Result 1 - 10 of total 434
The North-Western medical and surgical journal
2023 Volume 6, Issue 10, Page(s) 449–450
| Language | English |
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| Publishing date | 2023-06-15 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Crop Science. 2023 , v. 63, no. 3 p.1397-1407
2023
Abstract: Inverse genetic correlations between cured leaf yields and alkaloid accumulation in flue‐cured tobacco (Nicotiana tabacum L.) complicate the development of higher yielding cultivars while maintaining alkaloids at commercially acceptable levels. ... ...
| Abstract | Inverse genetic correlations between cured leaf yields and alkaloid accumulation in flue‐cured tobacco (Nicotiana tabacum L.) complicate the development of higher yielding cultivars while maintaining alkaloids at commercially acceptable levels. Introgression of genomic regions from exotic source material that positively affect alkaloid levels, but with less of a corresponding negative influence on yielding ability, could enhance long‐term efforts to develop improved cultivars. Germplasm accessions “TI 464” and “TI 959” were previously identified as being potentially useful for this purpose. In this study, the relationships between yield and alkaloid accumulation were investigated in BC₁F₁ populations derived from crosses with these materials and found to be slightly negative or slightly positive. Derived BC₁F₂ families were used to calculate heritability estimates for alkaloid accumulation on a single plant basis that were low to intermediate in magnitude. The relationships between alkaloid levels of leaves from individual stalk positions and alkaloid levels averaged over all stalk positions were determined. The third stalk position was found to be the most predictive of average alkaloid levels. Selection for alkaloid levels using a single leaf from this stalk position could increase breeding efficiency. BC₄F₆ lines carrying low genomic contributions from either TI 464 or TI 959 were generated and evaluated as lines per se and in F₁ hybrid combinations with a very high‐yielding inbred line with increased leaf number. Performance of these materials indicated that TI 464 and, to a lesser extent TI 959, may be useful for developing higher yielding tobacco cultivars with acceptable alkaloid levels. |
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| Keywords | Nicotiana tabacum ; alkaloids ; cultivars ; flue-cured tobacco ; genetic correlation ; genomics ; germplasm ; heritability ; hybrids ; inbred lines ; introgression ; leaves |
| Language | English |
| Dates of publication | 2023-05 |
| Size | p. 1397-1407. |
| Publishing place | John Wiley & Sons, Ltd |
| Document type | Article ; Online |
| Note | JOURNAL ARTICLE |
| ZDB-ID | 410209-5 |
| ISSN | 0011-183X |
| ISSN | 0011-183X |
| DOI | 10.1002/csc2.20954 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 1450: Show issues | ||||
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2020 Volume 552, Issue 7685, Page(s) S78
| Language | English |
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| Publishing date | 2020-02-21 |
| Publishing country | England |
| Document type | News |
| ZDB-ID | 120714-3 |
| ISSN | 1476-4687 ; 0028-0836 |
| ISSN (online) | 1476-4687 |
| ISSN | 0028-0836 |
| DOI | 10.1038/d41586-017-08314-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 26: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 244: Show issues |
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GeoHealth
2024 Volume 8, Issue 3, Page(s) e2023GH000991
Abstract: Wildfires are increasing in frequency and intensity, with significant consequences that impact human health. A scoping review was conducted to: (a) understand wildfire-related health effects, (b) identify and describe environmental exposure and health ... ...
| Abstract | Wildfires are increasing in frequency and intensity, with significant consequences that impact human health. A scoping review was conducted to: (a) understand wildfire-related health effects, (b) identify and describe environmental exposure and health outcome data sources used to research the impacts of wildfire exposures on health, and (c) identify gaps and opportunities to leverage exposure and health data to advance research. A literature search was conducted in PubMed and a sample of 83 articles met inclusion criteria. A majority of studies focused on respiratory and cardiovascular outcomes. Hospital administrative data was the most common health data source, followed by government data sources and health surveys. Wildfire smoke, specifically fine particulate matter (PM |
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| Language | English |
| Publishing date | 2024-03-13 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2471-1403 |
| ISSN (online) | 2471-1403 |
| DOI | 10.1029/2023GH000991 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2018 Volume 552, Issue 7685, Page(s) S78
| MeSH term(s) | Antineoplastic Combined Chemotherapy Protocols/economics ; Cost Control ; Cost-Benefit Analysis ; Drug Costs ; Drug Industry/economics ; Health Policy ; Humans ; Immunotherapy/economics ; Insurance, Health/economics ; Neoplasms/economics ; Neoplasms/immunology ; Neoplasms/therapy ; Policy Making ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Quality of Life ; Quality-Adjusted Life Years ; Receptors, Antigen, T-Cell/therapeutic use ; Survival Analysis |
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| Chemical Substances | Receptors, Antigen, T-Cell ; tisagenlecleucel (Q6C9WHR03O) |
| Language | English |
| Publishing date | 2018-01-04 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 120714-3 |
| ISSN | 1476-4687 ; 0028-0836 |
| ISSN (online) | 1476-4687 |
| ISSN | 0028-0836 |
| DOI | 10.1038/d41586-017-08314-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 26: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 244: Show issues |
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Seminars in thoracic and cardiovascular surgery
2022 Volume 35, Issue 1, Page(s) 125–126
| MeSH term(s) | Humans ; Young Adult ; Aortic Valve/surgery ; Treatment Outcome ; Heart Valve Diseases/surgery ; Aortic Valve Insufficiency/surgery ; Pulmonary Valve/surgery ; Retrospective Studies ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation/methods ; Follow-Up Studies |
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| Language | English |
| Publishing date | 2022-04-09 |
| Publishing country | United States |
| Document type | Editorial |
| ZDB-ID | 1038278-1 |
| ISSN | 1532-9488 ; 1043-0679 |
| ISSN (online) | 1532-9488 |
| ISSN | 1043-0679 |
| DOI | 10.1053/j.semtcvs.2022.04.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2747: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2023 Volume 41, Issue 16, Page(s) 3051–3058
Abstract: Patients with cancer face an array of financial consequences as a result of their diagnosis and treatment, collectively referred to as financial toxicity (FT). In the past 10 years, the body of literature on this subject has grown tremendously, with a ... ...
| Abstract | Patients with cancer face an array of financial consequences as a result of their diagnosis and treatment, collectively referred to as financial toxicity (FT). In the past 10 years, the body of literature on this subject has grown tremendously, with a recent focus on interventions and mitigation strategies. In this review, we will briefly summarize the FT literature, focusing on the contributing factors and downstream consequences on patient outcomes. In addition, we will put FT into context with our emerging understanding of the role of social determinants of health and provide a framework for understanding FT across the cancer care continuum. We will then discuss the role of the oncology community in addressing FT and outline potential strategies that oncologists and health systems can implement to reduce this undue burden on patients with cancer and their families. |
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| MeSH term(s) | Humans ; Cost of Illness ; Financial Stress ; Neoplasms/drug therapy ; Medical Oncology ; Oncologists |
| Language | English |
| Publishing date | 2023-04-18 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 604914-x |
| ISSN | 1527-7755 ; 0732-183X |
| ISSN (online) | 1527-7755 |
| ISSN | 0732-183X |
| DOI | 10.1200/JCO.22.01799 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1847: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
2018 Volume 21, Issue 7, Page(s) 991–995
Abstract: The Food and Drug Administration has announced the potential for mandated lowering of nicotine levels in combustible cigarettes. The World Health Organization has recommended a lowering of cigarette filler nicotine levels to below 0.4 mg/g. To devise ... ...
| Abstract | The Food and Drug Administration has announced the potential for mandated lowering of nicotine levels in combustible cigarettes. The World Health Organization has recommended a lowering of cigarette filler nicotine levels to below 0.4 mg/g. To devise appropriate nicotine control strategies, regulators must consider technical feasibility, timelines for compliance, and potential impediments to implementation. Outlined here is previously unsummarized information on genetic approaches that might be used to reduce nicotine levels in cured tobacco leaves. For the benefit of regulators, altered alkaloid or toxicant profiles that might result by implementation of some of these methodologies are discussed. Also mentioned are potential licensing or regulatory impediments to use of some of the technologies per se. Implications: An understanding of technical feasibility of plant-based nicotine reduction technologies, along with the potential for corresponding alterations in alkaloid or toxicant profiles, is needed by regulators to develop effective nicotine control strategies with minimal impediments or undesirable consequences. |
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| MeSH term(s) | Alkaloids/adverse effects ; Alkaloids/genetics ; Genetic Engineering/methods ; Genetic Engineering/trends ; Humans ; Nicotine/adverse effects ; Nicotine/genetics ; Tobacco Products/adverse effects ; United States ; United States Food and Drug Administration/trends ; World Health Organization |
| Chemical Substances | Alkaloids ; Nicotine (6M3C89ZY6R) |
| Language | English |
| Publishing date | 2018-01-31 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 1452315-2 |
| ISSN | 1469-994X ; 1462-2203 |
| ISSN (online) | 1469-994X |
| ISSN | 1462-2203 |
| DOI | 10.1093/ntr/nty022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5789: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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JTCVS techniques
2021 Volume 7, Page(s) 43–44
| Language | English |
|---|---|
| Publishing date | 2021-04-10 |
| Publishing country | United States |
| Document type | Editorial ; Comment |
| ISSN | 2666-2507 |
| ISSN (online) | 2666-2507 |
| DOI | 10.1016/j.xjtc.2021.04.004 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Canadian Medical Association journal
2010 Volume 37, Issue 3, Page(s) 253–256
| Language | English |
|---|---|
| Publishing date | 2010-03-22 |
| Publishing country | Canada |
| Document type | Journal Article |
| ZDB-ID | 215506-0 |
| ISSN | 1488-2329 ; 0008-4409 ; 0820-3946 |
| ISSN (online) | 1488-2329 |
| ISSN | 0008-4409 ; 0820-3946 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ua VI Zs.136: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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