LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia

    Aïssatou Bailo Diallo / Benjamin Coiffard / Raoul Desbriere / Maria Katsogiannou / Xavier Donato / Florence Bretelle / Soraya Mezouar / Jean-Louis Mege

    International Journal of Molecular Sciences, Vol 24, Iss 2363, p

    2023  Volume 2363

    Abstract: Circadian rhythms have been described in numerous tissues of living organisms and are necessary for homeostasis. The understanding of their role in normal and pathological pregnancy is only just emerging. It has been established that clock genes are ... ...

    Abstract Circadian rhythms have been described in numerous tissues of living organisms and are necessary for homeostasis. The understanding of their role in normal and pathological pregnancy is only just emerging. It has been established that clock genes are expressed in the placenta of animals and humans, but the rhythmicity of placenta immune cells is not known. Macrophages from healthy placenta of women at term were isolated and the expression of clock genes BMAL1, CLOCK, PER2, CRY2, and NR1D1 was assessed by qRT-PCR every 4 h over 24 h. Raw data were treated with cosinor analysis to evaluate the significance of the oscillations. Placental macrophages exhibited significant circadian expression of clock genes but one third of placental macrophages lost clock gene rhythmicity; the clock gene oscillations were restored by co-culture with trophoblasts. We wondered if melatonin, a key hormone regulating circadian rhythm, was involved in the oscillations of placental cells. We showed that macrophages and trophoblasts produced melatonin and expressed MT2 receptor. In women who developed preeclampsia during pregnancy, circadian oscillations of placental macrophages were lost and could not be rescued by coculture with trophoblasts from healthy women. Moreover, production and oscillations of melatonin were altered in preeclamptic macrophages. For the first time to our knowledge, this study shows circadian rhythms and melatonin production by placental macrophages. It also shows that preeclampsia is associated with a disruption of the circadian rhythm of placental cells. These results represent a new scientific breakthrough that may contribute to the prevention and treatment of obstetrical pathologies.
    Keywords circadian rhythm ; placental cells ; macrophages ; trophoblasts ; melatonin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Oxytocin versus prostaglandins for labour Induction of women with an unfavourable cervix after 24 hours of cervical ripening (OPIC)

    Norbert Winer / Franck Perrotin / Solène Brunet-Houdard / Loïc Sentilhes / Denis Gallot / Thiphaine Barjat / Caroline Diguisto / Amélie Le Gouge / Guillaume Legendre / Raoul Desbriere / Marion De Berti / Fanny Monmousseau / Aude Girault / Jordan Pozzi / Bertrand Gachon

    BMJ Open, Vol 13, Iss

    protocol for an open multicentre randomised non-inferiority trial

    2023  Volume 4

    Abstract: Introduction It remains uncertain whether the most appropriate management for women with an unfavourable cervix after 24 hours of cervical ripening is repeating the ripening procedure or proceeding directly to induction by oxytocin. No adequately powered ...

    Abstract Introduction It remains uncertain whether the most appropriate management for women with an unfavourable cervix after 24 hours of cervical ripening is repeating the ripening procedure or proceeding directly to induction by oxytocin. No adequately powered trial has compared these strategies. We hypothesise that induction of labour with oxytocin among women who have just undergone an ineffective first ripening procedure is not associated with a higher risk of caesarean delivery than a repeated cervical ripening with prostaglandins.Methods and analysis We will conduct a multicentre, non-inferiority, open-label, randomised controlled trial aimed at comparing labour induction by oxytocin with a second cervical ripening that uses prostaglandins (slow-release vaginal dinoprostone; oral misoprostol 25 µg; dinoprostone vaginal gel 2 mg). Women (n=1494) randomised in a 1:1 ratio in 10 French maternity units must be ≥18 years with a singleton fetus in vertex presentation, at a term from ≥37+0 weeks of gestation, and have just completed a 24-hour cervical ripening procedure by any method (pharmacological or mechanical) with a Bishop score ≤6. Exclusion criteria comprise being in labour, having more than 3 contractions per 10 min, or a prior caesarean delivery or a history of uterine surgery, or a fetus with antenatally suspected severe congenital abnormalities or a non-reassuring fetal heart rate. The primary endpoint will be the caesarean delivery rate, regardless of indication. Secondary outcomes concern delivery, perinatal morbidity, maternal satisfaction and health economic evaluations. The nature of the assessed procedures prevents masking the study investigators and patients to group assignment.Ethics and dissemination All participants will provide written informed consent. The ethics committee ‘Comité de Protection des Personnes Ile de France VII’ approved this study on 2 April 2021 (No 2021-000989-15). Study findings will be submitted for publication and presented at relevant conferences.Trial registration number ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Grandmaternal cells in cord blood

    Karlin R. Karlmark / Marina El Haddad / Xavier-Côme Donato / Gabriel V. Martin / Florence Bretelle / Nathalie Lesavre / Jean-François Cocallemen / Marielle Martin / Christophe Picard / Tiffany Albentosa / Jean Roudier / Raoul Desbriere / Nathalie C. Lambert

    EBioMedicine, Vol 74, Iss , Pp 103721- (2021)

    2021  

    Abstract: Abstracts: Background: During pregnancy a feto-maternal exchange of cells through the placenta conducts to maternal microchimerism (Mc) in the child and fetal Mc in the mother. Because of this bidirectional traffic of cells, pregnant women have also ... ...

    Abstract Abstracts: Background: During pregnancy a feto-maternal exchange of cells through the placenta conducts to maternal microchimerism (Mc) in the child and fetal Mc in the mother. Because of this bidirectional traffic of cells, pregnant women have also acquired maternal cells in utero from their mother and could transfer grandmaternal (GdM) cells to their child through the maternal bloodstream during pregnancy. Thus, cord blood (CB) samples could theoretically carry GdMMc. Nevertheless this has never been demonstrated. Methods: Using Human Leukocyte Antigen (HLA)-specific quantitative PCR assays on three-generation families, we were able to test 28 CB samples from healthy primigravid women for GdMMc in whole blood (WB) and isolated cells (PBMC, T, B, granulocytes, stem cells). Findings: Five CB samples (18%) had GdMMc which could not be confounded with maternal source, with quantities 100 fold lower than maternal Mc in WB and PBMC. Risk of aneuploidies and/or related invasive prenatal procedures significantly correlated with the presence of GdMMc in CB (p=0.024). Significantly decreased HLA compatibility was observed in three-generation families from CB samples carrying GdMMc (p=0.019). Interpretation: Transgenerational transfer of cells could have implications in immunology and evolution. Further analyses will be necessary to evaluate whether GdMMc in CB is a passive or immunologically active transfer and whether invasive prenatal procedures could trigger GdMMc. Funding: Provence-Alpes-Côte d'Azur APEX grant # 2012_06549E, 2012_11786F and 2014_03978) and the Foundation for Medical Research (FRM Grant #ING20140129045).
    Keywords Cord blood ; grandmaternal microchimerism ; HLA compatibility ; three generations ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Are men ready to use thermal male contraception? Acceptability in two French populations

    Marie Amouroux / Roger Mieusset / Raoul Desbriere / Pierre Opinel / Gilles Karsenty / Marine Paci / Sara Fernandes / Blandine Courbiere / Jeanne Perrin

    PLoS ONE, Vol 13, Iss 5, p e

    New fathers and new providers.

    2018  Volume 0195824

    Abstract: Since the 1970s, international research has actively pursued hormonal male contraception (HMC) and, to a lesser extent, thermal male contraception (TMC). Although the efficacy of TMC has been confirmed in limited populations, its acceptability has not ... ...

    Abstract Since the 1970s, international research has actively pursued hormonal male contraception (HMC) and, to a lesser extent, thermal male contraception (TMC). Although the efficacy of TMC has been confirmed in limited populations, its acceptability has not been studied in either potential users or potential prescribers.A cross-sectional descriptive multicentre study of potential male users of TMC (new fathers) and potential prescribers of TMC (new providers) was conducted between November 2016 and February 2017.The participants completed a 3-part survey, and their responses were evaluated to i) determine their socio-demographic profiles; ii) identify personal experiences with contraception; and iii) gauge the participants' knowledge, interest and preference for male contraception, particularly TMC. For new providers only, the survey included a fourth part to evaluate professional experience with male contraception.The participation rate was 51% for new fathers (305 NFs) and 34% for new providers (300 NPs, including 97 men (male new providers, MNPs) and 203 women (female new providers, FNPs)). Only 3% of NFs and 15% of NPs knew about TMC (including 26% of the MNPs and 10% of the FNPs, p<0.01). After reading information on TMC, new fathers were significantly less willing to try TMC (29%) than were new providers (40%) (p<0.01). The 3 main advantages of TMC for the new fathers included the following factors: "natural" (52%), "without side effects" (38%) and "non-hormonal" (36%). The main disadvantages were "lengthy wear time" (56%), "daily undergarment wear" (43%) and "concern about possible discomfort" (39%).Young male and female providers have limited knowledge of male contraception, are interested in further information and would generally prescribe TMC to their patients. Successful expansion of the use of male contraception, including TMC, would require distribution of better information to potential users and providers.
    Keywords Medicine ; R ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system

    Caroline Diguisto / Amélie Le Gouge / Chloé Arthuis / Norbert Winer / Olivier Parant / Christophe Poncelet / Celine Chauleur / Jacob Hannigsberg / Guillaume Ducarme / Denis Gallot / Rene Gabriel / Raoul Desbriere / Gael Beucher / Cyrille Faraguet / Helene Isly / Patrick Rozenberg / Bruno Giraudeau / Franck Perrotin / Groupe de Recherche en Obstétrique et Gynécologie (GROG)

    PLoS Medicine, Vol 18, Iss 2, p e

    The MAGPOP randomised controlled trial.

    2021  Volume 1003448

    Abstract: Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method ... ...

    Abstract Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, ≥41+0 and ≤42+0 weeks' gestation, a Bishop score <6, intact membranes, and no history of cesarean delivery for whom induction of labour was decided were randomised to either mechanical cervical ripening with a Cook Cervical Ripening Balloon or pharmacological cervical ripening by a Propess vaginal pessary serving as a prostaglandin E2 slow-release system. The primary outcome was the rate of cesarean for nonreassuring fetal status, with an independent endpoint adjudication committee determining whether the fetal heart rate was nonreassuring. Secondary outcomes included delivery (time from cervical ripening to delivery, number of patients requiring analgesics), maternal and neonatal outcomes. Between January 2017 and December 2018, 1,220 women were randomised in a 1:1 ratio, 610 allocated to a silicone double balloon catheter, and 610 to the Propess vaginal pessary for the slow release of dinoprostone. The mean age of women was 31 years old, and 80% of them were of white ethnicity. The cesarean rates for nonreassuring fetal status were 5.8% (35/607) in the mechanical ripening group and 5.3% (32/609) in the pharmacological ripening group ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Leptotrichia amnionii and the Female Reproductive Tract

    Vijay A.K.B. Gundi / Raoul Desbriere / Bernard La Scola

    Emerging Infectious Diseases, Vol 10, Iss 11, Pp 2056-

    2004  Volume 2057

    Keywords letter ; reproductive tract ; leptotrichia ; 16S rRNA gene sequence ; France ; Comoros ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2004-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Women and health professionals’ perspectives on a conditional cash transfer programme to improve pregnancy follow-up

    Celine Chauleur / Jacob Hannigsberg / Philippe Merviel / Marc Bardou / Franck Perrotin / Thomas Schmitz / Olivier Picone / Jeanne Sibiude / Karine Chemin / Dominique Dallay / Frédéric Coatleven / Loïc Sentilhes / Céline Brochot / Astrid Eckman-Lacroix / Elise Thellier / Frédérique Falchier / Philippe Deruelle / Muriel Doret / Xavier Carcopino-Tusoli /
    Nicolas Meunier-Beillard / Hervé Fernandez / Vincent Villefranque / Caroline Diguisto / Damien Subtil / Clémence Houssin / Philippe Gillard / Laurent Mandelbrot / Aurelie Godard-Marceau / Nathalie Lesavre / Claude Virtos / Elodie Debras / Aude Bourtembourg / Claire Toubin / Danièle Addes / Véronique Uguen / Cleo Tourbot / Caroline Lelievre / Christophe Tremouilhac / Anne-Hélène Saliou / Aurelie Derrieu / Stephanie Auget / Anne Legourrierec / Anne Leroux / Julie Fort-Jacquier / Marion Serclerat / Nathalie Laurenceau / Audrey Renouleau / Eliane Catteau / Julie Blanc / Candice Ronin / Laurence Piechon / Séverine Puppo / Fanny Greco / Sandrine Pettazzoni / Muriel Athlani / Amina Desvignes / Annie Petiteau / Amina El Yaakoubi / Valérie Bechadergue / Valérie Vaugirard / Marie-Emmanuelle Neveu / Caroline Geyl / Marie-Victoire Senat / Claire Colmant / Marie Houllier / Myriam Virlouet / Marion Mir / Yasmina Bejaoui / Hélène Le Cornu / Lauriane Nikel / Elodie Gustave / Amandine Stadler / Ahmad Mehdi / Tiphaine Barjat / Suzanne Lima / Thomas Corsini / Anne Genod / Charlotte Vermesch / Cécile Fanget / Marianne Perrot / Manuela Munoz / Sylvie Pitaval / Fanny Magand / Françoise Baldi / Stephanie Bret / Anne-Lise Verdier / Christelle Denis / Carine Arlicot / Jérôme Potin / Stéphanie Chretien / Julie Paternotte / Nathalie Trignol / Élisabeth Blin / Camille Mathieu / Anne Dubreuil / Anne Viallon Pelletier / Catherine Guerin / Chloé Arthuis / Christophe Vayssieres / Olivier Parant / Marion Groussolles / Maria Denis / M Mathieu Morin / Marie-Thérèse Bavoux / Juliette Pelloux / Anne-Claire Jambon / Madeleine Santraine / Veronique Lebuffe / Pascale Broux / Thierry Dzukou / Magloire Gnansounou / Didier Hubert / Claire Djazet / Ludivine Destoop / Marine Derue / Pierrick Theret / Dominique Delzenne / Stéphanie Daussin / Alice Fraissinet / Mélanie Vannerum / Cyril Faraguet / Laurence Landais / Mariana Radu / Anne Rouget / Sena Al Sudani / Bernard Guillon / Estelle Wucher / Véronique Selva / Sandrine Reviron / Francis Schwetterlé / Cécile Chassande / Véronique Grandin / Eliane Krtoliza / Patrick Becher / Marie Sarrau / Claire Lecoq / Elsa Lutringer / Denis Roux / Noémie Berge / Clémentine Barbier / Anne Heron / Audrey Farina-Bracquart / Marie-Paule Curtet / Evelyne Lefebure / Marie-Hélène Le Douarin / Hassan Al Rayes / Émilie Magne / Nathalie Destampes / Émilie Ricard / Pascale Ghezzi / Catherine Guillen / Fanny Alazard / Marie-Thé Campanaro / Florence Mojard / Magalie David-Reynard / Patricia Fuma / Remy De Montgolfier / Capucine Neel / Guillaume Legendre / Isabelle Andre / Sylvie Nordstrom / Brigitte Guionnet / Catherine Crenn Hebert / Chloé Dussaux / Karine Achaintre / Anne Wagner / Martine Werveake / Eloïse De Gouville / George Theresin / Marie Pierre Couetoux / Lydia Caillaud / Marie-Pierre Fernandez / Sabrina Bottet / M Alain Almodovar / Elisa Etienne / Véronique Guiteras / Angélique Torres / N. Roche / Myriam Nassef / Christine Abel-Faure / Marie Louvet / Carole Ettori / Guillaume Ducarme / Valérie Bonnenfant-Mezeray / Laurence Szezot-Renaudeau / Marie-Pierre Berte / Elodie Netier-Herault / Stéphanie Manson-Gallone / Franck Mauviel / Nathalie Agostini / Marine Mazeaud / Jean-Claude Dausset / Isabelle De Murcia / Emilie Alliot / Anne-Marie Bes / Magali Biferi Magali / Hélène Heckenroth / Sophie Morange / Gersende Chiuot / Audrey Gnisci / Annie Allegre / Laetitia Lecq / Eva Balenbois / Claire Tourette / Aude Figarella / Dio Andriamanjay / Pauline Vignoles / Catherine Cazelles / Véronique Lejeune Saada / Benafsheh Kashani / Isabelle Chevalier / Muriel Terrieres / Audrey Cointement / Valérie Benhaïm / Najat Lindoune / Anne-Sophie Maisonneuve / M Frédéric Daubercy / Guilia Mencattini / Vanessa Combaud / Isabelle Moya / Xavier-Côme Donato / Raoul Desbriere / Marie Lafon / Véronique Baudet

    BMJ Open, Vol 13, Iss

    a qualitative analysis of the NAITRE randomised controlled study

    2023  Volume 3

    Abstract: Objectives Women of low socioeconomic status have been described as having suboptimal prenatal care, which in turn has been associated with poor pregnancy outcomes. Many types of conditional cash transfer (CCT) programmes have been developed, including ... ...

    Abstract Objectives Women of low socioeconomic status have been described as having suboptimal prenatal care, which in turn has been associated with poor pregnancy outcomes. Many types of conditional cash transfer (CCT) programmes have been developed, including programmes to improve prenatal care or smoking cessation during pregnancy, and their effects demonstrated. However, ethical critiques have included paternalism and lack of informed choice. Our objective was to determine if women and healthcare professionals (HPs) shared these concerns.Design Prospective qualitative research.Setting We included economically disadvantaged women, as defined by health insurance data, who participated in the French NAITRE randomised trial assessing a CCT programme during prenatal follow-up to improve pregnancy outcomes. The HP worked in some maternities participating in this trial.Participants 26 women, 14 who received CCT and 12 who did not, mostly unemployed (20/26), and - 7 HPs.Interventions We conducted a multicentre cross-sectional qualitative study among women and HPs who participated in the NAITRE Study to assess their views on CCT. The women were interviewed after childbirth.Results Women did not perceive CCT negatively. They did not mention feeling stigmatised. They described CCT as a significant source of aid for women with limited financial resources. HP described the CCT in less positive terms, for example, expressing concern about discussing cash transfer at their first medical consultation with women. Though they emphasised ethical concerns about the basis of the trial, they recognised the importance of evaluating CCT.Conclusions In France, a high-income country where prenatal follow-up is free, HPs were concerned that the CCT programme would change their relationship with patients and wondered if it was the best use of funding. However, women who received a cash incentive said they did not feel stigmatised and indicated that these payments helped them prepare for their baby’s birth.Trial registration number NCT02402855
    Keywords Medicine ; R
    Subject code 300
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top