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  1. Article ; Online: Stevens-Johnson syndrome in children.

    Ramien, Michele L

    Current opinion in pediatrics

    2022  Volume 34, Issue 4, Page(s) 341–348

    Abstract: Purpose of review: The concept of Stevens-Johnson syndrome (SJS) in children is evolving. This manuscript reviews recent advances with the lens of new terminology namely infection-triggered reactive infectious mucocutaneous eruption and drug-induced ... ...

    Abstract Purpose of review: The concept of Stevens-Johnson syndrome (SJS) in children is evolving. This manuscript reviews recent advances with the lens of new terminology namely infection-triggered reactive infectious mucocutaneous eruption and drug-induced epidermal necrolysis, with the objective of integrating this novel terminology practically.
    Recent findings: Traditionally considered to exist on a spectrum with toxic epidermal necrolysis, SJS in children is more often caused or triggered by infections instead of medications. Proposed pediatric-specific terminology can be applied to literature to gain further insights into blistering severe cutaneous adverse reactions.
    Summary: Distinguishing infection-triggered from drug-triggered blistering reactions is useful for 3 main reasons: (1) early clinically recognizable different features such as isolated or predominant mucositis, (2) different initial management depending on trigger, (3) avoiding the label of a drug reaction on cases triggered by infection.
    MeSH term(s) Child ; Humans ; Stevens-Johnson Syndrome/diagnosis ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/therapy
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of Drug-Induced Epidermal Necrolysis (DEN) in Pediatric Patients: Moving from Drug-Induced Stevens-Johnson Syndrome, Overlap and Toxic Epidermal Necrolysis to a Single Unifying Diagnosis of DEN.

    Ramien, Michele L / Mansour, Danny / Shear, Neil H

    Paediatric drugs

    2022  Volume 24, Issue 4, Page(s) 307–319

    Abstract: Pediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threating blistering diseases triggered by medications that affect the skin and mucosae. Drug-induced epidermal necrolysis is a better term for medication- ... ...

    Abstract Pediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threating blistering diseases triggered by medications that affect the skin and mucosae. Drug-induced epidermal necrolysis is a better term for medication-triggered cases because there is a spectrum of disease severity that otherwise is divided into the separate entities of SJS, overlap SJS/TEN, and TEN. This manuscript reviews the management of drug-induced epidermal necrolysis (DEN), including diagnosis, investigations to exclude differential diagnoses, and treatment. Diagnosis of DEN relies on clinical features and a detailed medication history. The primary differential diagnosis is reactive infectious mucocutaneous eruption, which can be clinically distinguished by its disproportionate mucous membrane involvement relative to (sparse or absent) skin lesions. Identification and discontinuation of culprit medications is the mainstay of treatment of DEN. Early initiation of immunomodulatory therapy may prevent progression, reducing maximal disease severity and the risk of sequelae. A checklist approach to detailed management of DEN is proposed.
    MeSH term(s) Child ; Diagnosis, Differential ; Humans ; Severity of Illness Index ; Stevens-Johnson Syndrome/diagnosis ; Stevens-Johnson Syndrome/etiology ; Stevens-Johnson Syndrome/therapy
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1492748-2
    ISSN 1179-2019 ; 1174-5878
    ISSN (online) 1179-2019
    ISSN 1174-5878
    DOI 10.1007/s40272-022-00515-0
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  3. Article ; Online: Capillary Malformation-Arteriovenous Malformation Syndrome.

    Sibley, Christopher D / Ramien, Michele L

    JAMA dermatology

    2019  Volume 155, Issue 6, Page(s) 733

    MeSH term(s) Arteriovenous Malformations/diagnosis ; Arteriovenous Malformations/genetics ; Capillaries/abnormalities ; Child ; Humans ; Magnetic Resonance Angiography ; Male ; Port-Wine Stain/diagnosis ; Port-Wine Stain/genetics ; p120 GTPase Activating Protein/genetics
    Chemical Substances RASA1 protein, human ; p120 GTPase Activating Protein
    Language English
    Publishing date 2019-05-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2019.0319
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  4. Article ; Online: Mucocutaneous Eruptions in Acutely Ill Pediatric Patients-Think of Mycoplasma pneumoniae (and Other Infections) First.

    Ramien, Michele L / Bruckner, Anna L

    JAMA dermatology

    2019  Volume 156, Issue 2, Page(s) 124–125

    MeSH term(s) Child ; Community-Acquired Infections ; Exanthema ; Humans ; Mycoplasma pneumoniae ; Pneumonia, Mycoplasma/diagnosis ; Stevens-Johnson Syndrome
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2019.3589
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  5. Article ; Online: Prescribing patterns and preferences for moderate-to-severe pediatric (<12 years of age) atopic dermatitis: A survey of Canadian practitioners.

    Ramien, Michele L / Jain, Vipul / Bergman, James / Marcoux, Danielle / Lara-Corrales, Irene

    JAAD international

    2023  Volume 14, Page(s) 87–89

    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2023.10.003
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  6. Article ; Online: Lichen sclerosus of the upper eyelid in a paediatric patient: a novel presentation.

    Kryshtalskyj, Michael T / Agi, Jorge / Ramien, Michele L / Kurek, Kyle C / Kherani, Femida

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  Volume 58, Issue 6, Page(s) e267–e268

    MeSH term(s) Humans ; Child ; Lichen Sclerosus et Atrophicus/diagnosis ; Eyelids/surgery
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.07.012
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  7. Article ; Online: A retrospective single-centre case series of paediatric blistering severe cutaneous adverse reactions: evaluation using new diagnostic classification confirms value of British Association of Dermatologists' guidelines.

    Aaron, Michelle / Ramien, Michele L / Powell, Julie / McCuaig, Catherine C / Marcoux, Danielle / Piram, Maryam / Hatami, Afshin / Coulombe, Jérôme

    Clinical and experimental dermatology

    2023  Volume 48, Issue 5, Page(s) 550–552

    MeSH term(s) Humans ; Child ; Dermatologists ; Retrospective Studies ; Skin Diseases
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Letter
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad014
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  8. Article ; Online: Treatment of

    Li, Heidi Oi-Yee / Colantonio, Sophia / Ramien, Michele L

    Journal of cutaneous medicine and surgery

    2019  Volume 23, Issue 6, Page(s) 608–612

    Abstract: Background: Mycoplasma pneumoniae: Objective: This case series aims to describe the potential efficacy of cyclosporine A (CsA) in the treatment of MIRM.: Methods: The present case series details our use of CsA early in the course of MIRM in 3 ... ...

    Abstract Background: Mycoplasma pneumoniae
    Objective: This case series aims to describe the potential efficacy of cyclosporine A (CsA) in the treatment of MIRM.
    Methods: The present case series details our use of CsA early in the course of MIRM in 3 pediatric patients.
    Results: Rapid clinical resolution was observed following CsA therapy.
    Conclusions: We suggest that early initiation of CsA may be an effective therapeutic option for MIRM.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/therapeutic use ; Child, Preschool ; Cyclosporine/therapeutic use ; Exanthema/drug therapy ; Exanthema/microbiology ; Exanthema/pathology ; Eye/pathology ; Female ; Humans ; Male ; Mouth/pathology ; Mucositis/drug therapy ; Mucositis/microbiology ; Mucositis/pathology ; Mycoplasma pneumoniae ; Pneumonia, Mycoplasma/drug therapy ; Pneumonia, Mycoplasma/microbiology ; Pneumonia, Mycoplasma/pathology ; Skin/pathology ; Stevens-Johnson Syndrome
    Chemical Substances Anti-Bacterial Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475419874444
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  9. Article ; Online: Recommendations for Vaccination in Children with Atopic Dermatitis Treated with Dupilumab: A Consensus Meeting, 2020.

    Martinez-Cabriales, Sylvia A / Kirchhof, Mark G / Constantinescu, Cora M / Murguia-Favela, Luis / Ramien, Michele L

    American journal of clinical dermatology

    2021  Volume 22, Issue 4, Page(s) 443–455

    Abstract: Dupilumab is the only biologic therapy currently approved in Europe and the United States for severe atopic dermatitis in patients 6 years of age or older. Off-label use is rationalized in younger children with severe atopic dermatitis. Decisions about ... ...

    Abstract Dupilumab is the only biologic therapy currently approved in Europe and the United States for severe atopic dermatitis in patients 6 years of age or older. Off-label use is rationalized in younger children with severe atopic dermatitis. Decisions about vaccination for children on dupilumab are complex and depend on both the child's current treatment and the type of vaccination required. To achieve consensus on recommendations for vaccination of pediatric patients with atopic dermatitis treated with or planning to start dupilumab, a review of the literature and a modified-Delphi process was conducted by a working group of 5 panelists with expertise in dermatology, immunology, infectious diseases and vaccination. Here, we provide seven recommendations for vaccination of pediatric patients with atopic dermatitis treated with or planning to start dupilumab. These recommendations serve to guide physicians' decisions about vaccination in children with atopic dermatitis treated with dupilumab. Furthermore, we highlight an unmet need for research to determine how significantly dupilumab affects cellular and humoral immune responses to vaccination with live attenuated and inactivated vaccines.
    MeSH term(s) Allergy and Immunology/standards ; Antibodies, Monoclonal, Humanized/adverse effects ; Child ; Consensus Development Conferences as Topic ; Delphi Technique ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Dermatology/standards ; Humans ; Immunity, Cellular/drug effects ; Immunity, Humoral/drug effects ; Immunogenicity, Vaccine ; Practice Guidelines as Topic ; Severity of Illness Index ; Vaccination/adverse effects ; Vaccination/standards
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2021-06-02
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1502476-3
    ISSN 1179-1888 ; 1175-0561
    ISSN (online) 1179-1888
    ISSN 1175-0561
    DOI 10.1007/s40257-021-00607-6
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  10. Article ; Online: Response to Reader Comment Regarding "Approach to Chilblains During the COVID-19 Pandemic".

    Ladha, Malika A / Luca, Nadia / Constantinescu, Cora / Naert, Karen / Ramien, Michele L

    Journal of cutaneous medicine and surgery

    2021  Volume 25, Issue 3, Page(s) 344–345

    MeSH term(s) Biopsy ; COVID-19 ; Chilblains/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475421997405
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