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  1. Article ; Conference proceedings: Cutaneous Squamous Cell Carcinoma of Head and Neck – A Case Series

    Kasaboglu, Julide / Terziev, Ivan / Popov, Todor Miroslavov / Rangachev, Julian

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1746621
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.95: Show issues Location:
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  2. Article ; Online: A pilot study reveals the potential of miR-31-3p and miR-196a-5p as non-invasive biomarkers in advanced laryngeal cancer.

    Kyurkchiyan, Silva Garo / Popov, Todor Miroslavov / Shakola, Felitsiya / Rangachev, Julian / Mitev, Vanyo Ivanov / Kaneva, Radka

    Folia medica

    2021  Volume 63, Issue 3, Page(s) 355–364

    Abstract: Introduction: Recently, miRNAs have become popular molecules used as non-invasive biomarkers in cancer diseases.: Aim: The aim of the study was to explore the expression of four miRNAs isoforms: miR-31-3p, miR-196a-5p, miR-210-3p and miR-424-5p in ... ...

    Abstract Introduction: Recently, miRNAs have become popular molecules used as non-invasive biomarkers in cancer diseases.
    Aim: The aim of the study was to explore the expression of four miRNAs isoforms: miR-31-3p, miR-196a-5p, miR-210-3p and miR-424-5p in plasma and tissue samples from patients with advanced laryngeal squamous cell carcinoma (LSCC) and healthy controls.
    Materials and methods: Fresh-frozen tumour and normal laryngeal tissue as well as plasma samples were obtained from 22 patients diagnosed with advanced LSCC. The control group included plasma samples from 21 cancer-free volunteers. Total RNA (including miRNAs) extraction, reverse transcription and real time qPCR were the laboratory techniques used in the study. The obtained results were analyzed using SPSS software v. 23.
    Results: We found that miR-31-3p, miR-196a-5p, and miR-210-3p levels were significantly elevated in laryngeal tumour tissue, but only the levels of miR-31-3p and miR-196a-5p were significantly upregulated in the plasma LSCC target group. Positive correlation was obtained for miR-31-3p (rs=0.443, p=0.039) and miR-196a-5p (rs=0.548; p=0.008) between plasma and adjacent tumour tissue LSCC samples. ROC analyses were used to evaluate the discriminative power of both miRNAs alone and in combination. The combination of miR-31-3p and miR-196a-5p showed best results with AUC=0.978 (95% CI: 0.945-1.000, p.
    MeSH term(s) Biomarkers, Tumor/genetics ; Humans ; Laryngeal Neoplasms/genetics ; MicroRNAs/genetics ; MicroRNAs/supply & distribution ; Pilot Projects ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Biomarkers, Tumor ; MIRN31 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2021-07-01
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 300275-5
    ISSN 1314-2143 ; 0430-8638 ; 0204-8043
    ISSN (online) 1314-2143
    ISSN 0430-8638 ; 0204-8043
    DOI 10.3897/folmed.63.e55346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 972: Show issues Location:
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  3. Article ; Online: Novel insights into laryngeal squamous cell carcinoma from association study of aberrantly expressed miRNAs, lncRNAs and clinical features in Bulgarian patients.

    Garo Kyurkchiyan, Silva / Miroslavov Popov, Todor / Stancheva, Gergana / Rangachev, Julian / Ivanov Mitev, Vanyo / Petrova Popova, Diana / Petrova Kaneva, Radka

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology

    2020  Volume 25, Issue 1, Page(s) 357–366

    Abstract: Purpose: Laryngeal cancer is one of most common and aggressive head and neck cancers with poor prognosis and great necessity for improvement of treatment modalities. MicroRNAs (miRs) are among the most investigated molecules recently due to their ... ...

    Abstract Purpose: Laryngeal cancer is one of most common and aggressive head and neck cancers with poor prognosis and great necessity for improvement of treatment modalities. MicroRNAs (miRs) are among the most investigated molecules recently due to their potential as diagnostic and prognostic biomarkers in cancer. The purpose of our study was to explore the association of certain clinicopathological features with the expression levels of some known cancer associated non-coding (nc) RNAs: miR-21 and miR-31 in both of their isoforms, miR-145-5p, miR-55-5p, miR-196a-5p, miR-210-3p, miR-221-3p, miR-222-3p, miR-424-5p, lncRNA MALAT1 and lncRNA HOTAIR.
    Methods: Expression levels of the chosen markers were investigated in laryngeal squamous cell carcinoma (LSCC) and normal samples in 82 Bulgarian patients via RT-qPCR, and the results were analyzed with SPSS v23.0 statistical software.
    Results: All of the explored ncRNAs were significantly deregulated in LSCC samples, suggesting their involvement in laryngeal carcinogenesis. New significant association were found between the expression levels of miR-21-5p, miR-222-3p, HOTAIR and family history. Moreover, miR-424-5p showed potential as marker for subglottic LSCC location, and "passenger" miR-31-3p was significantly upregulated in well and moderately differentiated LSCC.
    Conclusion: Our results enrich the knowledge about ncRNA involvement in LSCC tumorigenesis. Further studies are needed to evaluate the clinical utility of the differently expressed ncRNAs as potential diagnostic and prognostic biomarkers in LSCC.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bulgaria ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Female ; Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Male ; MicroRNAs/metabolism ; Middle Aged ; RNA, Long Noncoding/metabolism
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2020-04-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2040386-0
    ISSN 2241-6293 ; 1107-0625
    ISSN (online) 2241-6293
    ISSN 1107-0625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5438: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Cricotracheal Resection in a Patient with Severe Subglottic Stenosis - Advantages of a Temporary Non-Cannulated Tracheostomy.

    Popov, Todor Miroslavov / Marinov, Tzvetomir / Rangachev, Julian / Konov, Dimitar / Belitova, Maya

    Balkan medical journal

    2017  Volume 34, Issue 2, Page(s) 165–167

    Abstract: Background: Stenosis in the area of the cricotracheal segment is still a challenging problem to be dealt with. Post-intubational cases mark an increase in recent years due to the advances in intensive care, thoracic surgery and neurosurgery departments.! ...

    Abstract Background: Stenosis in the area of the cricotracheal segment is still a challenging problem to be dealt with. Post-intubational cases mark an increase in recent years due to the advances in intensive care, thoracic surgery and neurosurgery departments.
    Case report: This paper describes a case report of a patient with severe subglottic stenosis (grade III according to the Cotton-Myer scale), introduces a new option in cricotracheal resections - postoperative temporary non-cannulated tracheostomy and describes its advantages.
    Conclusion: This variation of classical operative techniques provides additional fixation of the trachea, thus relieving any transitory tension on the anastomosis; acts as a valve and decreases the air-pressure in the upper airways during coughing and sneezing in the post-operative period; and is an easy access point for video tracheoscopy of the anastomosis.
    Language English
    Publishing date 2017-04-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3123
    ISSN (online) 2146-3131
    ISSN 2146-3123
    DOI 10.4274/balkanmedj.2016.0108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Conference proceedings: Local recurrence of laryngeal carcinoma

    Skerleva, Desislava / Stoyanov, Stefan / Rangachev, Julian / Assenova, Katya

    2011  , Page(s) 11hnod256

    Event/congress 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; Freiburg i. Br.; Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 2011
    Keywords Medizin, Gesundheit
    Publishing date 2011-04-19
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/11hnod256
    Database German Medical Science

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  6. Article ; Online: Local recurrence of laryngeal carcinoma

    Skerleva, Desislava / Stoyanov, Stefan / Rangachev, Julian / Assenova, Katya

    GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

    2011  Volume 7, Page(s) 13

    Abstract: Stoma recurrence following total laryngectomy is one of the most severe complications with extremely poor prognosis. : Objective: The aim of our study is to analyze the risk factors for stoma recurrence development and to highlight the measures for ... ...

    Abstract Stoma recurrence following total laryngectomy is one of the most severe complications with extremely poor prognosis.
    Objective: The aim of our study is to analyze the risk factors for stoma recurrence development and to highlight the measures for prevention.
    Materials and methods: We preformed retrospective study on 530 patients who underwent total laryngectomy at Queen Giovanna Hospital end Ministry of Interior Medical Institute, Sofia for a period of 2 years.
    Results: Stoma recurrence developed in 9 cases. Our analysis reveals that primary site, T stage, preoperative tracheotomy and paratracheal lymph node metastasis are significant risk factors for stoma recurrence.
    Conclusion: In spite of extensive surgery, radio and chemotherapy the prognosis is very poor. Considering the high rate of mortality, the prevention and intensive follow-up for patients with risk factors is of great importance in order to reduce the frequency of this disease.
    Keywords Medizin, Gesundheit ; Onkologie
    Publishing date 2011-04-14
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Article ; Online
    ISSN 1865-1038
    ISSN (online) 1865-1038
    DOI 10.3205/cpo000602
    Database German Medical Science

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  7. Article: Relative quantitative expression of hypoxia-inducible factor-1α, -2α and -3α, and vascular endothelial growth factor A in laryngeal carcinoma.

    Popov, Todor Miroslavov / Goranova, Teodora / Stancheva, Gergana / Kaneva, Radka / Dikov, Tihomir / Chalakov, Ivan / Rangachev, Julian / Konov, Dimitar / Todorov, Spiridon / Stoyanov, Orlin / Mitev, Vanio

    Oncology letters

    2015  Volume 9, Issue 6, Page(s) 2879–2885

    Abstract: The aim of the present study was to determine the relative quantitative expression of hypoxia-inducible factor (HIF)-1α, -2α and -3α, and VEGF-A in laryngeal carcinoma. A total of 63 patients with carcinoma of the larynx were enrolled in the study. Total ...

    Abstract The aim of the present study was to determine the relative quantitative expression of hypoxia-inducible factor (HIF)-1α, -2α and -3α, and VEGF-A in laryngeal carcinoma. A total of 63 patients with carcinoma of the larynx were enrolled in the study. Total RNA was isolated from fresh, frozen normal and tumor tissues of each patient, and quantitative polymerase chain reaction was performed. HIF-1α was upregulated in the majority of patients (44 patients; 69.84%). By contrast, only 7 (11.11%) patients from the whole group displayed HIF-2α overexpression, while the HIF-3α isoform was silenced in the majority of patients (48 patients, 76.19%). A small group of 5 (7.94%) patients exhibited significant overexpression of the HIF-3α isoform. VEGF-A expression was significantly higher (P<0.05) in patients with upregulated HIF-1α (2.72±1.41 RQ) compared with patients without upregulated HIF-1α (1.86±1.46 RQ). There was a moderate positive correlation between mRNA expression levels of HIF-1α and VEGF-A (r
    Language English
    Publishing date 2015-03-24
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2015.3070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Auditory outcome after cochlear implantation in patients with congenital nonsyndromic hearing loss: influence of the GJB2 status.

    Popov, Todor Miroslavov / Stancheva, Iglika / Kachakova, Darina L / Rangachev, Julian / Konov, Dimitar / Varbanova, Sonya / Mitev, Vanio Ivanov / Kaneva, Radka P / Popova, Diana Petrova

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2014  Volume 35, Issue 8, Page(s) 1361–1365

    Abstract: Objective: To compare the audiologic outcome after cochlear implantation between 2 groups of patients with congenital nonsyndromic sensorineural hearing loss.: Study design: Retrospective cohort study.: Setting: Department of Otorhinolaryngology, ... ...

    Abstract Objective: To compare the audiologic outcome after cochlear implantation between 2 groups of patients with congenital nonsyndromic sensorineural hearing loss.
    Study design: Retrospective cohort study.
    Setting: Department of Otorhinolaryngology, University hospital (tertiary referral center).
    Patients: From a bigger pool of implanted patients, 2 groups, each numbering 30 were enrolled. The patients from the first group were diagnosed with a Connexin 26 mutation (GJB2), whereas all of the patients from the second cohort were with a wild type genotype. Both groups were age matched, 1 to 7 years old at the age of implantation, with diagnosed congenital nonsyndromic sensorineural hearing loss.
    Main outcome measures: Both groups were evaluated with the help evaluation of auditory responses to speech/EARS/test battery - LiP test (Listening Progress Profile), MTP tests 3,6,12 (Monosyllabic-Trochee-Polysyllabic Test), GASP test (Glendonald Auditory Screening Procedure), and others. Follow-up period was at least 36 months.
    Results: Mean test scores were compared at the 1st, 6th, 12th, 24th, and 36th month. LiP outcome was significantly better (p < 0.05) for the GJB2-related cohort for the whole follow-up period except at the first month. MTP3, 6, and 12 tests displayed the same statistically significant outcome in favor of the first group. In the open-set test GASP, the difference was apparent: 1.22, 2.40, 5.59, and 7.40 mean scores at the 6th, 12th, 24, and 36th months for the first cohort versus 0.00, 0.07, 0.81, and 1.74 for the GJB2-unrelated patients.
    Conclusion: The results from our study suggest that children with GJB2-related deafness show better auditory performance after cochlear implantation than age-matched children with GJB2-nonrelated sensorineural hearing loss.
    MeSH term(s) Child ; Child, Preschool ; Cochlear Implantation ; Cohort Studies ; Connexin 26 ; Connexins/genetics ; Deafness/genetics ; Deafness/surgery ; Female ; Genotype ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/surgery ; Humans ; Infant ; Male ; Mutation ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Connexins ; GJB2 protein, human ; Connexin 26 (127120-53-0)
    Language English
    Publishing date 2014-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000000348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1554: Show issues Location:
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