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  1. AU="Ranford, David"
  2. AU=Cash Kevin J AU=Cash Kevin J
  3. AU="Mosavi Anari, Seyed Alireza"
  4. AU="Spijkers, Sanne Nm"
  5. AU=Leven Dante
  6. AU="Reichelt, Andreas Christian"
  7. AU="Kandel, Rupesh"
  8. AU=SteelFisher Gillian K
  9. AU="Valdés, Alberto"
  10. AU="Lin, Kuan"
  11. AU="McKeown, Martin J"
  12. AU="Pal, Aditya"
  13. AU=Birnkrant David J
  14. AU=Dettenmeier Patricia
  15. AU="Iorio, R."
  16. AU=Bashir Mohamad
  17. AU="Uruchurtu, Ashley S S"
  18. AU="Giuliano, Gabriele"

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  1. Artikel ; Online: Safety review of current systemic treatments for severe chronic rhinosinusitis with nasal polyps and future directions.

    Ranford, David / Hopkins, Claire

    Expert opinion on drug safety

    2021  Band 20, Heft 10, Seite(n) 1177–1189

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Biological Products/administration & dosage ; Biological Products/adverse effects ; Chronic Disease ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Humans ; Nasal Polyps/drug therapy ; Nasal Polyps/pathology ; Rhinitis/drug therapy ; Rhinitis/pathology ; Severity of Illness Index ; Sinusitis/drug therapy ; Sinusitis/pathology
    Chemische Substanzen Anti-Bacterial Agents ; Biological Products ; Glucocorticoids
    Sprache Englisch
    Erscheinungsdatum 2021-05-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2021.1926981
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Primary aspergillosis of the larynx causing acute airway distress.

    Ranford, David / Kang, Chong / Kelly, Mairead / Volpini, Luigi

    BMJ case reports

    2021  Band 14, Heft 4

    Abstract: Laryngeal aspergillosis is most commonly seen as a secondary infection that spreads from the lungs and tracheobronchial tree. Primary invasive aspergillosis of the larynx is rare and most likely seen in an immunocompromised patient. We present a case of ... ...

    Abstract Laryngeal aspergillosis is most commonly seen as a secondary infection that spreads from the lungs and tracheobronchial tree. Primary invasive aspergillosis of the larynx is rare and most likely seen in an immunocompromised patient. We present a case of a 59-year-old woman who presented with progressive dysphonia and subsequently acute stridor. She is a non-smoker with a recent diagnosis of acute myeloid leukaemia. Fibreoptic nasendoscopy revealed a left sided vocal cord lesion ball valving into the glottic space. Histology taken during emergency debulking confirmed
    Mesh-Begriff(e) Aspergillosis/complications ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Aspergillus fumigatus ; Female ; Hoarseness ; Humans ; Laryngeal Diseases/complications ; Laryngeal Diseases/diagnosis ; Larynx/diagnostic imaging ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2021-04-09
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240434
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Tracheostomy, ventilatory wean, and decannulation in COVID-19 patients.

    Tornari, Chrysostomos / Surda, Pavol / Takhar, Arunjit / Amin, Nikul / Dinham, Alison / Harding, Rachel / Ranford, David A / Archer, Sally K / Wyncoll, Duncan / Tricklebank, Stephen / Ahmad, Imran / Simo, Ricard / Arora, Asit

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Band 278, Heft 5, Seite(n) 1595–1604

    Abstract: Purpose: COVID-19 patients requiring mechanical ventilation can overwhelm existing bed capacity. We aimed to better understand the factors that influence the trajectory of tracheostomy care in this population to facilitate capacity planning and improve ... ...

    Abstract Purpose: COVID-19 patients requiring mechanical ventilation can overwhelm existing bed capacity. We aimed to better understand the factors that influence the trajectory of tracheostomy care in this population to facilitate capacity planning and improve outcomes.
    Methods: We conducted an observational cohort study of patients in a high-volume centre in the worst-affected region of the UK including all patients that underwent tracheostomy for COVID-19 pneumonitis ventilatory wean from 1st March 2020 to 10th May 2020. The primary outcome was time from insertion to decannulation. The analysis utilised Cox regression to account for patients that are still progressing through their tracheostomy pathway.
    Results: At the point of analysis, a median 21 days (IQR 15-28) post-tracheostomy and 39 days (IQR 32-45) post-intubation, 35/69 (57.4%) patients had been decannulated a median of 17 days (IQR 12-20.5) post-insertion. The overall median age was 55 (IQR 48-61) with a male-to-female ratio of 2:1. In Cox regression analysis, FiO
    Conclusion: Higher FiO
    Mesh-Begriff(e) COVID-19 ; Device Removal ; Female ; Humans ; Male ; Middle Aged ; Respiration, Artificial ; SARS-CoV-2 ; Tracheostomy
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06187-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ul II Zs.50: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Artikel ; Online: Timing of Tracheostomy for Prolonged Respiratory Wean in Critically Ill Coronavirus Disease 2019 Patients: A Machine Learning Approach.

    Takhar, Arunjit / Surda, Pavol / Ahmad, Imran / Amin, Nikul / Arora, Asit / Camporota, Luigi / Denniston, Poppy / El-Boghdadly, Kariem / Kvassay, Miroslav / Macekova, Denisa / Munk, Michal / Ranford, David / Rabcan, Jan / Tornari, Chysostomos / Wyncoll, Duncan / Zaitseva, Elena / Hart, Nicholas / Tricklebank, Stephen

    Critical care explorations

    2020  Band 2, Heft 11, Seite(n) e0279

    Abstract: Objectives: To propose the optimal timing to consider tracheostomy insertion for weaning of mechanically ventilated patients recovering from coronavirus disease 2019 pneumonia. We investigated the relationship between duration of mechanical ventilation ... ...

    Abstract Objectives: To propose the optimal timing to consider tracheostomy insertion for weaning of mechanically ventilated patients recovering from coronavirus disease 2019 pneumonia. We investigated the relationship between duration of mechanical ventilation prior to tracheostomy insertion and in-hospital mortality. In addition, we present a machine learning approach to facilitate decision-making.
    Design: Prospective cohort study.
    Setting: Guy's & St Thomas' Hospital, London, United Kingdom.
    Patients: Consecutive patients admitted with acute respiratory failure secondary to coronavirus disease 2019 requiring mechanical ventilation between March 3, 2020, and May 5, 2020.
    Interventions: Baseline characteristics and temporal trends in markers of disease severity were prospectively recorded. Tracheostomy was performed for anticipated prolonged ventilatory wean when levels of respiratory support were favorable. Decision tree was constructed using C4.5 algorithm, and its classification performance has been evaluated by a leave-one-out cross-validation technique.
    Measurements and main results: One-hundred seventy-six patients required mechanical ventilation for acute respiratory failure, of which 87 patients (49.4%) underwent tracheostomy. We identified that optimal timing for tracheostomy insertion is between day 13 and day 17. Presence of fibrosis on CT scan (odds ratio, 13.26; 95% CI [3.61-48.91];
    Conclusions: We propose that the optimal window for consideration of tracheostomy for ventilatory weaning is between day 13 and 17. Late predictors of mortality may serve as adverse factors when considering tracheostomy, and our decision tree provides a degree of decision support for clinicians.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000279
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Tracheostomy, ventilatory wean, and decannulation in COVID-19 patients

    Tornari, Chrysostomos / Surda, Pavol / Takhar, Arunjit / Amin, Nikul / Dinham, Alison / Harding, Rachel / Ranford, David A / Archer, Sally K / Wyncoll, Duncan / Tricklebank, Stephen / Ahmad, Imran / Simo, Ricard / Arora, Asit

    Eur. arch. oto-rhino-laryngol

    Abstract: PURPOSE: COVID-19 patients requiring mechanical ventilation can overwhelm existing bed capacity. We aimed to better understand the factors that influence the trajectory of tracheostomy care in this population to facilitate capacity planning and improve ... ...

    Abstract PURPOSE: COVID-19 patients requiring mechanical ventilation can overwhelm existing bed capacity. We aimed to better understand the factors that influence the trajectory of tracheostomy care in this population to facilitate capacity planning and improve outcomes. METHODS: We conducted an observational cohort study of patients in a high-volume centre in the worst-affected region of the UK including all patients that underwent tracheostomy for COVID-19 pneumonitis ventilatory wean from 1st March 2020 to 10th May 2020. The primary outcome was time from insertion to decannulation. The analysis utilised Cox regression to account for patients that are still progressing through their tracheostomy pathway. RESULTS: At the point of analysis, a median 21 days (IQR 15-28) post-tracheostomy and 39 days (IQR 32-45) post-intubation, 35/69 (57.4%) patients had been decannulated a median of 17 days (IQR 12-20.5) post-insertion. The overall median age was 55 (IQR 48-61) with a male-to-female ratio of 2:1. In Cox regression analysis, FiO2 at tracheostomy ≥ 0.4 (HR 1.80; 95% CI 0.89-3.60; p = 0.048) and last pre-tracheostomy peak cough flow (HR 2.27; 95% CI 1.78-4.45; p = 0.001) were independent variables associated with prolonged time to decannulation. CONCLUSION: Higher FiO2 at tracheostomy and higher pre-tracheostomy peak cough flow are associated with increased delay in COVID-19 tracheostomy patient decannulation. These finding comprise the most comprehensive report of COVID-19 tracheostomy decannulation to date and will assist service planning for future peaks of this pandemic.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #692740
    Datenquelle COVID19

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  6. Artikel ; Online: Tracheostomy, ventilatory wean, and decannulation in COVID-19 patients

    Tornari, Chrysostomos / Surda, Pavol / Takhar, Arunjit / Amin, Nikul / Dinham, Alison / Harding, Rachel / Ranford, David A. / Archer, Sally K. / Wyncoll, Duncan / Tricklebank, Stephen / Ahmad, Imran / Simo, Ricard / Arora, Asit

    European Archives of Oto-Rhino-Laryngology ; ISSN 0937-4477 1434-4726

    2020  

    Schlagwörter Otorhinolaryngology ; General Medicine ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1007/s00405-020-06187-1
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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