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Article ; Online: An Approach for Measuring Complexity Degree of International Engineering Projects

Qianqian Ju / Yankun Sun / Ran Chen

Sustainability, Vol 15, Iss 9791, p

2023 Volume 9791

Abstract: With the increasing trend of globalization, countries actively join the international engineering market, increasing the complexity of projects. An appropriate method for assessing project complexity can help project managers recognize the current ... ...

Abstract	With the increasing trend of globalization, countries actively join the international engineering market, increasing the complexity of projects. An appropriate method for assessing project complexity can help project managers recognize the current situation and solve problems. However, existing complexity studies ignored the contribution of human element. The impact of human activities on the complexity of socio-economic systems is concerned in the Harmony Management Theory (HMT), therefore, this study proposed a complexity measurement based on the Harmony Management Theory. Firstly, an evaluation indicator system including three dimensions of organizational, technological, and environmental complexity is proposed through a literature review, Back-Propagation Neural Network-Decision Making Trial and Evaluation Laboratory (BP-DEMATEL) method, and Interval-valued intuitionistic Fuzzy Sets (IIFS) are used to calculate complexity scores. Then, a case study of Yawan high-speed railway project is conducted to verify the effectiveness of the proposed method. The main conclusions are as follows: (1) The complexity measurement based on harmony theory can be carried out from three aspects: Organization, technology, and environment. (2) The overall complexity performance of case project is 0.52, showing a medium level. (3) Technical complexity is the most important factor of the case project. The method proposed in this study can identify the influencing factors of complexity and calculate the comprehensive evaluation value of complexity. Based on the final quantified results, managers can formulate appropriate measures and match the project with appropriate resources so as to improve the performance of International Engineering Projects (IEPs).
Keywords	international engineering projects (IEPs) ; IEPs complexity (CIEPs) ; CIEPs measurement ; project management ; Harmony Management Theory (HMT) ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research progress of platelet apoptosis mechanism in antineoplastic drugs-induced thrombopenia

Hao-ran CHEN

Medical Journal of Chinese People's Liberation Army, Vol 44, Iss 1, Pp 80-

2019 Volume 85

Abstract: Platelets are the blood cells essential for human hemostasis, wound healing and human health. Drug-induced thrombopenia refers to a disease in which the drug causes platelet counts fall below the normal range (<100×109/L), resulting in a series of ... ...

Abstract	Platelets are the blood cells essential for human hemostasis, wound healing and human health. Drug-induced thrombopenia refers to a disease in which the drug causes platelet counts fall below the normal range (<100×109/L), resulting in a series of symptoms, including bleeding, nausea, vomiting, and abdominal pain, etc. The antineoplastic drugs-induced thrombopenia increases not only the potential bleeding risk of patients, but may also reduce the dose of anti-tumor drugs and prolong the treatment interval, or even lead to the ceasing of antitumor therapy in serious cases, which affects the clinical efficacy and survival of patients, leading to the increased medical costs. In recent years, a large number of studies have confirmed that antineoplastic drugs-induced thrombopenia is a disease caused through a non-immune-mediation, including platelet apoptosis. The research status has been reviewed in present paper of platelet apoptosis mechanism in antineoplastic drugs-induced thrombopenia to provide theoretical basis for clinical practice and scientific research. DOI:10.11855/j.issn.0577-7402.2019.01.14
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Chinese
Publishing date	2019-01-01T00:00:00Z
Publisher	Editorial Board of Medical Journal of Chinese People's Liberation Army
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fluorination Improves the Electro-Optical Properties of Benzoxazole-Terminated Liquid Crystals in High Birefringence Liquid Crystal Mixtures

Ran Chen / Zihao Mao / Zhongwei An / Xinbing Chen / Pei Chen

Molecules, Vol 28, Iss 3019, p

Experimental and Theoretical Investigations

2023 Volume 3019

Abstract: Aromatic heterocyclic liquid crystal (LC) materials have received much attention from LC chemists for their high birefringence and large dielectric anisotropy, yet few have reported their properties in LC mixtures. In this work, a series of fluorinated ... ...

Abstract	Aromatic heterocyclic liquid crystal (LC) materials have received much attention from LC chemists for their high birefringence and large dielectric anisotropy, yet few have reported their properties in LC mixtures. In this work, a series of fluorinated benzoxazole liquid crystal compounds were synthesized to evaluate their electro-optical properties in high birefringence LC mixtures, with the expectation of further establishing the theoretical basis and experimental evidence for their applications in LC photonics. Firstly, the effects of the lateral fluorine substituent positions on the molecular synthetic yield, mesomorphic and solubility properties were comparatively investigated. Afterwards, we focused on the fluorination effects on the core electro-optical properties, including birefringence, dielectric anisotropy and further investigation of the viscoelastic coefficient of high birefringence LC mixtures. Research results showed that the benzoxazole liquid crystal compounds possess low melting points, wide nematic phase intervals and good solubility by appropriate lateral fluorine substitution, which is beneficial to further improve the electro-optical properties of high birefringence LC mixtures. Meanwhile, the theoretical and experimental results corroborate each other to well reveal the structure–property relationship. This study demonstrates that fluorination would promote promising applications of benzoxazole-terminated liquid crystals in emerging LC optical devices.
Keywords	liquid crystal mixture ; high birefringence ; benzoxazole ; large dielectric anisotropy ; DFT calculations ; Organic chemistry ; QD241-441
Subject code	535
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-Resolution Mapping of Mangrove Species Height in Fujian Zhangjiangkou National Mangrove Nature Reserve Combined GF-2, GF-3, and UAV-LiDAR

Ran Chen / Rong Zhang / Chuanpeng Zhao / Zongming Wang / Mingming Jia

Remote Sensing, Vol 15, Iss 24, p

2023 Volume 5645

Abstract: Mangroves as an important blue carbon ecosystem have a unique ability to sequester and store large amounts of carbon. The height of mangrove forest is considered to be a critical factor in evaluating carbon sink capacity. However, considering the highly ... ...

Abstract	Mangroves as an important blue carbon ecosystem have a unique ability to sequester and store large amounts of carbon. The height of mangrove forest is considered to be a critical factor in evaluating carbon sink capacity. However, considering the highly complicated nature of the mangrove system, accurate estimation of mangrove species height is challenging. Gaofen-2 (GF-2) panchromatic and multispectral sensor (PMS), Gaofen-3 (GF-3) SAR images, and unmanned aerial vehicle-light detection and ranging (UAV-LiDAR) data have the capability to capture detailed information about both the horizontal and vertical structures of mangrove forests, which offer a cost-effective and reliable approach to predict mangrove species height. To accurately estimate mangrove species height, this study obtained a variety of characteristic parameters from GF-2 PMS and GF-3 SAR data and utilized the canopy height model (CHM) derived from UAV-LiDAR data as the observed data of mangrove forest height. Based on these parameters and the random forest (RF) regression algorithm, the mangrove species height result had a root-mean-square error (RMSE) of 0.91 m and an R 2 of 0.71. The Kandelia obovate (KO) exhibited the tallest tree height, reaching a maximum of 9.6 m. The polarization features, HH, VV, and texture feature, mean_1 (calculated based on the mean value of blue band in GF-2 image), had a reasonable correlation with canopy height. Among them, the most significant factor in determining the height of mangrove forest was HH. In areas where it is difficult to conduct field surveys, the results provided an opportunity to update access to acquire forest structural attributes.
Keywords	tree height ; GF-2 optical ; GF-3 SAR ; UAV-LiDAR ; random forest ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Representations of temperature in the spinal cord.

Ran, Chen

Temperature (Austin, Tex.)

2017 Volume 4, Issue 3, Page(s) 214–216

Language	English
Publishing date	2017-03-20
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2332-8940
ISSN	2332-8940
DOI	10.1080/23328940.2017.1308453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electro-optic response of bipolar nematic liquid crystal confined in oblate spheroid

Chenjing Yang / Ran Chen / Leyun Feng / Rui Zhang / Dong Chen

Frontiers in Soft Matter, Vol

2022 Volume 2

Abstract: Electro-optic response of liquid crystals (LCs) relies on the molecular reorientation of LCs under external electric field and is important for a wide spectrum of applications. Here, we uncover an interesting electro-optic response of 5CB nematic LC ... ...

Abstract	Electro-optic response of liquid crystals (LCs) relies on the molecular reorientation of LCs under external electric field and is important for a wide spectrum of applications. Here, we uncover an interesting electro-optic response of 5CB nematic LC confined in an oblate spheroid and subjected to external electric field. Under the planar anchoring, the nematic LC spheroid adopts a bipolar structure with the bipolar axis laid in the horizontal film plane. When a threshold electric field EF, is applied, the bipolar structure reorients from the horizontal configuration (LC molecules align along long axis direction) to the vertical configuration (LC molecules align along short axis direction), involving the competition of elastic energy, surface anchoring energy and electric field energy. In contrast to bipolar nematic LC droplets, the vertical configuration does not relax to the low-energy horizontal configuration after removing E; we argue that is due to the oblate shape of the nematic LC spheroid, which traps the bipolar structure in a local energy minimum. We use continuum simulation to demonstrate the detailed response and the reorientation dynamics of bipolar nematic spheroids under E field, showing consistent results with the experiments and confirming the proposed switching mechanism. Nevertheless, the vertical configuration of the bipolar structure could relax to the low-energy horizontal configuration by thermal cycling. Our studies provide clear experimental results that show the characteristics of the electro-optic response of oblate LC spheroids, which have both fundamental and practical implications.
Keywords	bipolar structure ; electro-optic response ; nematic spheroid ; planar anchoring ; liquid crystal ; Chemistry ; QD1-999 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Polymers and polymer manufacture ; TP1080-1185
Subject code	541 ; 612
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Applying a Hybrid Kano/Quality Function Deployment Integration Approach to Wood Desk Designs for Open-Plan Offices

Jianhua Lyu / Ran Chen / Lingyun Yang / Jialei Wang / Ming Chen

Forests, Vol 13, Iss 1825, p

2022 Volume 1825

Abstract: In order to better serve the users of wood desks in open-plan offices, the Kano model is used to analyze the problems encountered by users in the office. Combined with quality function deployment (QFD), this study conducted an analysis of the weighted ... ...

Abstract	In order to better serve the users of wood desks in open-plan offices, the Kano model is used to analyze the problems encountered by users in the office. Combined with quality function deployment (QFD), this study conducted an analysis of the weighted average of users’ needs and the importance of engineering measures of product technical characteristics. The proposed system uses an integrated Kano–QFD model to identify users’ specific needs and scene experience with a more complete service system. Through the hybrid approach of the Kano model and QFD development and design technology, the wood desks in open-plan offices are optimized to improve the rationality and scientific nature of office furniture and enhance its market competitiveness.
Keywords	Kano–QFD integration model ; wood desk design ; open-plan office ; hybrid approach ; Plant ecology ; QK900-989
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Difluorovinyl Liquid Crystal Diluters Improve the Electro-Optical Properties of High-∆ n Liquid Crystal Mixture for AR Displays

Jiaxing Tang / Zihao Mao / Zhongwei An / Ran Chen / Xinbing Chen / Pei Chen

Molecules, Vol 28, Iss 2458, p

2023 Volume 2458

Abstract: A liquid crystal (LC) mixture in liquid crystal on silicon (LCoS) is the core material for augmented reality (AR) displays. However, a LC mixture with high birefringence (Δ n ) and large dielectric anisotropy (Δ ε ) possesses high viscosity ( γ 1 ), ... ...

Abstract	A liquid crystal (LC) mixture in liquid crystal on silicon (LCoS) is the core material for augmented reality (AR) displays. However, a LC mixture with high birefringence (Δ n ) and large dielectric anisotropy (Δ ε ) possesses high viscosity ( γ 1 ), which results in a slow response time of LCoS devices for AR displays. This work proposes to apply difluorovinyl-based LC diluters to fine balance the low viscosity, high ∆ n , and large ∆ ε of the LC mixture for a fast response time. Through studying their effects on the key electro-optical properties of a high-∆ n LC mixture, it is found that doping these diluter molecules to a high-∆ n LC mixture can decrease the viscoelastic coefficient ( γ 1 / K 11 ), increase ∆ ε and the figure of merit, maintain a wide nematic phase temperature range, a high clearing point, and ∆ n . It also means that these diluters could effectively regulate the relationship between ∆ n , ∆ ε , and γ 1 in the LC mixtures to achieve a fine balance of various excellent properties and further improve the LC device’s response time. The widespread applications of these liquid crystal diluters in emerging liquid crystal optical devices are foreseeable.
Keywords	high birefringence liquid crystal ; diluter molecule ; AR displays ; large dielectric anisotropy ; low viscosity ; Organic chemistry ; QD241-441
Subject code	535
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins

Ran Chen / Jie Zhou / Wei Xie

Toxins, Vol 13, Iss 319, p

2021 Volume 319

Abstract: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis ( M. tb ). It is regarded as a major health threat all over the world, mainly because of its high mortality and drug-resistant nature. Toxin-antitoxin (TA) systems are modules ...

Abstract	Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis ( M. tb ). It is regarded as a major health threat all over the world, mainly because of its high mortality and drug-resistant nature. Toxin-antitoxin (TA) systems are modules ubiquitously found in prokaryotic organisms, and the well-studied MazEF systems (MazE means “what is it?” in Hebrew) are implicated in the formation of “persister cells” in the M. tb pathogen. Here, we report cocrystal structures of M. tb MazF-mt1 and -mt9, two important MazF members responsible for specific mRNA and tRNA cleavages, respectively, in complexes with truncated forms of their cognate antitoxin peptides. These peptides bind to the toxins with comparable affinities to their full-length antitoxins, which would reduce the RNA-cleavage capacities of the toxins in vitro. After structural analysis of the binding modes, we systemically tested the influence of the substitutions of individual residues in the truncated MazE-mt9 peptide on its affinity. This study provides structural insight into the binding modes and the inhibition mechanisms between the MazE/F-mt TA pairs. More importantly, it contributes to the future design of peptide-based antimicrobial agents against TB and potentially relieves the drug-resistance problems by targeting novel M. tb proteins.
Keywords	Tuberculosis ; Mycobacterium tuberculosis ; TA system ; MazEF ; antimicrobial peptide ; cocrystal structure ; Medicine ; R
Subject code	540
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The relationship between aspirin consumption and hepatocellular carcinoma

Shuai Wang / Lijuan Zuo / Zhaojin Lin / Zhiqin Yang / Ran Chen / Yan Xu

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

a systematic review and meta-analysis

2023 Volume 14

Abstract: Abstract Background Recent studies have shown that aspirin consumption may reduce the risk of hepatocellular carcinoma (HCC), but their correlation is still not fully understood. This meta-analysis aimed to investigate the correlation between aspirin ... ...

Abstract	Abstract Background Recent studies have shown that aspirin consumption may reduce the risk of hepatocellular carcinoma (HCC), but their correlation is still not fully understood. This meta-analysis aimed to investigate the correlation between aspirin consumption and HCC. Methods A systematic literature search was conducted on PubMed, Scopus, Cochrane Library, EMBASE, and Web of Science databases. The search period was from the establishment of the database to July 1, 2022 with no language restrictions. Results A total of 19 studies including three prospective studies and 16 retrospective ones with 2,217,712 patients were included. Compared with those who did not take aspirin, those who took aspirin had a 30% lower risk of HCC (hazard ratio [HR] = 0.70, 95% confidence interval [CI] 0.63–0.76, I 2 = 84.7%, P < 0.001). Subgroup analysis showed that aspirin significantly reduced the risk of HCC by 19% in Asia (HR = 0.81, 95% CI 0.80–0.82, I 2 = 85.2%, P < 0.001) and by 33% (HR = 0.67, 95% CI 0.61–0.73, I 2 = 43.6%, P = 0.150) in Europe and the U.S with no significant difference. Moreover, in patients with HBV or HCV infection, aspirin reduced 19% and 24% of the risk of HCC, respectively. However, aspirin administration might increase risks of gastrointestinal bleeding in patients with chronic liver disease (HR = 1.14, 95% CI 0.99–1.31, I 2 = 0.0%, P = 0.712). Sensitivity analysis showed no significant difference of results after excluding individual studies, suggesting that the results were robust. Conclusion Aspirin may reduce the risk of HCC in both healthy population and patients with chronic liver disease. However, attention should be paid to adverse events such as gastrointestinal bleeding in patients with chronic liver disease.
Keywords	Aspirin ; Hepatocellular carcinoma ; Meta-analysis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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