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  1. AU="Ramsden, Jeremy"
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  1. Book: Bioinformatics

    Ramsden, Jeremy

    An Introduction

    (Computational Biology)

    2021  

    Abstract: This comprehensive textbook/reference presents a self-contained guide to bioinformatics, defined in its broadest sense as the application of information science to biology. -- -- Thoroughly updated and considerably expanded, this third edition now ... ...

    Author's details Dr. Jeremy Ramsden is Hon. Prof. of Nanotechnology in the Department of Biomedical Research at the University of Buckingham, UK
    Series title Computational Biology
    Abstract This comprehensive textbook/reference presents a self-contained guide to bioinformatics, defined in its broadest sense as the application of information science to biology. -- -- Thoroughly updated and considerably expanded, this third edition now includes material on the growing array of “-omics”; covering metagenomics, toxicogenomics, glycomics, lipidomics, microbiomics, and phenomics. New chapters have also been added on ecosystems management and the nervous system. Emphasis is placed on ...
    Keywords Lehrbuch ; NBII010 ; FINT060 ; algorithms ; Biology ; complexity ; Genome ; knowledgerepresentation ; sequenceanalysis ; Algorithms ; Bioinformatics ; Complexity ; Knowledge Representation ; Sequence Analysis
    Language English
    Size 428 p.
    Edition 4
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_23
    Format 160 x 241 x 29
    ISBN 9783030456061 ; 3030456064
    Database PDA

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  2. Book: Biomedical surfaces

    Ramsden, Jeremy

    (Engineering in medicine & biology)

    2008  

    Author's details Jeremy Ramsden
    Series title Engineering in medicine & biology
    Keywords Biocompatible Materials ; Surface Properties
    Language English
    Size XVIII, 270 S. : Ill., graph. Darst.
    Publisher Artech House
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015663066
    ISBN 978-1-59693-240-1 ; 1-59693-240-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 5150 order for loan Magazin

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  3. Article ; Online: Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes.

    Chikviladze, Marika / Mamulashvili, Nino / Sepashvili, Maia / Narmania, Nana / Ramsden, Jeremy / Shanshiashvili, Lali / Mikeladze, David

    IBRO neuroscience reports

    2023  Volume 16, Page(s) 127–134

    Abstract: Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space. MBP shows extensive post-translational modifications, including deimination/ ... ...

    Abstract Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space. MBP shows extensive post-translational modifications, including deimination/citrullination. Deiminated MBP is structurally less ordered, susceptible to proteolytic attack, and more immunogenic than unmodified MBP. This study investigated the effect of the deiminated/citrullinated isomer of MBP(C8) and the unmodified isomer of MBP(C1) on cultured primary astrocytes.
    Methods: MBP charge isomers were isolated/purified from bovine brain. Primary astrocyte cultures were prepared from the 2-day-old Wistar rats. For evaluation of glutamate release/uptake a Fluorimetric glutamate assay was used. Expression of peroxisome proliferator-activated receptor-gamma(PPAR-γ), excitatory amino acid transporter 2(EAAT2), the inhibitor of the nuclear factor kappa-B(ikB) and high mobility group-B1(HMGB1) protein were assayed by Western blot analysis. IL-17A expression was determined in cell medium by ELISA.
    Results: We found that MBP(C8) and MBP(C1) acted differently on the uptake/release of glutamate in astrocytes: C1 increased glutamate uptake and did not change its release, whereas C8 decreased glutamate release but did not change its uptake. Both isomers increased the expression of PPAR-γ and EAAT2 to the same degree. Western blots of cell lysates revealed decreased expression of ikB and increased expression of HMGB1 proteins after treatment of astrocytes by C8. Moreover, C8-treated cells released more nitric oxide and proinflammatory IL-17A than C1-treated cells.
    Conclusions: These data suggest that the most immunogenic deiminated isomer C8, in parallel to the decreases in glutamate release, elicits an inflammatory response and enhances the secretion of proinflammatory molecules via activation of nuclear factor kappa B(NF-kB).
    Summary statement: The most modified-citrullinated myelin basic protein charge isomer decreases glutamate release, elicits an inflammatory response and enhances the secretion of proinflammatory molecules via activation of nuclear factor kappa B in astrocytes.
    Language English
    Publishing date 2023-12-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Bioinformatics

    Ramsden, Jeremy

    an introduction

    (Computational Biology ; 21)

    2015  

    Abstract: This comprehensive textbook/reference presents a self-contained guide to bioinformatics, defined in its broadest sense as the application of information science to biology. Thoroughly updated and considerably expanded, this third edition now includes ... ...

    Author's details by Jeremy Ramsden
    Series title Computational Biology ; 21
    Abstract This comprehensive textbook/reference presents a self-contained guide to bioinformatics, defined in its broadest sense as the application of information science to biology. Thoroughly updated and considerably expanded, this third edition now includes material on the growing array of “-omics”; covering metagenomics, toxicogenomics, glycomics, lipidomics, microbiomics, and phenomics. New chapters have also been added on ecosystems management and the nervous system. Emphasis is placed on providing both a firm grounding in the core concepts, and a clear overview of the complete field of bioinformatics. Topics and features: Explains the fundamentals of information science relevant to biology, discussing set theory, combinatorics, probability, likelihood, clustering, pattern recognition, randomness, complexity, systems, and networks Covers both organismal (ontogeny and phylogeny, as well as genome structure) and molecular aspects Critically examines the most important practical applications of bioinformatics, providing detailed descriptions of both the experimental process and the analysis of the data Provides a varied selection of problems throughout the book, to stimulate further thinking Contains an extensive bibliography offering a guide to further reading and to the latest reported research Combining the successful formula of the previous editions with significantly enhanced new content, this textbook serves as a complete study companion for undergraduates and the beginning graduate student. With its invaluable insights into the state-of-the-art of bioinformatics, the book is also ideal for physical scientists seeking a succinct guide to biology, and for biological scientists wishing to better understand the physicochemical and mathematical aspects underpinning the applications
    Keywords Bioinformatics ; Biology/Data processing ; Computer science ; Cytology ; Systems theory
    Language English
    Size Online-Ressource (XIX, 308 S. 34 illus), online resource
    Edition 3rd ed.
    Publisher Springer
    Publishing place London
    Document type Book ; Online
    ISBN 9781447167013 ; 9781447167020 ; 1447167015 ; 1447167023
    DOI 10.1007/978-1-4471-6702-0
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book: Bioinformatics

    Ramsden, Jeremy

    an introduction

    (Computational biology ; 21)

    2015  

    Author's details Jeremy Ramsden
    Series title Computational biology ; 21
    Language English
    Size XIX, 308 S., Ill., graph. Darst., 24 cm
    Edition 3rd ed.
    Publisher Springer
    Publishing place London ;Heidelberg u.a.
    Document type Book
    Note Author: Jeremy Ramsden (The University of Buckingham, Buckingham, UK) ; Includes bibliographical references and index
    ISBN 9781447167013 ; 9781447167020 ; 1447167015 ; 1447167023
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article: Is it time for biocatalysis in fragment-based drug discovery?

    Ramsden, Jeremy I / Cosgrove, Sebastian C / Turner, Nicholas J

    Chemical science

    2020  Volume 11, Issue 41, Page(s) 11104–11112

    Abstract: The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to ... ...

    Abstract The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d0sc04103c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Applied nanotechnology

    Ramsden, Jeremy

    the conversion of research results to products

    (Micro and Nano Technologies)

    2014  

    Abstract: Applied Nanotechnology takes an integrated approach to the scientific, commercial and social aspects of nanotechnology, exploring: The relationship between nanotechnology and innovationThe changing economics and business models required to commercialize ...

    Author's details Jeremy J. Ramsden, University of Buckingham, Buckingham, UK
    Series title Micro and Nano Technologies
    Abstract Applied Nanotechnology takes an integrated approach to the scientific, commercial and social aspects of nanotechnology, exploring: The relationship between nanotechnology and innovationThe changing economics and business models required to commercialize innovations in nanotechnology Product design case studies Applications in various sectors, including information technology, composite materials, energy, and agriculture The role of government in promoting nanotechnology The potential future of molecular self-assembly in industrial production In this 2e, new chapters have been added on energ
    Keywords Nanostructured materials industry ; Nanotechnology
    Language English
    Size Online-Ressource (235 pages), illustrations
    Edition Second edition
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781455731893 ; 1455731897
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article: Rapid inactivation of SARS-CoV-2 by titanium dioxide surface coating.

    Micochova, Petra / Chadha, Ambika / Hesseloj, Timi / Fraternali, Franca / Ramsden, Jeremy J / Gupta, Ravindra K

    Wellcome open research

    2021  Volume 6, Page(s) 56

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.16577.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Data evaluation for surface-sensitive label-free methods to obtain real-time kinetic and structural information of thin films: A practical review with related software packages.

    Saftics, Andras / Kurunczi, Sándor / Peter, Beatrix / Szekacs, Inna / Ramsden, Jeremy J / Horvath, Robert

    Advances in colloid and interface science

    2021  Volume 294, Page(s) 102431

    Abstract: Interfacial layers are important in a wide range of applications in biomedicine, biosensing, analytical chemistry and the maritime industries. Given the growing number of applications, analysis of such layers and understanding their behavior is becoming ... ...

    Abstract Interfacial layers are important in a wide range of applications in biomedicine, biosensing, analytical chemistry and the maritime industries. Given the growing number of applications, analysis of such layers and understanding their behavior is becoming crucial. Label-free surface sensitive methods are excellent for monitoring the formation kinetics, structure and its evolution of thin layers, even at the nanoscale. In this paper, we review existing and commercially available label-free techniques and demonstrate how the experimentally obtained data can be utilized to extract kinetic and structural information during and after formation, and any subsequent adsorption/desorption processes. We outline techniques, some traditional and some novel, based on the principles of optical and mechanical transduction. Our special focus is the current possibilities of combining label-free methods, which is a powerful approach to extend the range of detected and deduced parameters. We summarize the most important theoretical considerations for obtaining reliable information from measurements taking place in liquid environments and, hence, with layers in a hydrated state. A thorough treamtmaent of the various kinetic and structural quantities obtained from evaluation of the raw label-free data are provided. Such quantities include layer thickness, refractive index, optical anisotropy (and molecular orientation derived therefrom), degree of hydration, viscoelasticity, as well as association and dissociation rate constants and occupied area of subsequently adsorbed species. To demonstrate the effect of variations in model conditions on the observed data, simulations of kinetic curves at various model settings are also included. Based on our own extensive experience with optical waveguide lightmode spectroscopy (OWLS) and the quartz crystal microbalance (QCM), we have developed dedicated software packages for data analysis, which are made available to the scientific community alongside this paper.
    Language English
    Publishing date 2021-04-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 210507-x
    ISSN 1873-3727 ; 0001-8686
    ISSN (online) 1873-3727
    ISSN 0001-8686
    DOI 10.1016/j.cis.2021.102431
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Book: Spiritual motivation

    Ramsden, Jeremy

    new thinking for business and management

    2007  

    Author's details ed. by Jeremy Ramsden
    Keywords Weltanschauung ; Religion ; Ethik ; Management ; Führungsstil ; Arbeitspsychologie ; Japan ; Welt
    Language English
    Size XXXI, 217 S., graph. Darst., 23cm
    Publisher Palgrave Macmillan
    Publishing place Basingstoke u.a.
    Document type Book
    Note Formerly CIP ; Includes bibliographical references and index
    ISBN 0230542913 ; 9780230542914
    Database ECONomics Information System

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