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Article ; Online: Design and Synthesis of Indazole-Indole Hybrid via

Kar, Abhishek / Rana, Gopal / Sahoo, Rajkamal / Ghosh, Sourav / Jana, Umasish

2024 Volume 89, Issue 10, Page(s) 7295–7302

Abstract: In this report, ... ...

Abstract	In this report, a
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.4c00377
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Article ; Online: Efficacy of Salivary Urea and Creatinine Compared to Serum Levels in Chronic Kidney Disease Patients

Afreen Arshad Choudhry / Ketki Khandhadiya / Shailesh Kumar / Rana Gopal Singh / Mahendra Prasad

Journal of Clinical and Diagnostic Research, Vol 18, Iss 01, Pp 05-

A Cross-sectional Study

2024 Volume 08

Abstract: Introduction: Chronic Kidney Disease (CKD) has become an impending health concern due to the massive rise in the number of patients with diabetes mellitus and hypertension. Monitoring CKD patients typically requires regular invasive testing, and a simple ...

Abstract	Introduction: Chronic Kidney Disease (CKD) has become an impending health concern due to the massive rise in the number of patients with diabetes mellitus and hypertension. Monitoring CKD patients typically requires regular invasive testing, and a simple diagnostic test that does not involve venipuncture would greatly benefit patients and healthcare professionals. Extensive research is being conducted to explore the use of saliva as a Non invasive tool for evaluation of systemic diseases like CKD. However, most of these studies have focused on End Stage Renal Disease (ESRD) patients. Aim: To investigate the correlation between salivary urea and creatinine levels and their serum counterparts in CKD patients and healthy controls. Additionally, the study aimed to assess the efficacy of salivary urea and creatinine compared to serum urea and creatinine in predicting CKD. Materials and Methods: The present cross-sectional study was conducted between January 2021 and July 2022 in the Department of Biochemistry, in collaboration with the Department of Medicine, at Heritage Institute of Medical Sciences in Varanasi, Uttar Pradesh, India. The study included a total of 60 participants: 30 CKD patients (stage 1-3) and 30 age-matched healthy controls. Serum and salivary urea were analysed using the Urease-Glutamate Dehydrogenase (GLDH) method, and creatinine was measured using the Modified Jaffe’s method on the Dirui-300B autoanalyser. Data were statistically analysed using Pearson’s correlation coefficient. The sensitivity, specificity, and Area Under the Curve (AUC) of salivary urea and creatinine were evaluated in comparison to their serum counterparts. Results: The participants consisted of 30 CKD patients with a mean age of 54.8±8.8 years and 30 age-matched healthy controls with a mean age of 52.42±8.4 years. A significant difference in salivary urea and creatinine levels was observed between the control and CKD groups. There was a strong and significant correlation (p-value <0.01) between salivary creatinine and ...
Keywords	non invasive biomarkers ; salivary analytes ; salivary biomarkers ; Medicine ; R
Subject code	630
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article ; Online: DDQ/Fe(NO

Rana, Gopal / Kar, Abhishek / Kundal, Sandip / Musib, Dulal / Jana, Umasish

The Journal of organic chemistry

2023 Volume 88, Issue 2, Page(s) 838–851

Abstract: In the present study, we herein report a DDQ-catalyzed new protocol for the synthesis of substituted 3-acylindoles. Being a potential system for virtual hydrogen storage, introduction of catalytic DDQ in combination with Fe( ... ...

Abstract	In the present study, we herein report a DDQ-catalyzed new protocol for the synthesis of substituted 3-acylindoles. Being a potential system for virtual hydrogen storage, introduction of catalytic DDQ in combination with Fe(NO
MeSH term(s)	Humans ; SARS-CoV-2 ; Molecular Docking Simulation ; Ligands ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; Indoles/pharmacology
Chemical Substances	Ligands ; Antiviral Agents ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Indoles
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c02009
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Article ; Online: The synthesis of indole-3-carbinols (I3C) and their application to access unsymmetrical bis(3-indolyl)methanes (BIMs) bearing a quaternary sp

Kundal, Sandip / Rana, Gopal / Kar, Abhishek / Jana, Umasish

Organic & biomolecular chemistry

2022 Volume 20, Issue 26, Page(s) 5234–5238

Abstract: In the present study, the novel synthesis ... ...

Abstract	In the present study, the novel synthesis of
MeSH term(s)	Carbon ; Indoles ; Water
Chemical Substances	Indoles ; Water (059QF0KO0R) ; Carbon (7440-44-0) ; indole-3-carbinol (C11E72455F)
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob00502f
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Article ; Online: Iron(III)-catalyzed synthesis of indole-xanthydrol hybrid through oxidative cycloisomerization/hydroxylation reaction.

Kar, Abhishek / Rana, Gopal / Chanda, Rupsa / Jana, Umasish

Organic & biomolecular chemistry

2022 Volume 20, Issue 43, Page(s) 8545–8553

Abstract: An efficient one-pot synthesis of an indole-xanthydrol hybrid is described in the presence of catalytic combinations of Fe(NO ... 3 ... ) ... 3 ... /FeCl ... 3 ... This strategy involves a series of reactions such as allylic oxidation, isomerisation, ...

Abstract	An efficient one-pot synthesis of an indole-xanthydrol hybrid is described in the presence of catalytic combinations of Fe(NO<sub>3</sub>)<sub>3</sub>/FeCl<sub>3</sub>. This strategy involves a series of reactions such as allylic oxidation, isomerisation, cyclisation and hydroxylation reactions in a tandem manner. This protocol offers several advantages including mild reaction conditions, operational simplicity, high selectivity, good yields and easily accessible starting materials. The synthetic utility of this protocol was further demonstrated by the one-pot synthesis of the highly substituted xanthene containing bis-indolylmethane derivative. The preliminary mechanistic studies reveal that the reaction is initiated by the generation of radicals in the presence of catalytic iron(III)-salts.
MeSH term(s)	Iron ; Hydroxylation ; Catalysis ; Xanthenes ; Indoles ; Oxidative Stress
Chemical Substances	Iron (E1UOL152H7) ; xanthydrol (7131M69IKF) ; Xanthenes ; Indoles
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01727j
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Article ; Online: Mutational screening of PKD1 and PKD2 in Indian ADPKD patients identified 95 genetic variants.

Raj, Sonam / Singh, Rana Gopal / Das, Parimal

Mutation research

2020 Volume 821, Page(s) 111718

Abstract: Background: Mutation screening of autosomal dominant polycystic kidney disease (ADPKD) cases imply the major involvement of PKD1 mutations in 85% of patients while rest of the cases harbor mutation in PKD2, DNAJB11 and GANAB. This essentially indicates ... ...

Abstract	Background: Mutation screening of autosomal dominant polycystic kidney disease (ADPKD) cases imply the major involvement of PKD1 mutations in 85% of patients while rest of the cases harbor mutation in PKD2, DNAJB11 and GANAB. This essentially indicates that individual's genotype holds the key for disease susceptibility and its severity. Methods: For finding genetic variability underlying the disease pathophysiology, 84 Indian ADPKD cases, 31 family members (12 susceptible) and 122 age matched control were screened for PKD1 and PKD2 using Sanger sequencing, PCR-RFLP and ARMS-PCR. Results: Genetic screening of Indian ADPKD cases revealed total 67 variants in PKD1 and 28 variants in PKD2. Among the identified variants in PKD1 and PKD2 genes, 35.79% were novel variants and 64.2% recurrent. Further, subcategorization of PKD1 variants showed 14 truncation/frameshift, 21 nonsynonymous, 25 synonymous and 7 intronic variants. Moreover, we observed 40 families with PKD1 pathogenic variants, 7 families with PKD2 pathogenic variants, 9 families with PKD1 & PKD2 pathogenic variants, and 26 families with PKD1/PKD2/PKD1-PKD2 non-pathogenic genetic variants. Conclusion: Present study represented genetic background of Indian ADPKD cases which will be helpful in disease management as well as finding the genetically matched donor for kidney transplant.
MeSH term(s)	Adult ; Case-Control Studies ; DNA Mutational Analysis ; Female ; Humans ; India/epidemiology ; Male ; Mutation ; Pedigree ; Polycystic Kidney, Autosomal Dominant/epidemiology ; Polycystic Kidney, Autosomal Dominant/genetics ; TRPP Cation Channels/genetics
Chemical Substances	TRPP Cation Channels ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein
Language	English
Publishing date	2020-08-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206607-5
ISSN	1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2020.111718
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Article ; Online: DDQ/FeCl

Kar, Abhishek / Chakraborty, Baitan / Kundal, Sandip / Rana, Gopal / Jana, Umasish

Organic & biomolecular chemistry

2021 Volume 19, Issue 4, Page(s) 906–910

Abstract: A series of diverse and complex hybrid structures of indole bearing fluorene were obtained in the presence of DDQ with high regioselectivity under mild conditions from biaryl tethered 3-(methylene)indoline in good to excellent yields. The strategy ... ...

Abstract	A series of diverse and complex hybrid structures of indole bearing fluorene were obtained in the presence of DDQ with high regioselectivity under mild conditions from biaryl tethered 3-(methylene)indoline in good to excellent yields. The strategy involves tandem allylic Csp
Language	English
Publishing date	2021-01-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d0ob00413h
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Article ; Online: A noncovalent hybrid of [Pd(phen)(OAc)

Pal, Mrityunjoy / Musib, Dulal / Pal, Maynak / Rana, Gopal / Bag, Gobinda / Dutta, Subrata / Roy, Mithun

Organic & biomolecular chemistry

2021 Volume 19, Issue 23, Page(s) 5072–5076

Abstract: We developed a novel Pd-catalysed enantioselective synthesis of C-N bonds using the chiral scaffold of DNA. The non-covalently linked [Pd(phen)(OAc)2] with st-DNA catalysed the Markonicov hydroamination of β-nitrostyrene with methoxyamine for the first ... ...

Abstract	We developed a novel Pd-catalysed enantioselective synthesis of C-N bonds using the chiral scaffold of DNA. The non-covalently linked [Pd(phen)(OAc)2] with st-DNA catalysed the Markonicov hydroamination of β-nitrostyrene with methoxyamine for the first time with >75% enantiomeric excess (ee) in an aqueous buffer (pH 7.4) at room temperature.
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d1ob00714a
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Article: Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations

Raj, Sonam / Parimal Das / Rana Gopal Singh

Journal of genetics. 2017 Dec., v. 96, no. 6

2017

Abstract: Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease. Autosomal dominant polycystic kidney disease (ADPKD) is more prevalent and leading cause of dialysis and kidney transplant. Linkage ... ...

Abstract	Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease. Autosomal dominant polycystic kidney disease (ADPKD) is more prevalent and leading cause of dialysis and kidney transplant. Linkage analysis revealed some closely linked loci, two of which are identified as PKD1, PKD2 and an unidentified locus to ADPKD. This study was performed using PCR and automated DNA sequencing in 84 cases and 80 controls to test potential candidature of PKD2 as underlying cause of PKD by in silico and statistical analyses. Two associated symptoms, hypertension (19%) and liver cyst (31%) have major contribution to PKD. Gender-based analysis revealed that familial female patients (27%) and familial male patients (33%) are more hypertensive. Liver cyst, the second major contributing symptom presented by large percentage of sporadic males (46%). Genetic screening of all 15 exons of PKD2 revealed eight pathogenic (c.854_854delG, c.915C>A, c.973C>T, c.1050_1050delC, c.1604_1604delT, c.1790T>C, c.2182_2183delAG, c.2224C>T) and eight likely pathogenic (g.11732A>G, c.646T>C, c.1354A>G, g.39212G>C, c.1789C>A, c.1849C>A, c.2164G>T, c.2494A>G) DNA sequence variants. In our study, 27.38% (23/84) cases shown pathogenic / likely pathogenic variants in PKD2 gene. Some regions of PKD2 prone for genetic variation suggested to be linked with disease pathogenesis. This noticeable hot spot regions hold higher frequency (50%) of pathogenic / likely pathogenic genetic variants constituting single nucleotide variants than large deletion and insertion that actually represents only 41.08% of coding sequence of PKD2. Statistically significant association for IVS3-22AA genotype was observed with PKD, while association of IVS4+62C>T was found insignificant.
Keywords	automation ; autosomal dominant polycystic kidney disease ; dialysis ; DNA ; exons ; females ; genetic testing ; genetic variation ; genotype ; hypertension ; kidney transplant ; liver ; loci ; males ; pathogenesis ; patients ; polymerase chain reaction ; screening ; sequence analysis ; statistical analysis
Language	English
Dates of publication	2017-12
Size	p. 885-893.
Publishing place	Springer India
Document type	Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
DOI	10.1007/s12041-017-0824-5
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Article ; Online: Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations.

Raj, Sonam / Singh, Rana Gopal / Das, Parimal

Journal of genetics

2017 Volume 96, Issue 6, Page(s) 885–893

Abstract	Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease. Autosomal dominant polycystic kidney disease (ADPKD) is more prevalent and leading cause of dialysis and kidney transplant. Linkage analysis revealed some closely linked loci, two of which are identified as PKD1, PKD2 and an unidentified locus to ADPKD. This study was performed using PCR and automated DNA sequencing in 84 cases and 80 controls to test potential candidature of PKD2 as underlying cause of PKD by in silico and statistical analyses. Two associated symptoms, hypertension (19%) and liver cyst (31%) havemajor contribution to PKD. Gender-based analysis revealed that familial female patients (27%) and familialmale patients (33%) are more hypertensive. Liver cyst, the second major contributing symptom presented by large percentage of sporadic males (46%). Genetic screening of all 15 exons of PKD2 revealed eight pathogenic (c.854_854delG, c.915C>A, c.973C>T, c.1050_1050delC, c.1604_1604delT, c.1790T>C, c.2182_2183delAG, c.2224C>T) and eight likely pathogenic (g.11732A>G, c.646T>C, c.1354A>G, g.39212G>C, c.1789C>A, c.1849C>A, c.2164G>T, c.2494A>G)DNA sequence variants. In our study, 27.38% (23/84) cases shown pathogenic / likely pathogenic variants in PKD2 gene. Some regions of PKD2 prone for genetic variation suggested to be linked with disease pathogenesis. This noticeable hot spot regions hold higher frequency (50%) of pathogenic / likely pathogenic genetic variants constituting single nucleotide variants than large deletion and insertion that actually represents only 41.08% of coding sequence of PKD2. Statistically significant association for IVS3-22AA genotype was observed with PKD, while association of IVS4+62C>T was found insignificant.
MeSH term(s)	Asian Continental Ancestry Group/genetics ; DNA Mutational Analysis ; Exons/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic Testing ; Genetic Variation/genetics ; Genotype ; Humans ; India/epidemiology ; Male ; Mutation ; Polycystic Kidney, Autosomal Dominant/epidemiology ; Polycystic Kidney, Autosomal Dominant/genetics ; Sequence Analysis, DNA ; TRPP Cation Channels/genetics
Chemical Substances	TRPP Cation Channels ; polycystic kidney disease 2 protein
Language	English
Publishing date	2017-12-08
Publishing country	India
Document type	Journal Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
DOI	10.1007/s12041-017-0824-5
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