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  1. Article ; Online: Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections.

    Ramakrishnan, Reshma / Singh, Ashish Kumar / Singh, Simran / Chakravortty, Dipshikha / Das, Debasis

    The Journal of biological chemistry

    2022  Volume 298, Issue 9, Page(s) 102352

    Abstract: Drug resistance by pathogenic microbes has emerged as a matter of great concern to mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms against drugs and the host immune system. A major line of microbial defense is the ... ...

    Abstract Drug resistance by pathogenic microbes has emerged as a matter of great concern to mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms against drugs and the host immune system. A major line of microbial defense is the biofilm, which comprises extracellular polymeric substances that are produced by the population of microorganisms. Around 80% of chronic bacterial infections are associated with biofilms. The presence of biofilms can increase the necessity of doses of certain antibiotics up to 1000-fold to combat infection. Thus, there is an urgent need for strategies to eradicate biofilms. Although a few physicochemical methods have been developed to prevent and treat biofilms, these methods have poor efficacy and biocompatibility. In this review, we discuss the existing strategies to combat biofilms and their challenges. Subsequently, we spotlight the potential of enzymes, in particular, polysaccharide degrading enzymes, for biofilm dispersion, which might lead to facile antimicrobial treatment of biofilm-associated infections.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Bacteria ; Biofilms ; Polysaccharides
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Polysaccharides
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chirally Twisted Ultrathin Polydopamine Nanoribbons: Synthesis and Spontaneous Assembly of Silver Nanoparticles on Them.

    Awasthi, Anand Kumar / Bhagat, Somnath D / Ramakrishnan, Reshma / Srivastava, Aasheesh

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2019  Volume 25, Issue 56, Page(s) 12905–12910

    Abstract: Polydopamine (PDA) is a synthetic polymeric material with immense potential in biomedical and surface functionalization applications. Herein, we have screened self-assemblies formed by Phenylalanine-based amphiphiles (Phe-AMPs) as soft templates for ... ...

    Abstract Polydopamine (PDA) is a synthetic polymeric material with immense potential in biomedical and surface functionalization applications. Herein, we have screened self-assemblies formed by Phenylalanine-based amphiphiles (Phe-AMPs) as soft templates for preparing chiral PDA nanostructures. Our study revealed that the amphiphile 2 endowed with a primary amine residue afforded chirally-twisted ultrathin nanoribbons of PDA under optimized conditions. The chirality at the Phe residue of 2 modulated the twist-chirality of the PDA nanoribbons; the l-2 resulted in nanoribbons with right-handed twist, whereas the d-2 induced a left-handed twist to the ribbons. The racemic mixture of these two amphiphiles produced flat, achiral tapes. The PDA ribbon thickness was ≈5.86±0.40 nm, whereas its width and length were ≈133.5±3.2 nm and >5000 nm, respectively. Upon dialysis, hollow PDA nanotubes were obtained due to curling of the PDA nanoribbons. These PDA-nanoarchitectures were employed to spontaneously form and assemble Ag-nanoparticles along the edges of the PDA nanoribbons. In this work we are reporting chirality controlled synthesis of PDA nanostructures for the first time.
    Language English
    Publishing date 2019-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201902600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficacy of rebamipide 2% ophthalmic solution in the treatment of dry eyes.

    Shrivastava, Saurabh / Patkar, Priyanka / Ramakrishnan, Reshma / Kanhere, Minal / Riaz, Zahna

    Oman journal of ophthalmology

    2018  Volume 11, Issue 3, Page(s) 207–212

    Abstract: Aim: The aim of this study is to evaluate the efficacy of 2% rebamipide ophthalmic solution on the tear functions and ocular surface status in patients with dry eyes.: Materials and methods: A prospective study was carried out on forty eyes of ... ...

    Abstract Aim: The aim of this study is to evaluate the efficacy of 2% rebamipide ophthalmic solution on the tear functions and ocular surface status in patients with dry eyes.
    Materials and methods: A prospective study was carried out on forty eyes of patients having signs and symptoms of dry eye. Two percent rebamipide ophthalmic solution was applied four times a day for a period of 4 weeks. Patients were evaluated on the basis of dry eye-related symptom score, tear film break-up time (TFBUT), tear meniscus height, fluorescein ocular surface staining score (FOSS), and the Schirmer's test at the end of 2, 4, 6, and 12 weeks and their values were compared with the baseline.
    Results: Significant improvement was noted in the mean dry eye-related symptom score, TBUT, and the FOSS values from the baseline at the end of 2, 4, 8, and 12 weeks. The values of tear meniscus height and Schirmer's test were improved at the end of 8 weeks but were not statistically significant.
    Conclusion: Nearly 2% rebamipide ophthalmic solution provided relief in the symptoms of patients having dry eyes. It also prevented further ocular surface damage and aided in stabilizing the tear film.
    Language English
    Publishing date 2018-04-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/ojo.OJO_29_2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Anterior ischemic optic neuropathy following dengue fever.

    Ramakrishnan, Reshma / Shrivastava, Saurabh / Deshpande, Shrikant / Patkar, Priyanka

    Oman journal of ophthalmology

    2016  Volume 9, Issue 3, Page(s) 160–163

    Abstract: Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; ...

    Abstract Dengue fever is caused by a flavivirus. This infection is endemic in the tropics and warm temperate regions of the world. Ocular manifestations of dengue fever include subconjunctival, vitreous, and retinal haemorrhages; posterior uveitis; optic neuritis; and maculopathies, haemorrhage, and oedema. However anterior ischemic optic neuropathy is a rare presentation. Optic nerve ischemia most frequently occurs at the optic nerve head, where structural crowding of nerve fibers and reduction of the vascular supply may combine to impair perfusion to a critical degree and produce optic disc oedema. Here we present a case of anterior ischemic optic neurapathy associated with dengue fever.
    Language English
    Publishing date 2016-11-02
    Publishing country India
    Document type Case Reports
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/0974-620X.192272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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