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  1. Article: Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency.

    Ranke, Michael B

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 720419

    Abstract: The syndrome of impaired GH secretion (GH deficiency) in childhood and adolescence had been identified at the end of the ... ...

    Abstract The syndrome of impaired GH secretion (GH deficiency) in childhood and adolescence had been identified at the end of the 19
    MeSH term(s) Adolescent ; Body Height/drug effects ; Child ; Child Development/drug effects ; Dwarfism, Pituitary/drug therapy ; Growth Disorders/drug therapy ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Hormone Replacement Therapy ; Human Growth Hormone/deficiency ; Human Growth Hormone/pharmacology ; Human Growth Hormone/therapeutic use ; Humans ; Puberty/drug effects ; Time Factors
    Chemical Substances Human Growth Hormone (12629-01-5)
    Language English
    Publishing date 2021-09-01
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.720419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An overview of growth hormone therapy in pediatric cases documented in the Kabi International Growth Study (Pfizer International Growth Database).

    Geffner, Mitchell E / Ranke, Michael B / Wajnrajch, Michael P

    Annals of pediatric endocrinology & metabolism

    2024  Volume 29, Issue 1, Page(s) 3–11

    Abstract: The Kabi International Growth Study (KIGS) was first established in 1987 and is the largest pharmaco-epidemiological study of recombinant human growth hormone (rhGH). KIGS is aimed at evaluating long-term safety and treatment outcomes in pediatric ... ...

    Abstract The Kabi International Growth Study (KIGS) was first established in 1987 and is the largest pharmaco-epidemiological study of recombinant human growth hormone (rhGH). KIGS is aimed at evaluating long-term safety and treatment outcomes in pediatric subjects who received Genotropin rhGH therapy (Pfizer, New York, NY, USA) as prescribed by physicians in real-world clinical practice settings. KIGS data have been used to answer multiple research questions related to growth, growth prediction, and growth hormone treatment, leading to the publication of 129 peer-reviewed manuscripts and 24 biannual reports, outcomes from 10 expert meetings, and 3 books. The KIGS has shown that rhGH is safe and increases both the short-term height gain and adult height in patients with GH deficiency (GHD) and multiple other non-GHD conditions associated with short stature.
    Language English
    Publishing date 2024-02-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2346206.103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Proposal to Develop New References for Serum IGF-I Levels in Children

    Ranke, Michael B.

    Journal of clinical research in pediatric endocrinology

    2020  Volume 12, Issue 2, Page(s) 140–142

    MeSH term(s) Child ; Child, Preschool ; Female ; Growth Disorders/blood ; Growth Disorders/diagnosis ; Human Growth Hormone/deficiency ; Humans ; Insulin-Like Growth Factor I/analysis ; Male ; Reference Values
    Chemical Substances IGF1 protein, human ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2020-03-11
    Publishing country Turkey
    Document type Journal Article ; Practice Guideline
    ZDB-ID 2641608-6
    ISSN 1308-5735 ; 1308-5727
    ISSN (online) 1308-5735
    ISSN 1308-5727
    DOI 10.4274/jcrpe.galenos.2020.2020.0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Diagnostics of endocrine function in children and adolescents

    Ranke, Michael B.

    80 tables

    2011  

    Author's details ed. Martin B. Ranke
    Keywords Hormones / analysis ; Endocrine Diseases / diagnosis ; Child ; Adolescent ; Kind ; Heranwachsender ; Endokrinologische Funktionsdiagnostik
    Subject Endokrinologische Diagnostik ; Adoleszent ; Erwachsener ; Junger Erwachsener ; Heranwachsende ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size XII, 535 S. : Ill., graph. Darst.
    Edition 4., rev. and extended ed.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016763464
    ISBN 978-3-8055-9414-1 ; 9783805594158 ; 3-8055-9414-3 ; 3805594151
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Pediatric Growth Hormone Deficiency (GHD) in the Recombinant Human GH (rhGH) Era.

    Ranke, Michael B

    Pediatric endocrinology reviews : PER

    2018  Volume 16, Issue Suppl 1, Page(s) 63–69

    Abstract: During the phase of using hGH extracted from pituitaries (pit hGH) - 1958-1985 - fundamental experience related to the diagnosis and treatment was accumulated. However, since recombinant hGH (rhGH) had become available diagnosis and treatment of GHD were ...

    Abstract During the phase of using hGH extracted from pituitaries (pit hGH) - 1958-1985 - fundamental experience related to the diagnosis and treatment was accumulated. However, since recombinant hGH (rhGH) had become available diagnosis and treatment of GHD were conducted world-wide in a more standardized way. Treatment with rhGH was also accompanied by documentations in large international pharmaco-epidemiological surveys, which provided new insight. Despite of this development the treatment of children and adolescents with GHD raises still issues related to the most effective and efficacious as well as safe use of rhGH. This brief review attempts to discuss a few aspects related to these topics as they have developed during the rhGH era.
    MeSH term(s) Child ; Dwarfism, Pituitary ; Human Growth Hormone ; Humans ; Insulin-Like Growth Factor I ; Recombinant Proteins
    Chemical Substances Recombinant Proteins ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2018-10-31
    Publishing country Israel
    Document type Journal Article ; Review
    ZDB-ID 2434390-0
    ISSN 1565-4753
    ISSN 1565-4753
    DOI 10.17458/per.vol16.2018.r.ghdeficiencyrecombinant
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Hypogonadismus in der Adoleszenz

    Ranke, Michael B.

    Therapien zur Optimierung von Feminisierung, Maskulinisierung und Wachstum

    2008  

    Author's details hrsg. von Michael B. Ranke
    Keywords Jugend ; Hypogonadismus ; Hormontherapie
    Subject Hormonsubstitution ; Hormonbehandlung ; Hormonabhängige Therapie ; Hormonbeeinflussbare Therapie ; Hormonersatztherapie ; Hormonersatzbehandlung ; Jugend ; Jugendalter ; Jugendlicher ; Teenager
    Subject code 616.680610835
    Language German
    Size 143 S. : Ill., graph. Darst., 25 cm
    Publisher Verl. Wiss. Scripten
    Publishing place Auerbach
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016171195
    ISBN 978-3-937524-67-2 ; 3-937524-67-3
    Database Catalogue ZB MED Medicine, Health

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  7. Book: Growth hormone therapy in pediatrics

    Ranke, Michael B.

    20 years of KIGS ; 133 tables

    2007  

    Author's details ed. Michael B. Ranke
    Keywords Growth Disorders / drug therapy ; Growth Hormone / therapeutic use ; Databases, Factual ; Longitudinal Studies ; Infant ; Adolescent ; Child ; Kind ; Krankheit ; Somatotropin
    Subject Somatropin ; Genotropin ; CAS 12629-01-5 ; HGH ; Somatotropes Hormon ; STH ; Wachstumshormon ; Menschliches Wachstumshormon ; Growth Hormone ; GH ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size XVI, 519 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015099922
    ISBN 978-3-8055-8256-8 ; 3-8055-8256-0
    Database Catalogue ZB MED Medicine, Health

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  8. Book ; Conference proceedings: Interdisciplinary Workshop on Thyroid Function and Thyroid Hormone Therapy in the Premature Infant

    Ranke, Michael B.

    June 25 - 26, 2005, Tübingen

    (Journal of pediatric endocrinology & metabolism ; 20, Suppl. 1)

    2007  

    Event/congress Interdisciplinary Workshop on Thyroid Function and Thyroid Hormone Therapy in the Premature Infant (2005, Tübingen)
    Author's details convenors: Michael B. Ranke
    Series title Journal of pediatric endocrinology & metabolism ; 20, Suppl. 1
    The journal of pediatric endocrinology and metabolism
    Collection The journal of pediatric endocrinology and metabolism
    Language English
    Size S. 93 - 169 : Ill., graph. Darst.
    Publisher Freund
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015010482
    Database Catalogue ZB MED Medicine, Health

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  9. Book ; Conference proceedings: Methods to determine insulin sensitivity in clinical practice

    Ranke, Michael B.

    growth hormone and cognition ; 8th KIGS KIMS Expert Meeting on Growth Hormone and Growth Disorders ; Paris, France, February 4 - 5, 2005 ; 22 tables

    (Hormone research ; 64, Suppl. 3)

    2006  

    Event/congress KIGS KIMS Expert Meeting on Growth Hormone and Growth Disorders (8, 2005, Paris)
    Author's details guest ed. M. B. Ranke
    Series title Hormone research ; 64, Suppl. 3
    Collection
    Language English
    Size 115 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT015707240
    ISBN 3-8055-8063-0 ; 978-3-8055-8063-2
    Database Catalogue ZB MED Medicine, Health

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  10. Book ; Conference proceedings: Skeletal muscle as a response target

    Ranke, Michael B.

    the link between growth and metabolism

    (Hormone research ; 66, Suppl. 1)

    2006  

    Event/congress KIGS KIMS Expert Meeting on Growth Hormone and Growth Disorders (9, 2006, Stresa)
    Author's details 9th KIGS KIMS Expert Meeting on Growth Hormone and Growth Disorders, Stresa, Italy, March 2006. Guest ed. M. B. Ranke
    Series title Hormone research ; 66, Suppl. 1
    Collection
    Keywords Somatotropin ; Wachstumsstörung
    Subject Somatropin ; Genotropin ; CAS 12629-01-5 ; HGH ; Somatotropes Hormon ; STH ; Wachstumshormon ; Menschliches Wachstumshormon ; Growth Hormone ; GH
    Language English
    Size 105 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT014977770
    ISBN 3-8055-8244-7 ; 978-3-8055-8244-5
    Database Catalogue ZB MED Medicine, Health

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