Article ; Online: The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration.
2024 Volume 221, Page(s) 114041
Abstract: The genus Elephantopus L. is a valuable resource rich in sesquiterpenoids with structural diversity and various bioactivities, showing great potential for applications in medicinal field and biological industry. Up to now, over 129 sesquiterpenoids have ... ...
| Abstract | The genus Elephantopus L. is a valuable resource rich in sesquiterpenoids with structural diversity and various bioactivities, showing great potential for applications in medicinal field and biological industry. Up to now, over 129 sesquiterpenoids have been isolated and identified from this plant genus, including 114 germacrane-type, 7 guaianolide-type, 5 eudesmane-type, 1 elemanolide-type, and 2 bis-sesquiterpenoids. These sesquiterpenoids were reported to show a diverse range of pharmacological properties, including cytotoxic, anti-tumor, anti-inflammatory, antimicrobial, and antiprotozoal. Consequently, some of them were identified as active scaffolds in the design and development of drugs. Considering that there is currently no overview available that covers the sesquiterpenoids and their biological activities in the Elephantopus genus, this article aims to comprehensively review the chemical structures, biosynthetic pathways, pharmacological properties, and structure-activity relationship of sesquiterpenoids found in the Elephantopus genus, which will establish a theoretical framework that can guide further research and exploration of sesquiterpenoids from Elephantopus plants as promising therapeutic agents. |
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| MeSH term(s) | Molecular Structure ; Structure-Activity Relationship ; Asteraceae/chemistry ; Plant Extracts/chemistry ; Sesquiterpenes/chemistry ; Anti-Inflammatory Agents/pharmacology |
| Chemical Substances | Plant Extracts ; Sesquiterpenes ; Anti-Inflammatory Agents |
| Language | English |
| Publishing date | 2024-03-03 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 208884-8 |
| ISSN | 1873-3700 ; 0031-9422 |
| ISSN (online) | 1873-3700 |
| ISSN | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114041 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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