Article ; Online: Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection.
Human & experimental toxicology
2022 Volume 41, Page(s) 9603271211073708
Abstract: Current human immunodeficiency virus treatments need to be periodically administered lifelong. In this study we assess the effect of repeated doses of an anti-HIV peptide drug candidate in C57BL6 strain. Two schemes of up to 15 administrations and one of ...
| Abstract | Current human immunodeficiency virus treatments need to be periodically administered lifelong. In this study we assess the effect of repeated doses of an anti-HIV peptide drug candidate in C57BL6 strain. Two schemes of up to 15 administrations and one of 30, daily dosing for 5 days per week, all by the subcutaneous route were evaluated. Different dose concentrations of the peptide were assayed. CIGB-210 treated animals showed no symptoms or abnormal behavior as compared with placebo. All the animals gained weight during the study. Macroscopic evaluation showed no alterations in any of the organs studied. Microscopic analysis of the tissues did not show morphological changes in thymus, stomach, small and large intestines, kidney, brain, or cerebellum. The proliferative response of splenocytes and their capacity to secrete gamma interferon were not compromised by the repeated administration of CIGB-210. There were not statistically significant differences for any of the parameters evaluated during the study among treated and non-treated groups. We can conclude that CIGB-210 is well tolerated in C57BL6 mice in the dose concentration range explored and merits subsequent toxicological studies. |
|---|---|
| MeSH term(s) | Animals ; Anti-HIV Agents/therapeutic use ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Drugs, Investigational/therapeutic use ; Female ; HIV Infections/drug therapy ; Humans ; Mice ; Mice, Inbred C57BL ; Peptides/therapeutic use |
| Chemical Substances | Anti-HIV Agents ; Drugs, Investigational ; Peptides |
| Language | English |
| Publishing date | 2022-02-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1027454-6 |
| ISSN | 1477-0903 ; 0144-5952 ; 0960-3271 |
| ISSN (online) | 1477-0903 |
| ISSN | 0144-5952 ; 0960-3271 |
| DOI | 10.1177/09603271211073708 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1697: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.