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Article ; Online: Method for evaluating the fit of custom-fit Continuous Positive Airway Pressure masks using finite element analysis.

Martelly, Erica / Rana, Sandeep / Shimada, Kenji

Computer methods in biomechanics and biomedical engineering

2024 , Page(s) 1–18

Abstract: Continuous Positive Airway Pressure (CPAP) is a common therapy used to treat breathing disorders such as obstructive sleep apnea. In previous work, we designed a custom-fit CPAP mask to address comfort and leakage issues patients often experience. This ... ...

Abstract	Continuous Positive Airway Pressure (CPAP) is a common therapy used to treat breathing disorders such as obstructive sleep apnea. In previous work, we designed a custom-fit CPAP mask to address comfort and leakage issues patients often experience. This paper presents a method to create a finite element (FE) model to evaluate the fit of the custom-fit mask before fabrication. The model includes details such as a skull to represent the variable soft tissue thicknesses on the face, and two strap configurations, original and X. The model was tested on four subjects and results show that the X strap configuration results in a more even stress distribution, measured by standard deviation, on the face compared to the original strap, indicating better fit. The simulations also show gaps in the stress distribution that seem to correspond to areas of leakage based on two initial
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2024.2341120
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Zs.A 6374: Show issues

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Article ; Online: Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation.

Rana, Sandeep / Natarajan, Amarnath

Signal transduction and targeted therapy

2021 Volume 6, Issue 1, Page(s) 142

MeSH term(s)	Polymerization ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-021-00556-w
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Article: Microwave-assisted extraction of dragon fruit seed oil: Fatty acid profile and functional properties

Boyapati, Tejaswi / Rana, Sandeep Singh / Ghosh, Payel

Journal of the Saudi Society of Agricultural Sciences. 2022 Aug. 15,

2022

Abstract: Dragon fruit is gaining its popularity in all over the world. The seed of the dragon fruit is highly nutritious in terms of essential fatty acid. The utilization of seed oils is getting increasingly common these days. In this work, a comparative analysis ...

Abstract	Dragon fruit is gaining its popularity in all over the world. The seed of the dragon fruit is highly nutritious in terms of essential fatty acid. The utilization of seed oils is getting increasingly common these days. In this work, a comparative analysis was undertaken for control and microwave-assisted extraction (MAE) samples, using the RSM-CCD (Response Surface Methodology – Central composite Design) design, to determine the influences power and time on dragon fruit seed oil's Yield, PV, DPPH, and polyphenol content. The optimization was done, where the extraction yield (34.30 %), PV (3.23 me quiiv O₂/kg), DPPH (69.65 %), and polyphenol (96.71 mg GAE/g) was observed. While comparing with the control sample the antioxidant activity of the seed oil in terms of (%DPPH, FRAP and ORAC) was better in microwave treated sample. The saturated fatty acid is 25 % with a monounsaturated fatty acid 20 % and Polyunsaturated fatty acid of 55 %. High amount of tocopherol content was determined having 93 % of γ -tocopherol. Dragon fruit seed oil has the possibility to be a good source for the functional components in the near future due to the presence of antioxidant compounds and essential fats.
Keywords	Hylocereus ; antioxidant activity ; antioxidants ; essential fatty acids ; fatty acid composition ; microwave treatment ; monounsaturated fatty acids ; polyphenols ; polyunsaturated fatty acids ; response surface methodology ; saturated fatty acids ; seed oils
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2635379-9
ISSN	1658-077X
ISSN	1658-077X
DOI	10.1016/j.jssas.2022.08.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Recent Advances in the Extraction of Pectin from Various Sources and Industrial Applications.

Riyamol / Gada Chengaiyan, Jeevitha / Rana, Sandeep Singh / Ahmad, Faraz / Haque, Shafiul / Capanoglu, Esra

ACS omega

2023 Volume 8, Issue 49, Page(s) 46309–46324

Abstract: Pectin is a structural polysaccharide present in plants that primarily consists of galacturonic acid units. This Review discusses the chemistry of pectin, including its composition and molecular weight. Pectin is conventionally extracted from ... ...

Abstract	Pectin is a structural polysaccharide present in plants that primarily consists of galacturonic acid units. This Review discusses the chemistry of pectin, including its composition and molecular weight. Pectin is conventionally extracted from agricultural waste (fruit and vegetable peels) using an acidic or basic aqueous medium at high temperatures. These processes are time- and energy-consuming and also result in severe environmental problems due to the production of acidic effluents and equipment corrosion. As pectin usage is increasing in food industries for developing different products and it is also used as an excipient in pharmaceutical products, better extraction procedures are required to maximize the yield and purity. The Review encompasses various alternate green approaches for the extraction of pectin, including traditional acid extraction and various emerging technologies such as deep eutectic solvent-based extraction, enzyme-assisted extraction, subcritical fluid extraction, ultrasound-assisted extraction, and microwave-based extraction, and evaluates the yield and physicochemical characteristics of the extracted pectin. This work aims to provide a platform for attracting more thorough research focused on the engineering of novel and more efficient green methods for the extraction of pectin and its utilization for various biotechnological purposes.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c04010
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Article: Isolated cerebral mucormycosis: A case discussion.

Saini, Harneel / Mann, Harinoor / Saini, Ishveen / Bhanot, Nitin / Kelly, Kevin / Rana, Sandeep

IDCases

2023 Volume 33, Page(s) e01821

Abstract: We report a case of a 32-year-old male with a history of type 1 diabetes, inhaled drug use, and alcohol use disorder, who presented with encephalopathy, holocranial headaches, neck pain, confusion, and generalized tonic-clonic seizures. The patient ... ...

Abstract	We report a case of a 32-year-old male with a history of type 1 diabetes, inhaled drug use, and alcohol use disorder, who presented with encephalopathy, holocranial headaches, neck pain, confusion, and generalized tonic-clonic seizures. The patient initially presented at a rural community hospital with a fever and was found to be in diabetic ketoacidosis (DKA). He was also hemodynamically stable but stuporous, prompting intubation to protect his airway. Despite initial treatment measures, his neurological condition worsened and he remained ventilator-dependent. Key findings include a high glucose level, presence of ketones, and evidence of drug use. Blood cultures showed no growth, but his febrile state persisted. Cerebrospinal fluid (CSF) analysis revealed mild pleocytosis, hyperglycorrhachia but normal protein, with no growth. Neuroimaging showed right hemispheric slowing on EEG and diffusion restriction in the right frontal lobe on MRI. The patient's neurological status worsened on the second day of admission, manifesting as sluggish pupillary reflexes, right third nerve palsy, and decerebrate posturing. Emergent MRI suggested cerebral edema, leading to initiation of hypertonic saline. This case highlights the diagnostic challenges and critical management considerations in a patient with multiple comorbidities presenting with unexplained neurological deterioration, emphasizing the importance of a comprehensive and timely approach to diagnosis and treatment.
Language	English
Publishing date	2023-06-19
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01821
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Article ; Online: Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications.

Singh, Ranjit / Priya, Himani / Kumar, Simmi Ranjan / Trivedi, Dipika / Prasad, Niranjan / Ahmad, Faraz / Chengaiyan, Jeevitha Gada / Haque, Shafiul / Rana, Sandeep Singh

ACS omega

2024 Volume 9, Issue 9, Page(s) 9974–9990

Abstract: Gum ghatti, popularly known as Indian gum and obtained ... ...

Abstract	Gum ghatti, popularly known as Indian gum and obtained from
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08198
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Article ; Online: Demographics and clinical characteristics of primary lateral sclerosis: case series and a review of literature.

Ramanathan, Ramnath Santosh / Rana, Sandeep

Neurodegenerative disease management

2018 Volume 8, Issue 1, Page(s) 17–23

Abstract: Aim: Primary lateral sclerosis (PLS) is a form of motor neuron disease involving only upper motor neurons. In some patients presenting as PLS, the disease progresses to involve lower motor neurons and thereby converting to amyotrophic lateral sclerosis ( ...

Abstract	Aim: Primary lateral sclerosis (PLS) is a form of motor neuron disease involving only upper motor neurons. In some patients presenting as PLS, the disease progresses to involve lower motor neurons and thereby converting to amyotrophic lateral sclerosis (ALS). However, pure forms of PLS do exist. Our aim was to study epidemiological and clinical characteristics of pure PLS patients treated at our neuromuscular clinic. Methods: We retrospectively reviewed 15 patients from July 2011 to October 2014 with PLS treated at the neuromuscular disorder clinic at our hospital. Data collection included patient demographics, age and site of onset, duration of symptoms and duration of follow-up. We also studied clinical features such as bulbar involvement; pseudobulbar affect; depression; spasms/pain; bladder involvement; diagnostic work up, in other words, MRI; brain/electromyography findings; clinical course, namely years to wheelchair; and need for gastrostomy tube requirement baclofen pump placement. We also tried to find a correlation between PLS and environmental factors such as urban/suburban/rural living, consumption of well water, socioeconomic status/occupation and history of trauma. Results: Male-to-female ratio was 1:2, mean age at onset of symptoms was 58.6 years, with the oldest patient being an 84-year-old female at the time of onset of symptoms. Mean duration of follow-up was 51 months. Mean duration of symptoms was 77.4 months. About eight (53%) patients presented with bulbar symptoms in the form of spastic speech and dysphagia, pseudobulbar affect, developed depression and had bladder involvement. Seven (47%) patients presented with symmetric spasticity in the extremities. A third of the patients required baclofen for spasticity and a third required gastrostomy tube placement for dysphagia. None of them had abnormal neuroimaging or electrodiagnostic testing. Only one patient had history of trauma. About half of the patients were from lower socioeconomic status as well as middle class. One of the patients had consumed well water during younger years and three (20%) patients lived in the rural area. Conclusion: Though on review of literature there is no clear consensus about the existence of PLS as a distinct disease entity, we believe that there are rare cases of motor neuron disease with progressive upper motor neuron symptoms that throughout their course never convert to ALS. Our series highlights the demographic and clinical features of these patients and underscores the longer survival of these patients when compared with ALS.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Motor Neuron Disease/classification ; Motor Neuron Disease/diagnosis ; Motor Neuron Disease/epidemiology ; Motor Neuron Disease/therapy ; Retrospective Studies
Language	English
Publishing date	2018-01-10
Publishing country	England
Document type	Journal Article ; Review
ISSN	1758-2032
ISSN (online)	1758-2032
DOI	10.2217/nmt-2017-0051
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Article ; Online: Neurological Emergencies in the Intensive Care Unit.

Ogbebor, Osakpolor / Tariq, Shahzaib / Jaber, Tariq / Super, Jamie / Bhanot, Nitin / Rana, Sandeep / Malik, Khalid

Critical care nursing quarterly

2022 Volume 46, Issue 1, Page(s) 17–34

Abstract: Neurological emergencies carry significant morbidity and mortality, and it is necessary to have a multidisciplinary approach involving the emergency physician, the neurologist, the intensivist, and the critical care nursing staff. These disorders can be ... ...

Abstract	Neurological emergencies carry significant morbidity and mortality, and it is necessary to have a multidisciplinary approach involving the emergency physician, the neurologist, the intensivist, and the critical care nursing staff. These disorders can be broadly divided into noninfectious and infectious etiologies. In this article, we review a few of the neurological emergencies that present to the neurological intensive unit, with emphasis on convulsive status epileptics, myasthenia gravis, Guillain-Barré syndrome, meningitis, encephalitis, and brain abscess.
MeSH term(s)	Humans ; Emergencies ; Intensive Care Units ; Critical Care Nursing
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	639095-x
ISSN	1550-5111 ; 0887-9303
ISSN (online)	1550-5111
ISSN	0887-9303
DOI	10.1097/CNQ.0000000000000435
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Article ; Online: Etiology and incidence of postpartum depression among birthing women in the scenario of pandemics, geopolitical conflicts and natural disasters: a systematic review.

Pillai, Lakshmi / Srivastava, Shayna / Ajin, Akhil / Rana, Sandeep Singh / Mathkor, Darin Mansor / Haque, Shafiul / M Tambuwala, Murtaza / Ahmad, Faraz

Journal of psychosomatic obstetrics and gynaecology

2023 Volume 44, Issue 1, Page(s) 2278016

Abstract: Postpartum depression (PPD) is classified under postpartum psychiatric disorders and initiates soon after birthing, eliciting neuropsychological and behavioral deficits in mothers and offspring. Globally, PPD is estimated to be associated with 130-190 ... ...

Abstract	Postpartum depression (PPD) is classified under postpartum psychiatric disorders and initiates soon after birthing, eliciting neuropsychological and behavioral deficits in mothers and offspring. Globally, PPD is estimated to be associated with 130-190 per 1000 birthing. The severity and incidences of PPD have aggravated in the recent years due to the several unfavorable environmental and geopolitical circumstances. The purpose of this systematic review hence is to explore the contributions of recent circumstances on the pathogenesis and incidence of PPD. The search, selection and retrieval of the articles published during the last three years were systematically performed. The results from the primary studies indicate that unfavorable contemporary socio-geopolitical and environmental circumstances (e.g. Covid-19 pandemic, political conflicts/wars, and natural calamities; such as floods and earthquakes) detrimentally affect PPD etiology. A combination of socio-economic and psychological factors, including perceived lack of support and anxiousness about the future may contribute to drastic aggravation of PPD incidences. Finally, we outline some of the potential treatment regimens (e.g. inter-personal psycho- and art-based therapies) that may prove to be effective in amelioration of PPD-linked symptoms in birthing women, either alone or in complementation with traditional pharmacological interventions. We propose these psychological and art-based intervention strategies may beneficially counteract the negative influences of the unfortunate recent events across multiple cultures, societies and geographical regions.
MeSH term(s)	Female ; Humans ; Depression, Postpartum/psychology ; Pandemics ; Incidence ; Postpartum Period/psychology ; Mothers/psychology ; Risk Factors ; Natural Disasters
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	604816-x
ISSN	1743-8942 ; 0167-482X
ISSN (online)	1743-8942
ISSN	0167-482X
DOI	10.1080/0167482X.2023.2278016
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Article ; Online: Neuroprotection by agmatine: Possible involvement of the gut microbiome?

Saha, Priyanka / Panda, Subhrajita / Holkar, Aayusha / Vashishth, Rahul / Rana, Sandeep Singh / Arumugam, Mohanapriya / Ashraf, Ghulam Md / Haque, Shafiul / Ahmad, Faraz

Ageing research reviews

2023 Volume 91, Page(s) 102056

Abstract: Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely linked to the pathogeneses of several brain disorders. Importantly, exogenous agmatine ... ...

Abstract	Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely linked to the pathogeneses of several brain disorders. Importantly, exogenous agmatine has been shown to act as a potent neuroprotectant in varied pathologies, including brain ageing and associated comorbidities. The antioxidant, anxiolytic, analgesic, antidepressant and memory-enhancing activities of agmatine may derive from its ability to regulate several cellular pathways; including cell metabolism, survival and differentiation, nitric oxide signalling, protein translation, oxidative homeostasis and neurotransmitter signalling. This review briefly discusses mammalian metabolism of agmatine and then proceeds to summarize our current understanding of neuromodulation and neuroprotection mediated by agmatine. Further, the emerging exciting bidirectional links between agmatine and the resident gut microbiome and their implications for brain pathophysiology and ageing are also discussed.
MeSH term(s)	Animals ; Agmatine/metabolism ; Agmatine/pharmacology ; Brain/metabolism ; Gastrointestinal Microbiome ; Mammals/metabolism ; Neuroprotection ; Neuroprotective Agents/pharmacology
Chemical Substances	Agmatine (70J407ZL5Q) ; Neuroprotective Agents
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2023.102056
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