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  1. Article ; Online: In vitro activity of ceftazidime-avibactam against gram-negative bacteria in patients with bacteremia and skin and soft-tissue infections in Colombia 2019-2021.

    Lemos-Luengas, Elkin Vladimir / Rentería-Valoyes, Sixta / Muñoz, Diana Marcela Almario / Gonzalez, Cinthya Katherine Galindo / Guerrón-Gómez, Gabriela / Ramos-Castaneda, Jorge Andres

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 2, Page(s) 116235

    Abstract: Objectives: Ceftazidime-avibactam (CAZ-AVI) is an option for infections caused by MDR gram-negative bacilli. In this study, we aimed to analyze the in vitro antimicrobial activity of CAZ-AVI and other antimicrobial agents against gram-negative bacilli ... ...

    Abstract Objectives: Ceftazidime-avibactam (CAZ-AVI) is an option for infections caused by MDR gram-negative bacilli. In this study, we aimed to analyze the in vitro antimicrobial activity of CAZ-AVI and other antimicrobial agents against gram-negative bacilli that were collected in Colombia between 2019 and 2021 from patients with bacteremia and skin and soft-tissue infections (SSTIs).
    Methods: A total of 600 Enterobacterales and 259 P. aeruginosa strains were analyzed. The phenotypic resistance of isolates, particularly non-susceptibility to meropenem, multidrug-resistant (MDR) isolates, and difficult-to-treat (DTR) P. aeruginosa, was evaluated according to CLSI breakpoints.
    Results: Enterobacterales had the most susceptibility to CAZ-AVI (96.5 %) and tigecycline (95 %). Tigecycline and CAZ-AVI were the antimicrobial agents with the most in vitro activity against carbapenem-resistant Enterobacterales (CRE). CAZ-AVI was the antimicrobial treatment with the most activity against P. aeruginosa.
    Conclusions: Tigecycline and CAZ-AVI were the antimicrobial agents with the most activity against CRE and MDR Enterobacterales. For P. aeruginosa, CAZ-AVI was the antimicrobial treatment with the most in vitro activity.
    MeSH term(s) Humans ; Ceftazidime/pharmacology ; Soft Tissue Infections/microbiology ; Soft Tissue Infections/drug therapy ; Colombia ; Azabicyclo Compounds/pharmacology ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Drug Combinations ; Bacteremia/microbiology ; Bacteremia/drug therapy ; Gram-Negative Bacteria/drug effects ; Tigecycline/pharmacology ; Pseudomonas aeruginosa/drug effects ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/drug therapy ; Enterobacteriaceae/drug effects ; Skin Diseases, Bacterial/microbiology ; Skin Diseases, Bacterial/drug therapy
    Chemical Substances avibactam, ceftazidime drug combination ; Ceftazidime (9M416Z9QNR) ; Azabicyclo Compounds ; Anti-Bacterial Agents ; Drug Combinations ; Tigecycline (70JE2N95KR)
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Factores asociados a complicaciones infecciosas posoperatorias en pacientes con urolitiasis

    Osorio-Manrique, Javier / Ramos-Castaneda, Jorge Andres / Garcia-Landazabal, Elsa / Molano-Garcia, Maria Paula

    Revista Urología Colombiana / Colombian Urology Journal

    2021  Volume 30, Issue 02, Page(s) 105–111

    Abstract: Introducción: Se encuentran múltiples tratamientos para la urolitiasis, los cuales dependen en gran medida del tamaño y la ubicación de la litiasis. Dentro de las opciones terapéuticas se encuentran la expulsión activa, utilización de ondas de choque, ... ...

    Abstract Introducción: Se encuentran múltiples tratamientos para la urolitiasis, los cuales dependen en gran medida del tamaño y la ubicación de la litiasis. Dentro de las opciones terapéuticas se encuentran la expulsión activa, utilización de ondas de choque, las ureterolitotomias, y procedimientos endoscópicos, todas con diferentes tasas de efectividad y riesgo de complicación infecciosa. El objetivo del estudio fue evaluar los factores asociados a la complicación infecciosa posterior al procedimiento urológico en pacientes con urolitiasis.
    Métodos: Estudio de casos y controles anidado a una cohorte de pacientes programados para procedimientos urológicos como tratamiento para la urolitiasis durante el periodo 2015 - 2019. Se consideraron casos, aquellos con complicación infecciosa posoperatoria dentro de los 30 días posteriores al procedimiento urológico. Los controles se seleccionaron de la cohorte inicial y fueron los pacientes que no presentaron complicación infecciosa.
    Resultados: En el periodo de estudio, fueron atendidos 350 pacientes con litiasis renal, con un total de 1258 cálculos. El número promedio de cálculos por paciente fue de 3,59; la prevalencia de litiasis bilateral fue del 57%, siendo similar la cantidad de cálculos en el lado izquierdo (promedio = 1,4) y en el derecho (promedio = 1,44). La tasa de complicación infecciosa posquirúrgica fue del 4% (n= 14) y se asoció con la presencia de al menos un cálculo mayor de 20 mm (OR 4,49 IC95% 1,39–14,52).
    Conclusión: La tasa de complicación infecciosa posoperatoria en pacientes con urolitiasis y programados para procedimientos urológicos es baja. Una longitud del cálculo mayor de 20 mm es un factor asociado a la infección posoperatoria.
    Keywords urolitisiasis ; infección ; procedimiento urológico ; urolitisiasis ; infection ; urological procedure
    Language Spanish
    Publishing date 2021-02-04
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2102771-7
    ISSN 2027-0119 ; 0120-789X ; 2027-0119
    ISSN (online) 2027-0119
    ISSN 0120-789X ; 2027-0119
    DOI 10.1055/s-0040-1721322
    Database Thieme publisher's database

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  3. Article: Multisystemic Inflammatory Syndrome in Children From the South of Colombia: One Year of Experience.

    Pérez López, Pilar / Carvajal Duque, Darling / Salgado García, Doris Martha / Vega Vega, Martha Rocío / Ramos-Castaneda, Jorge Andrés / Ardila Gómez, Iván José / Romero, Andrés Felipe

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 838922

    Abstract: Background: Multisystemic inflammatory syndrome in children (MIS-C) is one of the most severe presentations of COVID-19 infection in pediatrics. Currently, we have few studies that describe the characteristics of this condition in Colombian children.: ...

    Abstract Background: Multisystemic inflammatory syndrome in children (MIS-C) is one of the most severe presentations of COVID-19 infection in pediatrics. Currently, we have few studies that describe the characteristics of this condition in Colombian children.
    Objective: To describe the clinical and epidemiological characteristics of children hospitalized with MIS-C in Neiva, Colombia.
    Methods: Observational follow-up study of a cohort of children with MIS-C for 12 months (May 15, 2020, to May 30, 2021) in two hospitals in the city of Neiva. Epidemiological data, clinical characteristics, laboratory characteristics, cardiological evaluation, treatment, and clinical outcomes were analyzed.
    Results: We included 34 patients who met the diagnosis of MIS-C. The median age was 68 months. Some type of nutritional issue was observed by 43.75% of those under 5 years of age and by 27.78% of those over 5 years of age. Gastrointestinal symptoms were the most frequent, with vomiting, diarrhea, and abdominal pain being the most frequent by 79, 70, and 67%, respectively. By 77% of the patients, a history of SARS-COV-2 infection was documented through IgG. In the echocardiogram, 35.4% of the patients had systolic dysfunction, followed by coronary involvement by 35%.
    Conclusion: This study describes a series of cases of children with MIS-C in Colombia. Gastrointestinal manifestations were predominant. Mortality was high in comparison to other countries but similar to that reported in Colombia. This fact was associated with relevant pathological background. More training is required for physicians in order to have a better understanding of the disease so as to have an early diagnosis and timely treatment.
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.838922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Abdominal manifestation of multisystemic inflammatory syndrome in children.

    Ardila Gómez, Iván José / López, Pilar Pérez / Duque, Darling Carvajal / García, Doris Martha Salgado / Romero, Andres Felipe / Vega, Martha Rocío Vega / Ramos Castañeda, Jorge Andres

    Journal of pediatric surgery case reports

    2021  Volume 74, Page(s) 102042

    Abstract: Summary: Multisystemic inflammatory syndrome (MIS-C) can develop as a complication of SARS CoV-2 infection, involving the gastrointestinal system mainly by vasoconstriction, edema, glandular hyperplasia, and a procoagulant state leading to direct tissue ...

    Abstract Summary: Multisystemic inflammatory syndrome (MIS-C) can develop as a complication of SARS CoV-2 infection, involving the gastrointestinal system mainly by vasoconstriction, edema, glandular hyperplasia, and a procoagulant state leading to direct tissue injury.
    Method: ology: a series of cases including 8 patients with MIS-C treated in two highly complex institutions is presented. These patients, had abdominal symptoms of surgical management.
    Results: The average age was 9.5 years and the most frequent symptoms were fever, abdominal pain, diarrhea (100%); in addition, 87.5% presented shock. The diagnosis of SARS CoV-2 was confirmed by RT-PCR test in 37.5%, antigen 12.5% and the rest of the patients showed IgM and IgG antibodies. In laboratories, the increase in acute phase reactants, Erythrocyte Sedimentation Rate (ESR), C-reactive protein, procalcitonin, as well as troponin, D dimer and proBNP, is highlighted. The surgical outcome documented 2 patients with a normal appendix, 3 patients with edematous appendicitis, and 3 patients with complicated appendicitis.
    Conclusions: patients with MIS-C display abdominal symptoms similar to those present in surgical emergencies and a non-negligible number of cases require surgical exploration. This condition poses a new differential diagnosis to the surgical abdomen in pediatric patients.
    Language English
    Publishing date 2021-09-16
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2715451-8
    ISSN 2213-5766
    ISSN 2213-5766
    DOI 10.1016/j.epsc.2021.102042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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