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Article ; Online: Top Ten Tips Palliative Care Clinicians Should Know About Managing Immune-Mediated Endocrine Toxicities in Cancer.

Ferreira, Michelle N / Rao, Meghana / Kamal, Arif H / Shariff, Afreen

2022 Volume 25, Issue 11, Page(s) 1715–1720

Abstract: Immune checkpoint inhibitors (ICI), such as PD-1/PDL-1 and CTLA-4, have become widely used in the treatment of solid and hematological malignancies; their use and side effects are increasingly seen in the palliative care (PC) population. These drugs can ... ...

Abstract	Immune checkpoint inhibitors (ICI), such as PD-1/PDL-1 and CTLA-4, have become widely used in the treatment of solid and hematological malignancies; their use and side effects are increasingly seen in the palliative care (PC) population. These drugs can result in immune-mediated endocrinopathies; the thyroid is the most common endocrine gland affected, but the pituitary, adrenals, and pancreas may be affected as well. Symptoms may be insidious and nonspecific. A high index of suspicion and routine laboratory monitoring allows for prompt diagnosis and treatment, which can significantly improve symptoms and increase quality of life. In this study, we present an approach to monitoring and initial management of ICI-induced endocrinopathies in the PC patient population.
MeSH term(s)	Humans ; Immunotherapy/adverse effects ; Palliative Care ; Quality of Life ; Neoplasms/therapy ; Endocrine System Diseases/chemically induced ; Endocrine System Diseases/epidemiology
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2022.0204
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Article ; Online: Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit all?

Advani, Sonali D / North, Rebecca / Turner, Nicholas A / Ahmadi, Sahra / Denniss, Julia / Francis, Adero / Johnson, Rachel / Hasan, Anum / Mirza, Faryal / Pardue, Sarah / Rao, Meghana / Rosshandler, Yasmin / Tang, Helen / Schmader, Kenneth E / Anderson, Deverick J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: In a multi-hospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ... ...

Abstract	In a multi-hospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis parameters was poor in older women.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae230
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Article ; Online: Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS.

Moya, Maria V / Kim, Rachel D / Rao, Meghana N / Cotto, Bianca A / Pickett, Sarah B / Sferrazza, Caroline E / Heintz, Nathaniel / Schmidt, Eric F

Cell reports

2022 Volume 38, Issue 12, Page(s) 110556

Abstract: Many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), lead to the selective degeneration of discrete cell types in the CNS despite the ubiquitous expression of many genes linked to disease. Therapeutic advancement depends on ... ...

Abstract	Many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), lead to the selective degeneration of discrete cell types in the CNS despite the ubiquitous expression of many genes linked to disease. Therapeutic advancement depends on understanding the unique cellular adaptations that underlie pathology of vulnerable cells in the context of disease-causing mutations. Here, we employ bacTRAP molecular profiling to elucidate cell type-specific molecular responses of cortical upper motor neurons in a preclinical ALS model. Using two bacTRAP mouse lines that label distinct vulnerable or resilient projection neuron populations in motor cortex, we show that the regulation of oxidative phosphorylation (Oxphos) pathways is a common response in both cell types. However, differences in the baseline expression of genes involved in Stem and the handling of reactive oxygen species likely lead to the selective degeneration of the vulnerable cells. These results provide a framework to identify cell-type-specific processes in neurodegenerative disease.
MeSH term(s)	Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Motor Cortex/metabolism ; Motor Neurons/metabolism ; Neurodegenerative Diseases/metabolism ; Superoxide Dismutase/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.110556
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Article: Pitch count adherence and injury assessment of youth baseball in South Carolina.

Eichinger, Josef K / Goodloe, J Brett / Lin, Jackie J / Greenhouse, Alyssa / Rao, Meghana V / Friedman, Richard J / Roberts, James R

Journal of orthopaedics

2020 Volume 21, Page(s) 62–68

Abstract: Introduction: Overuse injury in youth overhead athletes remains a concern. The introduction of pitch count guidelines was designed to limit the number of pitches per game. South Carolina is considered a warm weather climate which has been proven to ... ...

Abstract	Introduction: Overuse injury in youth overhead athletes remains a concern. The introduction of pitch count guidelines was designed to limit the number of pitches per game. South Carolina is considered a warm weather climate which has been proven to expose overhead athletes to higher risk for injury. The purpose of this study was to detect baseline rates of arm pain and sequelae (injury, surgery, impact on participation) among southern youth baseball/softball players to better counsel players, parents, coaches and league administration on the prevention of arm injury. Methods: A survey was distributed to 14 pediatric practices within the South Carolina Pediatric Practice Research Network. The 2-page survey included 28 closed-ended and descriptive questions that investigated physical and psychosocial responses during and after play. Additional questions were conducted on adherence and understanding of USA Baseball guidelines and pitch counting behavior. Results: Two hundred and seventy three surveys were completed by parents of baseball/softball players. The players' average age was 11.6 years, who played on an average of 1.78 teams/leagues for 5.2 months each year. Only 26% of baseball players answered "Sometimes", "Often" or "Always" to their arm hurting. Arm fatigue, older age, parent/coach frustration with play, and months played were statistically significantly associated with arm pain. The survey revealed 58.9% of families were familiar with pitch count guidelines. Discussion: Arm pain is relatively prevalent among the South Carolina youth baseball community and worse in older players and experience fatigue. This survey found lower percentage of youth overhead athletes experiencing arm discomfort when compared to prior studies. It is important for warm weather climate athletes to abide by guidelines, as they are more susceptible to arm injury. Increased recognition, education and compliance with pitch count guidelines will help protect these youth athletes from overuse injury. Level of evidence: IV, Descriptive Epidemiology Study.
Language	English
Publishing date	2020-02-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2020.01.049
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Article: Local drug delivery systems in the management of periodontitis: A scientific review

H.R., Rajeshwari / Dhamecha, Dinesh / Jagwani, Satveer / Rao, Meghana / Jadhav, Kiran / Shaikh, Shabana / Puzhankara, Lakshmi / Jalalpure, Sunil

Journal of controlled release. 2019 Aug. 10, v. 307

2019

Abstract: Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic ... ...

Abstract	Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic agents via systemic and local means as an adjunct to mechanical therapy has revolutionized the arena of periodontal therapy. Selection of a right antimicrobial agent with appropriate route of drug administration is the key to successful periodontal therapy. Irrigating systems, fibers, gels, strips, films, microparticles, nanoparticles and low dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aims to deliver antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects on other body sites. The present review aim to summarize the current state-of-the-art technology on LDDS in periodontal therapy ensuring the the practitioners are able to choose LDD agents which are custom made for a specific clinical condition.
Keywords	adverse effects ; anti-infective agents ; drug delivery systems ; drugs ; gels ; microparticles ; nanoparticles ; periodontitis ; tissues
Language	English
Dates of publication	2019-0810
Size	p. 393-409.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2019.06.038
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Local drug delivery systems in the management of periodontitis: A scientific review.

H R, Rajeshwari / Dhamecha, Dinesh / Jagwani, Satveer / Rao, Meghana / Jadhav, Kiran / Shaikh, Shabana / Puzhankara, Lakshmi / Jalalpure, Sunil

Journal of controlled release : official journal of the Controlled Release Society

2019 Volume 307, Page(s) 393–409

Abstract	Periodontitis (PD) is a microbial disease of tooth supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery of therapeutic agents via systemic and local means as an adjunct to mechanical therapy has revolutionized the arena of periodontal therapy. Selection of a right antimicrobial agent with appropriate route of drug administration is the key to successful periodontal therapy. Irrigating systems, fibers, gels, strips, films, microparticles, nanoparticles and low dose antimicrobial agents are some of the local drug delivery systems (LDDS) available in the field, which aims to deliver antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects on other body sites. The present review aim to summarize the current state-of-the-art technology on LDDS in periodontal therapy ensuring the the practitioners are able to choose LDD agents which are custom made for a specific clinical condition.
MeSH term(s)	Animals ; Drug Delivery Systems ; Gels ; Humans ; Nanoparticles ; Periodontitis/drug therapy ; Therapeutic Irrigation
Chemical Substances	Gels
Language	English
Publishing date	2019-06-27
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2019.06.038
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Article ; Online: The Effect of Screw Design and Cortical Augmentation on Insertional Torque and Compression in Coracoid-Glenoid Fixation in a Sawbones Model.

Rabinowitz, Justin / Lin, Jackie J / Greenhouse, Alyssa / Rao, Meghana V / Provencher, Matthew / Parada, Stephen / Friedman, Richard J / Eichinger, Josef K

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2019 Volume 36, Issue 3, Page(s) 689–695

Abstract: Purpose: To compare screw insertional torque and coracoid-glenoid compression from 4 fixation techniques with different screw design parameters and cortical augmentation for the Latarjet procedure.: Methods: Simulated Latarjet procedures were ... ...

Abstract	Purpose: To compare screw insertional torque and coracoid-glenoid compression from 4 fixation techniques with different screw design parameters and cortical augmentation for the Latarjet procedure. Methods: Simulated Latarjet procedures were performed with 4 fixation techniques using laminated polyurethane blocks with dimensions similar to the coracoid-glenoid construct. The groups included DePuy Synthes Mitek 3.5-mm partially threaded screws with top hats, Arthrex 3.75-mm fully threaded screws with a 2-hole plate, Arthrex 3.75-mm fully threaded screws, and Smith & Nephew 4.0-mm partially threaded screws. Screws were inserted using a digital torque-measuring screwdriver to determine maximum insertional torque. Pressure-sensitive film was used to measure the maximum contact pressure and the effective pressure distribution (EPD) between the coracoid and glenoid; the EPD represents the percentage of the film's surface area that experienced pressure greater than 10 MPa. One-way analysis of variance and post hoc tests were used for statistical analysis. Results: Significant differences were found between the 4 fixation groups for each variable measured. The 2 cortically augmented systems produced significantly higher maximum insertional torque than the non-cortically augmented systems (P < .001 for both). The 3.75-mm screws with a 2-hole plate yielded significantly higher contact pressures than the 4.0-mm screws (P = .028). This group also had a high EPD, with a mean value more than double the values of the non-cortically augmented systems (P = .037 and P < .001). Conclusions: Cortically augmented fixation methods showed higher maximum insertional torque, maximum contact pressure, and EPD between the surfaces of the coracoid and glenoid in this Sawbones model. Clinical relevance: Various implants are available for the Latarjet procedure, but their biomechanical characteristics have not yet been fully elucidated. Graft fracture and nonunion represent 2 modes of failure that may be related to insertional torque and coracoid-glenoid compression. This study compared screw insertional torque and compression achieved using 4 fixation techniques with different screw design parameters and cortical augmentation in a Sawbones model.
MeSH term(s)	Bone Screws ; Coracoid Process/transplantation ; Humans ; Joint Instability/surgery ; Materials Testing ; Models, Anatomic ; Prosthesis Design ; Shoulder Joint/surgery ; Torque
Language	English
Publishing date	2019-12-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2019.10.011
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Article ; Online: Serotonin receptor 4 in the hippocampus modulates mood and anxiety.

Karayol, Remzi / Medrihan, Lucian / Warner-Schmidt, Jennifer L / Fait, Ben W / Rao, Meghana N / Holzner, Eva B / Greengard, Paul / Heintz, Nathaniel / Schmidt, Eric F

Molecular psychiatry

2021 Volume 26, Issue 6, Page(s) 2334–2349

Abstract: Serotonin receptor 4 (5- ... ...

Abstract	Serotonin receptor 4 (5-HT
MeSH term(s)	Animals ; Anxiety ; Dentate Gyrus/metabolism ; Hippocampus/metabolism ; Mice ; Neurons/metabolism ; Receptors, Serotonin ; Receptors, Serotonin, 5-HT4/genetics ; Receptors, Serotonin, 5-HT4/metabolism
Chemical Substances	Receptors, Serotonin ; Receptors, Serotonin, 5-HT4 (158165-40-3)
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-020-00994-y
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Article: Racial and sex disparities in utilization rates for shoulder arthroplasty in the United States disparities in shoulder arthroplasty.

Eichinger, Josef K / Greenhouse, Alyssa R / Rao, Meghana V / Gordon, Eric R / Brinton, Daniel / Li, Xinning / Curry, Emily J / Friedman, Richard J

Journal of orthopaedics

2019 Volume 16, Issue 3, Page(s) 195–200

Abstract: Purpose: To investigate racial disparities in shoulder arthroplasty (SA), accounting for demographic factors such as sex and age.: Methods: Data for SAs (2011-2014) was queried from the Healthcare Cost and Utilization Project Nationwide Inpatient ... ...

Abstract	Purpose: To investigate racial disparities in shoulder arthroplasty (SA), accounting for demographic factors such as sex and age. Methods: Data for SAs (2011-2014) was queried from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Population-adjusted SA utilization rates, racial and sex differences by age, length of stay, insurer, and comorbidities were calculated. Results: Caucasians aged 45-64 are 54% more likely than African-Americans and 74% than Hispanics to receive surgery. For patients aged 65-84, the disparity is wider for African-Americans and narrower for Hispanics. Conclusions: Policymakers and physicians should focus on further national efforts to alleviate healthcare disparities.
Language	English
Publishing date	2019-02-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2019.02.029
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Article: Knowledge management in businesses using service-oriented architecture

Rao, Meghana / Daim, Turgul U

International journal of services, economics and management Vol. 2, No. 1 , p. 59-79

a practical implementation of Topic Maps using a case study of Amazon

2010 Volume 2, Issue 1, Page(s) 59–79

Institution	Amazon.com Inc
Author's details	Meghana Rao and Turgul U. Daim
Keywords	Wissensmanagement ; Geschäftsmodell ; Internetbasierter Dienst ; Unternehmensarchitektur
Language	English
Size	graph. Darst.
Publisher	Inderscience Enterprises
Publishing place	Genève
Document type	Article
ZDB-ID	2422828X
ISSN	1753-0822
Database	ECONomics Information System

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