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  1. Article ; Online: Macroscopic Fat in Adrenocortical Carcinoma: A Systematic Review.

    Ranathunga, Damithri S / Cherpak, Lindsay A / Schieda, Nicola / Flood, Trevor A / McInnes, Matthew D F

    AJR. American journal of roentgenology

    2019  Volume 214, Issue 2, Page(s) 390–394

    Abstract: OBJECTIVE. ...

    Abstract OBJECTIVE.
    MeSH term(s) Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Adrenal Cortex Neoplasms/diagnostic imaging ; Adrenal Cortex Neoplasms/pathology ; Adrenocortical Carcinoma/diagnostic imaging ; Adrenocortical Carcinoma/pathology ; Humans
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.19.21851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparing Survival Outcomes of Patients With LI-RADS-M Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas.

    Kierans, Andrea S / Lafata, Kyle J / Ludwig, Daniel R / Burke, Lauren M B / Chernyak, Victoria / Fowler, Kathryn J / Fraum, Tyler J / McGinty, Katrina A / McInnes, Matthew D F / Mendiratta-Lala, Mishal / Cunha, Guilherme Moura / Allen, Brian C / Hecht, Elizabeth M / Jaffe, Tracy A / Kalisz, Kevin R / Ranathunga, Damithri S / Wildman-Tobriner, Benjamin / Cardona, Diana M / Aslam, Anum /
    Gaur, Sonia / Bashir, Mustafa R

    Journal of magnetic resonance imaging : JMRI

    2022  Volume 57, Issue 1, Page(s) 308–317

    Abstract: Background: There is a sparsity of data evaluating outcomes of patients with Liver Imaging Reporting and Data System (LI-RADS) (LR)-M lesions.: Purpose: To compare overall survival (OS) and progression free survival (PFS) between hepatocellular ... ...

    Abstract Background: There is a sparsity of data evaluating outcomes of patients with Liver Imaging Reporting and Data System (LI-RADS) (LR)-M lesions.
    Purpose: To compare overall survival (OS) and progression free survival (PFS) between hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) meeting LR-M criteria and to evaluate factors associated with prognosis.
    Study type: Retrospective.
    Subjects: Patients at risk for HCC with at least one LR-M lesion with histologic diagnosis, from 8 academic centers, yielding 120 patients with 120 LR-M lesions (84 men [mean age 62 years] and 36 women [mean age 66 years]).
    Field strength/sequence: A 1.5 and 3.0 T/3D T
    Assessment: The imaging categorization of each lesion as LR-M was made clinically by a single radiologist at each site and patient outcome measures were collected.
    Statistical tests: OS, PFS, and potential independent predictors were evaluated by Kaplan-Meier method, log-rank test, and Cox proportional hazard model. A P value of <0.05 was considered significant.
    Results: A total of 120 patients with 120 LR-M lesions were included; on histology 65 were HCC and 55 were iCCA. There was similar median OS for patients with LR-M HCC compared to patients with iCCA (738 days vs. 769 days, P = 0.576). There were no significant differences between patients with HCC and iCCA in terms of sex (47:18 vs. 37:18, P = 0.549), age (63.0 ± 8.4 vs. 63.4 ± 7.8, P = 0.847), etiology of liver disease (P = 0.202), presence of cirrhosis (100% vs. 100%, P = 1.000), tumor size (4.73 ± 3.28 vs. 4.75 ± 2.58, P = 0.980), method of lesion histologic diagnosis (P = 0.646), and proportion of patients who underwent locoregional therapy (60.0% vs. 38.2%, P = 0.100) or surgery (134.8 ± 165.5 vs. 142.5 ± 205.6, P = 0.913). Using multivariable analysis, nonsurgical compared to surgical management (HR, 4.58), larger tumor size (HR, 1.19), and higher MELD score (HR, 1.12) were independently associated with worse OS.
    Data conclusion: There was similar OS in patients with LR-M HCC and LR-M iCCA, suggesting that LR-M imaging features may more closely reflect patient outcomes than histology.
    Evidence level: 3 TECHNICAL EFFICACY: Stage 5.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Aged ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Cholangiocarcinoma/diagnostic imaging ; Bile Duct Neoplasms/diagnostic imaging ; Bile Ducts, Intrahepatic ; Contrast Media
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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