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  1. AU="Rangarajan, Amith"
  2. AU="Alonso-Sánchez, Jesús"
  3. AU="Zhuo, J C"
  4. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  5. AU=Sundararaman T
  6. AU="Singla, Amit Kumar"
  7. AU="Shu, Ran"
  8. AU="Kim, Jiha"
  9. AU="MacDonald, Suzanne E."
  10. AU="Heather Limburg"
  11. AU="Gross, Boris"
  12. AU="Perkins, George H"
  13. AU="Jormanainen, J"
  14. AU="Pichardo-González, Priamo A"
  15. AU="Cannegieter, Suzanne"
  16. AU="Trocino, Giuseppe"
  17. AU="Emiliano, Thais Moura"
  18. AU=Sinelli Mariateresa
  19. AU="De-guo LÜ"
  20. AU="Benoit-Pilven, Clara"
  21. AU="Lanza, Stefania"
  22. AU="Chilingarian, A"
  23. AU="Baldovini, Nicolas"
  24. AU="López Rodríguez, David"
  25. AU="Alexander König"
  26. AU="Jakobsen, Henrik L"
  27. AU="Yong-Zhao Dai"
  28. AU="Tara L. Pukala"
  29. AU="Addo‐Danso, Shalom D."
  30. AU=Ficheux Q.
  31. AU="Tomoyo Sawada"
  32. AU="Mohammad Kawsar Sharif Siam"
  33. AU=Kushnareva Yulia
  34. AU="Canova, Christopher T"
  35. AU="Hasnaoui, Naoual"
  36. AU="Maradana, Jhansi"
  37. AU="Raggini, Elisa"
  38. AU="Baxter, A."
  39. AU="Jackson, Shirnae"
  40. AU="Schenzle, Lisa"
  41. AU="Veronica Phillips"
  42. AU="Braun, Jörg"
  43. AU="Cassandra E. Holbert"
  44. AU="Trevisan Alexandra"

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  1. Artikel ; Online: Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation.

    Garrido Ruiz, Diego / Sandoval-Perez, Angelica / Rangarajan, Amith Vikram / Gunderson, Emma L / Jacobson, Matthew P

    Biochemistry

    2022  Band 61, Heft 20, Seite(n) 2165–2176

    Abstract: Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important yet complex regulatory roles. Compared with the effects of post-translational modifications ... ...

    Abstract Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important yet complex regulatory roles. Compared with the effects of post-translational modifications such as phosphorylation, the effects of oxidation of cysteine to sulfenic, sulfinic, and sulfonic acid on protein structure and function remain relatively poorly characterized. We present an analysis of the role of cysteine reactivity as a regulatory factor in proteins, emphasizing the interplay between electrostatics and redox potential as key determinants of the resulting oxidation state. A review of current computational approaches suggests underdeveloped areas of research for studying cysteine reactivity through molecular simulations.
    Mesh-Begriff(e) Biophysics ; Cysteine/chemistry ; Oxidation-Reduction ; Proteins/chemistry ; Sulfenic Acids ; Sulfonic Acids
    Chemische Substanzen Proteins ; Sulfenic Acids ; Sulfonic Acids ; Cysteine (K848JZ4886)
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.2c00349
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: NCCP-ICS joint consensus-based clinical practice guidelines on medical thoracoscopy.

    Chawla, Rakesh K / Kumar, Mahendra / Madan, Arun / Dhar, Raja / Gupta, Richa / Gothi, Dipti / Desai, Unnati / Goel, Manoj / Swarankar, Rajesh / Nene, Amita / Munje, Radha / Chaudhary, Dhruv / Guleria, Randeep / Hadda, Vijay / Nangia, Vivek / Sindhwani, Girish / Chawla, Rajesh / Dutt, Naveen / Yuvarajan /
    Dalal, Sonia / Gaur, Shailendra Nath / Katiyar, Subodh / Samaria, Jai Kumar / Gupta, K B / Koul, Parvaiz A / Suryakant / Christopher, D J / Roy, Dhrubajyoti / Hazarika, Basant / Luhadia, Shanti Kumar / Jaiswal, Anand / Madan, Karan / Gupta, Prem Parkash / Prashad, B N B M / Yusuf, Nasser / James, Prince / Dhamija, Amit / Tomar, Veerotam / Parakh, Ujjwal / Khan, Ajmal / Garg, Rakesh / Singh, Sheetu / Joshi, Vinod / Sarangdhar, Nikhil / Chaudhary, Sushmita Roy / Nayar, Sandeep / Patel, Anand / Gupta, Mansi / Dixit, Rama Kant / Jain, Sushil / Gogia, Pratibha / Agarwal, Manish / Katiyar, Sandeep / Chawla, Aditya / Gonuguntala, Hari Kishan / Dosi, Ravi / Chinnamchetty, Vijya / Jindal, Apar / Sharma, Shubham / Chachra, Vaibhav / Samaria, Utsav / Nair, Avinash / Mohan, Shruti / Maitra, Gargi / Sinha, Ashish / Kochar, Rishabh / Yadav, Ajit / Choudhary, Gaurav / Arunachalam, M / Rangarajan, Amith / Sanjan, Ganesh

    Lung India : official organ of Indian Chest Society

    2024  Band 41, Heft 2, Seite(n) 151–167

    Abstract: Abstract: Medical Thoracoscopy (MT) is commonly performed by respiratory physicians for diagnostic as well as therapeutic purposes. The aim of the study was to provide evidence-based information regarding all aspects of MT, both as a diagnostic tool and ...

    Abstract Abstract: Medical Thoracoscopy (MT) is commonly performed by respiratory physicians for diagnostic as well as therapeutic purposes. The aim of the study was to provide evidence-based information regarding all aspects of MT, both as a diagnostic tool and therapeutic aid for pulmonologists across India. The consensus-based guidelines were formulated based on a multistep process using a set of 31 questions. A systematic search of published randomized controlled clinical trials, open labelled studies, case reports and guidelines from electronic databases, like PubMed, EmBase and Cochrane, was performed. The modified grade system was used (1, 2, 3 or usual practice point) to classify the quality of available evidence. Then, a multitude of factors were taken into account, such as volume of evidence, applicability and practicality for implementation to the target population and then strength of recommendation was finalized. MT helps to improve diagnosis and patient management, with reduced risk of post procedure complications. Trainees should perform at least 20 medical thoracoscopy procedures. The diagnostic yield of both rigid and semirigid techniques is comparable. Sterile-graded talc is the ideal agent for chemical pleurodesis. The consensus statement will help pulmonologists to adopt best evidence-based practices during MT for diagnostic and therapeutic purposes.
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_5_24
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

    Paolino, Jonathan / Dimitrov, Boris / Apsel Winger, Beth / Sandoval-Perez, Angelica / Rangarajan, Amith Vikram / Ocasio-Martinez, Nicole / Tsai, Harrison K / Li, Yuting / Robichaud, Amanda L / Khalid, Delan / Hatton, Charlie / Gillani, Riaz / Polonen, Petri / Dilig, Anthony / Gotti, Giacomo / Kavanagh, Julia / Adhav, Asmani A / Gow, Sean / Tsai, Jonathan /
    Li, Yen Der / Ebert, Benjamin L / Van Allen, Eliezer M / Bledsoe, Jacob / Kim, Annette S / Tasian, Sarah K / Cooper, Stacy L / Cooper, Todd M / Hijiya, Nobuko / Sulis, Maria Luisa / Shukla, Neerav N / Magee, Jeffrey A / Mullighan, Charles G / Burke, Michael J / Luskin, Marlise R / Mar, Brenton G / Jacobson, Matthew P / Harris, Marian H / Stegmaier, Kimberly / Place, Andrew E / Pikman, Yana

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Band 29, Heft 22, Seite(n) 4613–4626

    Abstract: Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to ...

    Abstract Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to inform therapy.
    Experimental design: We describe a cohort of 14 pediatric patients with relapsed or refractory T-ALL enrolled on the Leukemia Precision-based Therapy (LEAP) Consortium trial (NCT02670525) and a patient with T-LBL, discovering alterations in platelet-derived growth factor receptor-α (PDGFRA) in 3 of these patients. We identified a novel mutation in PDGFRA, p.D842N, and used an integrated structural modeling and molecular biology approach to characterize mutations at D842 to guide therapeutic targeting. We conducted a preclinical study of avapritinib in a mouse patient-derived xenograft (PDX) model of FIP1L1-PDGFRA and PDGFRA p.D842N leukemia.
    Results: Two patients with T-ALL in the LEAP cohort (14%) had targetable genomic alterations affecting PDGFRA, a FIP1-like 1 protein/PDGFRA (FIP1L1-PDGFRA) fusion and a novel mutation in PDGFRA, p.D842N. The D842N mutation resulted in PDGFRA activation and sensitivity to tested PDGFRA inhibitors. In a T-ALL PDX model, avapritinib treatment led to decreased leukemia burden, significantly prolonged survival, and even cured a subset of mice. Avapritinib treatment was well tolerated and yielded clinical benefit in a patient with refractory T-ALL.
    Conclusions: Refractory T-ALL has not been fully characterized. Alterations in PDGFRA or other targetable kinases may inform therapy for patients with refractory T-ALL who otherwise have limited treatment options. Clinical genomic profiling, in real time, is needed for fully informed therapeutic decision making.
    Mesh-Begriff(e) Humans ; Child ; Animals ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Mutation ; Receptor Protein-Tyrosine Kinases/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; T-Lymphocytes
    Chemische Substanzen Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-2562
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4223: Hefte anzeigen Standort:
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  4. Artikel: Guidelines for endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA): Joint Indian Chest Society (ICS)/Indian Association for Bronchology (IAB) recommendations.

    Mohan, Anant / Madan, Karan / Hadda, Vijay / Mittal, Saurabh / Suri, Tejas / Shekh, Irfan / Guleria, Randeep / Khader, Abdul / Chhajed, Prashant / Christopher, Devasahayam J / Swarnakar, Rajesh / Agarwal, Ritesh / Aggarwal, Ashutosh Nath / Aggarwal, Shubham / Agrawal, Gyanendra / Ayub, Irfan Ismail / Bai, Muniza / Baldwa, Bhvya / Chauhan, Abhishek /
    Chawla, Rakesh / Chopra, Manu / Choudhry, Dhruva / Dhar, Raja / Dhooria, Sahajal / Garg, Rakesh / Goel, Ayush / Goel, Manoj / Goyal, Rajiv / Gupta, Nishkarsh / Manjunath, B G / Iyer, Hariharan / Jain, Deepali / Khan, Ajmal / Kumar, Raj / Koul, Parvaiz A / Lall, Ajay / Arunachalam, M / Madan, Neha K / Mehta, Ravindra / Loganathan, N / Nath, Alok / Nangia, Vivek / Nene, Amita / Patel, Dharmesh / Pattabhiraman, V R / Raja, Arun / Rajesh, Benin / Rangarajan, Amith / Rathi, Vidushi / Sehgal, Inderpaul Singh / Shankar, Sujay H / Sindhwani, Girish / Singh, Pawan K / Srinivasan, Arjun / Talwar, Deepak / Thangakunam, Balamugesh / Tiwari, Pawan / Tyagi, Rahul / Chandra, V Naren / Sharada, V / Vadala, Rohit / Venkatnarayan, Kavitha

    Lung India : official organ of Indian Chest Society

    2023  Band 40, Heft 4, Seite(n) 368–400

    Abstract: Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and several innovations ... ...

    Abstract Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and several innovations have occurred, the indications for its use have expanded. However, several aspects of EBUS-TBNA are still not standardized. Hence, evidence-based guidelines are needed to optimize the diagnostic yield and safety of EBUS-TBNA. For this purpose, a working group of experts from India was constituted. A detailed and systematic search was performed to extract relevant literature pertaining to various aspects of EBUS-TBNA. The modified GRADE system was used for evaluating the level of evidence and assigning the strength of recommendations. The final recommendations were framed with the consensus of the working group after several rounds of online discussions and a two-day in-person meeting. These guidelines provide evidence-based recommendations encompassing indications of EBUS-TBNA, pre-procedure evaluation, sedation and anesthesia, technical and procedural aspects, sample processing, EBUS-TBNA in special situations, and training for EBUS-TBNA.
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_510_22
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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