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  1. Book: The healthcare professional’s guide to clinical cultural competence

    Srivastava, Rani H.

    2007  

    Title variant Guide to clinical cultural competence
    Author's details ed. by Rani H. Srivastava
    Keywords Transcultural Nursing ; Cross-Cultural Comparison ; Clinical Competence ; Cultural Diversity
    Language English
    Size XIII, 352 S. : Ill., graph. Darst.
    Publisher Mosby Elsevier
    Publishing place Toronto
    Publishing country Canada
    Document type Book
    HBZ-ID HT015006451
    ISBN 0-7796-9960-2 ; 978-0-7796-9960-5
    Database Catalogue ZB MED Medicine, Health

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  2. Conference proceedings ; Online: Weakly nonlinear analysis of rotating magnetoconvection with anisotropic diffusivities in earth’s core near the onset of oscillatory instability

    Yadagiri, R. / Rani, H. / Nayak, K. / Jozef, B.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: The influence of anisotropic diffusive coefficients on the stability of the horizontal fluid planar layer, rotating about vertical axis, and permeated by a horizontal homogeneous magnetic field is studied. The linear stability analysis is performed using ...

    Abstract The influence of anisotropic diffusive coefficients on the stability of the horizontal fluid planar layer, rotating about vertical axis, and permeated by a horizontal homogeneous magnetic field is studied. The linear stability analysis is performed using the separable solutions in the form of horizontal rolls. The onset of overstable motions is examined [1] as well as of stationary ones. The weakly nonlinear behaviour of the convective motions in the vicinity of primary instability threshold is studied. The efficiency to transport heat is compared between overstable and stationary modes. References: [1] T. Šoltis, J. Brestenský, (2009), Rotating magnetoconvection with anisotropic diffusivities in the Earth’s core, Physics of the Earth and Planetary Interiors, 178, 27-38.
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Conference proceedings ; Online: Weakly nonlinear analysis of rotating magnetoconvection with anisotropic diffusivities in earth’s core near the onset of stationary instability

    Rani, H. / Das, M. / Jozef, B. / Enrico, F.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: The influence of anisotropic diffusive coefficients on the stability of the horizontal fluid planar layer, rotating about vertical axis, and permeated by a horizontal homogeneous magnetic field is studied. The linear stability analysis is performed using ...

    Abstract The influence of anisotropic diffusive coefficients on the stability of the horizontal fluid planar layer, rotating about vertical axis, and permeated by a horizontal homogeneous magnetic field is studied. The linear stability analysis is performed using the separable solutions in the form of horizontal rolls. The onset of stationary motions is examined [1] for the present study. The weakly nonlinear behaviour of the convective motion in the vicinity of primary instability threshold is studied from the Landau-Ginzburg equation with cubic nonlinearity. This amplitude equation is obtained after using the multiple scale analysis and the modified normal mode solutions. The linear stability analysis of the amplitude equation is performed to investigate the secondary instabilities, such as Eckhaus instability and zig-zag instability. Reference: 1. T. Šoltis, J. Brestenský, (2009), Rotating magnetoconvection with anisotropic diffusivities in the Earth’s core, Physics of the Earth and Planetary Interiors, 178, 27-38.
    Subject code 532
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.

    Gehring, A / Huebner, K / Rani, H / Erlenbach-Wuensch, K / Merkel, S / Mahadevan, V / Grutzmann, R / Hartmann, A / Schneider-Stock, R

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2683

    Abstract: TROP2 is a powerful cancer driver in colorectal cancer cells. Divergent epigenetic regulation mechanisms for the corresponding TACSTD2 gene exist such as miRNAs or DNA methylation. However, the role of TACSTD2 promoter hypermethylation in colorectal ... ...

    Abstract TROP2 is a powerful cancer driver in colorectal cancer cells. Divergent epigenetic regulation mechanisms for the corresponding TACSTD2 gene exist such as miRNAs or DNA methylation. However, the role of TACSTD2 promoter hypermethylation in colorectal cancer has not been investigated yet. In this study, TROP2 expression strongly correlated with promoter methylation in different colorectal tumor cell lines. Treatment with 5-Azacytidine, a DNMT1 inhibitor, led to demethylation of the TACSTD2 promoter accompanied by an increase in TROP2 protein expression. TROP2 expression correlated with promoter methylation in vivo in human colon tumor tissue, thereby verifying promoter methylation as an important factor in the regulation of TROP2 expression in colorectal cancer. When performing a ChIP-Seq analysis in HCT116 and HT29 cells, we found that TACSTD2 promoter demethylation was accompanied by tri-methylation of H3K4. In silico analysis of GSE156613 data set confirmed that a higher binding of histone mark H3K4me3 around the TACSTD2 promoter was found in TACSTD2 high expressing tumors of colon cancer patients compared to the corresponding adjacent tumor tissue. Moreover, the link between TROP2 and the H3K4me3 code was even evident in tumors showing high intratumoral heterogeneity for TROP2 staining. Our data provide novel evidence for promoter demethylation and simultaneous gains of the active histone mark H3K4me3 across CpG-rich sequences, both being complementary mechanisms in the transcriptional regulation of TACSTD2 in colon cancer. The functional consequences of TROP2 loss in colorectal cancer needs to be further investigated.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Demethylation ; DNA Methylation ; Cell Line, Tumor ; Colonic Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Colorectal Neoplasms/pathology ; CpG Islands ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism
    Chemical Substances TACSTD2 protein, human ; Antigens, Neoplasm ; Cell Adhesion Molecules
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52437-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biphasic synovial sarcoma with epithelial predominance reminiscent of adenocarcinoma: a diagnostic challenge.

    Rani, Hephzibah / Rao, Ravikala Vittal / Badiger, Suresh / Holla, Sukesh

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Synovial sarcoma (SS) is a rare tumour of unknown origin with peak incidence between 10 and 35 years. Although it arises in juxta-articular location, SS is a misnomer and has no true relationship with synovium. In this case report, we present an elderly ... ...

    Abstract Synovial sarcoma (SS) is a rare tumour of unknown origin with peak incidence between 10 and 35 years. Although it arises in juxta-articular location, SS is a misnomer and has no true relationship with synovium. In this case report, we present an elderly female patient with a long-standing history of thigh mass which was initially misdiagnosed as metastatic adenocarcinoma deposits on fine needle aspiration cytology, and again misdiagnosed as malignant adnexal skin tumour on core needle biopsy and referred for further management. Here, we discuss the challenges faced in the diagnosis of SS on a small biopsy and ways to differentiate it from other morphological mimickers. Therefore, we aim to increase the awareness of soft tissue tumours that microscopically appear like adenocarcinoma, which is a potential diagnostic pitfall. We also highlight the importance of morphological diagnosis and the utility of molecular testing using fluorescence in situ hybridisation, to arrive at the correct diagnosis of SS.
    MeSH term(s) Humans ; Female ; Aged ; Sarcoma, Synovial/diagnosis ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/pathology ; Biopsy, Fine-Needle ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Oncogene Proteins, Fusion
    Chemical Substances Oncogene Proteins, Fusion
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Reliability of smartphone images to assess plaque score among preschool children: a pilot study.

    Vijyakumar, Magesh / Ashari, Asma / Yazid, Farinawati / Rani, Haslina / Kuppusamy, Elavarasi

    The Journal of clinical pediatric dentistry

    2024  Volume 48, Issue 2, Page(s) 143–148

    Abstract: This study assessed the reliability of smartphone images of plaque-disclosed anterior teeth for evaluating plaque scores among preschool children. Additionally, the reliability of plaque scores recorded from smartphone images of anterior teeth in ... ...

    Abstract This study assessed the reliability of smartphone images of plaque-disclosed anterior teeth for evaluating plaque scores among preschool children. Additionally, the reliability of plaque scores recorded from smartphone images of anterior teeth in representing the overall clinical plaque score was also assessed. Fifteen preschool children were recruited for this pilot study. The Simplified Debris Index (DI-S), the debris component of the Simplified Oral Hygiene Index, was used to record the plaque score. A plaque-disclosing tablet was used to disclose the plaque before the plaque score recording. Following that, the image of the anterior teeth (canine to canine) of both the upper and lower arch was captured using the smartphone. Each child had three different DI-S recorded. For the first recording of the overall clinical DI-S, the plaque score was recorded clinically from index teeth 55 (buccal), 51 (labial), 65 (buccal), 71 (labial), 75 (lingual) and 85 (lingual). For the second recording, anterior clinical DI-S, the plaque score was recorded clinically from the labial surfaces of six anterior teeth only (53, 51, 63, 73, 71 and 83). Two weeks later, anterior photographic DI-S (third recording) was done using the smartphone images of the same index teeth used for the second recording. The intra-class correlation coefficient (ICC) was calculated to evaluate the reliability of smartphone images in assessing plaque scores. The results showed high reliability (ICC = 0.987) between anterior clinical and anterior photographic examinations, indicating that smartphone images are highly reliable for evaluating plaque scores. Similarly, high reliability (ICC = 0.981) was also found for comparison between overall clinical DI-S and anterior photographic DI-S, indicating plaque scores recorded from smartphone images of anterior teeth alone can represent the overall clinical plaque score. This study suggests that smartphone images can be a valuable tool for remote screening and monitoring of oral hygiene in preschool children, contributing to better oral health outcomes.
    MeSH term(s) Humans ; Child, Preschool ; Pilot Projects ; Smartphone ; Reproducibility of Results ; Tooth ; Dental Plaque/diagnosis ; Dental Plaque Index
    Language English
    Publishing date 2024-03-03
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 1062408-9
    ISSN 1053-4628 ; 0145-5508
    ISSN 1053-4628 ; 0145-5508
    DOI 10.22514/jocpd.2024.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Understanding the influence of genotype and temperature on proteolytic activity in distinct barley genotypes

    Rani, Heena / Bhardwaj, Rachana D / Kaur, Simarjit

    Journal of Food Science. 2023 Apr., v. 88, no. 4 p.1718-1730

    2023  

    Abstract: This study aimed at investigating the effects of genotype and temperatures on the proteolytic activity in green malt of 48 barley genotypes, including 19 mutants, 15 hulled, 4 hulless, and 10 wild using enzyme assays based on casein, as substrate. During ...

    Abstract This study aimed at investigating the effects of genotype and temperatures on the proteolytic activity in green malt of 48 barley genotypes, including 19 mutants, 15 hulled, 4 hulless, and 10 wild using enzyme assays based on casein, as substrate. During malting, insoluble barley protein must be hydrolyzed into soluble peptides and free amino acids to supply the brewing yeast with sufficient nutrients to grow rapidly and metabolize glucose and other sugars into alcohol through fermentation. However, the relatively hot temperatures employed during kilning usually denature the proteolytic enzymes due to their thermolabile nature. Even though the hydrolytic activity of most of the proteases is destroyed during the kilning process, the malt includes a small fraction of thermostable proteases that can further degrade protein in the subsequent mashing process. Considering the higher temperature range employed in industrial kilning and mashing, three temperatures (37, 50, and 70°C) were selected to identify the genotypes possessing high activity at the higher range of temperatures as well as thermostable variant of the enzyme. The proteolytic activity in all the genotypes declined after 50°C depicting its optimum temperature. Overall proteolytic activity was observed to be positively correlated with the amino acids and negatively correlated with protein content. Three mutant (BL2086, BL2091, and BL2079) and one wild (WS 237) genotypes possessing proteolytic activity in a higher range at all the studied temperatures have the potential to be exploited in the breeding programs for incorporating trait of thermostable proteolytic activity into low malting efficiency cultivars. PRACTICAL APPLICATION: The optimal hydrolytic activities of carbohydrases and proteases during mashing are essential for producing high‐quality wort from malted barley to ensure that hydrolyzed molecules are available to brewers’ yeast to support fermentative metabolism. In this study, several barley cultivars were grown under identical environmental conditions but assayed at different temperatures. As result, four genotypes had been obtained that possessed optimal proteolytic activities at a higher temperature range and can be of great interest to breeders and maltsters for altering wort amino acid profiles and better exposure of starch to mashing enzymes, thereby increasing the fermentable sugar yield from the malt.
    Keywords alcohols ; amino acids ; barley ; barley protein ; casein ; cultivars ; fermentation ; genotype ; glucose ; hydrolysis ; malt ; malting barley ; mutants ; peptides ; protein content ; proteinases ; proteolysis ; starch ; temperature ; thermal stability ; yeasts
    Language English
    Dates of publication 2023-04
    Size p. 1718-1730.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.16509
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Understanding the influence of genotype and temperature on proteolytic activity in distinct barley genotypes.

    Rani, Heena / Bhardwaj, Rachana D / Kaur, Simarjit

    Journal of food science

    2023  Volume 88, Issue 4, Page(s) 1718–1730

    Abstract: This study aimed at investigating the effects of genotype and temperatures on the proteolytic activity in green malt of 48 barley genotypes, including 19 mutants, 15 hulled, 4 hulless, and 10 wild using enzyme assays based on casein, as substrate. During ...

    Abstract This study aimed at investigating the effects of genotype and temperatures on the proteolytic activity in green malt of 48 barley genotypes, including 19 mutants, 15 hulled, 4 hulless, and 10 wild using enzyme assays based on casein, as substrate. During malting, insoluble barley protein must be hydrolyzed into soluble peptides and free amino acids to supply the brewing yeast with sufficient nutrients to grow rapidly and metabolize glucose and other sugars into alcohol through fermentation. However, the relatively hot temperatures employed during kilning usually denature the proteolytic enzymes due to their thermolabile nature. Even though the hydrolytic activity of most of the proteases is destroyed during the kilning process, the malt includes a small fraction of thermostable proteases that can further degrade protein in the subsequent mashing process. Considering the higher temperature range employed in industrial kilning and mashing, three temperatures (37, 50, and 70°C) were selected to identify the genotypes possessing high activity at the higher range of temperatures as well as thermostable variant of the enzyme. The proteolytic activity in all the genotypes declined after 50°C depicting its optimum temperature. Overall proteolytic activity was observed to be positively correlated with the amino acids and negatively correlated with protein content. Three mutant (BL2086, BL2091, and BL2079) and one wild (WS 237) genotypes possessing proteolytic activity in a higher range at all the studied temperatures have the potential to be exploited in the breeding programs for incorporating trait of thermostable proteolytic activity into low malting efficiency cultivars. PRACTICAL APPLICATION: The optimal hydrolytic activities of carbohydrases and proteases during mashing are essential for producing high-quality wort from malted barley to ensure that hydrolyzed molecules are available to brewers' yeast to support fermentative metabolism. In this study, several barley cultivars were grown under identical environmental conditions but assayed at different temperatures. As result, four genotypes had been obtained that possessed optimal proteolytic activities at a higher temperature range and can be of great interest to breeders and maltsters for altering wort amino acid profiles and better exposure of starch to mashing enzymes, thereby increasing the fermentable sugar yield from the malt.
    MeSH term(s) Temperature ; Hordeum/metabolism ; Saccharomyces cerevisiae/metabolism ; Endopeptidases/metabolism ; Sugars/metabolism ; Seedlings/chemistry ; Amino Acids/analysis ; Genotype ; Beer
    Chemical Substances Endopeptidases (EC 3.4.-) ; Sugars ; Amino Acids
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241615-3
    ISSN 1750-3841 ; 0022-1147
    ISSN (online) 1750-3841
    ISSN 0022-1147
    DOI 10.1111/1750-3841.16509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Breastfeeding practices for infants with inherited metabolic disorders

    Allison Buckingham / Aileen Kenneson / Rani H. Singh

    Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100865- (2022)

    A survey of registered dietitians in the United States and Canada

    2022  

    Abstract: Background: Breast milk is considered the optimal first food for infants. Breastfeeding infants with inherited metabolic disorders (IMDs) is complex due to the critical need to manage intake of specific macronutrients depending on the type of IMD. ... ...

    Abstract Background: Breast milk is considered the optimal first food for infants. Breastfeeding infants with inherited metabolic disorders (IMDs) is complex due to the critical need to manage intake of specific macronutrients depending on the type of IMD. Objective: To describe current practices of registered dietitians (RD) who treat patients with IMDs regarding the incorporation of breastmilk into disease management. Design: Cross-sectional survey.Participants/setting:online survey conducted in December 2020 of 66 RDs who treat patients with IMDs in the United States and Canada.Main outcome measures:the survey focused on personal demographics, clinic characteristics, institutional feeding protocols for infants with IMDs, confidence in working with breastfeeding parents of infants with IMDs, and knowledge about breastfeeding with questions derived from the Iowa Infant Feeding Attitudes Scale.Statistical analysis performed:.Fisher's exact test was used for comparisons. Results: Most RDs were confident or very confident in their ability to provide nutritional guidance for breastfeeding infants with IMDs. Half of the participants reported that they had received training on breastfeeding of infants of IMDs. For infants with phenylketonuria (PKU), most RDs include breastfeeding as part of nutritional management. Breastfeeding is less likely to be used in the management of infants with other aminoacidopathies and fatty acid oxidation disorders. Use of measured expressed breastmilk was preferred, including for aminoacidopathies other than PKU, organic acidemias, and fatty acid oxidation disorders. Knowledge about breastfeeding varied. Less than half of RDs referred mothers to a lactation specialist somewhat regularly or frequently. Conclusions: Our survey found variation in experience, training, and use of breastfeeding-related nutritional management protocols in IMDs. A lack of formal training programs for the nutritional management of IMDs may account for some of this variation. Future research, including the collection of ...
    Keywords Breastfeeding ; Inherited metabolic disorders ; Practices ; Registered dietitians ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Presentation and management of N-acetylglutamate synthase deficiency

    Aileen Kenneson / Rani H. Singh

    Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-

    a review of the literature

    2020  Volume 10

    Abstract: Abstract Background N-Acetylglutamate synthase (NAGS) deficiency is an extremely rare autosomal recessive metabolic disorder affecting the urea cycle, leading to episodes of hyperammonemia which can cause significant morbidity and mortality. Since its ... ...

    Abstract Abstract Background N-Acetylglutamate synthase (NAGS) deficiency is an extremely rare autosomal recessive metabolic disorder affecting the urea cycle, leading to episodes of hyperammonemia which can cause significant morbidity and mortality. Since its recognition in 1981, NAGS deficiency has been treated with carbamylglutamate with or without other measures (nutritional, ammonia scavengers, dialytic, etc.). We conducted a systematic literature review of NAGS deficiency to summarize current knowledge around presentation and management. Methods Case reports and case series were identified using the Medline database, as well as references from other articles and a general internet search. Clinical data related to presentation and management were abstracted by two reviewers. Results In total, 98 cases of NAGS deficiency from 79 families, in 48 articles or abstracts were identified. Of these, 1 was diagnosed prenatally, 57 were neonatal cases, 34 were post-neonatal, and 6 did not specify age at presentation or were asymptomatic at diagnosis. Twenty-one cases had relevant family history. We summarize triggers of hyperammonemic episodes, diagnosis, clinical signs and symptoms, and management strategies. DNA testing is the preferred method of diagnosis, although therapeutic trials to assess response of ammonia levels to carbamylglutamate may also be helpful. Management usually consists of treatment with carbamylglutamate, although the reported maintenance dose varied across case reports. Protein restriction was sometimes used in conjunction with carbamylglutamate. Supplementation with citrulline, arginine, and sodium benzoate also were reported. Conclusions Presentation of NAGS deficiency varies by age and symptoms. In addition, both diagnosis and management have evolved over time and vary across clinics. Prompt recognition and appropriate treatment of NAGS deficiency with carbamylglutamate may improve outcomes of affected individuals. Further research is needed to assess the roles of protein restriction and supplements in the treatment of NAGS deficiency, especially during times of illness or lack of access to carbamylglutamate.
    Keywords N-Acetylglutamate synthase ; NAGS ; N-Acetylglutamate synthase deficiency ; Inherited metabolic disorder ; Urea cycle ; Hyperammonemia ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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