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  1. Article ; Online: End-colostomy parastomal hernia repair: a systematic review on laparoscopic and robotic approaches.

    Sarno, G / Iacone, B / Tedesco, A / Gargiulo, A / Ranieri, A / Giordano, A / Tramontano, S / Bracale, U

    Hernia : the journal of hernias and abdominal wall surgery

    2024  

    Abstract: Introduction: Parastomal hernia (PSH) is the most common and challenging complication after stoma creation, with an estimated 50% incidence 2 years after the index surgery. Mesh repair is the treatment of choice. Laparoscopic and/or robotic approaches ... ...

    Abstract Introduction: Parastomal hernia (PSH) is the most common and challenging complication after stoma creation, with an estimated 50% incidence 2 years after the index surgery. Mesh repair is the treatment of choice. Laparoscopic and/or robotic approaches allow acceptable outcomes.
    Materials and methods: A systematic literature review from January 2012 to November 2023 was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Embase, PubMed, and Scopus search were performed to select articles dealing with minimally invasive surgical treatment for PSH after end colostomy.
    Results: 603 studies were found, and 24 were chosen. When compared to open surgery, laparoscopy showed decreased postoperative complications and recurrence. The main laparoscopic approaches are the keyhole (KH), the Sugarbaker (SB), and the sandwich technique. Continuous improvement in surgery, mesh technology, and surgeons' expertise led to an amelioration of surgical outcome and recurrence rate after repair. Recent studies showed comparable outcomes for SB and KH techniques, while novel surgical approaches have been proposed in an attempt to further increase the operative and long-term results. Reports on PSH robotic repairs are scarce and describe small series results, suggesting a role of the initial learning curve as a risk factor for complications.
    Conclusion: End-colostomy PSH surgical repair still represents a challenge for surgeons. Recent evidence has not shown a significant advantage in postoperative complications and recurrence with a specific repair among SB, KH, and sandwich technique. The paucity of data on robotic surgery does not allow to draw definitive conclusion. Further primary, multicentric, and larger cohort studies are needed.
    Language English
    Publishing date 2024-04-16
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1388125-5
    ISSN 1248-9204 ; 1265-4906
    ISSN (online) 1248-9204
    ISSN 1265-4906
    DOI 10.1007/s10029-024-03026-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5390: Show issues Location:
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  2. Article ; Online: Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders.

    Ranieri, Annaluisa / La Monica, Ilaria / Di Iorio, Maria Rosaria / Lombardo, Barbara / Pastore, Lucio

    Genes

    2024  Volume 15, Issue 4

    Abstract: Neurodevelopmental disorders are a group of complex multifactorial disorders characterized by cognitive impairment, communication deficits, abnormal behaviour, and/or motor skills resulting from abnormal neural development. Copy number variants (CNVs) ... ...

    Abstract Neurodevelopmental disorders are a group of complex multifactorial disorders characterized by cognitive impairment, communication deficits, abnormal behaviour, and/or motor skills resulting from abnormal neural development. Copy number variants (CNVs) are genetic alterations often associated with neurodevelopmental disorders. We evaluated the diagnostic efficacy of the array-comparative genomic hybridization (a-CGH) method and its relevance as a routine diagnostic test in patients with neurodevelopmental disorders for the identification of the molecular alterations underlying or contributing to the clinical manifestations. In the present study, we analysed 1800 subjects with neurodevelopmental disorders using a CGH microarray. We identified 208 (7%) pathogenetic CNVs, 2202 (78%) variants of uncertain significance (VOUS), and 504 (18%) benign CNVs in the 1800 patients analysed. Some alterations contain genes potentially related to neurodevelopmental disorders including
    MeSH term(s) Humans ; Neurodevelopmental Disorders/genetics ; DNA Copy Number Variations/genetics ; Female ; Male ; Comparative Genomic Hybridization ; Italy ; Child ; Adolescent ; Child, Preschool
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15040427
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  3. Book ; Article ; Online: Hybrid (Solo)Self-Employment and Upskilling

    Pouliakas, Konstantinos / Ranieri, Antonio

    Is Online Platform Work a Path Towards Entrepreneurship?

    2022  

    Abstract: The increasing use of online labour platforms as intermediaries for finding work – known as crowdwork or gig work – is a new form of 'hybrid' (solo)self-employment that hinges on the borders of dependent and self-employment. In this study we use a novel ... ...

    Abstract The increasing use of online labour platforms as intermediaries for finding work – known as crowdwork or gig work – is a new form of 'hybrid' (solo)self-employment that hinges on the borders of dependent and self-employment. In this study we use a novel international dataset of online platform workers, the Cedefop Crowdlearn dataset, to analyse if engagement in hybrid digital self-employment could augment individuals' skills and hence potentially act as a stepping stone towards fuller entrepreneurship. We also examine if a digital proto-entrepreneurial experience is sustainable over time by analysing crowdworkers' satisfaction from their work. The paper's findings provide some support to the hypothesis that hybrid work experiences, especially when platform work is carried out alongside another dependent job, can facilitate additional and varied skill development done via one's secondary platform activity and potentially spur fuller entrepreneurial commitment. However, such skill formation dividends are deficient for part-time hybrids who are mostly driven towards solo self-employment out of necessity, making their journey from proto- to full entrepreneurship less feasible. Our paper provides additional evidence to the marked diversity and hybridity of different forms of (solo)self-employment in modern labour markets.
    Keywords ddc:330 ; J22 ; J24 ; J62 ; J28 ; L26 ; J49 ; hybrid self-employment ; platform/gig economy ; crowdworkers ; skills ; learning ; entrepreneurship ; digitalisation
    Subject code 331
    Language English
    Publisher Bonn: Institute of Labor Economics (IZA)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The role of intracranial hypertension in the chronification of migraine.

    De Simone, R / Ranieri, A

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2015  Volume 36 Suppl 1, Page(s) 23–28

    Abstract: Besides a similar clinical presentation, idiopathic intracranial hypertension (IIH) and chronic migraine (CM) also share relevant risk factors, show a higher prevalence of allodynic symptoms and both respond to topiramate. Moreover, sinus stenosis, a ... ...

    Abstract Besides a similar clinical presentation, idiopathic intracranial hypertension (IIH) and chronic migraine (CM) also share relevant risk factors, show a higher prevalence of allodynic symptoms and both respond to topiramate. Moreover, sinus stenosis, a radiological marker of IIH, in CM patients is much more prevalent than expected. As a consequence of these striking similarities, IIH without papilledema (IIHWOP) may be easily misdiagnosed as CM. Actually, IIHWOP has been found in up to 14 % of CM clinical series. Considering that, on one hand, an asymptomatic sinus stenosis-associated raised intracranial pressure (ICP) may be highly prevalent in the general population, and on the other, that IIH clinical presentation with chronic headache may require a migraine predisposition, we have proposed that an overlooked IIHWOP could represent a risk factor for migraine progression. This hypothesis prompted us to investigate the prevalence of IIHWOP and its possible role in the process of migraine chronification in a consecutive series of CM patients selected for unresponsiveness to medical treatment and evidence of significant sinus stenosis. The main finding of our study is that the large majority of such patients actually suffer from a chronic headache secondary to IIHWOP. This implies that an IIHWOP mimicking CM is much more prevalent than believed, is commonly misdiagnosed as CM on the basis of ICHD criteria and is strictly predicted by refractoriness to preventive treatments. However, our data fully comply with the alternative hypothesis that an overlooked IIHWOP, although highly prevalent amongst healthy individuals, in migraine-prone subjects is a powerful (and modifiable) risk factor for the progression and the refractoriness of pain. The normalization of ICP by even a single LP with CSF withdrawal may be effective in a significant proportion of patients with a long history of refractory chronic headache, who represent about one-fifth of the patients screened in our study. We suggest that IIHWOP should be considered in all patients with almost daily migraine pain, with evidence of sinus stenosis and unresponsive to medical treatment, referred to specialized headache clinics.
    MeSH term(s) Cardiovascular System/physiopathology ; Chronic Disease ; Constriction, Pathologic/physiopathology ; Disease Progression ; Humans ; Intracranial Hypertension/epidemiology ; Intracranial Hypertension/physiopathology ; Migraine Disorders/epidemiology ; Migraine Disorders/physiopathology ; Prevalence ; Risk Factors
    Language English
    Publishing date 2015-05
    Publishing country Italy
    Document type News
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-015-2164-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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  5. Article ; Online: The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors.

    Statello, Luisa / Fernandez-Justel, José Miguel / González, Jovanna / Montes, Marta / Ranieri, Alessia / Goñi, Enrique / Mas, Aina M / Huarte, Maite

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 978

    Abstract: Besides the well-characterized protein network involved in the replication stress response, several regulatory RNAs have been shown to play a role in this critical process. However, it has remained elusive whether they act locally at the stressed forks. ... ...

    Abstract Besides the well-characterized protein network involved in the replication stress response, several regulatory RNAs have been shown to play a role in this critical process. However, it has remained elusive whether they act locally at the stressed forks. Here, by investigating the RNAs localizing on chromatin upon replication stress induced by hydroxyurea, we identified a set of lncRNAs upregulated in S-phase and controlled by stress transcription factors. Among them, we demonstrate that the previously uncharacterized lncRNA lncREST (long non-coding RNA REplication STress) is transcriptionally controlled by p53 and localizes at stressed replication forks. LncREST-depleted cells experience sustained replication fork progression and accumulate un-signaled DNA damage. Under replication stress, lncREST interacts with the protein NCL and assists in engaging its interaction with RPA. The loss of lncREST is associated with a reduced NCL-RPA interaction and decreased RPA on chromatin, leading to defective replication stress signaling and accumulation of mitotic defects, resulting in apoptosis and a reduction in tumorigenic potential of cancer cells. These findings uncover the function of a lncRNA in favoring the recruitment of replication proteins to sites of DNA replication.
    MeSH term(s) Chromatin/genetics ; DNA Replication/genetics ; RNA, Long Noncoding/genetics ; Replication Protein A/metabolism ; S Phase/genetics ; DNA Damage
    Chemical Substances Chromatin ; RNA, Long Noncoding ; Replication Protein A
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45183-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Parallel Factorization to Implement Group Analysis in Brain Networks Estimation.

    Ranieri, Andrea / Pichiorri, Floriana / Colamarino, Emma / de Seta, Valeria / Mattia, Donatella / Toppi, Jlenia

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 3

    Abstract: When dealing with complex functional brain networks, group analysis still represents an open issue. In this paper, we investigated the potential of an innovative approach based on PARAllel FActorization (PARAFAC) for the extraction of the grand average ... ...

    Abstract When dealing with complex functional brain networks, group analysis still represents an open issue. In this paper, we investigated the potential of an innovative approach based on PARAllel FActorization (PARAFAC) for the extraction of the grand average connectivity matrices from both simulated and real datasets. The PARAFAC approach was solved using three different numbers of rank-one tensors (PAR-FACT). Synthetic data were parametrized according to different levels of three parameters: network dimension (NODES), number of observations (SAMPLE-SIZE), and noise (SWAP-CON) in order to investigate the way they affect the grand average estimation. PARAFAC was then tested on a real connectivity dataset, derived from EEG data of 17 healthy subjects performing wrist extension with left and right hand separately. Findings on both synthetic and real data revealed the potential of the PARAFAC algorithm as a useful tool for grand average extraction. As expected, the best performances in terms of FPR, FNR, and AUC were achieved for great values of sample size and low noise level. A crucial role has been revealed for the PAR-FACT parameter, revealing that an increase in the number of rank-one tensors solving the PARAFAC problem leads to an increase in FPR values and, thus, to a worse grand average estimation.
    MeSH term(s) Humans ; Algorithms ; Brain ; Brain Mapping/methods
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23031693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Commentary: Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory Headache.

    De Simone, Roberto / Ranieri, Angelo

    Frontiers in neurology

    2019  Volume 10, Page(s) 39

    Language English
    Publishing date 2019-01-29
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2019.00039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Short-Term CO

    Santin, Marco / Brizzolara, Stefano / Castagna, Antonella / Ranieri, Annamaria / Tonutti, Pietro

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 15

    Abstract: ... High ... ...

    Abstract High CO
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11151973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Identification of a

    Falcone, Noemi / Ranieri, Annaluisa / Vitale, Andrea / Pastore, Lucio / Lombardo, Barbara

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Psychomotor developmental delay is a disorder with a prevalence of 12-18% in the pediatric population, characterized by the non-acquisition of motor, cognitive and communication skills during the child's development, in relation to chronological age. An ... ...

    Abstract Psychomotor developmental delay is a disorder with a prevalence of 12-18% in the pediatric population, characterized by the non-acquisition of motor, cognitive and communication skills during the child's development, in relation to chronological age. An appropriate neuropsychomotor evaluation and the use of new technologies, such as Array Comparative Genomic Hybridization (a-CGH) and Next-generation sequencing (NGS), can contribute to early diagnosis and improving the quality of life. In this case, we have analyzed a boy aged 2 years and 8 months, with a diagnosis of psychomotor developmental delay, mainly in the area of communication and language. The a-CGH analysis identified three
    MeSH term(s) Child ; Comparative Genomic Hybridization ; Developmental Disabilities/genetics ; Gene Deletion ; Humans ; Male ; Quality of Life
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reader response: Idiopathic intracranial hypertension: The veno glymphatic connections.

    De Simone, Roberto / Ranieri, Angelo

    Neurology

    2019  Volume 93, Issue 1, Page(s) 43

    MeSH term(s) Humans ; Pseudotumor Cerebri
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007736
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