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  1. Article ; Online: The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.

    Martínez-Gómez, Laura Edith / Martinez-Armenta, Carlos / Tusie-Luna, Teresa / Vázquez-Cárdenas, Paola / Vidal-Vázquez, Rosa P / Ramírez-Hinojosa, Juan P / Gómez-Martín, Diana / Vargas-Alarcón, Gilberto / Posadas-Sánchez, Rosalinda / Fragoso, José Manuel / de la Peña, Aurora / Rodríguez-Pérez, José Manuel / Mata-Miranda, Mónica M / Vázquez-Zapién, Gustavo J / Martínez-Cuazitl, Adriana / Martínez-Ruiz, Felipe de J / Zayago-Angeles, Dulce M / Ramos-Tavera, Luis / Méndez-Aguilera, Alberto /
    Camacho-Rea, María Del C / Ordoñez-Sánchez, María L / Segura-Kato, Yayoi / Suarez-Ahedo, Carlos / Olea-Torres, Jessel / Herrera-López, Brígida / Pineda, Carlos / Martínez-Nava, Gabriela A / López-Reyes, Alberto

    Frontiers in immunology

    2024  Volume 15, Page(s) 1335963

    Abstract: Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (: Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we ... ...

    Abstract Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (
    Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
    Results: According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84;
    Discussion: Our data suggest that the rs75603675
    MeSH term(s) Humans ; COVID-19/genetics ; Serine Proteases ; SARS-CoV-2 ; Diabetes Mellitus, Type 2 ; Cross-Sectional Studies
    Chemical Substances Serine Proteases (EC 3.4.-)
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1335963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implication of myddosome complex genetic variants in outcome severity of COVID-19 patients.

    Martínez-Gómez, Laura E / Martinez-Armenta, Carlos / Medina-Luna, Daniel / Ordoñez-Sánchez, María Luisa / Tusie-Luna, Tere / Ortega-Peña, Silvestre / Herrera-López, Brígida / Suarez-Ahedo, Carlos / Jimenez-Gutierrez, Guadalupe Elizabeth / Hidalgo-Bravo, Alberto / Vázquez-Cárdenas, Paola / Vidal-Vázquez, Rosa P / Ramírez-Hinojosa, Juan P / Martinez Matsumoto, Pilar Miyoko / Vargas-Alarcón, Gilberto / Posadas-Sánchez, Rosalinda / Fragoso, José-Manuel / Martínez-Ruiz, Felipe de J / Zayago-Angeles, Dulce M /
    Mata-Miranda, Mónica Maribel / Vázquez-Zapién, Gustavo Jesús / Martínez-Cuazitl, Adriana / Andrade-Alvarado, Javier / Granados, Julio / Ramos-Tavera, Luis / Camacho-Rea, María Del Carmen / Segura-Kato, Yayoi / Rodríguez-Pérez, José Manuel / Coronado-Zarco, Roberto / Franco-Cendejas, Rafael / López-Jácome, Luis Esau / Magaña, Jonathan J / Vela-Amieva, Marcela / Pineda, Carlos / Martínez-Nava, Gabriela Angélica / López-Reyes, Alberto

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 56, Issue 5, Page(s) 939–950

    Abstract: Background/purpose(s): During a viral infection, the immune response is mediated by the toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed the lives of ... ...

    Abstract Background/purpose(s): During a viral infection, the immune response is mediated by the toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed the lives of more than 6.8 million people around the world.
    Methods: We carried out a cross-sectional with a population of 618 SARS-CoV-2-positive unvaccinated subjects and further classified based on severity: 22% were mild, 34% were severe, 26% were critical, and 18% were deceased. Toll Like Receptor 7 (TLR7) single-nucleotide polymorphisms (rs3853839, rs179008, rs179009, and rs2302267) and MyD88 (rs7744) were genotyped using TaqMan OpenArray. The association of polymorphisms with disease outcomes was performed by logistic regression analysis adjusted by covariates.
    Results: A significant association of rs3853839 and rs7744 of the TLR7 and MyD88 genes, respectively, was found with COVID-19 severity. The G/G genotype of the rs3853839 TLR7 was associated with the critical outcome showing an Odd Ratio = 1.98 (95% IC = 1.04-3.77). The results highlighted an association of the G allele of MyD88 gene with severe, critical and deceased outcomes. Furthermore, in the dominant model (AG + GG vs. AA), we observed an Odd Ratio = 1.70 (95% CI = 1.02-2.86) with severe, Odd Ratio = 1.82 (95% CI = 1.04-3.21) with critical, and Odd Ratio = 2.44 (95% CI = 1.21-4.9) with deceased outcomes.
    Conclusion: To our knowledge this work represents an innovative report that highlights the significant association of TLR7 and MyD88 gene polymorphisms with COVID-19 outcomes and the possible implication of the MyD88 variant with D-dimer and IFN-α concentrations.
    MeSH term(s) Humans ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/metabolism ; Genetic Predisposition to Disease ; Myeloid Differentiation Factor 88/genetics ; Cross-Sectional Studies ; COVID-19/genetics ; SARS-CoV-2 ; Genotype ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances Toll-Like Receptor 7 ; Myeloid Differentiation Factor 88
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ACE

    Martínez-Gómez, Laura E / Herrera-López, Brígida / Martinez-Armenta, Carlos / Ortega-Peña, Silvestre / Camacho-Rea, María Del Carmen / Suarez-Ahedo, Carlos / Vázquez-Cárdenas, Paola / Vargas-Alarcón, Gilberto / Rojas-Velasco, Gustavo / Fragoso, José Manuel / Vidal-Vázquez, Patricia / Ramírez-Hinojosa, Juan P / Rodríguez-Sánchez, Yunuen / Barrón-Díaz, David / Moreno, Mariana L / Martínez-Ruiz, Felipe de J / Zayago-Angeles, Dulce M / Mata-Miranda, Mónica Maribel / Vázquez-Zapién, Gustavo Jesús /
    Martínez-Cuazitl, Adriana / Barajas-Galicia, Edith / Bustamante-Silva, Ludwing / Zazueta-Arroyo, Diana / Rodríguez-Pérez, José Manuel / Hernández-González, Olivia / Coronado-Zarco, Roberto / Lucas-Tenorio, Vania / Franco-Cendejas, Rafael / López-Jácome, Luis Esau / Vázquez-Juárez, Rocío Carmen / Magaña, Jonathan J / Cruz-Ramos, Marlid / Granados, Julio / Hernández-Doño, Susana / Delgado-Saldivar, Diego / Ramos-Tavera, Luis / Coronado-Zarco, Irma / Guajardo-Salinas, Gustavo / Muñoz-Valle, José Francisco / Pineda, Carlos / Martínez-Nava, Gabriela Angélica / López-Reyes, Alberto

    Frontiers in immunology

    2022  Volume 13, Page(s) 812940

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing the death of more than 5 million people worldwide. The genetic ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing the death of more than 5 million people worldwide. The genetic background represents a factor that predisposes the way the host responds to SARS-CoV-2 infection. In this sense, genetic variants of
    MeSH term(s) Alleles ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/genetics ; COVID-19/virology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/virology ; Genotype ; Humans ; Male ; Peptidyl-Dipeptidase A/genetics ; Polymorphism, Single Nucleotide/genetics ; SARS-CoV-2/pathogenicity
    Chemical Substances ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.812940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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