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  1. Article: Corrigendum: Serum D-dimer is not predictive of placenta-mediated complications in pregnancy at high risk: the multicentric prospective cohort AngioPred study.

    Hovine, Agathe / Chauleur, Céline / Gauld, Christophe / Rancon, Florence / Gris, Jean-Christophe / Tardy, Brigitte / Giraud, Antoine / Raia-Barjat, Tiphaine

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1391391

    Abstract: This corrects the article DOI: 10.3389/fcell.2023.1115622.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2023.1115622.].
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1391391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Serum D-dimer is not predictive of placenta-mediated complications in pregnancy at high risk: The multicentric prospective cohort AngioPred study.

    Hovine, Agathe / Chauleur, Céline / Gault, Christophe / Rancon, Florence / Gris, Jean-Christophe / Tardy, Brigitte / Giraud, Antoine / Raia-Barjat, Tiphaine

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1115622

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1115622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fetal Movement Counting in Prolonged Pregnancies: The COMPTAMAF Prospective Randomized Trial.

    Moniod, Louise / Hovine, Agathe / Trombert, Béatrice / Rancon, Florence / Zufferey, Paul / Chauveau, Laura / Chauleur, Céline / Raia-Barjat, Tiphaine

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 12

    Abstract: In prolonged pregnancies, the risks of neonatal morbidity and mortality are increased. The aim of this trial was to assess the benefits of maternal information about fetal movement (FM) counting on neonatal outcomes in prolonged pregnancy. It was a ... ...

    Abstract In prolonged pregnancies, the risks of neonatal morbidity and mortality are increased. The aim of this trial was to assess the benefits of maternal information about fetal movement (FM) counting on neonatal outcomes in prolonged pregnancy. It was a prospective, single center, randomized, open-label study conducted from October 2019 to March 2022. Intention-to-treat analyses were performed on 278 patients randomized into two 1:1 groups (control group and FM counting group). The primary outcome was a composite score of neonatal morbidity (presence of two of the following items: fetal heart rate abnormality at delivery, Apgar score of <7 at 5 min, umbilical cord arterial pH of <7.20, and acute respiratory distress with mutation in neonatal intensive care unit). There was no significant difference between the two groups in the rate of neonatal morbidity (14.0% in the FM counting group versus 22.9% in the standard information group; p = 0.063; OR 0.55, 95% CI 0.29−1.0). In this study, fetal movement counting for women in prolonged pregnancy failed to demonstrate a significant reduction in adverse neonatal outcomes.
    Language English
    Publishing date 2022-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10122569
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  4. Article ; Online: EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications.

    Raia-Barjat, Tiphaine / Chauleur, Céline / Collet, Constance / Rancon, Florence / Hoffmann, Pascale / Desseux, Morgane / Lemaitre, Nicolas / Benharouga, Mohamed / Giraud, Antoine / Alfaidy, Nadia

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19921

    Abstract: Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth ... ...

    Abstract Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women.
    MeSH term(s) Humans ; Pregnancy ; Female ; Infant, Newborn ; Premature Birth ; Pregnancy Trimester, Third ; Pregnant Women ; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived ; Cohort Studies ; Prospective Studies ; Placenta ; Risk Factors
    Chemical Substances Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46883-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vitamin D deficiency during late pregnancy mediates placenta-associated complications.

    Raia-Barjat, Tiphaine / Sarkis, Camille / Rancon, Florence / Thibaudin, Lise / Gris, Jean-Christophe / Alfaidy, Nadia / Chauleur, Céline

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 20708

    Abstract: During pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high ... ...

    Abstract During pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high risk. A prospective multicenter cohort study of 200 pregnant patients was conducted. The vitamin D level of patients with placenta-mediated complications was lower at 32 weeks compared to uncomplicated pregnancies (P = 0.001). At 32 weeks, the risk of occurrence of PMCs was five times higher in patients with vitamin D deficiency (RR: 5.14 95% CI (1.50-17.55)) compared to patients with normal vitamin D levels. There was a strong, inverse relationship between serum 25(OH)D levels at 32 weeks and the subsequent risk of PMCs (P = 0.001). At 32 weeks, the vitamin D level of patients with late-onset PMCs was lower than the one of patients with early-onset PMCs and of patients without PMCs (P < 0.0001). These results suggest a role of vitamin D in the maintenance of placental performance and therefore in the prevention of the onset of late PMC.
    MeSH term(s) Female ; Humans ; Placenta/blood supply ; Pre-Eclampsia/blood ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/etiology ; Prospective Studies ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-00250-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stepped wedge cluster randomised controlled trial to assess the effectiveness of an optimisation strategy for general anaesthesia on postoperative morbidity and mortality in elderly patients (the OPTI-AGED study): a study protocol.

    Molliex, Serge / Passot, Sylvie / Futier, Emmanuel / Bonnefoi, Marlène / Rancon, Florence / Lemanach, Yannick / Pereira, Bruno

    BMJ open

    2018  Volume 8, Issue 6, Page(s) e021053

    Abstract: Introduction: Elderly patients constitute an increasingly large proportion of the high-risk surgical group. In adult patients, several specific intraoperative approaches such as cardiac output-guided haemodynamic therapy, depth of anaesthesia monitoring ...

    Abstract Introduction: Elderly patients constitute an increasingly large proportion of the high-risk surgical group. In adult patients, several specific intraoperative approaches such as cardiac output-guided haemodynamic therapy, depth of anaesthesia monitoring (DAM) or lung-protective ventilation (LPV) are designed to reduce postoperative mortality and surgical complications. However, none of these approaches has been specifically performed in the elderly, and no evaluation of a multimodal optimisation strategy for general anaesthesia has been achieved in this population.
    Aims: The objective of this study is to assess, in high-risk patients aged 75 years and over undergoing high-risk surgery, the effectiveness of combined optimisation of anaesthesia involving goal-directed haemodynamic therapy (GDHT), LPV and electroencephalographic DAM on postoperative morbidity and mortality. The primary outcome of the study is a composite criterion associating major postoperative complications and mortality occurring within the 30 first postoperative days. The secondary outcomes are 1-year postoperative autonomy and mortality.
    Methods and analysis: This prospective, randomised, controlled, multicentre trial using a stepped wedge cluster design will be conducted in 27 French university centres. Patients aged 75 years and over, undergoing femoral head fractures and major intraperitoneal or vascular elective surgeries will be included after informed consent. They will benefit from usual care in the 'control group' and from a combined optimisation of general anaesthesia involving GDHT, LPV and DAM in the 'optimisation group'. The cluster's crossover will be unidirectional, from control to optimisation, and randomised. Data will be recorded at inclusion, the day of surgery, 7 days, 30 days and 1year postoperatively and collected into a hosted electronic case report form. The primary outcome of the study is a composite criterion associating major postoperative complications and mortality occurring within the 30 first postoperative days. The secondary outcomes are 1- year postoperative autonomy and mortality.
    Ethics and dissemination: This protocol was approved by the ethics committee Sud-Est 1 and the French regulatory agency. The finding of the trial will be disseminated through peer-reviewed journals and conferences TRIAL REGISTRATION NUMBER: NCT02668250; Pre-results.
    MeSH term(s) Aged ; Aged, 80 and over ; Anesthesia, General/methods ; Cluster Analysis ; Elective Surgical Procedures/adverse effects ; Elective Surgical Procedures/mortality ; Female ; Hemodynamics ; Humans ; Male ; Morbidity ; Multicenter Studies as Topic ; Postoperative Complications/mortality ; Postoperative Complications/prevention & control ; Prospective Studies ; Randomized Controlled Trials as Topic ; Risk Factors ; Survival Analysis ; Time Factors
    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2017-021053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Use of the Delphi method to facilitate antithrombotics prescription during pregnancy.

    Chauleur, Celine / Gris, Jean Christophe / Laporte, Sylvie / Rancon, Florence / Varlet, Marie-Noëlle / Decousus, Herve / Mismetti, Patrick

    Thrombosis research

    2010  Volume 126, Issue 2, Page(s) 88–92

    Abstract: Introduction: Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, ...

    Abstract Introduction: Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis.
    Materials and methods: A Delphi exercise was conducted to collect 19 French experts' opinions on pregnancy-related VTE.
    Results: Experts with an active interest in clinical research and care of VTE and placental vascular complications were selected. The risk score was classified by an anonymous computer vote. A scoring system for VTE risk in pregnant women was developed, each score being associated with a specific treatment: graduated elastic compression stockings, aspirin, prophylactic Low Molecular Weight Heparin (LMWH: variable durations), or adjusted-dose of LMWH through pregnancy and postpartum.
    Conclusions: Our simple consensual scoring system offers an individual estimation of thrombosis risk during pregnancy together with its related therapeutic strategy, in accordance with most of the new international recommendations. The accuracy of our individual risk score-based therapeutic guidance is currently being prospectively evaluated in a multicenter trial.
    MeSH term(s) Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Delphi Technique ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/prevention & control ; Risk Assessment ; Risk Factors ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2010.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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