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  1. Article ; Online: Determining the Young's Modulus of the Bacterial Cell Envelope.

    Lee, Junsung / Jha, Karan / Harper, Christine E / Zhang, Wenyao / Ramsukh, Malissa / Bouklas, Nikolaos / Dörr, Tobias / Chen, Peng / Hernandez, Christopher J

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 5, Page(s) 2956–2966

    Abstract: Bacteria experience substantial physical forces in their natural environment, including forces caused by osmotic pressure, growth in constrained spaces, and fluid shear. The cell envelope is the primary load-carrying structure of bacteria, but the ... ...

    Abstract Bacteria experience substantial physical forces in their natural environment, including forces caused by osmotic pressure, growth in constrained spaces, and fluid shear. The cell envelope is the primary load-carrying structure of bacteria, but the mechanical properties of the cell envelope are poorly understood; reports of Young's modulus of the cell envelope of
    MeSH term(s) Staphylococcus aureus/physiology ; Staphylococcus aureus/drug effects ; Vibrio cholerae/physiology ; Escherichia coli/physiology ; Escherichia coli/drug effects ; Elastic Modulus ; Finite Element Analysis ; Cell Membrane/physiology ; Cell Membrane/drug effects ; Cell Wall/drug effects
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.4c00105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: Investigating the cellular mechanism of age-related stem cell dysfunction

    Leucht, Philipp / Ramsukh, Malissa / Morgani, Sophie / Leclerc, Kevin / Sambon, Margaux / Remark, Lindsey

    2023  , Page(s) AB91–2614

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou542
    Database German Medical Science

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  3. Article ; Online: Hox genes are crucial regulators of periosteal stem cell identity.

    Leclerc, Kevin / Remark, Lindsey H / Ramsukh, Malissa / Josephson, Anne Marie / Palma, Laura / Parente, Paulo E L / Sambon, Margaux / Lee, Sooyeon / Lopez, Emma Muiños / Morgani, Sophie M / Leucht, Philipp

    Development (Cambridge, England)

    2023  Volume 150, Issue 6

    Abstract: Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is crucial for the successful generation and application of future therapeutics. Here, ... ...

    Abstract Periosteal stem and progenitor cells (PSPCs) are major contributors to bone maintenance and repair. Deciphering the molecular mechanisms that regulate their function is crucial for the successful generation and application of future therapeutics. Here, we pinpoint Hox transcription factors as necessary and sufficient for periosteal stem cell function. Hox genes are transcriptionally enriched in periosteal stem cells and their overexpression in more committed progenitors drives reprogramming to a naïve, self-renewing stem cell-like state. Crucially, individual Hox family members are expressed in a location-specific manner and their stem cell-promoting activity is only observed when the Hox gene is matched to the anatomical origin of the PSPC, demonstrating a role for the embryonic Hox code in adult stem cells. Finally, we demonstrate that Hoxa10 overexpression partially restores the age-related decline in fracture repair. Together, our data highlight the importance of Hox genes as key regulators of PSPC identity in skeletal homeostasis and repair.
    MeSH term(s) Humans ; Adult ; Genes, Homeobox/genetics ; Homeodomain Proteins/genetics ; Stem Cells ; Bone and Bones ; Adult Stem Cells
    Chemical Substances Homeodomain Proteins
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 91: Show issues

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  4. Article ; Online: Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging.

    Lopez, Emma Muiños / Leclerc, Kevin / Ramsukh, Malissa / Parente, Paulo El / Patel, Karan / Aranda, Carlos J / Josephson, Anna M / Remark, Lindsey H / Kirby, David J / Buchalter, Daniel B / Hadi, Tarik / Morgani, Sophie M / Ramkhelawon, Bhama / Leucht, Philipp

    Bone

    2022  Volume 157, Page(s) 116324

    Abstract: Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful ... ...

    Abstract Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful healing. Here, we precisely define the systemic and local immune cell response after femur fracture in young and aging mice and identify increased toll-like receptor signaling as a potential culprit for the abnormal immune cell recruitment observed in aging animals. Myd88, an upstream regulator of TLR-signaling lies at the core of this aging phenotype, and local treatment of femur fractures with a Myd88 antagonist in middle-aged mice reverses the aging phenotype of impaired fracture healing, thus offering a promising therapeutic target that could overcome the negative impact of aging on bone regeneration.
    MeSH term(s) Adaptive Immunity ; Aging ; Animals ; Bone Regeneration ; Fracture Healing ; Fractures, Bone ; Immunity, Innate ; Mice ; Myeloid Differentiation Factor 88/genetics
    Chemical Substances Myeloid Differentiation Factor 88
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2021.116324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1571: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 332: Show issues

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  5. Article: Loss of Notch signaling in skeletal stem cells enhances bone formation with aging.

    Remark, Lindsey H / Leclerc, Kevin / Ramsukh, Malissa / Lin, Ziyan / Lee, Sooyeon / Dharmalingam, Backialakshmi / Gillinov, Lauren / Nayak, Vasudev V / El Parente, Paulo / Sambon, Margaux / Atria, Pablo J / Ali, Mohamed A E / Witek, Lukasz / Castillo, Alesha B / Park, Christopher Y / Adams, Ralf H / Tsirigos, Aristotelis / Morgani, Sophie M / Leucht, Philipp

    Bone research

    2023  Volume 11, Issue 1, Page(s) 50

    Abstract: Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation ... ...

    Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed that Notch signaling becomes elevated in SSPCs during aging. To examine the role of increased Notch activity, we deleted Nicastrin, an essential Notch pathway component, in SSPCs in vivo. Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair. Thus, Notch regulates SSPC cell fate decisions, and moderating Notch signaling ameliorates the skeletal aging phenotype, increasing bone mass even beyond that of young mice. Finally, we identified the transcription factor Ebf3 as a downstream mediator of Notch signaling in SSPCs that is dysregulated with aging, highlighting it as a promising therapeutic target to rejuvenate the aged skeleton.
    MeSH term(s) Animals ; Mice ; Osteogenesis/genetics ; Adipocytes ; Adiposity ; Aging/genetics ; Arthrodesis ; Mice, Knockout ; Psychomotor Agitation
    Language English
    Publishing date 2023-09-27
    Publishing country China
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2803313-9
    ISSN 2095-6231 ; 2095-4700
    ISSN (online) 2095-6231
    ISSN 2095-4700
    DOI 10.1038/s41413-023-00283-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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