LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 85

Search options

  1. Article ; Online: The relationship between inguinal hernia and minimally-invasive surgery for prostate cancer: A systematic review of the literature.

    Bertolo, R / Mir Maresma, M C / Bove, P / Rubio-Briones, J / Ramírez-Backhaus, M

    Actas urologicas espanolas

    2020  Volume 44, Issue 3, Page(s) 131–138

    Abstract: Objective: We aimed to perform a systematic review about the relationship between inguinal hernia and surgery for prostate cancer.: Background: Diagnosis of abdominal wall defects and prostate cancer may be either synchronous or metachronous. The ... ...

    Title translation La relación entre hernia inguinal y cirugía mínimamente invasiva para el cáncer de próstata: revisión sistemática de la literatura.
    Abstract Objective: We aimed to perform a systematic review about the relationship between inguinal hernia and surgery for prostate cancer.
    Background: Diagnosis of abdominal wall defects and prostate cancer may be either synchronous or metachronous. The convenience and safety of combined prostatectomy and hernioplasty, the incidence of hernias after prostatectomy and the feasibility of prostatectomy in patients with previous laparoscopic hernioplasty are still debated.
    Methods: PubMed and Embase were queried by dedicated search strings. Two researchers independently reviewed the pooled references and selected the articles of interest, including reviews.
    Results: Sixty-five studies were evaluated, 22 of them analysed the feasibility and the outcomes of a combined surgery, namely one-stage radical prostatectomy and herniorrhaphy or hernioplasty. Literature evidences support the combined intervention to patients suffering from an inguinal hernia and a prostate cancer amenable of radical prostatectomy. Sixteen studies addressing the potential increase in the occurrence of inguinal hernia after radical prostatectomy were evaluated. Approximately 15% of patients who undergo retro-pubic radical prostatectomy will develop inguinal hernia. It is suggested that the incidence might be lower in laparoscopic prostatectomy series, particularly in case of transperitoneal approach. The median time to the appearance of the hernia is around 6 months. After evaluation of 14 studies, it is concluded that laparoscopic hernioplasty does not preclude prostatectomy but hinders further pelvic surgery.
    Conclusions: One-stage combined hernioplasty and radical prostatectomy may be accepted except in cases of lymph-nodes dissection and/or positive hydro-distress test of the urethro-vesical anastomosis. Accurate patient's counselling and dedicated consent form are mandatory, in the setting of an experienced multidisciplinary team.
    MeSH term(s) Hernia, Inguinal/complications ; Hernia, Inguinal/epidemiology ; Hernia, Inguinal/surgery ; Herniorrhaphy/methods ; Humans ; Incidence ; Laparoscopy ; Male ; Postoperative Complications/epidemiology ; Prostatectomy/methods ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/surgery
    Language Spanish
    Publishing date 2020-02-10
    Publishing country Spain
    Document type Journal Article ; Systematic Review
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuro.2019.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: European Association of Urology biochemical recurrence risk groups after radical prostatectomy: External validation and identification of independent risk factors for progression and death.

    Sopeña Sutil, R / Vázquez-Martul, D / De Pablos-Rodríguez, P / Peña Vallejo, E / Altez Fernández, C / Gómez-Ferrer Lozano, A / Téigell Tobar, J / Rollón Prieto, G / Coy García, A / Ramírez Backhaus, M / Chantada Abal, V / Rodríguez Antolín, A

    Actas urologicas espanolas

    2023  Volume 47, Issue 7, Page(s) 422–429

    Abstract: Background: The EAU proposed a progression and death risk classification in patients with biochemical recurrence after radical prostatectomy (PR).: Objective: To validate the EAU BCR-risk classification in our setting and to find factors related to ... ...

    Abstract Background: The EAU proposed a progression and death risk classification in patients with biochemical recurrence after radical prostatectomy (PR).
    Objective: To validate the EAU BCR-risk classification in our setting and to find factors related to progression and death.
    Material and methods: Multicenter, retrospective, observational study including 2140 patients underwent RP between 2011 and 2015. Patients with BCR were identified and stratified in low risk (PSA-DT >1yr and pGS <8) or high-risk (PSA-DT ≤1yr or pGS ≥8) grouping. PSA and metastatic free survival (PSA-PFS, MFS), cancer specific survival (CSS) and overall survival (OS) were calculated (Kaplan Meier curves and log-rank test). Independent risk factors were identified (Cox regression).
    Results: 427 patients experienced BCR (32.3% low-risk and 67.7% high-risk). Median PSA-PFS was 135,0 mo (95% CI 129,63-140,94) and 115,0 mo (95% CI 104,02-125,98) (p<0,001), for low and high-risk groups, respectively. There were also significant differences in MFS and OS. The EAU BCR risk grouping was independent factor for PSA-progression (HR 2.55, p 0.009). Time from PR to BCR, was an independent factor for metastasis onset (HR 0.43, 95% CI 0.18-0.99; p 0.044) and death (HR 0.17, 95% CI 0.26.0.96; 23 p 0.048). Differences in MFS (p 0.001) and CSS (p 0.004) were found for <12, ≥12-<36 and ≥36 months from PR to BCR. Others independent factors were early salvage radiotherapy and PSA at BCR.
    Conclusions: High-risk group is a prognostic factor for biochemical progression, but it has a limited accuracy on MP and death in our setting. The inclusion of other factors could increase its predictive power.
    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen ; Retrospective Studies ; Urology ; Risk Factors ; Prostatectomy/adverse effects
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language Spanish
    Publishing date 2023-02-04
    Publishing country Spain
    Document type Observational Study ; Multicenter Study ; Journal Article
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Stereotactic body radiation therapy in patients with metachronous oligorecurrent prostate cancer: A single-center experience.

    de Pablos-Rodríguez, P / la Rosa, A / Rebez, G / Mascarós Martínez, J M / González Pérez, V / Arribas Alpuente, L / Rubio-Briones, J / Ramírez-Backhaus, M

    Actas urologicas espanolas

    2022  Volume 46, Issue 4, Page(s) 238–244

    Abstract: Introduction and objective: Metachronous oligorecurrence in prostate cancer (PCa) occurs in patients with localized disease who, after failed radical treatment, develop oligometastases. Metastasis-directed stereotactic radiotherapy (SBRT) aims to delay ... ...

    Abstract Introduction and objective: Metachronous oligorecurrence in prostate cancer (PCa) occurs in patients with localized disease who, after failed radical treatment, develop oligometastases. Metastasis-directed stereotactic radiotherapy (SBRT) aims to delay androgen deprivation therapy. In this study, we report our experience to elucidate the role of SBRT in a selected population of patients with metachronous oligorecurrence.
    Material and methods: Retrospective analysis of patients treated with SBRT for oligorecurrent PCa between November 2015 and December 2020. We detailed clinicopathological characteristics at disease onset (age, PSA, stage, primary treatment), clinical scenario at diagnosis of oligorecurrence (PSA, PSA velocity, metastases characteristics), progression-free survival, castration resistance-free survival, dose, and toxicity of SBRT.
    Results: Thirty-eight SBRT treatments were applied to 13 lymph node and 25 bone metastases in a total of 28 patients. After a follow-up of 34.57 months (21.17-57.59), 17 patients had radiological progression of the disease and 11 presented castration resistant PCa. PFS and CRFS were 21.93 and 44.13 months, respectively. Only 2 patients presented grade 1 toxicity.
    Conclusions: In patients with metachronous oligorecurrent PCa, SBRT constitutes a safe and effective treatment that allows delaying the onset of androgen deprivation therapy and the time to castration resistance, assuming low levels of toxicity.
    MeSH term(s) Androgen Antagonists/therapeutic use ; Androgens/therapeutic use ; Humans ; Male ; Neoplasm Recurrence, Local/radiotherapy ; Prostate-Specific Antigen ; Prostatic Neoplasms/pathology ; Radiosurgery/adverse effects ; Retrospective Studies
    Chemical Substances Androgen Antagonists ; Androgens ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language Spanish
    Publishing date 2022-03-20
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2021.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Is Unilateral Lymphadenectomy an Option in Selected Patients with Prostate Cancer?

    Kassab, Baraa Nakdali / De Pablos-Rodríguez, Pedro / Ferrer, Álvaro Gómez / García, Antonio Coy / Fons, Ana Calatrava / Aragón, Fuensanta / Ramón-Borja, Juan Casanova / Ramírez-Backhaus, Miguel

    Archivos espanoles de urologia

    2024  Volume 77, Issue 2, Page(s) 129–134

    Abstract: Background: Evidence regarding the relationship between the laterality of lymph node invasion (LNI) and the prostatic lobe affected is limited. Our aim was to review our records of patients with exclusively unilateral localised prostate cancer (PCa) ... ...

    Abstract Background: Evidence regarding the relationship between the laterality of lymph node invasion (LNI) and the prostatic lobe affected is limited. Our aim was to review our records of patients with exclusively unilateral localised prostate cancer (PCa) with metastatic LN involvement.
    Methods: Between 2006 and 2023, after radical prostatectomy and extended pelvic lymphadenectomy at our centre, thirty patients with intermediate-high risk unilateral PCa and pN1 disease were identified. To perform a retrospective study, data were obtained from a prospective collected database approved by the ethical committee at the Valencian Oncology Institute Foundation. Descriptive and comparative statistical analysis was made using software R. The Fisher's Exact test was employed to analyse the categorical variables. In terms of continuous variables, both tumour volume and number of nodes retrieved exhibited normality; Hence Student's
    Results: The median age and prostate specific antigen (PSA) at diagnosis were 66 years old (interquartile range (IQR): 63.3-70.9) and 14.6 ng/mL (IQR: 7.4-21.5), respectively. Median follow-up time was 67 months (IQR: 35.9-92.9). Nineteen patients (63%) had a Gleason score of 7, and the rest had a Gleason score of 8-10. Most patients (73%) had locally advanced disease. Baseline characteristics were comparable between groups (
    Conclusions: In our experience, the majority of patients with unilateral PCa had exclusively ipsilateral LNI. However, sparing contralateral LN dissection in unilateral PCa should not be an option. To date, extended pelvic LN dissection remains the gold standard for N-staging and cannot be replaced yet by unilateral pelvic LN dissection until high quality evidence supports this scenario.
    MeSH term(s) Male ; Humans ; Aged ; Retrospective Studies ; Prospective Studies ; Lymphatic Metastasis ; Lymph Node Excision ; Prostatic Neoplasms/diagnosis ; Prostatectomy
    Language English
    Publishing date 2024-04-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 211673-x
    ISSN 0004-0614
    ISSN 0004-0614
    DOI 10.56434/j.arch.esp.urol.20247702.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1312: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Does active surveillance avoid overtreatment in prostate cancer? Lessons learned from salvage radical prostatectomies.

    Polo Alonso, E / Ramírez-Backhaus, M / Wei, G / Mascarós, J M / Aragón Rodriguez, F / Gómez-Ferrer, Á / Collado, A / Calatrava Fons, A / Rubio-Briones, J

    Actas urologicas espanolas

    2021  Volume 45, Issue 5, Page(s) 373–382

    Abstract: Objective: Determine whether our institution´s active surveillance (AS) protocol is a suitable strategy to minimise prostate cancer overtreatment.: Material and methods: Retrospective analysis of 516 patients on AS after prostate cancer diagnosis. ... ...

    Abstract Objective: Determine whether our institution´s active surveillance (AS) protocol is a suitable strategy to minimise prostate cancer overtreatment.
    Material and methods: Retrospective analysis of 516 patients on AS after prostate cancer diagnosis. Population divided into "per-protocol" vs "induced" AS depending on fulfilment of protocol´s inclusion criteria. Radical prostatectomies after AS were selected and stratified based on: reclassification, progression or patient anxiety. Clinicopathological features and biochemical relapse-free survival were studied. Primary endpoint was overtreatment ratio based on the presence of insignificant prostate cancer and adverse pathological features in the surgical specimen. Kaplan-Meier curves were used to estimate the biochemical relapse-free survival and compared with log-rank test.
    Results: 304 patients fulfilled inclusion criteria; 100 proceeded to radical prostatectomy (31% "induced", 69% "per-protocol" AS). Surgery indications were reclassification, progression and anxiety in 66%, 18% and 16% of patients respectively. Rate of positive lymph nodes was higher in the progression group (11%) compared to reclassification and anxiety (5% and 0% respectively, P = .002). Positive surgical margins were more frequently reported in the progression cohort compared to reclassification (28% vs 20%). Median follow-up from diagnosis until last radical prostatectomy was 48.3 months (32.4-70). 3 year biochemical relapse-free survival in the salvage radical prostatectomy was 85.4% (95 CI 78.3-93.2). Insignificant cancer was noticed in 7% of patients (Epstein´s vs 24% Wolters´ criteria). Rate of patients with adverse pathological features was 36%.
    Conclusions: The majority of patients who underwent salvage surgery after AS were not overtreated. Radical prostatectomy should be considered a safe rescue treatment.
    MeSH term(s) Humans ; Male ; Medical Overuse ; Prostatectomy ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Watchful Waiting
    Language Spanish
    Publishing date 2021-05-20
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2021.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Radiation therapy for oligorecurrence in prostate cancer. Preliminary results of our centre.

    González Ruiz de León, C / Ramírez Backhaus, M / Sobrón Bustamante, M / Casaña, J / Arribas, L / Rubio-Briones, J

    Actas urologicas espanolas

    2017  Volume 41, Issue 10, Page(s) 646–651

    Abstract: Introduction and objective: There is growing interest in the use of more aggressive therapeutic modalities for treating metastatic prostate cancer. In this study, we examine the use of stereotactic body radiation therapy (SBRT) for patients with ... ...

    Title translation Radioterapia para la oligorrecurrencia en cáncer de próstata. Resultados preliminares en nuestro centro.
    Abstract Introduction and objective: There is growing interest in the use of more aggressive therapeutic modalities for treating metastatic prostate cancer. In this study, we examine the use of stereotactic body radiation therapy (SBRT) for patients with oligorecurrent prostate cancer. We analysed the biochemical response and toxicity of patients who underwent this therapy at our centre.
    Material and method: We selected patients who experienced oligorecurrence between January 2015 to December 2016 and were administered SBRT. The association of androgen deprivation (AD) was left in each case to the decision of the tumour committee. We describe the clinical situation at diagnosis of oligorecurrence, the treatment administered and the biochemical response. We considered a biochemical response to be a 50% reduction in the absolute prostate-specific antigen (PSA) readings.
    Results: SBRT was administered to 11 patients with bone (82%) and/or lymph node oligometastasis (18%). The treatment regimen for bone oligometastasis was 27Gy divided into 3 sessions, while the treatment for lymph node oligometastasis reached 70Gy. Seven patients had no treatment at the time of diagnosis, 2 were in the castration-resistant phase, 1 patient was in the off phase of intermittent AD, and 1 patient had adjuvant AD for pN1. Seven patients presented a biochemical response with a PSA reduction of 75-100%. The response was not assessable in 4 patients due to the continuing adjuvant AD. With a mean follow-up of 10.5 months, only 2 patients had progressed. Grade 1 gastrointestinal toxicity was detected in only 1 patient.
    Conclusion: Our data suggest that the use of SBRT in carefully selected patients with metastatic oligorecurrence of prostate cancer can achieve biochemical response and potentially delay progression and the use of systemic treatments.
    MeSH term(s) Aged ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/radiotherapy ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/radiotherapy ; Radiosurgery/adverse effects ; Treatment Outcome
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language Spanish
    Publishing date 2017-07-21
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 604530-3
    ISSN 1699-7980 ; 0210-4806
    ISSN (online) 1699-7980
    ISSN 0210-4806
    DOI 10.1016/j.acuro.2017.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1621: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Sentinel Lymph Node Biopsy in Prostate Cancer: An Overview of Diagnostic Performance, Oncological Outcomes, Safety, and Feasibility.

    Rossin, Giulio / Zorzi, Federico / De Pablos-Rodríguez, Pedro / Biasatti, Arianna / Marenco, Josè / Ongaro, Luca / Perotti, Alessandro / Tulone, Gabriele / Traunero, Fabio / Piasentin, Andrea / Gomez-Ferrer, Alvaro / Zucchi, Alessandro / Trombetta, Carlo / Simonato, Alchiede / Rubio-Briones, José / Bartoletti, Riccardo / Ramírez-Backhaus, Miguel / Claps, Francesco

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 15

    Abstract: Sentinel node biopsy (SNB) for prostate cancer (PCa) represents an innovative technique aimed at improving nodal staging accuracy. The routinary adoption of this procedure in patients undergoing radical prostatectomy (RP) might be crucial to identify ... ...

    Abstract Sentinel node biopsy (SNB) for prostate cancer (PCa) represents an innovative technique aimed at improving nodal staging accuracy. The routinary adoption of this procedure in patients undergoing radical prostatectomy (RP) might be crucial to identify candidates who could effectively benefit from extensive pelvic lymph nodal dissection (ePLND). Despite some promising results, SNB for PCa is still considered experimental due to the lack of solid evidence and procedural standardization. In this regard, our narrative review aimed to analyze the most recent literature in this field, providing an overview of both the diagnostic accuracy measures and the oncological outcomes of SNB.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13152543
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Enzalutamide and Quality of Life in Biochemically Recurrent Prostate Cancer.

    Freedland, Stephen J / Gleave, Martin / De Giorgi, Ugo / Rannikko, Antti / Pieczonka, Christopher M / Tutrone, Ronald F / Venugopal, Balaji / Woo, Henry H / Ramirez-Backhaus, Miguel / Supiot, Stephane / Lantz, Anna / Ganguli, Arijit / Ivanova, Jasmina / Kral, Pavol / Huang, Shu-Pin / Saad, Fred / Shore, Neal D

    NEJM evidence

    2023  Volume 2, Issue 12, Page(s) EVIDoa2300251

    Abstract: Enzalutamide and Quality of Life in Prostate CancerFreedland et al. present the health-related quality of life outcomes for patients with biochemically recurrent prostate cancer who were randomly assigned to enzalutamide plus leuprolide, enzalutamide ... ...

    Abstract Enzalutamide and Quality of Life in Prostate CancerFreedland et al. present the health-related quality of life outcomes for patients with biochemically recurrent prostate cancer who were randomly assigned to enzalutamide plus leuprolide, enzalutamide monotherapy, or leuprolide alone (EMBARK trial). The key objectives were to determine differences in time to first and confirmed clinically meaningful deterioration in pain and time to first and confirmed clinically meaningful deterioration in functional status. There were no differences among the key outcomes among all three groups.
    MeSH term(s) Male ; Humans ; Quality of Life ; Leuprolide ; Prostatic Neoplasms, Castration-Resistant/chemically induced ; Phenylthiohydantoin/adverse effects ; Benzamides ; Nitriles
    Chemical Substances enzalutamide (93T0T9GKNU) ; Leuprolide (EFY6W0M8TG) ; Phenylthiohydantoin (2010-15-3) ; Benzamides ; Nitriles
    Language English
    Publishing date 2023-10-22
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDoa2300251
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Personalised indocyanine-guided lymphadenectomy for prostate cancer: a randomised clinical trial.

    de Pablos-Rodríguez, Pedro / Claps, Francesco / Rebez, Giacomo / Vidal Crespo, Natalia / Gómez-Ferrer, Álvaro / Mascarós, Juan Manuel / Collado Serra, Argimiro / Caltrava Fons, Ana / Rubio-Briones, José / Casanova Ramon Borja, Juan / Ramírez Backhaus, Miguel

    BJU international

    2023  Volume 132, Issue 5, Page(s) 591–599

    Abstract: Objectives: To study the safety and efficacy of a personalised indocyanine-guided pelvic lymph node dissection (PLND) against extended PLND (ePLND) during radical prostatectomy (RP).: Patients and methods: Patients who were candidates for RP and ... ...

    Abstract Objectives: To study the safety and efficacy of a personalised indocyanine-guided pelvic lymph node dissection (PLND) against extended PLND (ePLND) during radical prostatectomy (RP).
    Patients and methods: Patients who were candidates for RP and lymphadenectomy, with intermediate- or high-risk prostate cancer (PCa) according to the National Comprehensive Cancer Network guidelines, were enrolled in this randomised clinical trial. Randomisation was made 1:1 to indocyanine green (ICG)-PLND (only ICG-stained LNs) or ePLND (obturator fossa, external, internal, and common iliac and presacral LNs). The primary endpoint was the complication rate within 3 months after RP. Secondary endpoints included: rate of major complications (Clavien-Dindo Grade III-IV), time to drainage removal, length of stay, percentage of patients classified as pN1, number of LNs removed, number of metastatic LNs, rate of patients with undetectable prostate-specific antigen (PSA), biochemical recurrence (BCR)-free survival, and rate of patients with androgen-deprivation therapy at 24 months.
    Results: A total of 108 patients were included with a median follow-up of 16 months. In all, 54 were randomised to ICG-PLND and 54 to ePLND. The postoperative complication rate was higher in the ePLND (70%) vs the ICG-PLND group (32%) (P < 0.001). Differences between major complications in both groups were not statically significant (P = 0.7). The pN1 detection rate was higher in the ICG-PLND group (28%) vs the ePLND group (22%); however, this difference was not statistically significant (P = 0.7). The rate of undetectable PSA at 12 months was 83% in the ICG-PLND vs 76% in the ePLND group, which was not statistically significant. Additionally, there were no statistically significant differences in BCR-free survival between groups at the end of the analysis.
    Conclusions: Personalised ICG-guided PLND is a promising technique to stage patients with intermediate- and high-risk PCa properly. It has shown a lower complication rate than ePLND with similar oncological outcomes at short-term follow-up.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen ; Androgen Antagonists ; Lymphatic Metastasis ; Lymph Node Excision/adverse effects ; Lymph Node Excision/methods ; Pelvis/surgery ; Prostatectomy/adverse effects ; Prostatectomy/methods
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; Androgen Antagonists
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 13: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Prognostic Impact of Sarcopenia in Patients with Advanced Prostate Carcinoma: A Systematic Review.

    de Pablos-Rodríguez, Pedro / Del Pino-Sedeño, Tasmania / Infante-Ventura, Diego / de Armas-Castellano, Aythami / Ramírez Backhaus, Miguel / Ferrer, Juan Francisco Loro / de Pablos-Velasco, Pedro / Rueda-Domínguez, Antonio / Trujillo-Martín, María M

    Journal of clinical medicine

    2022  Volume 12, Issue 1

    Abstract: Prostate cancer (PCa) is the second most common cancer in men and the fifth leading cause of death from cancer. The possibility of sarcopenia being a prognostic factor in advanced PCa patients has recently become a subject of interest. The aim of the ... ...

    Abstract Prostate cancer (PCa) is the second most common cancer in men and the fifth leading cause of death from cancer. The possibility of sarcopenia being a prognostic factor in advanced PCa patients has recently become a subject of interest. The aim of the present study was to evaluate the prognostic value of sarcopenia in advanced prostate carcinoma. A systematic review was conducted in Medline, EMBASE, and Web of Science (March, 2021). The quality of studies was assessed using the Quality in Prognosis Studies tool. Meta-analyses for overall, cancer-specific, and progression-free survival were performed. Nine studies (n = 1659) were included. Sarcopenia was borderline associated with a shorter overall survival (HR = 1.20, 95% CI: 1.01, 1.44, P = 0.04, I2 = 43%) but was significantly associated with progression-free survival (HR = 1.61, 95% CI: 1.26, 2.06, P < 0.01; k = 3; n = 588). Available evidence supports sarcopenia as an important prognostic factor of progression-free survival in patients with advanced PCa. However, sarcopenia has a weak association with a shorter overall survival. The evidence on the role of sarcopenia in prostate-cancer-specific survival is insufficient and supports the need for further research. Patient summary: The literature was reviewed to determine whether the loss of muscle mass (sarcopenia) affects the survival in patients with advanced PCa. Patients with advanced PCa and sarcopenia were found to have a shorter progression-free survival (the length of time during and after treatment of a cancer that the patient lives with the disease but it does not get worse), but sarcopenia did not have much influence on the overall survival and cancer-specific survival (the length of time from either the date of diagnosis or the start of treatment to the date of death due to the cancer).
    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12010057
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top