LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 98

Search options

  1. Book ; Online ; E-Book: Central nervous system metastases

    Ramakrishna, Rohan / Magge, Rajiv S. / Baaj, Ali A. / Knisely, Jonathan P. S.

    diagnosis and treatment

    2020  

    Author's details Rohan Ramakrishna, Rajiv S. Magge, Ali A. Baaj, Jonathan P. S. Knisely editors
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxv, 734 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020519948
    ISBN 978-3-030-42958-4 ; 9783030429577 ; 3-030-42958-X ; 3030429571
    DOI 10.1007/978-3-030-42958-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Radiosurgery and Immunotherapy in the Treatment of Brain Metastases.

    Ramakrishna, Rohan / Formenti, Silvia

    World neurosurgery

    2019  Volume 130, Page(s) 615–622

    Abstract: Radiation therapy represents a mainstay of treatment for patients with brain metastases. Recently, the widespread adoption of immune checkpoint blockade has led to keen interest in treating cancers with checkpoint inhibitors in place of, or as an adjunct ...

    Abstract Radiation therapy represents a mainstay of treatment for patients with brain metastases. Recently, the widespread adoption of immune checkpoint blockade has led to keen interest in treating cancers with checkpoint inhibitors in place of, or as an adjunct to, traditional chemotherapy. However, with the exception of melanoma, immune checkpoint blockade in solid tumors has failed to achieve significant brain control in patients with brain metastases. The possibility of combining immune checkpoint blockade with radiation for the treatment of brain and other metastases represents an exciting new strategy that is in its early stages of investigation. Success with this combinatorial strategy has the potential to result in enhanced rates of brain control, less brain exposure to radiation, and improved cognitive outcomes. In this review, we discuss the mechanisms behind this synergy, describe its limitations, and suggest ways to move the field forward.
    MeSH term(s) Brain Neoplasms/immunology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Combined Modality Therapy/methods ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Radiosurgery/methods ; Treatment Outcome
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.04.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Analysis of gliomas DNA methylation: Assessment of pre-analytical variables.

    Bomsztyk, Karol / Mar, Daniel / Denisenko, Oleg / Powell, Suzanne / Vishnoi, Monika / Delegard, Jennifer / Patel, Anoop / Ellenbogen, Richard G / Ramakrishna, Rohan / Rostomily, Robert

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Precision oncology is driven by molecular biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O6-methylguanine-DNA methyltransferase ( ...

    Abstract Precision oncology is driven by molecular biomarkers. For glioblastoma multiforme (GBM), the most common malignant adult primary brain tumor, O6-methylguanine-DNA methyltransferase (
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.26.586350
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Impact of Medicaid insurance on outcomes following endoscopic transsphenoidal pituitary surgery.

    Younus, Iyan / Gerges, Mina / Schwartz, Theodore H / Ramakrishna, Rohan

    Journal of neurosurgery

    2020  Volume 134, Issue 3, Page(s) 801–806

    Abstract: Objective: Despite the rise of studies in the neurosurgical literature suggesting that patients with Medicaid insurance have inferior outcomes, there remains a paucity of data on the impact of insurance on outcomes after endonasal endoscopic ... ...

    Abstract Objective: Despite the rise of studies in the neurosurgical literature suggesting that patients with Medicaid insurance have inferior outcomes, there remains a paucity of data on the impact of insurance on outcomes after endonasal endoscopic transsphenoidal surgery (EETS). Given the increasing importance of complications in quality-based healthcare metrics, the objective of this study was to assess whether Medicaid insurance type influences outcomes in EETS for pituitary adenoma.
    Methods: The authors analyzed a prospectively acquired database of EETS for pituitary adenoma from 2005 to 2018 at NewYork-Presbyterian Hospital, Weill Cornell Medicine. All patients with Medicaid insurance were identified. As a control group, the clinical, socioeconomic, and radiographic data of all other patients in the series with non-Medicaid insurance were reviewed. Statistical significance was determined with an alpha < 0.05 using Pearson chi-square and Fisher's exact tests for categorical variables and the independent-samples t-test for continuous variables.
    Results: Of 584 patients undergoing EETS for pituitary adenoma, 57 (10%) had Medicaid insurance. The maximum tumor diameter was significantly larger for Medicaid patients (26.1 ± 12 vs 23.1 ± 11 mm for controls, p < 0.05). Baseline comorbidities including diabetes mellitus, hypertension, smoking history, and BMI were not significantly different between Medicaid patients and controls. Patients with Medicaid insurance had a significantly higher rate of any complication (14% vs 7% for controls, p < 0.05) and long-term cranial neuropathy (5% vs 1% for controls, p < 0.05). There were no statistically significant differences in endocrine outcome or vision outcome. The mean postoperative length of stay was significantly longer for Medicaid patients compared to the controls (9.4 ± 31 vs 3.6 ± 3 days, p < 0.05). This difference remained significant even when accounting for outliers (5.6 ± 2.5 vs 3.0 ± 2.7 days for controls, p < 0.05). The most common causes of extended length of stay greater than 1 standard deviation for Medicaid patients were management of perioperative complications and disposition challenges. The rate of 30-day readmission was 7% for Medicaid patients and 4.4% for controls, which was not a statistically significant difference.
    Conclusions: The authors found that larger tumor diameter, longer postoperative length of stay, higher rate of complications, and long-term cranial neuropathy were significantly associated with Medicaid insurance. There were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
    MeSH term(s) Adenoma/surgery ; Adult ; Aged ; Body Mass Index ; Comorbidity ; Cranial Nerve Diseases/epidemiology ; Cranial Nerve Diseases/etiology ; Databases, Factual ; Endoscopy/economics ; Endoscopy/methods ; Female ; Humans ; Length of Stay ; Male ; Medicaid/statistics & numerical data ; Middle Aged ; Natural Orifice Endoscopic Surgery ; Neurosurgical Procedures/economics ; Neurosurgical Procedures/methods ; Nose ; Patient Readmission/economics ; Patient Readmission/statistics & numerical data ; Pituitary Neoplasms/surgery ; Postoperative Complications/economics ; Postoperative Complications/epidemiology ; Prospective Studies ; Sphenoid Bone/surgery ; Treatment Outcome ; United States ; Vision Disorders/epidemiology ; Vision Disorders/etiology
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2020.1.JNS192707
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.135: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Inpatient and outpatient case prioritization for patients with neuro-oncologic disease amid the COVID-19 pandemic: general guidance for neuro-oncology practitioners from the AANS/CNS Tumor Section and Society for Neuro-Oncology.

    Ramakrishna, Rohan / Zadeh, Gelareh / Sheehan, Jason P / Aghi, Manish K

    Journal of neuro-oncology

    2020  Volume 147, Issue 3, Page(s) 525–529

    Abstract: The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs ... ...

    Abstract The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for institutions and governments to help adjudicate treatment allocations to patients with neuro-oncologic disease.
    MeSH term(s) Betacoronavirus/isolation & purification ; Brain Neoplasms/therapy ; Brain Neoplasms/virology ; COVID-19 ; Central Nervous System Neoplasms/therapy ; Central Nervous System Neoplasms/virology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Disease Management ; Health Personnel/standards ; Humans ; Inpatients/statistics & numerical data ; Outpatients/statistics & numerical data ; Pandemics ; Personal Protective Equipment/standards ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Practice Guidelines as Topic/standards ; SARS-CoV-2 ; Societies, Medical
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-020-03488-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Neurosurgical Guidelines in a Medicolegal Minefield.

    Pannullo, Susan C / Ramakrishna, Rohan

    World neurosurgery

    2016  Volume 96, Page(s) 602–603

    MeSH term(s) Evidence-Based Medicine ; Humans ; Practice Guidelines as Topic
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.05.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The evolution of stereotactic radiosurgery in neurosurgical practice.

    Trifiletti, Daniel M / Ruiz-Garcia, Henry / Quinones-Hinojosa, Alfredo / Ramakrishna, Rohan / Sheehan, Jason P

    Journal of neuro-oncology

    2021  Volume 151, Issue 3, Page(s) 451–459

    Abstract: Introduction: Stereotactic radiosurgery (SRS) was born in an attempt to treat complex intracranial pathologies in a fashion whereby open surgery would create unnecessary or excessive risk. To create this innovation, it was necessary to harness advances ... ...

    Abstract Introduction: Stereotactic radiosurgery (SRS) was born in an attempt to treat complex intracranial pathologies in a fashion whereby open surgery would create unnecessary or excessive risk. To create this innovation, it was necessary to harness advances in other fields such as engineering, physics, radiology, and computer science.
    Methods: We review the history of SRS to provide context to today's current state, as well as guide future advancement in the field.
    Results: Since time of Lars Leksell, the young Swedish neurosurgeon who pioneered the development of the SRS, the collegial and essential partnership between neurosurgeons, radiation oncologists and physicists has given rise to radiosurgery as a prominent and successful tool in neurosurgical practice.
    Conclusion: We examine how neurosurgeons have helped foster the SRS evolution and how this evolution has impacted neurosurgical practice as well as that of radiation oncology and neuro-oncology.
    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Neurosurgeons ; Neurosurgery/history ; Neurosurgery/trends ; Neurosurgical Procedures/history ; Neurosurgical Procedures/trends ; Radiosurgery/history ; Radiosurgery/trends ; Sweden
    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-020-03392-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Beyond guidelines: analysis of current practice patterns of AANS/CNS tumor neurosurgeons.

    Bander, Evan D / Sherman, Jonathan H / Bettegowda, Chetan / Aghi, Manish K / Sheehan, Jason / Ramakrishna, Rohan

    Journal of neuro-oncology

    2021  Volume 151, Issue 3, Page(s) 361–366

    Abstract: Introduction: Evidence-based medicine guidelines are increasingly published and sanctioned by organized neurosurgery. However, implementation, interpretation, and use of clinical guidelines may vary substantially on a regional, national and ... ...

    Abstract Introduction: Evidence-based medicine guidelines are increasingly published and sanctioned by organized neurosurgery. However, implementation, interpretation, and use of clinical guidelines may vary substantially on a regional, national and international basis. Survey research can help bridge the gap by providing a snapshot of neurosurgeon attitudes, knowledge, and practices. The American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Section on Tumors formed a Survey Committee to formalize the process by which surveys are submitted and reviewed before distribution to our membership. The goal of this committee is to provide peer-review so that collected information will be scientifically robust and useful to the neurosurgical community.
    Methods: Surveys submitted to the AANS/CNS tumor section between 2015 and 2019 were reviewed and metrics such as response rate and publication status assessed.
    Results: Six surveys were submitted to the Survey Committee of the AANS/CNS section on tumors between 2015 and 2019. Four have been circulated to section members, of which three have been published. Response rate has averaged 19% (range 16-23%), a majority of respondents (mean 70%) practice in academic settings.
    Conclusions: The AANS/CNS Section on Tumors Survey Committee has and continues to help promote and improve the practice of surveying our community to answer important questions that can advance future training, research, and practice. There remains significant room for improvement in response rates, but ongoing tumor section efforts to increase member engagement will likely improve these numbers.
    MeSH term(s) Central Nervous System Neoplasms/surgery ; Evidence-Based Medicine ; Guidelines as Topic ; Humans ; Neurosurgeons ; Neurosurgery/standards ; Neurosurgical Procedures/standards ; Societies, Medical ; Surveys and Questionnaires
    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-020-03389-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Advances in Glioblastoma Operative Techniques.

    Bander, Evan D / Magge, Rajiv / Ramakrishna, Rohan

    World neurosurgery

    2018  Volume 116, Page(s) 529–538

    Abstract: Numerous studies have demonstrated the importance of gross total resection in improving patient survival in glioblastoma (GBM). Advances in surgical tools and techniques such as intra-operative imaging, fluorescent agents, and functional imaging ... ...

    Abstract Numerous studies have demonstrated the importance of gross total resection in improving patient survival in glioblastoma (GBM). Advances in surgical tools and techniques such as intra-operative imaging, fluorescent agents, and functional imaging sequences are allowing for better identification of tumor borders and vital eloquent cortex in order to safely achieve higher rates of complete resections. Furthermore, due to the limits of surgical resection alone, new minimally invasive techniques for treatment of GBM are under development. These advances are crucial for improving neurosurgical care and outcomes in this difficult patient population.
    MeSH term(s) Brain Neoplasms/surgery ; Glioblastoma/surgery ; Humans ; Monitoring, Intraoperative/methods ; Neuronavigation/methods ; Neurosurgical Procedures/methods ; Ultrasonography/methods
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Immunotherapy in Glioblastoma.

    Wilcox, Jessica A / Ramakrishna, Rohan / Magge, Rajiv

    World neurosurgery

    2018  Volume 116, Page(s) 518–528

    Abstract: Glioblastoma evades conventional therapies through a variety of mechanisms, including suppression of the immune system. This immunosuppressive microenvironment provides a potential target for treatment. There are several immunotherapies being actively ... ...

    Abstract Glioblastoma evades conventional therapies through a variety of mechanisms, including suppression of the immune system. This immunosuppressive microenvironment provides a potential target for treatment. There are several immunotherapies being actively investigated, including inhibition of immune checkpoint regulators, development of antitumor vaccinations from both dendritic cell and tumor peptide components, adoptive transfer of supercharged and durable T lymphocytes, and generation of oncolytic viruses. Although immunotherapy has already demonstrated efficacy for a variety of other malignancies, its efficacy in glioblastoma is still unclear. Identifying predictive biomarkers and improving the management of immune-related adverse effects will help to realize the full potential of these therapies.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Combined Modality Therapy/methods ; Dendritic Cells/drug effects ; Dendritic Cells/pathology ; Glioblastoma/drug therapy ; Glioblastoma/immunology ; Glioblastoma/pathology ; Humans ; Immunotherapy/methods ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top