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  1. Article ; Online: Infective endocarditis involving MitraClip

    Bertolino, Lorenzo / Ramadan, Mohammad Said / Zampino, Rosa / Durante-Mangoni, Emanuele

    Infection

    2023  Volume 51, Issue 5, Page(s) 1241–1248

    Abstract: Purpose: Progress of interventional cardiology has boosted the use of newer cardiac devices. These devices are perceived to be less prone to infections compared to traditional surgical prostheses, but little data are currently available. In this ... ...

    Abstract Purpose: Progress of interventional cardiology has boosted the use of newer cardiac devices. These devices are perceived to be less prone to infections compared to traditional surgical prostheses, but little data are currently available. In this systematic review (SR), we summarize current literature regarding the clinical characteristics, management, and outcomes of patients with MitraClip-related infective endocarditis (IE).
    Methods: We conducted a SR of PubMed, Google Scholar, Embase, and Scopus between January 2003 and March 2022. MitraClip-related IE was defined according to 2015 ESC criteria whereas MitraClip involvement as vegetation on the device or on the mitral valve. Risk of bias was assessed through standardized checklist and potential bias of underestimation cannot be excluded. Data regarding clinical presentation, echocardiography, management, and outcome were collected.
    Results: Twenty-six cases of MitraClip-related IE were retrieved. The median age of patients was 76 [61-83] years with a median EuroScore of 41%. Fever was present in 65.8% of patients followed by signs and symptoms of heart failure (42.3%). IE occurred early in 20 (76.9%) cases with a median time between MitraClip implantation and IE symptom onset of 5 [2-16] months. Staphylococcus aureus was the major causative microorganism (46%). Surgical mitral valve replacement was needed in 50% of patients. A conservative medical approach was considered in the remainder. The overall in-hospital mortality rate was 50% (surgical group: 38.4%; medical group: 58.3%; p = 0.433).
    Conclusion: Our results suggest that MitraClip-related IE affects elderly, comorbid patients, is mostly due to Staphylococcus aureus, and has a poor prognosis irrespective of the therapeutic approach. Clinicians must be aware of the features of this new entity among cardiovascular infections.
    MeSH term(s) Humans ; Aged ; Middle Aged ; Aged, 80 and over ; Heart Valve Prosthesis/adverse effects ; Treatment Outcome ; Endocarditis, Bacterial ; Endocarditis/diagnosis ; Endocarditis/etiology ; Mitral Valve ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02067-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  2. Article ; Online: Cardiac sequelae after coronavirus disease 2019 recovery: a systematic review.

    Ramadan, Mohammad Said / Bertolino, Lorenzo / Zampino, Rosa / Durante-Mangoni, Emanuele

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 9, Page(s) 1250–1261

    Abstract: Background: Coronavirus disease 2019 (COVID-19) has been implicated in a wide spectrum of cardiac manifestations following the acute phase of the disease.: Objectives: To assess the range of cardiac sequelae after COVID-19 recovery.: Data sources: ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has been implicated in a wide spectrum of cardiac manifestations following the acute phase of the disease.
    Objectives: To assess the range of cardiac sequelae after COVID-19 recovery.
    Data sources: PubMed, Embase, Scopus (inception through 17 February 2021) and Google scholar (2019 through 17 February 2021).
    Study eligibility criteria: Prospective and retrospective studies, case reports and case series.
    Participants: Adult patients assessed for cardiac manifestations after COVID-19 recovery.
    Exposure: Severe acute respiratory syndrome coronavirus 2 infection diagnosed by PCR.
    Methods: Systematic review.
    Results: Thirty-five studies (fifteen prospective cohort, seven case reports, five cross-sectional, four case series, three retrospective cohort and one ambidirectional cohort) evaluating cardiac sequelae in 52 609 patients were included. Twenty-nine studies used objective cardiac assessments, mostly cardiac magnetic resonance imaging (CMR) in 16 studies, echocardiography in 15, electrocardiography (ECG) in 16 and cardiac biomarkers in 18. Most studies had a fair risk of bias. The median time from diagnosis/recovery to cardiac assessment was 48 days (1-180 days). Common short-term cardiac abnormalities (<3 months) included increased T1 (proportion: 30%), T2 (16%), pericardial effusion (15%) and late gadolinium enhancement (11%) on CMR, with symptoms such as chest pain (25%) and dyspnoea (36%). In the medium term (3-6 months), common changes included reduced left ventricular global longitudinal strain (30%) and late gadolinium enhancement (10%) on CMR, diastolic dysfunction (40%) on echocardiography and elevated N-terminal proB-type natriuretic peptide (18%). In addition, COVID-19 survivors had higher risk (risk ratio 3; 95% CI 2.7-3.2) of developing heart failure, arrythmias and myocardial infarction.
    Conclusions: COVID-19 appears to be associated with persistent/de novo cardiac injury after recovery, particularly subclinical myocardial injury in the earlier phase and diastolic dysfunction later. Larger well-designed and controlled studies with baseline assessments are needed to better measure the extent of cardiac injury and its clinical impact.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Echocardiography ; Electrocardiography ; Heart Diseases/epidemiology ; Heart Diseases/etiology ; Humans ; Magnetic Resonance Imaging, Cine ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  3. Article: Interplay between Heart Disease and Metabolic Steatosis: A Contemporary Perspective.

    Ramadan, Mohammad Said / Russo, Vincenzo / Nigro, Gerardo / Durante-Mangoni, Emanuele / Zampino, Rosa

    Journal of clinical medicine

    2021  Volume 10, Issue 8

    Abstract: The liver-heart axis is a growing field of interest owing to rising evidence of complex bidirectional interplay between the two organs. Recent data suggest non-alcoholic fatty liver disease (NAFLD) has a significant, independent association with a wide ... ...

    Abstract The liver-heart axis is a growing field of interest owing to rising evidence of complex bidirectional interplay between the two organs. Recent data suggest non-alcoholic fatty liver disease (NAFLD) has a significant, independent association with a wide spectrum of structural and functional cardiac diseases, and seems to worsen cardiovascular disease (CVD) prognosis. Conversely, the effect of cardiac disease on NAFLD is not well studied and data are mostly limited to cardiogenic liver disease. We believe it is important to further investigate the heart-liver relationship because of the tremendous global health and economic burden the two diseases pose, and the impact of such investigations on clinical decision making and management guidelines for both diseases. In this review, we summarize the current knowledge on NAFLD diagnosis, its systemic manifestations, and associations with CVD. More specifically, we review the pathophysiological mechanisms that govern the interplay between NAFLD and CVD and evaluate the relationship between different CVD treatments and NAFLD progression.
    Language English
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10081569
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  4. Article ; Online: Cardiac complications during the active phase of COVID-19: review of the current evidence.

    Ramadan, Mohammad Said / Bertolino, Lorenzo / Marrazzo, Tommaso / Florio, Maria Teresa / Durante-Mangoni, Emanuele

    Internal and emergency medicine

    2021  Volume 16, Issue 8, Page(s) 2051–2061

    Abstract: Growing reports since the beginning of the pandemic and till date describe increased rates of cardiac complications (CC) in the active phase of coronavirus disease 2019 (COVID-19). CC commonly observed include myocarditis/myocardial injury, arrhythmias ... ...

    Abstract Growing reports since the beginning of the pandemic and till date describe increased rates of cardiac complications (CC) in the active phase of coronavirus disease 2019 (COVID-19). CC commonly observed include myocarditis/myocardial injury, arrhythmias and heart failure, with an incidence reaching about a quarter of hospitalized patients in some reports. The increased incidence of CC raise questions about the possible heightened susceptibility of patients with cardiac disease to develop severe COVID-19, and whether the virus itself is involved in the pathogenesis of CC. The wide array of CC seems to stem from multiple mechanisms, including the ability of the virus to directly enter cardiomyocytes, and to indirectly damage the heart through systemic hyperinflammatory and hypercoagulable states, endothelial injury of the coronary arteries and hypoxemia. The induced CC seem to dramatically impact the prognosis of COVID-19, with some studies suggesting over 50% mortality rates with myocardial damage, up from ~ 5% overall mortality of COVID-19 alone. Thus, it is particularly important to investigate the relation between COVID-19 and heart disease, given the major effect on morbidity and mortality, aiming at early detection and improving patient care and outcomes. In this article, we review the growing body of published data on the topic to provide the reader with a comprehensive and robust description of the available evidence and its implication for clinical practice.
    MeSH term(s) Arrhythmias, Cardiac/etiology ; COVID-19/complications ; COVID-19/therapy ; COVID-19 Testing ; Disease Management ; Heart Diseases/complications ; Heart Diseases/etiology ; Heart Diseases/therapy ; Humans ; Myocarditis/etiology ; Prognosis ; Risk Factors
    Language English
    Publishing date 2021-05-27
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02763-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
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  5. Article: Cardiovascular Risk in Patients with Chronic Hepatitis C Treated with Direct Acting Antivirals.

    Ramadan, Mohammad Said / Boccia, Filomena / Moretto, Simona Maria / De Gregorio, Fabrizio / Gagliardi, Massimo / Iossa, Domenico / Durante-Mangoni, Emanuele / Zampino, Rosa

    Journal of clinical medicine

    2022  Volume 11, Issue 19

    Abstract: Background: Chronic hepatitis C (CHC) is associated with hepatic and extrahepatic complications, including cardiovascular disease (CVD). The effects of sustained virological response (SVR) and liver fibrosis on CVD risk are not well established. Aims: We ...

    Abstract Background: Chronic hepatitis C (CHC) is associated with hepatic and extrahepatic complications, including cardiovascular disease (CVD). The effects of sustained virological response (SVR) and liver fibrosis on CVD risk are not well established. Aims: We aim to assess the dynamics of Fibrosis-4 (FIB-4) and Atherosclerotic Cardiovascular Disease 2013 (ASCVD) scores up to three years after direct acting antivirals (DAA) treatment and explore the time-dependent association between the two scores. Methods: We included consecutive CHC patients treated with DAA and followed up with them for three years. Outcomes were changes from baseline (before DAA) in ASCVD and FIB-4 scores, measured at the end of treatment, 12-, 24-, and 36-months follow-up. Results: In total, 91 patients with CHC were finally included (median age: 66 years (IQR = 58−72 years); 43% females). Median follow-up was 2 years (1−3 years) and all patients reached SVR. The ASCVD score did not significantly change from baseline (Mean = 17.2%, 95% CI 14.1, 20.3), but the FIB-4 score significantly decreased at any time-point by an average of 0.8 (95% CI 0.78, 0.82, p < 0.001). Elevated FIB-4 scores at one (β = 1.16, p < 0.001) and three years (β = 2.52, p < 0.001) were associated with an increased ASCVD score. Clinically, two participants- with non-decreasing FIB-4 scores after treatment- had acute coronary syndrome at the end of treatment and one year follow-up, respectively. Conclusions: In our study, we found that FIB-4 and ASCVD scores exhibited a positive correlation irrespective of time-point after treatment. Larger studies are essential to further investigate the utility of FIB-4 scores in cardiovascular risk assessment.
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11195781
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  6. Article ; Online: Features of infective endocarditis in a contemporary cohort of persons who inject drugs: a matched comparison analysis of long-term prognostic factors.

    Ramadan, Mohammad Said / Bertolino, Lorenzo / Boccia, Filomena / Hamieh, Mahmoud / Peluso, Anna Maria / Gallo, Raffaella / Patauner, Fabian / De Santo, Luca Salvatore / Carozza, Antonio / Zampino, Rosa / Durante-Mangoni, Emanuele

    Internal and emergency medicine

    2023  Volume 19, Issue 2, Page(s) 455–464

    Abstract: The objective of the study was to assess the short- and long-term mortality of infective endocarditis (IE) among people who inject drugs (PWID). Using prospectively collected data on hospitalized patients (years 2000 through 2021) with IE, PWID were ... ...

    Abstract The objective of the study was to assess the short- and long-term mortality of infective endocarditis (IE) among people who inject drugs (PWID). Using prospectively collected data on hospitalized patients (years 2000 through 2021) with IE, PWID were identified and included in this study. Survival analysis was performed to analyze short- and long-term mortality and study their risk factors among PWID and a matched group of non-intravenous drug users (N-IDU). In a study of 485 patients admitted for IE, 55 (11%) of them were PWID. These PWID patients were 1:1 age- and sex- matched to an N-IDU group (N = 55 per group). Both groups had similar baseline comorbid conditions, including congestive heart failure, type 2 diabetes, and neoplastic diseases. However, PWID were more likely to have HCV co-infection (62% vs 16%, respectively, p < 0.001) and advanced liver disease/cirrhosis (52% vs 7.9%, respectively, p < 0.001). IE in PWID more often affected the tricuspid valve (42% vs 22%, respectively, p = 0.024) and presented with more embolic events (66% vs 35%, respectively, p < 0.01). S. aureus was the primary cause of IE in PWID (44% vs 21%, respectively, p = 0.01). After adjusting for other variables, PWID (HR = 2.99, 95% CI [1.06, 8.43], p = 0.038) and valve bioprosthetic replacement (HR = 5.37, 95% CI [1.3, 22.1], p = 0.02) were independently associated with increased mortality risk, whereas IE caused by tricuspid valve infection was associated with reduced mortality risk (HR = 0.25, 95% CI [0.06, 0.97], p = 0.046). In this cohort, PWID had increased risk of long-term mortality after hospital discharge for IE, when compared to matched N-IDU with similar baseline characteristics. The reasons behind the significant increase in mortality warrant further investigation.
    MeSH term(s) Humans ; Drug Users ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; Diabetes Mellitus, Type 2/complications ; Staphylococcus aureus ; Prognosis ; Endocarditis/etiology ; Endocarditis/complications ; Hepatitis C/complications ; Retrospective Studies ; Endocarditis, Bacterial/etiology ; Endocarditis, Bacterial/complications
    Language English
    Publishing date 2023-12-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03502-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Dalbavancin treatment for spondylodiscitis: multi-center clinical experience and literature review.

    Ramadan, Mohammad Said / Gallo, Raffaella / Lugarà, Marina / Gambardella, Michele / Oliva, Gabriella / Bertolino, Lorenzo / Andini, Roberto / Coppola, Nicola / Zampino, Rosa / Durante-Mangoni, Emanuele

    Journal of chemotherapy (Florence, Italy)

    2021  Volume 34, Issue 6, Page(s) 360–366

    Abstract: Dalbavancin is a novel lipoglycopeptide antibiotic, characterized by a broad spectrum of activity against Gram-positive cocci. However, its efficacy in spondylodiscitis treatment is not fully established. All adult patients diagnosed with ... ...

    Abstract Dalbavancin is a novel lipoglycopeptide antibiotic, characterized by a broad spectrum of activity against Gram-positive cocci. However, its efficacy in spondylodiscitis treatment is not fully established. All adult patients diagnosed with spondylodiscitis and treated with dalbavancin were included across four Italian medical centers from January 2018 to April 2021. We collected clinical and laboratory data, and presented follow-up findings along with a thorough literature review. 13 patients (mean age= 65 years) were included in this study. Dalbavancin was administered as first line treatment in six (46%) of the patients. Reasons for using Dalbavancin included treatment simplification (62%) and clinical failure of previous antibiotics (23%). In general, Dalbavancin was well tolerated with minimal adverse events, and clinical success was achieved in 11/13 (85%) of the patients during hospitalization with additional antibiotics required in the remaining two cases. Five months after discharge, no mortality was observed, however, 42% of patients required additional antibiotics for signs of infection on follow-up imaging. Our study suggests that Dalbavancin could be an effective and safe option in treating spondylodiscitis, however, the scarcity of studies on the topic is concerning. Thus, further studies with large samples and long-term follow-up are warranted to compare the efficacy of Dalbavancin with other available treatment options.
    MeSH term(s) Adult ; Aged ; Anti-Bacterial Agents ; Discitis/chemically induced ; Discitis/drug therapy ; Humans ; Teicoplanin/analogs & derivatives ; Teicoplanin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Teicoplanin (61036-62-2) ; dalbavancin (808UI9MS5K)
    Language English
    Publishing date 2021-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2021.2015649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 387: Show issues

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