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Article: Detection of pesticides using nanozymes: Trends, challenges and outlook

Naveen Prasad, Sanjana / Bansal, Vipul / Ramanathan, Rajesh

Trends in analytical chemistry. 2021 Nov., v. 144

2021

Abstract: Effective monitoring of pesticide residues in food and environmental samples is of high importance as these chemical residues undergo ongoing eco- and bio-accumulation, compromising the health of humans and animals alike. Several sensor platforms are ... ...

Abstract	Effective monitoring of pesticide residues in food and environmental samples is of high importance as these chemical residues undergo ongoing eco- and bio-accumulation, compromising the health of humans and animals alike. Several sensor platforms are being developed for the detection of pesticide residues in a range of sample matrices. A relatively new sensor platform that has gained enormous attention is based on the natural enzyme-mimicking catalytic activity of nanomaterials, more commonly referred to as nanozyme activity. In this review, we provide a critical overview of the recent advances in nanozyme-based sensing strategies for the detection of pesticides. The review highlights the salient features and the working principle of various nanozyme-based sensors, their integration with molecular recognition elements (MREs) to improve target specificity, and associated limitations that must be overcome to turn nanozyme sensors into mainstream analytical tools. The review further provides a critical outlook of nanozyme-based sensors for pesticide detection. The last section of the review outlines the steps that must be taken to realise the full potential of nanozyme-based sensors.
Keywords	analytical chemistry ; bioaccumulation ; catalytic activity ; pesticides
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2014041-1
ISSN	0165-9936
ISSN	0165-9936
DOI	10.1016/j.trac.2021.116429
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Approaches to the treatment of pilonidal sinus disease, clinical practice in 2019.

Isik, Arda / Ramanathan, Rajesh

International wound journal

2019 Volume 17, Issue 2, Page(s) 508–509

MeSH term(s)	Endoscopy/standards ; Pilonidal Sinus/surgery ; Practice Guidelines as Topic ; Sacrococcygeal Region ; Skin Diseases/surgery
Language	English
Publishing date	2019-11-11
Publishing country	England
Document type	Letter
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.13265
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Zs.A 6006: Show issues

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Article: Sunscreen testing: A critical perspective and future roadmap

Zou, Wenyue / Ramanathan, Rajesh / Urban, Sylvia / Sinclair, Craig / King, Kerryn / Tinker, Rick / Bansal, Vipul

Trends in analytical chemistry. 2022 June 15,

2022

Abstract: Sunscreens have become a mainstream consumer product for protection against the damaging ultraviolet (UV) radiation in sunlight. Before a sunscreen is released to the market, it must undergo a set of safety and efficacy tests established by a government ... ...

Abstract	Sunscreens have become a mainstream consumer product for protection against the damaging ultraviolet (UV) radiation in sunlight. Before a sunscreen is released to the market, it must undergo a set of safety and efficacy tests established by a government or relevant regulatory authority. Regulatory bodies rely on access to appropriate analytical methods to ensure product compliance. The current sunscreen testing standards, particularly those to evaluate the sunscreen efficacy, are far from ideal from both a regulatory and an ethical perspective. For instance, some tests mandate unwarranted exposure of UV radiation to humans and cannot be reliably replicated. This article aims to provide a comprehensive review of the existing sunscreen testing standards, while providing a critical perspective on associated challenges, demands and opportunities in improving analytical methods for sunscreen testing. This review will provide a roadmap for those interested in sunscreen testing, including manufacturers, regulatory bodies, policy makers and academic researchers.
Keywords	analytical chemistry ; compliance ; ethics ; issues and policy ; markets ; sunscreens ; ultraviolet radiation
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2014041-1
ISSN	0165-9936
ISSN	0165-9936
DOI	10.1016/j.trac.2022.116724
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Article: Bimetallic nanozyme mediated urine glucose monitoring through discriminant analysis of colorimetric signal

Naveen Prasad, Sanjana / Anderson, Samuel R. / Joglekar, Mugdha V. / Hardikar, Anandwardhan A. / Bansal, Vipul / Ramanathan, Rajesh

Biosensors & bioelectronics. 2022 Sept. 15, v. 212

2022

Abstract: The ability to detect glucose concentrations in human urine offers a non-invasive approach to monitor changes in blood glucose, kidney health and vascular complications associated with diabetes. We show the potential of employing catalytically active ... ...

Abstract	The ability to detect glucose concentrations in human urine offers a non-invasive approach to monitor changes in blood glucose, kidney health and vascular complications associated with diabetes. We show the potential of employing catalytically active nanoparticles directly grown on textiles to produce a dose-dependent colorimetric sensor for glucose. We use a galvanic replacement (GR) reaction for the synthesis of bimetallic nanoparticles. Here, Cu nanoparticles act as a sacrificial template that undergoes a spontaneous electroless GR reaction when exposed to metal ions of gold, silver, platinum, and palladium to form bimetallic Cu-M nanoparticles (M = Au, Ag, Pt, or Pd). The evaluation of their intrinsic peroxidase-mimicking catalytic activity (“nanozyme”) in comparison to that of the Cu nanozyme revealed that the bimetallic systems show a higher catalytic rate with the Cu–Pt nanozyme showing the highest catalytic efficiency. This property of the Cu–Pt nanozyme was then utilized to detect glucose in human urine using the glucose oxidase enzyme as a molecular recognition element. A key outcome of our study is the ability to detect urine glucose without requiring sample dilution which is an advantage over the gold standard GOx-POx method and significantly more reliable performance over commercial urine glucose dipsticks. The difference in the intensity of the colorimetric response between different glucose concentrations further allowed this sensor system to be combined with digital imaging tools for multivariate analysis.
Keywords	biosensors ; catalytic activity ; colorimetry ; copper nanoparticles ; diabetes ; discriminant analysis ; glucose ; glucose oxidase ; gold ; humans ; kidneys ; multivariate analysis ; palladium ; platinum ; silver ; urine
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114386
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Article: L-Cysteine as an Irreversible Inhibitor of the Peroxidase-Mimic Catalytic Activity of 2-Dimensional Ni-Based Nanozymes.

Liyanage, Piyumi Dinusha / Weerathunge, Pabudi / Singh, Mandeep / Bansal, Vipul / Ramanathan, Rajesh

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 5

Abstract: The ability to modulate the catalytic activity of inorganic nanozymes is of high interest. In particular, understanding the interactions of inhibitor molecules with nanozymes can bring them one step closer to the natural enzymes and has thus started to ... ...

Abstract	The ability to modulate the catalytic activity of inorganic nanozymes is of high interest. In particular, understanding the interactions of inhibitor molecules with nanozymes can bring them one step closer to the natural enzymes and has thus started to attract intense interest. To date, a few reversible inhibitors of the nanozyme activity have been reported. However, there are no reports of irreversible inhibitor molecules that can permanently inhibit the activity of nanozymes. In the current work, we show the ability of L-cysteine to act as an irreversible inhibitor to permanently block the nanozyme activity of 2-dimensional (2D) NiO nanosheets. Determination of the steady state kinetic parameters allowed us to obtain mechanistic insights into the catalytic inhibition process. Further, based on the irreversible catalytic inhibition capability of L-cysteine, we demonstrate a highly specific sensor for the detection of this biologically important molecule.
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11051285
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Article ; Online: Preoperative Biliary Drainage Is Associated with Increased Complications After Liver Resection for Proximal Cholangiocarcinoma.

Ramanathan, Rajesh / Borrebach, Jeffrey / Tohme, Samer / Tsung, Allan

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2018 Volume 22, Issue 11, Page(s) 1950–1957

Abstract: Background: Preoperative biliary drainage (PBD) prior to liver resection for hilar and intrahepatic cholangiocarcinoma (CCA) is common. While PBD for those with distal obstructions has been studied extensively and is associated with increased infectious ...

Abstract	Background: Preoperative biliary drainage (PBD) prior to liver resection for hilar and intrahepatic cholangiocarcinoma (CCA) is common. While PBD for those with distal obstructions has been studied extensively and is associated with increased infectious complications, the impact of PBD among patients undergoing hepatectomy for non-disseminated proximal CCA has yet to be clearly elucidated. Methods: Patients undergoing liver resection between 2014 and 2016 for non-disseminated hilar and intrahepatic CCA were analyzed using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Associations between PBD (percutaneous or endoscopic) and 30-day outcomes were evaluated. Results: There were 905 liver resections performed, with 186 (20.6%) for hilar CCA and 719 (79.4%) for intrahepatic CCA. Of those, 251/897 (28.0%) patients underwent PBD. Independent preoperative predictors of PBD were hilar CCA, major hepatectomy, open surgery, lower BMI, and higher preoperative bilirubin. Adjusting for preoperative variables, extent of resection, and bilirubin, PBD was independently associated with increased wound infection (OR 2.93), organ space infection (OR 3.63), sepsis (OR 3.17), renal insufficiency (OR 4.25), transfusion (OR 2.40), bile leak (OR 3.23), invasive intervention (OR 2.72), liver failure (OR 3.20), readmission (OR 3.01), reoperation (OR 2.32), and mortality (OR 4.24, all p < 0.05). Conclusions: Among patients undergoing hepatectomy for proximal CCA, PBD is associated with increased postoperative complications. These data suggest that avoidance of routine preoperative biliary drainage may decrease short-term complications.
MeSH term(s)	Aged ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/surgery ; Blood Transfusion/statistics & numerical data ; Cholangiocarcinoma/surgery ; Databases, Factual ; Drainage/adverse effects ; Drainage/statistics & numerical data ; Female ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Hepatectomy/mortality ; Humans ; Liver Failure/epidemiology ; Liver Failure/etiology ; Male ; Middle Aged ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Preoperative Care/adverse effects ; Renal Insufficiency/epidemiology ; Renal Insufficiency/etiology ; Reoperation/statistics & numerical data ; Sepsis/epidemiology ; Sepsis/etiology ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; United States/epidemiology
Language	English
Publishing date	2018-07-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-018-3861-3
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Differential interactions of α-synuclein conformers affect refolding and activity of proteins.

Bagree, Gayatri / Srivastava, Tulika / Mahasivam, Sanje / Sinha, Meetali / Bansal, Vipul / Ramanathan, Rajesh / Priya, Smriti / Sharma, Sandeep K

Journal of biochemistry

2022 Volume 173, Issue 2, Page(s) 107–114

Abstract: The accumulation of protein aggregates as intracellular inclusions interferes with cellular protein homeostasis leading to protein aggregation diseases. Protein aggregation results in the formation of several protein conformers including oligomers and ... ...

Abstract	The accumulation of protein aggregates as intracellular inclusions interferes with cellular protein homeostasis leading to protein aggregation diseases. Protein aggregation results in the formation of several protein conformers including oligomers and fibrils, where each conformer has its own structural characteristic and proteotoxic potential. The present study explores the effect of alpha-synuclein (α-syn) conformers on the activity and spontaneous refolding of firefly luciferase. Of the different conformers, α-syn monomers delayed the inactivation of luciferase under thermal stress conditions and enhanced the spontaneous refolding of luciferase. In contrast, the α-syn oligomers and fibrils adversely affected luciferase activity and refolding, where the oligomers inhibited spontaneous refolding, whereas a pronounced effect on the inactivation of native luciferase was observed in the case of fibrils. These results indicate that the oligomers and fibrils of α-syn interfere with the refolding of luciferase and promote its misfolding and aggregation. The study reveals the differential propensities of various conformers of a pathologically relevant protein in causing inactivation, structural modifications and misfolding of other proteins, consequently resulting in altered protein homeostasis.
MeSH term(s)	Humans ; alpha-Synuclein/chemistry ; alpha-Synuclein/metabolism ; Parkinson Disease/metabolism ; Protein Aggregates ; Protein Folding ; Fireflies ; Luciferases/chemistry ; Luciferases/metabolism
Chemical Substances	alpha-Synuclein ; Protein Aggregates ; SNCA protein, human ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2022-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvac095
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Uc I Zs.202: Show issues

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Article ; Online: Reactive Oxygen Species Sequestration Induced Synthesis of β-PbO and Its Polymorphic Transformation to α-PbO at Atomically Thin Regimes.

Ingle, Aviraj / Singh, Mandeep / Tawfik, Sherif Abdulkader / Murdoch, Billy James / Harrop Mayes, Edwin Lawrence / Sapountzis Spencer, Michelle Jeanette / Ramanathan, Rajesh / Bansal, Vipul

ACS nano

2022 Volume 16, Issue 7, Page(s) 10679–10691

Abstract: The emergence of attractive properties in materials at atomically thin regimes has seen an ongoing interest in two-dimensional (2D) materials. An aspect that has lacked focused attention is the effect of 2D material thickness on its crystal structure. As ...

Abstract	The emergence of attractive properties in materials at atomically thin regimes has seen an ongoing interest in two-dimensional (2D) materials. An aspect that has lacked focused attention is the effect of 2D material thickness on its crystal structure. As several layered materials naturally exist in mixed metastable phases, it raises an important question of whether a specific polymorph of these mixed-phase materials will be favored at atomically thin limits. This work attempts to address this issue by employing lead monoxide as a model 2D polymorphic system. We propose a reactive oxygen species (ROS) sequestration-mediated liquid-phase exfoliation (LPE) strategy for the facile synthesis of ultrathin PbO. This is followed by a suite of microscopic and spectroscopic analyses of the PbO nanosheets that reveals the polymorphic transformation of orthorhombic (β) PbO to its tetragonal (α) analogue with reduction in nanosheet thickness. The transformation process reveals an interesting crystal structure of ultrathin 2D PbO where [001]-oriented domains of α-PbO coexist alongside [100]-oriented regions of β-PbO. Density functional theory (DFT) calculations support our experimental data by revealing a higher thermodynamic stability of the tetragonal phase in PbO monolayers. These findings are likely to instigate interest in carefully evaluating the crystal structures of ultrathin 2D materials while promoting research in understanding the phase transformation across a range of 2D crystals.
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c02432
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Article ; Online: Bimetallic nanozyme mediated urine glucose monitoring through discriminant analysis of colorimetric signal.

Naveen Prasad, Sanjana / Anderson, Samuel R / Joglekar, Mugdha V / Hardikar, Anandwardhan A / Bansal, Vipul / Ramanathan, Rajesh

Biosensors & bioelectronics

2022 Volume 212, Page(s) 114386

Abstract	The ability to detect glucose concentrations in human urine offers a non-invasive approach to monitor changes in blood glucose, kidney health and vascular complications associated with diabetes. We show the potential of employing catalytically active nanoparticles directly grown on textiles to produce a dose-dependent colorimetric sensor for glucose. We use a galvanic replacement (GR) reaction for the synthesis of bimetallic nanoparticles. Here, Cu nanoparticles act as a sacrificial template that undergoes a spontaneous electroless GR reaction when exposed to metal ions of gold, silver, platinum, and palladium to form bimetallic Cu-M nanoparticles (M = Au, Ag, Pt, or Pd). The evaluation of their intrinsic peroxidase-mimicking catalytic activity ("nanozyme") in comparison to that of the Cu nanozyme revealed that the bimetallic systems show a higher catalytic rate with the Cu-Pt nanozyme showing the highest catalytic efficiency. This property of the Cu-Pt nanozyme was then utilized to detect glucose in human urine using the glucose oxidase enzyme as a molecular recognition element. A key outcome of our study is the ability to detect urine glucose without requiring sample dilution which is an advantage over the gold standard GOx-POx method and significantly more reliable performance over commercial urine glucose dipsticks. The difference in the intensity of the colorimetric response between different glucose concentrations further allowed this sensor system to be combined with digital imaging tools for multivariate analysis.
MeSH term(s)	Biosensing Techniques/methods ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Colorimetry/methods ; Discriminant Analysis ; Glucose/analysis ; Glycosuria ; Humans ; Metal Nanoparticles
Chemical Substances	Blood Glucose ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114386
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Zs.A 2275: Show issues

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Article ; Online: Urinary tract infections in surgical patients.

Ramanathan, Rajesh / Duane, Therese M

The Surgical clinics of North America

2014 Volume 94, Issue 6, Page(s) 1351–1368

Abstract: Catheter-associated urinary tract infections (CAUTI) are common in surgical patients. CAUTI are associated with adverse patient outcomes, and negatively affects public safety reporting and reimbursement. Inappropriate catheter use and prolonged catheter ... ...

Abstract	Catheter-associated urinary tract infections (CAUTI) are common in surgical patients. CAUTI are associated with adverse patient outcomes, and negatively affects public safety reporting and reimbursement. Inappropriate catheter use and prolonged catheter duration are major risk factors for CAUTI. CAUTI pathogenesis and treatment are complicated by the presence of biofilms. Prevention strategies include accurate identification and tracking of CAUTIs, and the development of institutional guidelines for the appropriate use, duration, alternatives, and removal of indwelling urinary catheters.
MeSH term(s)	Catheter-Related Infections/diagnosis ; Catheter-Related Infections/etiology ; Catheter-Related Infections/therapy ; Catheters, Indwelling/adverse effects ; Catheters, Indwelling/microbiology ; Cross Infection/diagnosis ; Cross Infection/etiology ; Cross Infection/therapy ; Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Risk Factors ; Urinary Catheterization/adverse effects ; Urinary Catheterization/methods ; Urinary Catheters/adverse effects ; Urinary Catheters/microbiology ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/etiology ; Urinary Tract Infections/therapy
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215713-5
ISSN	1558-3171 ; 0039-6109
ISSN (online)	1558-3171
ISSN	0039-6109
DOI	10.1016/j.suc.2014.08.007
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