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Article: A Rare Case of Sporadic Inclusion Body Myositis with Atypical Presentation

Chinnusamy, Manokaran / Janakiraman, Sathiyanarayanan / Arivazhagan, Ramesh Bala

Journal of Health and Allied Sciences NU

2021 Volume 12, Issue 03, Page(s) 333–335

Abstract: Sporadic inclusion body myositis (IBM) is the most common acquired inflammatory myopathy that occurs after the age of 50 years. IBM typically involves wrist and finger flexors and quadriceps, but all sporadic IBM may not have the classic presentation of ... ...

Abstract	Sporadic inclusion body myositis (IBM) is the most common acquired inflammatory myopathy that occurs after the age of 50 years. IBM typically involves wrist and finger flexors and quadriceps, but all sporadic IBM may not have the classic presentation of distal arm and proximal leg involvement. Treating physicians must be aware of this atypical presentation to avoid the misdiagnosis of IBM, leading to treatment with immunosuppressive agents. The aim of this study is to increase the awareness among physicians about the atypical presentation of IBM and to emphasize the importance of muscle biopsy in such cases. Here we report a case of 52 years old male diagnosed with sporadic IBM by muscle biopsy presented with atypical presentation.
Keywords	sporadic inclusion body myositis ; endomysial lymphonuclear infiltrates ; rimmed vacuoles ; fat infiltration ; creatine kinase
Language	English
Publishing date	2021-11-22
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2582-4953 ; 2582-4287
ISSN (online)	2582-4953
ISSN	2582-4287
DOI	10.1055/s-0041-1739230
Database	Thieme publisher's database

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Article ; Online: Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer.

Alagaratnam, Swethan / Loizidou, Marilena / Yang, Shi- Yu / Fuller, Barry / Ramesh, Bala

Journal of cancer research and clinical oncology

2020 Volume 146, Issue 11, Page(s) 2861–2870

Abstract: Purpose: IGF-1Ec is an isoform of Insulin-like growth factor 1 (IGF-1) and has recently been identified to be overexpressed in cancers including prostate and neuroendocrine tumours. The aim of this paper is to investigate the expression of IGF-1Ec in ... ...

Abstract	Purpose: IGF-1Ec is an isoform of Insulin-like growth factor 1 (IGF-1) and has recently been identified to be overexpressed in cancers including prostate and neuroendocrine tumours. The aim of this paper is to investigate the expression of IGF-1Ec in colorectal cancer and polyps compared to normal colon tissues and its association with recurrent disease using semi-quantitative immunohistochemistry. Methods: Immunohistochemistry for IGF-1Ec expression was performed for colorectal cancer, colorectal polyps and normal colonic tissues. The quantification of IGF-1Ec expression was performed with the use of Image J software and the IHC profiler plugin. Following ethics approval from the National Research Ethics Service (Reference 11/LO/1521), clinical information including recurrent disease on follow-up was collected for patients with colorectal cancer. Results: Immunohistochemistry was performed in 16 patients with colorectal cancer and 11 patients with colonic polyps and compared to normal colon tissues and prostate adenocarcinoma (positive control) tissues. Significantly increased expression of IGF-1Ec was demonstrated in colorectal cancer (p < 0.001) and colorectal polyps (p < 0.05) compared to normal colonic tissues. Colonic adenomas with high-grade dysplasia had significantly higher expression of IGF-1Ec compared to low-grade dysplastic adenomas (p < 0.001). Colorectal cancers without lymph node metastases at the time of presentation had significantly higher IGF-1Ec expression compared to lymph node-positive disease (p < 0.05). No correlation with recurrent disease was identified with IGF-1Ec expression. Conclusion: IGF-1Ec is significantly overexpressed in colorectal cancer and polyps compared to normal colon tissues offering a potential target to improve colonoscopic identification of colorectal polyps and cancer and intraoperative identification of colorectal tumours.
MeSH term(s)	Adenomatous Polyps/diagnosis ; Adenomatous Polyps/metabolism ; Adenomatous Polyps/pathology ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Colonic Polyps/diagnosis ; Colonic Polyps/metabolism ; Colonic Polyps/pathology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry/methods ; Insulin-Like Growth Factor I/analysis ; Insulin-Like Growth Factor I/metabolism ; Male
Chemical Substances	Biomarkers, Tumor ; IGF1 protein, human ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2020-08-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-020-03345-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Rare Case of Myocardial Infarction with Nonobstructive Coronary Arteries Due to Hereditary Thrombophilia

Arivazhagan, Ramesh Bala / Chinnusamy, Manokaran / Sarojadevi, Ashida Thulaseedharan / Janakiraman, Sathiyanarayanan

Journal of Health and Allied Sciences NU

2020 Volume 11, Issue 02, Page(s) 101–103

Abstract: Abstract: The incidence of acute myocardial infarction with nonobstructive coronary arteries in young age less than 20 years in India due to hereditary thrombophilia is uncommon. Combined protein S and protein C deficiency has an increased tendency for ... ...

Abstract	Abstract: The incidence of acute myocardial infarction with nonobstructive coronary arteries in young age less than 20 years in India due to hereditary thrombophilia is uncommon. Combined protein S and protein C deficiency has an increased tendency for coronary artery thrombosis in very young individuals. Acute myocardial infarction in young individuals has different risk factors profile, clinical presentation, and prognosis when compared with elderly population and hence incites the need for different approach in the management. Here we report a case of 17-year-old boy who presented with acute inferior wall myocardial infarction with nonobstructive coronary arteries due to hereditary protein C and protein S deficiency.
Keywords	MINOCA ; thrombophilia ; protein C and protein S deficiency ; anticoagulants ; recurrence of events
Language	English
Publishing date	2020-12-30
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2582-4953 ; 2582-4287
ISSN (online)	2582-4953
ISSN	2582-4287
DOI	10.1055/s-0040-1722427
Database	Thieme publisher's database

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Article ; Online: Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles.

Alagaratnam, Swethan / Yang, Shi-Yu / Loizidou, Marilena / Fuller, Barry / Ramesh, Bala

Anticancer research

2019 Volume 39, Issue 4, Page(s) 1705–1710

Abstract: Background/aim: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its ... ...

Abstract	Background/aim: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its expression has been demonstrated in malignancies including prostate cancer. Materials and methods: Near-infrared-emitting gold nanoparticles (AuNPs) were synthesized and conjugated to MGF. Following characterization and confirmation of conjugation, these AuNPs were used to investigate the expression of MGF in colon cancer cell lines (HT29 and SW620) and tissues comparing normal and colon cancer. The prostate cancer cell line PC3 and adenocarcinoma tissues were used as positive controls. Results: Colon cancer cell lines, adenocarcinoma tissues and polyp tissues demonstrated evidence of MGF peptide expression, which was not found in normal colon tissues and human umbilical vein endothelial cells. Conclusion: MGF appears to be overexpressed in colon cancer tissues, offering a potential unique target for imaging and drug delivery in colon cancer.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Fluorescent Antibody Technique ; Gold ; HT29 Cells ; Humans ; Metal Nanoparticles ; Microscopy, Confocal ; Microscopy, Fluorescence ; PC-3 Cells ; Quantum Dots ; STAT5 Transcription Factor/metabolism ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Biomarkers, Tumor ; STAT5 Transcription Factor ; STAT5A protein, human ; Tumor Suppressor Proteins ; Gold (7440-57-5)
Language	English
Publishing date	2019-04-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.13276
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Article: Ex vivo tracing of pancreatic neuroendocrine tumors with bio-conjugated fluorescent quantum dots: a paradigm of nanoparticle-based diagnostics.

Giorgakis, Emmanouil / Ramesh, Bala / Loizidou, Marilena

Annals of gastroenterology

2015 Volume 28, Issue 4, Page(s) 509–510

Language	English
Publishing date	2015-06-08
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
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Article ; Online: A STUDY OF FASTING AND POSTPRANDIAL LIPID ABNORMALITIES IN TYPE 2 DIABETES MELLITUS

Babu R / Shigil Mathew Varghese / Seetha Ramireddy M / Arun Kumar S / Ramesh Bala A

Journal of Evolution of Medical and Dental Sciences, Vol 5, Iss 60, Pp 4234-

2016 Volume 4238

Abstract: AIM 1. To assess the nature of fasting dyslipidaemia in type 2 diabetes mellitus and correlate the same with severity and duration of diabetes. 2. To assess the postprandial lipid abnormalities in type 2 diabetes and to compare it with that of the ... ...

Abstract	AIM 1. To assess the nature of fasting dyslipidaemia in type 2 diabetes mellitus and correlate the same with severity and duration of diabetes. 2. To assess the postprandial lipid abnormalities in type 2 diabetes and to compare it with that of the fasting lipid load in diabetics. METHODS The study was carried out in Vinayaka Missions Medical College and Hospital, Karaikal over a period of 2 years. A total of 50 patients with type 2 diabetes mellitus were included and were compared with 50 age and sex matched healthy controls fulfilling the inclusion and exclusion criteria. RESULTS In this study, the mean age±SD was 48.5±5.68 years. The mean HbA1c±SD was 7.48±1.517. All cases in fasting state had raised VLDL-C levels (Mean 50.39±60.27), raised total cholesterol (Mean 169.70±39.917), raised TGL (Mean 146.04±60.140), decreased LDL-C (Mean 92.3±27.699) when compared to control group. In the postprandial state, there was a significant raise in TGL level (Mean 188±68.59), raised total cholesterol (Mean180.74±38.46), decreased HDL-C (Mean 38.761±9.028) compared to the fasting state. CONCLUSION It was found that there was a raised in TGL levels in the postprandial state, raised VLDL-C and reduced LDL-C in fasting state, raised total cholesterol and reduced HDL-C seen in both fasting and postprandial states of diabetic patients
Keywords	Dyslipidaemia ; Prandial Lipid ; VLDL-C Level ; Diabetic Patients ; and HDL-C. ; Dentistry ; RK1-715 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	571
Language	English
Publishing date	2016-07-01T00:00:00Z
Publisher	Akshantala Enterprises
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fluorescence-guided laparoscopic surgery: what if we could label pancreatic cancer with biomarker-conjugated fluorescent quantum nanocrystals?

Giorgakis, Emmanouil / Loizidou, Marilena / Mavroeidis, Vasileios / Imber, Charles / Ramesh, Bala

Journal of the American College of Surgeons

2015 Volume 220, Issue 3, Page(s) 376–377

MeSH term(s)	Animals ; Antibodies, Monoclonal ; Antibodies, Neoplasm ; Carcinoembryonic Antigen/immunology ; Female ; Humans ; Laparoscopy/methods ; Optical Imaging/methods ; Pancreatectomy/methods ; Pancreatic Neoplasms/surgery
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neoplasm ; Carcinoembryonic Antigen
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1181115-8
ISSN	1879-1190 ; 1072-7515
ISSN (online)	1879-1190
ISSN	1072-7515
DOI	10.1016/j.jamcollsurg.2014.12.001
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Article: Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer

Hadi, Marym Mohammad / Nesbitt, Heather / Masood, Hamzah / Sciscione, Fabiola / Patel, Shiv / Ramesh, Bala S / Emberton, Mark / Callan, John F / MacRobert, Alexander / McHale, Anthony P / Nomikou, Nikolitsa

Journal of controlled release. 2021 Jan. 10, v. 329

2021

Abstract: Nano-formulations that are responsive to tumour-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel ... ...

Abstract	Nano-formulations that are responsive to tumour-related and externally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the efficacy of conventional therapeutic agents. Here, we describe the performance of a novel stimulus-responsive nanoparticulate platform for the targeted treatment of prostate cancer using sonodynamic therapy (SDT). The nanoparticles were prepared by self-assembly of poly(L-glutamic acid-L-tyrosine) co-polymer with hematoporphyrin. The nanoparticulate formulation was characterized with respect to particle size, morphology, surface charge and singlet oxygen production during ultrasound exposure. The response of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed and secreted in the tumour microenvironment of many solid tumours, was assessed. Our results showed that digestion with cathepsin B led to nanoparticle size reduction. In the absence of ultrasound, the formulation exhibited greater toxicity at acidic pH than at physiological pH, using the human prostate cells lines LNCaP and PC3 as targets. Nanoparticle cellular uptake was enhanced at acidic pH – a condition that was also associated with greater cathepsin B production. Nanoparticles exhibited enhanced ultrasound-induced cytotoxicity against both prostate cancer cell lines. Subsequent proof-of-concept in vivo studies demonstrated that, when ectopic human xenograft LNCaP tumours in SCID mice were treated with SDT using the systemically-administered nanoparticulate formulation at a single dose, tumour volumes decreased by up to 64% within 24 h. No adverse effects were observed in the nanoparticle-treated mice and their body weight remained stable. The potential of this novel formulation to deliver safe and effective treatment of prostate cancer is discussed.
Keywords	adverse effects ; antineoplastic activity ; body weight ; cathepsin B ; cell lines ; composite polymers ; cytotoxicity ; humans ; in vivo studies ; mice ; nanoparticles ; neoplasm cells ; oxygen production ; pH ; particle size ; prostatic neoplasms ; severe combined immunodeficiency ; singlet oxygen ; ultrasonics ; xenotransplantation
Language	English
Dates of publication	2021-0110
Size	p. 76-86.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2020.11.040
Database	NAL-Catalogue (AGRICOLA)

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Article: Synthesis of mercaptosuccinic acid/MercaptoPolyhedral oligomeric silsesquioxane coated cadmium telluride quantum dots in cell labeling applications.

Ghaderi, Shirin / Ramesh, Bala / Seifalian, Alexander M

Journal of nanoscience and nanotechnology

2012 Volume 12, Issue 6, Page(s) 4928–4935

Abstract: An aqueous synthesis method to obtain highly luminescent cadmium telluride nanocrystals is described. We have shown water-soluble semi-conductor quantum dots with high photoluminescence quantum yield have great potential for biological applications. The ... ...

Abstract	An aqueous synthesis method to obtain highly luminescent cadmium telluride nanocrystals is described. We have shown water-soluble semi-conductor quantum dots with high photoluminescence quantum yield have great potential for biological applications. The spectral properties of these nanocrystals can be easily tuned according to their particle size to yield multicolours simultaneously by a single excitation light source. A stable precursor material sodium tellurite is utilised instead of the traditional oxygen sensitive NaHTe or H2Te as Te source. We have introduced mercaptosuccinic acid and propylisobutyl polyhedral oligomeric silsesquioxane nanoparticles as novel capping agents to stabilize the nanocrystals, synthesized in borate-citrate buffering system. Inclusion of propylisobutyl polyhedral oligomeric silsesquioxane nanoparticles in the capping procedure showed enhanced stability and biocompatibility. The presence of mercaptosuccinic acid/propylisobutyl polyhedral oligomeric silsesquioxane coatings was confirmed by Fourier Transform Infrared spectroscopy and average sizes of 2-5 nm by transmission electron microscopy measurements. The functionalized and targeted quantum dots detected cancer cell death on exposure to some anticancer drugs. Studies have indicated that apoptotic cells can activate signaling pathways in dendritic cells via ligation of surface receptors. Cells treated with specific class of pro-apototic drug such as anthracyclines mount an anti-tumour immune response when introduced into mice. Apoptotic cells may be immunogenic or non-immunogenic depending on the presence of calreticulin on the plasma membrane of dying tumour cells. Here the confocal microscopy showed localization of conjugated mercaptosuccinic acid/propylisobutyl polyhedral oligomeric silsesquioxane cadmium telluride quantum dots on MCF-7 cells when exposed to cadmium ions at 50 microM, compared to coated quantum dots. We have used cadmium ions as a model drug as certain anticancer drugs (anthracyclines) induce translocation of calreticulin to the cell membrane, an indicator of apoptosis. Antibodies generated against a peptide to human calreticulin and conjugated to quantum dots detected the protein on cell membrane of stimulated cells were visualized by confocal microscopy. Stimulating natural immune response, against tumours has enormous potential to improve current regimens of cancer detection and therapy.
MeSH term(s)	Breast Neoplasms/pathology ; Cadmium Compounds/chemistry ; Cell Line, Tumor ; Humans ; Microscopy, Fluorescence/methods ; Nanocapsules/chemistry ; Nanocapsules/ultrastructure ; Organosilicon Compounds/chemistry ; Quantum Dots ; Staining and Labeling/methods ; Tellurium/chemistry ; Thiomalates/chemistry
Chemical Substances	Cadmium Compounds ; Nanocapsules ; Organosilicon Compounds ; Thiomalates ; 2-thiomalic acid (94239W5L4H) ; Tellurium (NQA0O090ZJ) ; cadmium telluride (STG188WO13)
Language	English
Publishing date	2012-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1533-4880
ISSN	1533-4880
DOI	10.1166/jnn.2012.4907
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Article ; Online: Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy.

Abbott, Geoffrey W / Ramesh, Bala / Srai, Surjit K

PloS one

2012 Volume 7, Issue 11, Page(s) e49070

Abstract: Recent studies have explored the utility of Fourier transform infrared spectroscopy (FTIR) in dynamic monitoring of soluble protein-protein interactions. Here, we investigated the applicability of FTIR to detect interaction between synthetic soluble and ... ...

Abstract	Recent studies have explored the utility of Fourier transform infrared spectroscopy (FTIR) in dynamic monitoring of soluble protein-protein interactions. Here, we investigated the applicability of FTIR to detect interaction between synthetic soluble and phospholipid-embedded peptides corresponding to, respectively, a voltage-gated potassium (Kv) channel inactivation domain (ID) and S4-S6 of the Shaker Kv channel (KV1; including the S4-S5 linker "pre-inactivation" ID binding site). KV1 was predominantly α-helical at 30°C when incorporated into dimyristoyl-l-α-phosphatidylcholine (DMPC) bilayers. Cooling to induce a shift in DMPC from liquid crystalline to gel phase reversibly decreased KV1 helicity, and was previously shown to partially extrude a synthetic S4 peptide. While no interaction was detected in liquid crystalline DMPC, upon cooling to induce the DMPC gel phase a reversible amide I peak (1633 cm(-1)) consistent with novel hydrogen bond formation was detected. This spectral shift was not observed for KV1 in the absence of ID (or vice versa), nor when the non-inactivating mutant V7E ID was applied to KV1 under similar conditions. Alteration of salt or redox conditions affected KV1-ID hydrogen bonding in a manner suggesting electrostatic KV1-ID interaction favored by a hairpin conformation for the ID and requiring extrusion of one or more KV1 domains from DMPC, consistent with ID binding to S4-S5. These findings support the utility of FTIR in detecting reversible interactions between soluble and membrane-embedded proteins, with lipid state-sensitivity of the conformation of the latter facilitating control of the interaction.
MeSH term(s)	Dimyristoylphosphatidylcholine/chemistry ; Hydrogen Bonding ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism ; Protein Interaction Maps ; Protein Structure, Tertiary ; Shaker Superfamily of Potassium Channels/chemistry ; Shaker Superfamily of Potassium Channels/metabolism ; Shaw Potassium Channels/chemistry ; Shaw Potassium Channels/metabolism ; Solubility ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	KCNC4 protein, human ; Lipid Bilayers ; Membrane Proteins ; Peptides ; Shaker Superfamily of Potassium Channels ; Shaw Potassium Channels ; Dimyristoylphosphatidylcholine (U86ZGC74V5)
Language	English
Publishing date	2012-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0049070
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