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  1. Article ; Online: Ligand-Dependent Downregulation of Guanylyl Cyclase/Natriuretic Peptide Receptor-A: Role of miR-128 and miR-195.

    Khurana, Madan L / Mani, Indra / Kumar, Prerna / Ramasamy, Chandramohan / Pandey, Kailash N

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Cardiac hormones act on the regulation of blood pressure (BP) and cardiovascular homeostasis. These hormones include atrial and brain natriuretic peptides (ANP, BNP) and activate natriuretic peptide receptor-A (NPRA), which enhance natriuresis, diuresis, ...

    Abstract Cardiac hormones act on the regulation of blood pressure (BP) and cardiovascular homeostasis. These hormones include atrial and brain natriuretic peptides (ANP, BNP) and activate natriuretic peptide receptor-A (NPRA), which enhance natriuresis, diuresis, and vasorelaxation. In this study, we established the ANP-dependent homologous downregulation of NPRA using human embryonic kidney-293 (HEK-293) cells expressing recombinant receptor and MA-10 cells harboring native endogenous NPRA. The prolonged pretreatment of cells with ANP caused a time- and dose-dependent decrease in
    MeSH term(s) Humans ; Guanylate Cyclase/genetics ; Guanylate Cyclase/metabolism ; Atrial Natriuretic Factor/genetics ; Atrial Natriuretic Factor/pharmacology ; Atrial Natriuretic Factor/metabolism ; Ligands ; Down-Regulation ; HEK293 Cells ; Cyclic GMP/metabolism ; MicroRNAs/genetics ; Natriuretic Peptide, Brain/metabolism
    Chemical Substances Guanylate Cyclase (EC 4.6.1.2) ; Atrial Natriuretic Factor (85637-73-6) ; Iodine-125 (GVO776611R) ; Ligands ; Cyclic GMP (H2D2X058MU) ; MicroRNAs ; Natriuretic Peptide, Brain (114471-18-0) ; MIRN128 microRNA, human ; MIRN195 microRNA, human
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway.

    Subramanian, Umadevi / Ramasamy, Chandramohan / Ramachandran, Samivel / Oakes, Joshua M / Gardner, Jason D / Pandey, Kailash N

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene ( ...

    Abstract The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (
    MeSH term(s) Actins/metabolism ; Animals ; Benzamides ; Collagen ; Connective Tissue Growth Factor ; Female ; Fibrosis ; Guanylate Cyclase/metabolism ; Male ; Matrix Metalloproteinase 2/metabolism ; Mice ; Monocyte Chemoattractant Proteins ; Natriuretic Peptides ; Proliferating Cell Nuclear Antigen/metabolism ; Pyrazoles ; Receptors, Atrial Natriuretic Factor/genetics ; Receptors, Atrial Natriuretic Factor/metabolism ; Signal Transduction ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factors
    Chemical Substances 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide ; Actins ; Benzamides ; Monocyte Chemoattractant Proteins ; Natriuretic Peptides ; Proliferating Cell Nuclear Antigen ; Pyrazoles ; Transforming Growth Factor beta1 ; Connective Tissue Growth Factor (139568-91-5) ; Transforming Growth Factors (76057-06-2) ; Collagen (9007-34-5) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Guanylate Cyclase (EC 4.6.1.2) ; Receptors, Atrial Natriuretic Factor (EC 4.6.1.2) ; atrial natriuretic factor receptor A (EC 4.6.1.2)
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911487
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  3. Article ; Online: Outcomes following balloon mitral valvuloplasty in pregnant females with mitral stenosis and significant sub valve disease with severe decompensated heart failure.

    Ananthakrishna Pillai, Ajith / Ramasamy, Chandramohan / V, Saranya Gousy / Kottyath, Harichandrakumar

    Journal of interventional cardiology

    2018  Volume 31, Issue 4, Page(s) 525–531

    Abstract: Background: Mitral stenosis may present with decompensated heart failure during pregnancy. Many patients do have advanced sub valve disease and present late with decompensated state. The outcomes of balloon mitral valvuloplasty (BMV) in such advanced ... ...

    Abstract Background: Mitral stenosis may present with decompensated heart failure during pregnancy. Many patients do have advanced sub valve disease and present late with decompensated state. The outcomes of balloon mitral valvuloplasty (BMV) in such advanced sub valve disease with severe heart failure in pregnancy has not been specifically studied till now.
    Methods: A descriptive study looking at the immediate and long-term outcomes of pregnant patients with MS who presented with severe heart failure and sub valve disease who had undergone BMV.
    Results: Ninety-six patients were studied. The mean gestational age was 23.4 ± 10.9 weeks .Mean SpO2 was 89% at admission,17% were in cardiogenic shock and 33.33 were on mechanical ventilation. The mean Wilkin's score was 9.71 ± 2.1 and sub valve score was 3.3 ± 0.12. BMV was successful in 77 (80.2%) patients and failed in 19. In 5.2% cases, acute severe MR occurred. There were 11 maternal deaths (six in failed and five in success group). A successful obstetric outcome was seen in 71 patients in success (92%) and 11/19 (57%) in failed (P < 0.001). The obstetric outcomes were better in success versus failure group. Anova post hoc analysis showed sustained gradient reductions at 1 and 5 year follow-up (P = 0.03) in success group.
    Conclusions: BMV offers substantial improvement in clinical outcomes among pregnant patients with MS and heart failure even with severe sub valve disease. The morality rate among failed was high at 31%. The obstetric outcomes were poor after a failed BMV. Outcomes following balloon mitral valvuloplasty in pregnant females with mitral stenosis and significant sub valve disease with severe decompensated heart failure.
    MeSH term(s) Adult ; Balloon Valvuloplasty/adverse effects ; Balloon Valvuloplasty/methods ; Female ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/surgery ; Humans ; India ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Stenosis/complications ; Mitral Valve Stenosis/diagnosis ; Mitral Valve Stenosis/mortality ; Mitral Valve Stenosis/surgery ; Outcome Assessment (Health Care) ; Postoperative Complications/diagnosis ; Postoperative Complications/mortality ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/surgery ; Severity of Illness Index ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/surgery ; Survival Analysis
    Language English
    Publishing date 2018-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036325-7
    ISSN 1540-8183 ; 0896-4327
    ISSN (online) 1540-8183
    ISSN 0896-4327
    DOI 10.1111/joic.12507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2719: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Hereditary Hemorrhagic Telangiectasia with Unusual Associations.

    Jain, Dheeraj / Viswanathan, Stalin / Ramasamy, Chandramohan

    Cureus

    2015  Volume 7, Issue 6, Page(s) e278

    Abstract: We describe a report of an elderly lady who was hospitalized with progressive worsening of breathlessness and fatigue of one month's duration. Clinical evaluation of the patient revealed hereditary hemorrhagic telangiectasia, interstitial lung disease, ... ...

    Abstract We describe a report of an elderly lady who was hospitalized with progressive worsening of breathlessness and fatigue of one month's duration. Clinical evaluation of the patient revealed hereditary hemorrhagic telangiectasia, interstitial lung disease, pulmonary hypertension without left heart failure, and bilateral gluteal calcinosis cutis. Initially, CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome was considered in view of the telangiectasia and calcinosis cutis, but a strong autosomal inheritance pattern and endoscopies (nasal and upper gastrointestinal) favored a diagnosis of hereditary hemorrhagic telangiectasia with rare associations.
    Language English
    Publishing date 2015-06-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.278
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  5. Article: Parasystole in a mahaim accessory pathway.

    Ramasamy, Chandramohan / Kumar, Senthil / Selvaraj, Raja J

    Indian pacing and electrophysiology journal

    2014  Volume 14, Issue 4, Page(s) 223–226

    Abstract: Automaticity has been described in Mahaim pathways, both spontaneously and during radiofrequency ablation. We describe an unusual case of automatic rhythm from a Mahaim pathway presenting as parasystole. The parasystolic beats were also found to initiate ...

    Abstract Automaticity has been described in Mahaim pathways, both spontaneously and during radiofrequency ablation. We describe an unusual case of automatic rhythm from a Mahaim pathway presenting as parasystole. The parasystolic beats were also found to initiate tachycardia, resulting in initial presentation with incessant tachycardia and tachycardia induced cardiomyopathy.
    Language English
    Publishing date 2014-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2123606-9
    ISSN 0972-6292
    ISSN 0972-6292
    DOI 10.1016/s0972-6292(16)30780-x
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  6. Article: A life threatening rash, an unexpected cause.

    Jain, Dhiraj / Viswanathan, Stalin / Ramasamy, Chandramohan

    Case reports in dermatological medicine

    2014  Volume 2014, Page(s) 146251

    Abstract: We describe a 74-year-old man with purpura fulminans and altered sensorium following an acute febrile illness. Intensive sepsis management was to no avail, until institution of doxycycline therapy following confirmation of scrub typhus. Empirical ... ...

    Abstract We describe a 74-year-old man with purpura fulminans and altered sensorium following an acute febrile illness. Intensive sepsis management was to no avail, until institution of doxycycline therapy following confirmation of scrub typhus. Empirical doxycycline needs to be considered in endemic areas for patients presenting with purpura fulminans.
    Language English
    Publishing date 2014-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2014/146251
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  7. Article ; Online: Seckel syndrome with severe sinus bradycardia.

    Ramasamy, Chandramohan / Satheesh, Santhosh / Selvaraj, Raja

    Indian journal of pediatrics

    2014  Volume 82, Issue 3, Page(s) 292–293

    Abstract: Seckel syndrome is an uncommon form of microcephalic dwarfism. The authors report a young boy with Seckel syndrome who presented with severe sinus bradycardia with symptoms of syncope and presyncope. Implantation of a permanent pacemaker was necessary in ...

    Abstract Seckel syndrome is an uncommon form of microcephalic dwarfism. The authors report a young boy with Seckel syndrome who presented with severe sinus bradycardia with symptoms of syncope and presyncope. Implantation of a permanent pacemaker was necessary in view of the severe symptoms. Although uncommon, cardiac abnormalities have been rarely reported in Seckel syndrome. This is the one of the few reports of rhythm abnormalities in this condition.
    MeSH term(s) Adolescent ; Bradycardia/complications ; Bradycardia/diagnosis ; Bradycardia/physiopathology ; Bradycardia/therapy ; Dwarfism/diagnosis ; Dwarfism/physiopathology ; Electrocardiography, Ambulatory/methods ; Facies ; Humans ; Male ; Microcephaly/diagnosis ; Microcephaly/physiopathology ; Pacemaker, Artificial ; Syncope/etiology ; Syncope/prevention & control ; Treatment Outcome
    Language English
    Publishing date 2014-09-04
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-014-1568-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Sequential Anterograde and Retrograde Conduction Block during Radiofrequency Ablation of an Accessory Pathway.

    Ramasamy, Chandramohan / Ramteke, Rahul / Balachander, Jayaraman / Selvaraj, Raja

    Indian pacing and electrophysiology journal

    2013  Volume 13, Issue 4, Page(s) 148–158

    Abstract: We present an interesting image showing sequential loss of anterograde, and subsequently, retrograde conduction during radiofrequency ablation of an accessory pathway. We discuss the possible mechanisms and prior literature concerning this interesting ... ...

    Abstract We present an interesting image showing sequential loss of anterograde, and subsequently, retrograde conduction during radiofrequency ablation of an accessory pathway. We discuss the possible mechanisms and prior literature concerning this interesting finding.
    Language English
    Publishing date 2013-08-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2123606-9
    ISSN 0972-6292
    ISSN 0972-6292
    DOI 10.1016/s0972-6292(16)30649-0
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  9. Article: Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

    Sheikh, Bashir Ahmad / Ayyasamy Rathinam / Leelavinothan Pari / Ramasamy Chandramohan

    Biochimie. 2015 May, v. 112

    2015  

    Abstract: Trans-anethole (TA), a terpenoid and a principle constituent of many essential oils from medicinal plants possess hypoglycemic and antioxidant activities. This study was undertaken to explore beneficial effects of TA on key enzymes of carbohydrate ... ...

    Abstract Trans-anethole (TA), a terpenoid and a principle constituent of many essential oils from medicinal plants possess hypoglycemic and antioxidant activities. This study was undertaken to explore beneficial effects of TA on key enzymes of carbohydrate metabolism in streptozotocin (STZ)-induced type 2 diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg BW). TA was administered to diabetic rats at a dose of 20, 40 and 80 mg/kg BW for 45 days. However, the dose at 80 mg/kg BW, resulted in a significant reduction in the levels of plasma glucose, glycosylated haemoglobin (HbA1c) and increase in the levels of insulin and haemoglobin (Hb). Upon administration of TA, the altered levels of liver glycolytic enzyme (hexokinase), hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) and gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in the liver and kidney of diabetic rats significantly reverted to near normal levels. In addition to this, TA also improved the hepatic and muscle glycogen content in diabetic rats. The histological studies showed the ameliorative effect of TA on the β-cells of pancreas in diabetic rats. The results were compared with glibenclamide, a standard oral hypoglycemic drug. These encouraging findings suggest that TA may be used as a propitious bioactive compound in the development of therapeutic agents against type 2 diabetes mellitus.
    Keywords albino ; animal disease models ; antioxidant activity ; bioactive compounds ; blood glucose ; essential oils ; glibenclamide ; glucose-6-phosphatase ; glucose-6-phosphate 1-dehydrogenase ; glycogen ; glycolysis ; glycosylation ; hemoglobin ; hexokinase ; hyperglycemia ; hypoglycemic agents ; insulin ; intraperitoneal injection ; islets of Langerhans ; kidneys ; liver ; males ; medicinal plants ; noninsulin-dependent diabetes mellitus ; rats ; streptozotocin ; terpenoids
    Language English
    Dates of publication 2015-05
    Size p. 57-65.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 120345-9
    ISSN 0300-9084
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2015.02.008
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 72/375: Show issues

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  10. Article ; Online: Wide complex tachycardia: what is the mechanism?

    Ramasamy, Chandramohan / Kumar, Senthil / Balachander, Jayaraman / Selvaraj, Raja J

    Journal of cardiovascular electrophysiology

    2014  Volume 25, Issue 2, Page(s) 220–221

    MeSH term(s) Adult ; Diagnosis, Differential ; Electrocardiography/methods ; Humans ; Male ; Tachycardia, Atrioventricular Nodal Reentry/complications ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Supraventricular/complications ; Tachycardia, Supraventricular/diagnosis
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.12269
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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