Article ; Online: Maternal environmental enrichment protects neonatal brains from hypoxic-ischemic challenge by mitigating brain energetic dysfunction and modulating glial cell responses.
2024 Volume 374, Page(s) 114713
Abstract: There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the newborn, even in case of neonatal brain hypoxia-ischemia (HI). The present study aimed to ... ...
| Abstract | There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the newborn, even in case of neonatal brain hypoxia-ischemia (HI). The present study aimed to investigate the effects of maternal environmental enrichment (EE) on HI-induced energetic and metabolic failure, along with subsequent neural cell responses in the early postnatal period. Male Wistar pups born to dams exposed to maternal EE or standard conditions (SC) were randomly divided into Sham-SC, HI-SC, Sham-EE, and HI-EE groups. Neonatal HI was induced on postnatal day (PND) 3. The Na |
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| MeSH term(s) | Animals ; Rats ; Female ; Male ; Pregnancy ; Animals, Newborn ; Rats, Wistar ; Brain/metabolism ; Hypoxia-Ischemia, Brain/metabolism ; Astrocytes/metabolism ; Neuromuscular Diseases ; Glucose/metabolism ; Adenosine Triphosphatases/metabolism | |||||
| Chemical Substances | Glucose (IY9XDZ35W2) ; Adenosine Triphosphatases (EC 3.6.1.-) | |||||
| Language | English | |||||
| Publishing date | 2024-02-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 207148-4 | |||||
| ISSN | 1090-2430 ; 0014-4886 | |||||
| ISSN (online) | 1090-2430 | |||||
| ISSN | 0014-4886 | |||||
| DOI | 10.1016/j.expneurol.2024.114713 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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