that tested positive in the MALDI-TOF MS-based resistance assay.
    Conclusions: The proposed protocol for the direct analysis of urine samples by MALDI-TOF MS is suitable for use in clinical laboratories to identify bacteria and detect carbapenemase activity, thus saving at least 24-48 h relative to current routine methods.
    Sprache Englisch
    Erscheinungsdatum 2017-05-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkw579
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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