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  1. Article ; Online: Genomic and Ancestral Variation Underlies the Severity of COVID-19 Clinical Manifestation in Individuals of European Descent

    Priyanka Upadhyai / Gokul Suresh / Rahul Parit / Ranajit Das

    Life, Vol 11, Iss 921, p

    2021  Volume 921

    Abstract: The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a wide spectrum of clinical phenotypes ranging from asymptomatic to symptomatic with mild or moderate presentation and ...

    Abstract The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a wide spectrum of clinical phenotypes ranging from asymptomatic to symptomatic with mild or moderate presentation and severe disease. COVID-19 susceptibility, severity and recovery have demonstrated high variability worldwide. Variances in the host genetic architecture may underlie the inter-individual and population-scale differences in COVID-19 presentation. We performed a genome-wide association analysis employing the genotyping data from AncestryDNA for COVID-19 patients of European descent and used asymptomatic subjects as the control group. We identified 621 genetic variants that were significantly distinct between asymptomatic and acutely symptomatic COVID-19 patients (multiple-testing corrected p -value < 0.001). These variants were found to be associated with pathways governing host immunity, such as interferon, interleukin and cytokine signalling, and known COVID-19 comorbidities, such as obesity and cholesterol metabolism. Further, our ancestry analysis revealed that the asymptomatic COVID-19 patients possess discernibly higher proportions of the Ancestral North Eurasian (ANE) and Eastern Hunter-Gatherer (EHG) ancestry, which was introduced to Europe through Bell Beaker culture (Yamnaya related) and lower fractions of Western Hunter-Gatherer (WHG) ancestry, while severely symptomatic patients have higher fractions of WHG and lower ANE/EHG ancestral components, thereby delineating the likely ancestral differences between the two groups.
    Keywords ancestral genetic variation in COVID-19 patients ; genome-wide association study for COVID-19 patients ; asymptomatic COVID-19 patients as control ; ANE and WHG ancestries in COVID-19 ; multiple regression with ancestral fractions ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Application of the geographic population structure (GPS) algorithm for biogeographical analyses of wild and captive gorillas

    Ranajit Das / Priyanka Upadhyai

    BMC Bioinformatics, Vol 20, Iss S1, Pp 17-

    2019  Volume 26

    Abstract: Abstract Background The utilization of high resolution genome data has important implications for the phylogeographical evaluation of non-human species. Biogeographical analyses can yield detailed understanding of their population biology and facilitate ... ...

    Abstract Abstract Background The utilization of high resolution genome data has important implications for the phylogeographical evaluation of non-human species. Biogeographical analyses can yield detailed understanding of their population biology and facilitate the geo-localization of individuals to promote their efficacious management, particularly when bred in captivity. The Geographic Population Structure (GPS) algorithm is an admixture based tool for inference of biogeographical affinities and has been employed for the geo-localization of various human populations worldwide. Here, we applied the GPS tool for biogeographical analyses and localization of the ancestral origins of wild and captive gorilla genomes, of unknown geographic source, available in the Great Ape Genome Project (GAGP), employing Gorillas with known ancestral origin as the reference data. Results Our findings suggest that GPS was successful in recapitulating the population history and estimating the geographic origins of all gorilla genomes queried and localized the wild gorillas with unknown geographical origin < 150 km of National Parks/Wildlife Reserves within the political boundaries of countries, considered as prominent modern-day abode for gorillas in the wild. Further, the GPS localization of most captive-born gorillas was congruent with their previously presumed ancestral homes. Conclusions Currently there is limited knowledge of the ancestral origins of most North American captive gorillas, and our study highlights the usefulness of GPS for inferring ancestry of captive gorillas. Determination of the native geographical source of captive gorillas can provide valuable information to guide breeding programs and ensure their appropriate management at the population level. Finally, our findings shine light on the broader applicability of GPS for protecting the genetic integrity of other endangered non-human species, where controlled breeding is a vital component of their conservation.
    Keywords Biogeography ; Admixture ; Geo-localization of non-human species ; Gorilla ancestry ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Editorial

    Ranajit Das / Tatiana V. Tatarinova / Elvira R. Galieva / Yuriy L. Orlov

    Frontiers in Genetics, Vol

    Association Between Individuals’ Genomic Ancestry and Variation in Disease Susceptibility

    2022  Volume 13

    Keywords genetic ancestry and disease susceptibility ; ancestry and genetic tapestry ; ancestry-specific medicine ; genomic profiling ; genomic healthcare ; personalized therapeutics ; Genetics ; QH426-470
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The impact of COVID-19 on pulmonary, neurological, and cardiac outcomes

    Pooja U. Shenoy / Hrushikesh Udupa / Jyothika KS / Sangeetha Babu / Nikshita K / Neha Jain / Ranajit Das / Priyanka Upadhyai

    Frontiers in Public Health, Vol

    evidence from a Mendelian randomization study

    2023  Volume 11

    Abstract: BackgroundLong COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects a significant proportion of individuals globally. It can ... ...

    Abstract BackgroundLong COVID is a clinical entity characterized by persistent health problems or development of new diseases, without an alternative diagnosis, following SARS-CoV-2 infection that affects a significant proportion of individuals globally. It can manifest with a wide range of symptoms due to dysfunction of multiple organ systems including but not limited to cardiovascular, hematologic, neurological, gastrointestinal, and renal organs, revealed by observational studies. However, a causal association between the genetic predisposition to COVID-19 and many post-infective abnormalities in long COVID remain unclear.MethodsHere we employed Mendelian randomization (MR), a robust genetic epidemiological approach, to investigate the potential causal associations between genetic predisposition to COVID-19 and long COVID symptoms, namely pulmonary (pneumonia and airway infections including bronchitis, emphysema, asthma, and rhinitis), neurological (headache, depression, and Parkinson’s disease), cardiac (heart failure and chest pain) diseases, and chronic fatigue. Using two-sample MR, we leveraged genetic data from a large COVID-19 genome-wide association study and various disorder-specific datasets.ResultsThis analysis revealed that a genetic predisposition to COVID-19 was significantly causally linked to an increased risk of developing pneumonia, airway infections, headache, and heart failure. It also showed a strong positive correlation with chronic fatigue, a frequently observed symptom in long COVID patients. However, our findings on Parkinson’s disease, depression, and chest pain were inconclusive.ConclusionOverall, these findings provide valuable insights into the genetic underpinnings of long COVID and its diverse range of symptoms. Understanding these causal associations may aid in better management and treatment of long COVID patients, thereby alleviating the substantial burden it poses on global health and socioeconomic systems.
    Keywords long COVID ; Mendelian randomization ; COVID-induced neurological disorders ; COVID-induced fatigue ; COVID-induced cardiac disease ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Synthesis, characterization, and evaluation of quaternary ammonium-based polymerizable antimicrobial monomers for prosthodontic applications

    Sowmya Rao / Nandish B.T / Namitha K. Preman / Renjith P. Johnson / Kishore Ginjupalli / Preethishree P. / Ashwini Prabhu / Ranajit Das / Jayaprakash K / Vidya Pai

    Heliyon, Vol 8, Iss 8, Pp e10374- (2022)

    2022  

    Abstract: The present study aims to synthesize and characterize two quaternary ammonium (QAM) based monomers such as - dimethyl-hexadecyl-methacryloxyethyl-ammonium iodide (DHMAI) and 2-dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) and assess ... ...

    Abstract The present study aims to synthesize and characterize two quaternary ammonium (QAM) based monomers such as - dimethyl-hexadecyl-methacryloxyethyl-ammonium iodide (DHMAI) and 2-dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) and assess their cytotoxicity and antimicrobial properties. The study also aims to incorporate the optimized concentration of these monomers as copolymerizing monomers into conventional Polymethyl methacrylate (PMMA) denture base resin and evaluate their suitability for prosthetic applications. DHMAI and DDMAI monomers were synthesized through a Menschutkin reaction and their chemical structure was characterized using FT-IR and 1H-NMR spectroscopy. Cytotoxicity was determined using Methyl Thiazolyl Tetrazolium (MTT) assay whereas antimicrobial activity was assessed using the agar-disc diffusion method. Subsequently, optimized concentrations of DHMAI or DDMAI, based on the cytotoxicity results, were added to conventional PMMA resin. Antimicrobial activity, cytotoxicity, surface hardness, and water sorption of PMMA denture base rein incorporated with DHMAI or DDMAI were evaluated. FT-IR and 1H-NMR results confirmed the structure of monomers and copolymerization of DHMAI and DDMAI with PMMA resin. DHMAI and DDMAI monomers were found to be cytocompatible with mouse fibroblast cells up to a concentration of 5 μg/mL and 20 μg/mL respectively. In addition, incorporation of DHMAI or DDMAI at 5 μg/mL and 20 μg/mL respectively into PMMA denture base material did not affect their cytocompatibility. PMMA denture base resin incorporated with DHMAI or DDMAI significantly reduced the adhesion of microbes. Further, an increase in the surface hardness and a reduction in the water sorption was observed. Hence DHMAI and DDMAI can be considered as potential candidates for imparting antimicrobial activity to polymeric denture base materials.
    Keywords Polymethyl methacrylate (PMMA) resin ; DHMAI ; Antimicrobial monomer ; Quaternary ammonium compounds ; Denture stomatitis (DS) ; Candida albicans ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Bimetallic magnetic nanoparticle as a new platform for fabrication of pyridoxine and pyridoxal-5′-phosphate imprinted polymer modified high throughput electrochemical sensor

    Patra, Santanu / Ekta Roy / Paramita Karfa / Prashant K. Sharma / Ranajit Das / Rashmi Madhuri / Sunil Kumar

    Biosensors & bioelectronics. 2015 Nov. 15, v. 73

    2015  

    Abstract: The present work describes the fabrication of a selective and sensitive molecularly imprinted polymer (MIP)-based electrochemical sensor using a combination of surface imprinting and nanotechnology. The fabricated sensor was used for the detection of two ...

    Abstract The present work describes the fabrication of a selective and sensitive molecularly imprinted polymer (MIP)-based electrochemical sensor using a combination of surface imprinting and nanotechnology. The fabricated sensor was used for the detection of two major components of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5′-phosphate (PLP) using the same MIP format. Herein, acrylic acid modified zero valent iron nanoparticles were combined with the copper nanoparticle, resulting in vinyl groups modified bimetallic Fe/Cu magnetic nanoparticles (BMNPs). These BMNPs have high surface to volume ratios, higher electro-catalytic activity, and are therefore, a suitable platform to synthesize specific MIP cavities for Py and PLP. Herein, two different MIP formats (for Py and PLP) were synthesized on the surface of vinyl silane modified pencil graphite electrodes by activator regenerated by an electron transfer-atom transfer radical polymerization (ARGET-ATRP) method. The sensor shows a good analytical performance for the detection of Py and PLP by a square wave stripping voltammetric technique (SWSV). The limit of detection (LOD) was calculated to be 0.040µgL−1 and 0.043µgL−1 for Py and PLP, respectively, at signal to noise ratio of 3. The sensors are highly selective for the templates and can detect them from multivitamin tablets, corn flakes, energy drinks, cerebrospinal fluid (CSF) and blood samples (serum, plasma and whole blood) without any interfering effect, suggesting the clinical applicability of the fabricated sensor. The sensor can also be used as better alternative to the commercially available ELISA kits which are rather complex, less sensitive and difficult to handle.
    Keywords acrylic acid ; biosensors ; blood sampling ; blood serum ; cerebrospinal fluid ; copper ; corn ; detection limit ; electrochemistry ; electrodes ; energy drinks ; enzyme-linked immunosorbent assay ; graphene ; iron ; molecular imprinting ; nanoparticles ; polymerization ; polymers ; pyridoxal phosphate ; pyridoxine
    Language English
    Dates of publication 2015-1115
    Size p. 234-244.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2015.06.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
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  7. Book: Labour and working class in Eastern India

    Gupta, Ranajit Das

    studies in colonial history

    1994  

    Author's details Ranajit Das Gupta
    Keywords Arbeit ; Agrarberufe ; Bergleute ; Arbeitskampf ; Indien ; Wirtschaftsgeschichte ; Großbritannien ; Kolonialismus ; 13*23*31*32*14*24*41*42 ; 16*26*36*46*56*61*62*63*64*65
    Language English
    Size XXX, 525 S
    Document type Book
    Note Enth. 9 Beitr.
    ISBN 8170741270 ; 9788170741275
    Database ECONomics Information System

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  8. Article: Soziale Sicherheit und Formen gegenseitiger Hilfe in Indien

    Gupta, Ranajit Das

    Internationale Revue für soziale Sicherheit 46 ,3, S. 59-80

    ein vorläufiger Überblick

    1993  

    Author's details Ranajit Das Gupta
    Keywords Soziale Sicherheit ; Indien
    Language German
    Publisher Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 205250-7 ; 2272584-2
    ISSN 1752-1726 ; 0379-0282
    ISSN (online) 1752-1726
    ISSN 0379-0282
    Database ECONomics Information System

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  9. Book: Plantation labour in colonial India

    Gupta, Ranajit Das

    (Working paper series : Indian Institute of Management, Calcutta ; 140)

    1990  

    Author's details by Ranajit Das Gupta
    Series title Working paper series : Indian Institute of Management, Calcutta ; 140
    Keywords Monokultur ; Arbeitsbeziehungen ; Indien ; Großbritannien ; Kolonialismus ; 12*21*13*31 ; 13*23*31*32
    Language English
    Size 42 S
    Document type Book
    Database ECONomics Information System

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  10. Book: Migrant workers, rural connexions and capitalism

    Gupta, Ranajit Das

    the Calcutta jute industrial labour 1890s to 1940s

    (Working paper series : Indian Institute of Management, Calcutta ; 98)

    1987  

    Author's details by Ranajit Das Gupta
    Series title Working paper series : Indian Institute of Management, Calcutta ; 98
    Keywords 24;34
    Language English
    Size 64 S
    Edition Received
    Document type Book
    Note Kopie
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