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  1. Article: E-cadherin Expression in Premalignant Lesions, Premalignant Conditions, Oral Squamous Cell Carcinoma, and Normal Mucosa: An Immunohistochemical Study.

    Kalaimani, Gnanambigai / Rao, Uma Devi K / Joshua, Elizabeth / Ranganathan, Kannan

    Cureus

    2023  Volume 15, Issue 8, Page(s) e44266

    Abstract: Background Oral squamous cell carcinoma (OSCC) is a multi-step process. Epithelial-mesenchymal transition (EMT) is an important step in the progression of OSCC. One of the components that influence EMT is E-cadherin. The aim of this study was to ... ...

    Abstract Background Oral squamous cell carcinoma (OSCC) is a multi-step process. Epithelial-mesenchymal transition (EMT) is an important step in the progression of OSCC. One of the components that influence EMT is E-cadherin. The aim of this study was to determine the expression of E-cadherin in oral submucous fibrosis (OSMF), various grades of epithelial dysplasia, OSCC, and to compare it with the expression in the normal mucosa. Material and methods E-cadherin immunohistochemical detection was done using a monoclonal antibody of clone EP-6
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluating and comparing the morphological and histopathological changes induced by erbium:yttrium-aluminum-garnet laser and diamond bur on enamel, dentin and pulp tissue.

    Shamsudeen, Shaik Mohamed / Thavarajah, Rooban / Joshua, Elizabeth / Rao, Uma Devi K / Kannan, Ranganathan

    Journal of investigative and clinical dentistry

    2019  Volume 10, Issue 4, Page(s) e12475

    Abstract: Aim: Lasers are used for different types of dental treatments. Using the erbium:yttrium-aluminum-garnet (Er:YAG) laser to remove dental hard tissue is simple, advantageous and influences the type of cavity preparation, whether conventional or ... ...

    Abstract Aim: Lasers are used for different types of dental treatments. Using the erbium:yttrium-aluminum-garnet (Er:YAG) laser to remove dental hard tissue is simple, advantageous and influences the type of cavity preparation, whether conventional or conservative in nature. The aim of the present study was to evaluate and compare the morphological and histopathological changes in the enamel, dentin and pulp tissue of the teeth treated by Er:YAG laser and conventional burs.
    Methods: A conventional class I cavity was prepared in orthodontic patients by laser and bur. The teeth were extracted and analyzed for morphological changes using a scanning electron microscope, ground sections and histopathological changes under a light microscope.
    Results: The time with laser was longer than the conventional methods. The lased cavity showed irregular appearance with absence of smear layer which is suitable for the resin restoration. The ground section and the histopathological study showed no differences between the groups.
    Conclusion: The Er:YAG laser is effective in the removal of dental hard tissue without damaging the pulp when coupled with ideal energy output. It is widely used in different dental fields. It needs time to be accepted by dentist and patients and further studies are required to explore its advantages.
    MeSH term(s) Aluminum ; Dental Cavity Preparation ; Dental Enamel ; Dentin ; Diamond ; Erbium ; Humans ; Lasers, Solid-State ; Microscopy, Electron, Scanning ; Yttrium
    Chemical Substances yttrium-aluminum-garnet ; Yttrium (58784XQC3Y) ; Diamond (7782-40-3) ; Erbium (77B218D3YE) ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2019-10-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2625845-6
    ISSN 2041-1626 ; 2041-1618
    ISSN (online) 2041-1626
    ISSN 2041-1618
    DOI 10.1111/jicd.12475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6922: Show issues Location:
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  3. Article: Immunohistochemical study of p53 and proliferating cell nuclear antigen expression in odontogenic keratocyst and periapical cyst.

    Sajeevan, Thara Purath / Saraswathi, Tillai Rajasekaran / Ranganathan, Kannan / Joshua, Elizabeth / Rao, Uma Devi K

    Journal of pharmacy & bioallied sciences

    2014  Volume 6, Issue Suppl 1, Page(s) S52–7

    Abstract: Introduction: p53 protein is a product of p53 gene, which is now classified as a tumor suppressor gene. The gene is a frequent target for mutation, being seen as a common step in the pathogenesis of many human cancers. Proliferating cell nuclear antigen ...

    Abstract Introduction: p53 protein is a product of p53 gene, which is now classified as a tumor suppressor gene. The gene is a frequent target for mutation, being seen as a common step in the pathogenesis of many human cancers. Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta and plays a critical role in initiation of cell proliferation.
    Aim: The aim of this study is to assess and compare the expression of p53 and PCNA in lining epithelium of odontogenic keratocyst (OKC) and periapical cyst (PA).
    Materials and methods: A total of 20 cases comprising 10 OKC and 10 PA were included in retrospective study. Three paraffin section of 4 μm were cut, one was used for routine hematoxylin and eosin stain, while the other two were used for immunohistochemistry. Statistical analysis was performed using Chi-square test.
    Results: The level of staining and intensity were assessed in all these cases. OKC showed PCNA expression in all cases (100%), whereas in perapical cyst only 60% of cases exhibited PCNA staining. (1) OKC showed p53 expression in 6 cases (60%) whereas in PA only 10% of the cases exhibited p53 staining. Chi-square test showed PCNA staining intensity was more significant than p53 in OKC. (2) The staining intensity of PA using p53, PCNA revealed that PCNA stating intensity was more significant than p53.
    Conclusion: OKC shows significant proliferative activity than PA using PCNA and p53. PCNA staining was more intense when compared with p53 in both OKC and PA.
    Language English
    Publishing date 2014-08-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/0975-7406.137388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A study of sister chromatid exchange in patients with dental amalgam restorations.

    Priya, E Lakshmi / Ranganathan, K / Rao, Uma Devi K / Joshua, Elizabeth / Mathew, Deepu George / Wilson, Kavitha

    Indian journal of dental research : official publication of Indian Society for Dental Research

    2014  Volume 25, Issue 6, Page(s) 772–776

    Abstract: Study background: Dental amalgam is still widely used as a restorative material in developing countries due to its low cost and ease of manipulation. The health risks associated with the components of this restorative material has always been a matter ... ...

    Abstract Study background: Dental amalgam is still widely used as a restorative material in developing countries due to its low cost and ease of manipulation. The health risks associated with the components of this restorative material has always been a matter of concern. Our study was designed to address this question regarding dental amalgam.
    Objective: To study sister chromatid exchange (SCE) as an indicator of systemic genotoxicity, due to the exposure from the components of amalgam restorations during its placement and chronic use.
    Materials and methods: Systemic genotoxicity in subjects exposed to amalgam during its placement (Group II; n=5) and subjects with chronic exposure to amalgam (Group III; n=5) were compared with controls (Group I; n=5) by SCE assay in cultured peripheral blood lymphocytes.
    Result: Subjects exposed to amalgam during its placement and subjects having chronic exposure to amalgam showed an increase in the frequency of SCE, but the change was not statistically significant (P=0.84, P=0.123 respectively).
    Conclusion: Systemic genotoxicity was not observed due to the components of amalgam restorations released during its placement and chronic use. The findings of this study can be considered as preliminary information on the systemic toxicity due to the components of amalgam restorations.
    MeSH term(s) Adolescent ; Adult ; Dental Amalgam/toxicity ; Dental Restoration, Permanent/adverse effects ; Female ; Humans ; Male ; Risk Assessment ; Risk Factors ; Sister Chromatid Exchange
    Chemical Substances Dental Amalgam (8049-85-2)
    Language English
    Publishing date 2014-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 1354886-4
    ISSN 1998-3603 ; 0970-9290
    ISSN (online) 1998-3603
    ISSN 0970-9290
    DOI 10.4103/0970-9290.152203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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