LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article ; Online: Transfer Learning for Mortality Prediction in Non-Small Cell Lung Cancer with Low-Resolution Histopathology Slide Snapshots.

Clark, Matthew / Meyer, Christopher / Ramos-Cejudo, Jaime / Elbers, Danne C / Pierce-Murray, Karen / Fricks, Rafael / Alterovitz, Gil / Rao, Luigi / Brophy, Mary T / Do, Nhan V / Grossman, Robert L / Fillmore, Nathanael R

Studies in health technology and informatics

2024 Volume 310, Page(s) 735–739

Abstract: High-resolution whole slide image scans of histopathology slides have been widely used in recent years for prediction in cancer. However, in some cases, clinical informatics practitioners may only have access to low-resolution snapshots of histopathology ...

Abstract	High-resolution whole slide image scans of histopathology slides have been widely used in recent years for prediction in cancer. However, in some cases, clinical informatics practitioners may only have access to low-resolution snapshots of histopathology slides, not high-resolution scans. We evaluated strategies for training neural network prognostic models in non-small cell lung cancer (NSCLC) based on low-resolution snapshots, using data from the Veterans Affairs Precision Oncology Data Repository. We compared strategies without transfer learning, with transfer learning from general domain images, and with transfer learning from publicly available high-resolution histopathology scans. We found transfer learning from high-resolution scans achieved significantly better performance than other strategies. Our contribution provides a foundation for future development of prognostic models in NSCLC that incorporate data from low-resolution pathology slide snapshots alongside known clinical predictors.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Precision Medicine ; Medical Informatics ; Machine Learning
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI231062
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Digital pathology

Kaplan, Keith J / Rao, Luigi K. F

historical perspectives, current concepts & future applications

2016

Author's details	Keith J. Kaplan, Luigi K.F. Rao, editors
MeSH term(s)	Diagnosis, Computer-Assisted ; Image Processing, Computer-Assisted ; Telepathology
Language	English
Size	viii, 116 pages :, color illustrations ;, 25 cm
Document type	Book
ISBN	9783319203782 ; 3319203789 ; 9783319203799 ; 3319203797
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Selection and Implementation of New Information Systems.

Kaplan, Keith J / Rao, Luigi K F

Clinics in laboratory medicine

2016 Volume 36, Issue 1, Page(s) 113–131

Abstract: The single most important element to consider when evaluating clinical information systems for a practice is workflow. Workflow can be broadly defined as an orchestrated and repeatable pattern of business activity enabled by the systematic organization ... ...

Abstract	The single most important element to consider when evaluating clinical information systems for a practice is workflow. Workflow can be broadly defined as an orchestrated and repeatable pattern of business activity enabled by the systematic organization of resources into processes that transform materials, provide services, or process information.
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2015.09.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1695: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Selection and Implementation of New Information Systems.

Kaplan, Keith J / Rao, Luigi K F

Surgical pathology clinics

2015 Volume 8, Issue 2, Page(s) 239–253

Abstract	The single most important element to consider when evaluating clinical information systems for a practice is workflow. Workflow can be broadly defined as an orchestrated and repeatable pattern of business activity enabled by the systematic organization of resources into processes that transform materials, provide services, or process information.
MeSH term(s)	Clinical Laboratory Information Systems/organization & administration ; Humans ; Pathology, Surgical/organization & administration ; Workflow
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1875-9157
ISSN (online)	1875-9157
DOI	10.1016/j.path.2015.02.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Longitudinal engagement of pathology residents: a proposed approach for informatics training.

Rao, Luigi K F / Gilbertson, John R

American journal of clinical pathology

2014 Volume 142, Issue 6, Page(s) 748–754

Abstract: Objectives: The intersecting of pathology training and practice and the utilization of information technology has become an increasingly common occurrence, and the most effective means of teaching residents informatics during these invaluable years has ... ...

Abstract	Objectives: The intersecting of pathology training and practice and the utilization of information technology has become an increasingly common occurrence, and the most effective means of teaching residents informatics during these invaluable years has yet to be firmly established. Methods: In offering the idea of longitudinal engagement that stresses early and extended trainee involvement, we attempt to provide a different manner of helping address some of the leading time-limited issues surrounding education in informatics. Results: The proposed model is intended to allow building off a base of fundamentals reached through introductory didactics, exposure to and active participation in departmental and hospital-wide administrative bodies, refining of initial skills gained through frequent mentoring and coaching, and combining these cumulative knowledge and experiential underpinnings with graduated responsibility in a particular area of expertise. Conclusions: In transforming the ways in which pathology residencies teach their trainees informatics, the prospects of realizing its potential utility are heightened.
MeSH term(s)	Clinical Competence/standards ; Humans ; Internship and Residency/methods ; Medical Informatics/education
Language	English
Publishing date	2014-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/AJCPWJ61RERWEDIK
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.91: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Allergic fungal sinusitis with massive intracranial extension presenting with tearing.

Petkar, Animesh / Rao, Luigi / Elizondo, Daniel R / Cutler, Jeffrey / Taillon, Donald / Magone, M Teresa

Ophthalmic plastic and reconstructive surgery

2011 Volume 27, Issue 4, Page(s) e98–100

Abstract: A 24-year-old male presented with tearing, and subsequent workup and imaging showed a mass with fluid involving the nasopharynx, the paranasal sinuses, and the posterior dehiscence of the left frontal sinus intracranially compressing the frontal lobe ... ...

Abstract	A 24-year-old male presented with tearing, and subsequent workup and imaging showed a mass with fluid involving the nasopharynx, the paranasal sinuses, and the posterior dehiscence of the left frontal sinus intracranially compressing the frontal lobe significantly. Microscopic examination confirmed the diagnosis of allergic fungal sinusitis. Endoscopic drainage and sinostomy was performed by the otolaryngology (ear-nose-throat) service. The patient was followed 9 months postoperatively and did well with resolution of the epiphora. Although epiphora alone is an unusual presentation of allergic fungal sinusitis, ophthalmologists need to be aware of this entity, as it may invade the orbit through the sinus cavities or compress on the nasolacrimal duct before it causes other mass-related symptoms. Radiology and the characteristic histopathologic findings are the most useful in establishing the correct diagnosis.
MeSH term(s)	Central Nervous System Fungal Infections/diagnosis ; Central Nervous System Fungal Infections/microbiology ; Central Nervous System Fungal Infections/surgery ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/microbiology ; Eye Infections, Fungal/surgery ; Fungi/isolation & purification ; Humans ; Lacrimal Apparatus Diseases/diagnosis ; Lacrimal Apparatus Diseases/microbiology ; Lacrimal Apparatus Diseases/surgery ; Magnetic Resonance Imaging ; Male ; Mycoses/diagnosis ; Mycoses/microbiology ; Mycoses/surgery ; Rhinitis, Allergic, Perennial/diagnosis ; Rhinitis, Allergic, Perennial/microbiology ; Rhinitis, Allergic, Perennial/surgery ; Sinusitis/diagnosis ; Sinusitis/microbiology ; Sinusitis/surgery ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0b013e3181f29c9d
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2159: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reproducibility of endocervical curettage diagnoses.

Zahn, Christopher M / Rao, Luigi K F / Olsen, Cara / Whitworth, Scott A / Washington, Antoine / Crothers, Barbara A

Obstetrics and gynecology

2011 Volume 118, Issue 2 Pt 1, Page(s) 240–248

Abstract: Objective: To estimate overall interobserver variability of histopathology diagnoses on endocervical curettage (ECC) specimens.: Methods: Five study pathologists, blinded to the original diagnosis, reviewed archived ECC specimens initially ... ...

Abstract	Objective: To estimate overall interobserver variability of histopathology diagnoses on endocervical curettage (ECC) specimens. Methods: Five study pathologists, blinded to the original diagnosis, reviewed archived ECC specimens initially interpreted as normal, low-grade dysplasia, and high-grade dysplasia. We assessed interobserver agreement and agreement between pathologists using the κ statistic and analyzed the effect of reducing diagnostic choices to two categories (one method using "normal and dysplasia" and another method using "normal and low-grade" and "high-grade or worse"). Results: A total of 90 specimens were reviewed. The overall observer agreement was moderate (κ = 0.52). For specific diagnoses, cases interpreted as normal or high-grade dysplasia demonstrated greater agreement than those interpreted as low-grade dysplasia. Individual pathologists' comparison κ values ranged from 0.31 to 0.80. Changing diagnostic options to a two-tiered system resulted in significant improvement in κ values for only 1 of 36 pathologist comparisons. Using the gynecologist pathologist consensus interpretation, study pathologists downgraded 44% of cases originally interpreted as high-grade. Conclusion: Interobserver agreement in the interpretation of ECC specimens is at best moderate, even between those with additional experience and training in gynecologic pathology. Furthermore, reducing diagnostic options to two categories did not improve agreement. It is concerning that important clinical decisions may be made based on an ECC diagnosis that is moderately or poorly reproducible. Level of evidence: II.
MeSH term(s)	Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/pathology ; Cervix Uteri/pathology ; Curettage ; Female ; Humans ; Observer Variation ; Reproducibility of Results ; Uterine Cervical Dysplasia/diagnosis ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology
Language	English
Publishing date	2011-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0b013e318223552d
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um I Zs.230: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: (with research data) Computational pathology to discriminate benign from malignant intraductal proliferations of the breast.

Dong, Fei / Irshad, Humayun / Oh, Eun-Yeong / Lerwill, Melinda F / Brachtel, Elena F / Jones, Nicholas C / Knoblauch, Nicholas W / Montaser-Kouhsari, Laleh / Johnson, Nicole B / Rao, Luigi K F / Faulkner-Jones, Beverly / Wilbur, David C / Schnitt, Stuart J / Beck, Andrew H

PloS one

2014 Volume 9, Issue 12, Page(s) e114885

Abstract: The categorization of intraductal proliferative lesions of the breast based on routine light microscopic examination of histopathologic sections is in many cases challenging, even for experienced pathologists. The development of computational tools to ... ...

Abstract	The categorization of intraductal proliferative lesions of the breast based on routine light microscopic examination of histopathologic sections is in many cases challenging, even for experienced pathologists. The development of computational tools to aid pathologists in the characterization of these lesions would have great diagnostic and clinical value. As a first step to address this issue, we evaluated the ability of computational image analysis to accurately classify DCIS and UDH and to stratify nuclear grade within DCIS. Using 116 breast biopsies diagnosed as DCIS or UDH from the Massachusetts General Hospital (MGH), we developed a computational method to extract 392 features corresponding to the mean and standard deviation in nuclear size and shape, intensity, and texture across 8 color channels. We used L1-regularized logistic regression to build classification models to discriminate DCIS from UDH. The top-performing model contained 22 active features and achieved an AUC of 0.95 in cross-validation on the MGH data-set. We applied this model to an external validation set of 51 breast biopsies diagnosed as DCIS or UDH from the Beth Israel Deaconess Medical Center, and the model achieved an AUC of 0.86. The top-performing model contained active features from all color-spaces and from the three classes of features (morphology, intensity, and texture), suggesting the value of each for prediction. We built models to stratify grade within DCIS and obtained strong performance for stratifying low nuclear grade vs. high nuclear grade DCIS (AUC = 0.98 in cross-validation) with only moderate performance for discriminating low nuclear grade vs. intermediate nuclear grade and intermediate nuclear grade vs. high nuclear grade DCIS (AUC = 0.83 and 0.69, respectively). These data show that computational pathology models can robustly discriminate benign from malignant intraductal proliferative lesions of the breast and may aid pathologists in the diagnosis and classification of these lesions.
MeSH term(s)	Breast/pathology ; Breast Neoplasms/classification ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Computational Biology ; Female ; Humans ; Hyperplasia/pathology ; Image Processing, Computer-Assisted/methods ; Neoplasm Grading ; Prognosis ; ROC Curve
Language	English
Publishing date	2014-12-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0114885
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The ongoing evolution of the core curriculum of a clinical fellowship in pathology informatics.

Quinn, Andrew M / Klepeis, Veronica E / Mandelker, Diana L / Platt, Mia Y / Rao, Luigi K F / Riedlinger, Gregory / Baron, Jason M / Brodsky, Victor / Kim, Ji Yeon / Lane, William / Lee, Roy E / Levy, Bruce P / McClintock, David S / Beckwith, Bruce A / Kuo, Frank C / Gilbertson, John R

Journal of pathology informatics

2014 Volume 5, Issue 1, Page(s) 22

Abstract: The Partners HealthCare system's Clinical Fellowship in Pathology Informatics (Boston, MA, USA) faces ongoing challenges to the delivery of its core curriculum in the forms of: (1) New classes of fellows annually with new and varying educational needs ... ...

Abstract	The Partners HealthCare system's Clinical Fellowship in Pathology Informatics (Boston, MA, USA) faces ongoing challenges to the delivery of its core curriculum in the forms of: (1) New classes of fellows annually with new and varying educational needs and increasingly fractured, enterprise-wide commitments; (2) taxing electronic health record (EHR) and laboratory information system (LIS) implementations; and (3) increasing interest in the subspecialty at the academic medical centers (AMCs) in what is a large health care network. In response to these challenges, the fellowship has modified its existing didactic sessions and piloted both a network-wide pathology informatics lecture series and regular "learning laboratories". Didactic sessions, which had previously included more formal discussions of the four divisions of the core curriculum: Information fundamentals, information systems, workflow and process, and governance and management, now focus on group discussions concerning the fellows' ongoing projects, updates on the enterprise-wide EHR and LIS implementations, and directed questions about weekly readings. Lectures are given by the informatics faculty, guest informatics faculty, current and former fellows, and information systems members in the network, and are open to all professional members of the pathology departments at the AMCs. Learning laboratories consist of small-group exercises geared toward a variety of learning styles, and are driven by both the fellows and a member of the informatics faculty. The learning laboratories have created a forum for discussing real-time and real-world pathology informatics matters, and for incorporating awareness of and timely discussions about the latest pathology informatics literature. These changes have diversified the delivery of the fellowship's core curriculum, increased exposure of faculty, fellows and trainees to one another, and more equitably distributed teaching responsibilities among the entirety of the pathology informatics asset in the network. Though the above approach has been in place less than a year, we are presenting it now as a technical note to allow for further discussion of evolving educational opportunities in pathology informatics and clinical informatics in general, and to highlight the importance of having a flexible fellowship with active participation from its fellows.
Language	English
Publishing date	2014-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2579241-6
ISSN	2153-3539 ; 2229-5089
ISSN (online)	2153-3539
ISSN	2229-5089
DOI	10.4103/2153-3539.137717
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Pathology informatics fellowship training: Focus on molecular pathology.

Mandelker, Diana / Lee, Roy E / Platt, Mia Y / Riedlinger, Gregory / Quinn, Andrew / Rao, Luigi K F / Klepeis, Veronica E / Mahowald, Michael / Lane, William J / Beckwith, Bruce A / Baron, Jason M / McClintock, David S / Kuo, Frank C / Lebo, Matthew S / Gilbertson, John R

Journal of pathology informatics

2014 Volume 5, Issue 1, Page(s) 11

Abstract: Background: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude ... ...

Abstract	Background: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude with information fundamentals, information systems, workflow and process, and governance and management. Currently, many of those seeking training in pathology informatics additionally choose training in a second subspecialty. Combining pathology informatics training with molecular pathology is a natural extension, as molecular pathology is a subspecialty with high potential for application of modern biomedical informatics techniques. Methods and results: Pathology informatics and molecular pathology fellows and faculty evaluated the current fellowship program's core curriculum topics and subtopics for relevance to molecular pathology. By focusing on the overlap between the two disciplines, a structured curriculum consisting of didactics, operational rotations, and research projects was developed for those fellows interested in both pathology informatics and molecular pathology. Conclusions: The scope of molecular diagnostics is expanding dramatically as technology advances and our understanding of disease extends to the genetic level. Here, we highlight many of the informatics challenges facing molecular pathology today, and outline specific informatics principles necessary for the training of future molecular pathologists.
Language	English
Publishing date	2014-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2579241-6
ISSN	2153-3539 ; 2229-5089
ISSN (online)	2153-3539
ISSN	2229-5089
DOI	10.4103/2153-3539.129444
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito