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  1. Article ; Online: Apoplejía hipofisaria en pacientes pediátricos: revisión sistemática.

    Picón Jaimes, Yelson Alejandro / Orozco Chinome, Javier Esteban / López Cepeda, Daniela / Quintana Pájaro, Loraine / Galindo-Velásquez, Hather / Ramos-Villegas, Yancarlos / Ripoll-Zapata, Vanessa / Morales-Núñez, María Angélica / Moscote Salazar, Luis Rafael

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2022  Volume 79, Issue 2, Page(s) 141–145

    Abstract: Introduction: Necrosis or hemorrhage associated with pituitary tumors is an infrequent complication. The term pituitary apoplexy is related to the development of an inflammatory process that leads to irritation of the meningeal and periselar areas. ... ...

    Title translation Pituitary apoplexy in pediatric patients: systematic review.
    Abstract Introduction: Necrosis or hemorrhage associated with pituitary tumors is an infrequent complication. The term pituitary apoplexy is related to the development of an inflammatory process that leads to irritation of the meningeal and periselar areas. Regardless of the mechanism (hemorrhage or infarction), the extent of the hemorrhage and necrosis will produce an increase in intraselar pressure which, in turn, will lead to a more or less pronounced compression of neighboring structures, thus explaining the broad spectrum clinical.
    Methods: We carried out a systematic review of cases published internationally. The analysis of 8 cases published in the literature was carried out, 5 cases in the male pediatric population (62.5%), and 3 cases of the female gender (37.5%).
    Results: The mean age was 12.8 years (SD ± 2.5). The clinical manifestations included: headache, impaired vision, nausea and vomiting, fever, cranial nerve involvement, and, to a lesser extent, compromise of consciousness. Seventy-five percent (n = 6) of the patients had a headache, 16.6% had a frontal location, 16.6% accompanied by retroorbital pain, and 66.6% did not specify the location. On the other hand, only 37.5% of the patients had nausea and/or vomiting. While 25% were admitted with fever and 12.5% (n = 1) had changes in the state of consciousness.
    Conclusion: Pituitary apoplexy is a pathology that requires a multidisciplinary approach at the pediatric level. Management directed by pediatric neurosurgery and endocrinology will allow us to offer our patients the best, evidence-based treatment available.
    MeSH term(s) Child ; Humans ; Pituitary Apoplexy ; Retrospective Studies
    Language Spanish
    Publishing date 2022-06-06
    Publishing country Argentina
    Document type Journal Article ; Systematic Review
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v79.n2.27984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurotropism of SARS-CoV 2: Mechanisms and manifestations.

    Conde Cardona, Giancarlos / Quintana Pájaro, Loraine D / Quintero Marzola, Iván D / Ramos Villegas, Yancarlos / Moscote Salazar, Luis R

    Journal of the neurological sciences

    2020  Volume 412, Page(s) 116824

    MeSH term(s) Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; Brain/virology ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Humans ; Nervous System Diseases/physiopathology ; Nervous System Diseases/virology ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Viral Tropism
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.116824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Congenital-neonatal hydrocephalus: therapeutic alternatives to derivation. A look at cell therapy.

    Uparela-Reyes, María J / Narváez-Rojas, Alexis R / Quintana-Pájaro, Loraine / Ramos-Villegas, Yancarlos / Moscote-Salazar, Luis R

    Cirugia y cirujanos

    2019  Volume 86, Issue 6, Page(s) 575–582

    Abstract: Introducción: La hidrocefalia de inicio fetal, perinatal y neonatal representa un gran reto terapéutico y a menudo cursa con un pronóstico neurológico pobre, debido a su etiología heterogénea, que incluye alteraciones del neurodesarrollo.: Objetivo: ... ...

    Title translation Hidrocefalia congénita-neonatal: alternativas terapéuticas a la derivación. Una mirada a la terapia celular.
    Abstract Introducción: La hidrocefalia de inicio fetal, perinatal y neonatal representa un gran reto terapéutico y a menudo cursa con un pronóstico neurológico pobre, debido a su etiología heterogénea, que incluye alteraciones del neurodesarrollo.
    Objetivo: Realizar una recopilación de los avances en terapia celular como propuesta que permite ampliar el espectro de tratamiento en la hidrocefalia congénita-neonatal.
    Desarrollo: Las intervenciones terapéuticas disponibles actualmente, como la derivación ventrículo-peritoneal y la tercera ventriculostomía, son insuficientes para resolver por completo la hidrocefalia y para prevenir o revertir los daños neurológicos asociados. Es por esto por lo que ha surgido la necesidad de crear nuevas alternativas terapéuticas a partir del conocimiento de los mecanismos fisiopatológicos que participan en el desarrollo de esta condición. Particularmente, la terapia celular con células madre neuronales y células madre mesenquimales ha demostrado, en estudios con animales y en estudios preclínicos con humanos, ser eficiente y segura para prevenir la hidrocefalia originada a partir de la disrupción de la zona ventricular y secundaria a la hemorragia intraventricular, con la consiguiente prevención de las secuelas neurológicas sensoriomotoras y cognitivas.
    Conclusiones: Hasta el momento no tenemos un tratamiento eficiente que ofrezca calidad de vida a los pacientes con hidrocefalia, y que esa alternativa terapéutica sea efectiva.
    Introduction: Fetal hydrocephalus, perinatal and neonatal represents a major therapeutic challenge and often has with poor neurological prognosis, due to its heterogeneous aetiology, including neurodevelopmental disorders.
    Objective: To make a collection of advances in cell therapy as a proposal that can extend the spectrum of treatment in congenita-neonatal hydrocephalus.
    Development: Therapeutic interventions available at present as the ventricle-peritoneal shunt and third ventriculostomy, are insufficient to fully resolve the hydrocephalus and to prevent or reverse the associated neurological damage. This is why what has emerged the need for new therapeutic alternatives based on the knowledge of physiopathological mechanisms involved in the development of this condition. In particular, cell therapy with neural stem cells and mesenchymal stem cells has proven in animal studies and preclinical studies with humans, efficiently and safely to prevent hydrocephalus originated from the disruption of the ventricular zone and secondary to intraventricular hemorrhage, with the consequent prevention of neurological sequelae sensorimotor and cognitive.
    Conclusions: So far, we do not have an efficient treatment that offers quality of life to patients with hydrocephalus, and that alternative therapy to be effective.
    MeSH term(s) Humans ; Hydrocephalus/surgery ; Infant, Newborn ; Stem Cell Transplantation
    Language Spanish
    Publishing date 2019-01-17
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.18000054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neurotropism of SARS-CoV 2

    Conde Cardona, Giancarlos / Quintana Pájaro, Loraine D. / Quintero Marzola, Iván D. / Ramos Villegas, Yancarlos / Moscote Salazar, Luis R.

    Journal of the Neurological Sciences

    Mechanisms and manifestations

    2020  Volume 412, Page(s) 116824

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.116824
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Neurotropism of SARS-CoV 2: Mechanisms and manifestations

    Conde Cardona, Giancarlos / Quintana Pájaro, Loraine D / Quintero Marzola, Iván D / Ramos Villegas, Yancarlos / Moscote Salazar, Luis R

    J Neurol Sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #65242
    Database COVID19

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  6. Article ; Online: Refractory traumatic intracranial hypertension: the role of decompressive craniectomy.

    Moscote-Salazar, Luis R / Alvis-Miranda, Hernando R L / Ramos-Villegas, Yancarlos / Quintana-Pajaro, Loraine / Rubiano, Andrés M / Alcalá-Cerra, Gabriel / González-Torres, Juan B / Narváez-Rojas, Alexis R

    Cirugia y cirujanos

    2019  Volume 87, Issue 3, Page(s) 358–364

    Abstract: Traumatic brain injury according to the World Health Organization estimates that by 2020 will be the third leading cause of morbidity and mortality worldwide. Intracranial hypertension refractory to medical management is the cause of increased mortality ... ...

    Title translation Hipertensión intracraneal traumática refractaria: el papel de la craniectomía descompresiva.
    Abstract Traumatic brain injury according to the World Health Organization estimates that by 2020 will be the third leading cause of morbidity and mortality worldwide. Intracranial hypertension refractory to medical management is the cause of increased mortality in neurotrauma. There are various measures to control intracranial hypertension, including surgical. Decompressive craniectomy has been routinely used to treat intracranial hypertension secondary to cerebral infarction, subarachnoid hemorrhage, intracerebral hemorrhage and trauma. We review the literature to describe the mechanisms, types and indications for this procedure.
    MeSH term(s) Brain Injuries/complications ; Decompressive Craniectomy/methods ; Humans ; Intracranial Hypertension/etiology ; Intracranial Hypertension/surgery
    Language English
    Publishing date 2019-08-27
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.18000081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ventriculitis associated with extraventricular drainage: etiology, diagnosis and treatment focused on neurocritic care units.

    Ulloque-Caamaño, Liezel / Mo-Carrascal, Joulen / Maraby, Johana / Narvaez-Rojas, Alexis / Quintana-Pajaro, Loraine / Ramos-Villegas, Yancarlos / Moscote-Salazar, Luis R

    Cirugia y cirujanos

    2019  Volume 87, Issue 2, Page(s) 230–240

    Abstract: Ventriculitis after extraventricular drainage is a very important neurosurgical complication in neurocritical care units. It is necessary to make an early diagnosis, given that the morbidity and mortality secondary to it can be variable, and complicate ... ...

    Title translation Ventriculitis asociada a drenaje extraventricular: etiología, diagnóstico y tratamiento enfocado a unidades de cuidados neurocríticos.
    Abstract Ventriculitis after extraventricular drainage is a very important neurosurgical complication in neurocritical care units. It is necessary to make an early diagnosis, given that the morbidity and mortality secondary to it can be variable, and complicate the evolution of neurocritical patients. Despite this, ventriculostomy continues to be an important pillar in monitoring and treatment. Given the urgency of ventriculitis associated with multiresistant germs, new antimicrobial drugs have emerged as part of the treatment, as intraventricular routes have been proposed within the new investigations. However, the foregoing does not yet have sufficient bases to be able to support it. The present review was carried out with the aim of contributing to an early diagnosis and treatment of ventriculitis associated with extra ventricular drainage in neurocritical patients, and in this way to contribute to improve survival and prevent fatal outcomes in these patients.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Central Nervous System Bacterial Infections/diagnosis ; Central Nervous System Bacterial Infections/drug therapy ; Cerebral Ventriculitis/cerebrospinal fluid ; Cerebral Ventriculitis/diagnosis ; Cerebral Ventriculitis/microbiology ; Cerebral Ventriculitis/therapy ; Critical Illness ; Drainage/adverse effects ; Drainage/methods ; Early Diagnosis ; Humans ; Intensive Care Units ; Prosthesis-Related Infections/cerebrospinal fluid ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/microbiology ; Ventriculostomy/adverse effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-02-14
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 730699-4
    ISSN 2444-054X ; 0009-7411
    ISSN (online) 2444-054X
    ISSN 0009-7411
    DOI 10.24875/CIRU.18000052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Approach to Emergent Neurotrauma-related Neurosurgical Procedures in Patients with Hepatic Disease

    Mendoza-Avendaño, María / Ramírez-Carvajal, Ana / Barreto-Herrera, Iván / Muñoz-Báez, Karen / Ramos-Villegas, Yancarlos / Shrivastava, Adesh / Janjua, Tariq / Moscote-Salazar, Luis Rafael / Agrawal, Amit

    Indian Journal of Neurotrauma

    2021  Volume 18, Issue 02, Page(s) 133–137

    Abstract: Liver diseases constitute a group of pathologies of extraordinary importance, because of the large number of patients who suffer from these as well as the consequences that they can have on these individuals if they undergo any surgical procedure. ... ...

    Abstract Liver diseases constitute a group of pathologies of extraordinary importance, because of the large number of patients who suffer from these as well as the consequences that they can have on these individuals if they undergo any surgical procedure. Therefore, these patients have greater risk of suffering unfavorable outcomes than a healthy person undergoing emergency neurosurgical procedures (ENP) for neurotrauma. For this reason, there is a need to classify these patients according to their surgical risk based on risk factors secondary to the concurrent hepatic derangements. Among the possible tools that allow us to stage patients with liver disease are the Child–Turcotte–Pugh (CTP) and model for end-stage liver disease (MELD) scales, which have proven utility in effectively predicting the outcomes, including morbidity and mortality in hepatic disease patients who are undergoing surgery. They also help to predict the risk of complications such as intracranial hemorrhage secondary to coagulopathy due to hepatic derangement.
    Keywords hepatopathies ; liver disease ; neurosurgery
    Language English
    Publishing date 2021-02-23
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2266738-6
    ISSN 2213-3739 ; 0973-0508 ; 2213-3739
    ISSN (online) 2213-3739
    ISSN 0973-0508 ; 2213-3739
    DOI 10.1055/s-0041-1725215
    Database Thieme publisher's database

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  9. Article: The Effect of Statins in Epilepsy: A Systematic Review.

    Quintana-Pájaro, Loraine De Jesús / Ramos-Villegas, Yancarlos / Cortecero-Sabalza, Eileen / Joaquim, Andrei F / Agrawal, Amit / Narvaez-Rojas, Alexis Rafael / Moscote-Salazar, Luis Rafael

    Journal of neurosciences in rural practice

    2018  Volume 9, Issue 4, Page(s) 478–486

    Abstract: Background and objectives: Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, used for the management of hypercholesterolemia and related atherosclerotic diseases. Several studies have indicated the neuroprotective ... ...

    Abstract Background and objectives: Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, used for the management of hypercholesterolemia and related atherosclerotic diseases. Several studies have indicated the neuroprotective effects of statins on several neuropathological conditions. However, the role of these medications in epilepsy is still unclear. The purpose is to evaluate and summarize the level of evidence on the efficacy of statins in neuronal hyperexcitability and the neuroinflammatory processes of epilepsy.
    Methods: A systematic review was performed. Eligibility Criteria: This review involved studies conducted in humans and nonhuman experimental models, covering the use of an inhibitor of HMG-CoA reductase, alone or accompanied by another medication, in epilepsy. Information Sources: A systematic literature search was performed in PubMed, Embase, Ebsco Host, Scopus, Science Direct, Medline, and LILACS. Risk of Bias: It was evaluated with the Newcastle-Ottawa Scale and the experimental studies were evaluated using the GRADE tool.
    Results: Twenty articles of the 183 evaluated were included. Sixteen studies were conducted in animal models and four studies in humans. Most studies in mice reported a reduction in epileptiform activity and reduction in systemic inflammation with the treatment of statins, potentially influencing epilepsy control. Few studies in humans were performed in the geriatric population with variable results (neuroinflammation, seizure prevention, cell death, prevention of kindling, increase in convulsive threshold, increase in latency, decrease in frequency of crisis, and reduction in mortality) related to reduction in the rate of hospitalizations, mortality, and prevention of epilepsy. Studies in mice found a decrease in interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha and an increase in IL-10 and endothelial nitric oxide synthase.
    Conclusions: The possible antiepileptic mechanism of statins may be related to the reduction in neuroinflammation mediated by a decrease in pro-inflammatory cytokines and action in the nitrergic system. Further studies evaluating the impact of statins on seizure control are necessary.
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.4103/jnrp.jnrp_110_18
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  10. Article: The Effect of Statins in Epilepsy: A Systematic Review

    Quintana-Pájaro, Loraine De Jesús / Ramos-Villegas, Yancarlos / Cortecero-Sabalza, Eileen / Joaquim, Andrei F. / Agrawal, Amit / Narvaez-Rojas, Alexis Rafael / Moscote-Salazar, Luis Rafael

    Journal of Neurosciences in Rural Practice

    2018  Volume 09, Issue 04, Page(s) 478–486

    Abstract: Background and Objectives: Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, used for the management of hypercholesterolemia and related atherosclerotic diseases. Several studies have indicated the neuroprotective ... ...

    Abstract Background and Objectives: Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, used for the management of hypercholesterolemia and related atherosclerotic diseases. Several studies have indicated the neuroprotective effects of statins on several neuropathological conditions. However, the role of these medications in epilepsy is still unclear. The purpose is to evaluate and summarize the level of evidence on the efficacy of statins in neuronal hyperexcitability and the neuroinflammatory processes of epilepsy.
    Methods: A systematic review was performed. Eligibility Criteria: This review involved studies conducted in humans and nonhuman experimental models, covering the use of an inhibitor of HMG-CoA reductase, alone or accompanied by another medication, in epilepsy. Information Sources: A systematic literature search was performed in PubMed, Embase, Ebsco Host, Scopus, Science Direct, Medline, and LILACS. Risk of Bias: It was evaluated with the Newcastle–Ottawa Scale and the experimental studies were evaluated using the GRADE tool.
    Results: Twenty articles of the 183 evaluated were included. Sixteen studies were conducted in animal models and four studies in humans. Most studies in mice reported a reduction in epileptiform activity and reduction in systemic inflammation with the treatment of statins, potentially influencing epilepsy control. Few studies in humans were performed in the geriatric population with variable results (neuroinflammation, seizure prevention, cell death, prevention of kindling, increase in convulsive threshold, increase in latency, decrease in frequency of crisis, and reduction in mortality) related to reduction in the rate of hospitalizations, mortality, and prevention of epilepsy. Studies in mice found a decrease in interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha and an increase in IL-10 and endothelial nitric oxide synthase.
    Conclusions: The possible antiepileptic mechanism of statins may be related to the reduction in neuroinflammation mediated by a decrease in pro-inflammatory cytokines and action in the nitrergic system. Further studies evaluating the impact of statins on seizure control are necessary.
    Language English
    Publishing date 2018-10-01
    Publisher Thieme Medical and Scientific Publishers Private Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.4103/jnrp.jnrp_110_18
    Database Thieme publisher's database

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