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Book ; Online ; E-Book: Congo Basin hydrology, climate, and biogeochemistry

Tshimanga, Raphael M. / Moukandi, Guy / Alsdorf, Douglas

a foundation for the future

(Geophysical Monograph Series)

2022

Abstract: The Congo River Basin is the world's second largest in terms of river discharge and drainage area. The largest is the better known Amazon River Basin. Because the Congo is much less studied compared to the Amazon, there are unanswered questions ... ...

Author's details	Raphael M. Tshimanga, Guy D. Moukandi N'kaya and Douglas Alsdorf, editors
Series title	Geophysical Monograph Series
Abstract	"The Congo River Basin is the world's second largest in terms of river discharge and drainage area. The largest is the better known Amazon River Basin. Because the Congo is much less studied compared to the Amazon, there are unanswered questions regarding the Congo's precipitation, hydrology, hydraulics, and carbon ecology. For example, based on a few remotely sensed altimeter measurements, it appears that the wetland water levels of the Cuvette Centrale are higher in elevation than the immediately adjacent Congo mainstem. The wetland does not appear to have large channels. Both of these observations are rather unlike what we find in the more familiar Amazon and its floodplain. Therefore, the question is open regarding how water exchanges between the world's second largest river and one of the world's largest wetlands. In turn, this question regarding hydrodynamics factors in to how carbon is exchanged and the role of precipitation in the wetland water balance. Questions like this are also evident for understanding how precipitation is driven by atmospheric jets, how much carbon is evading from the waters, and so on. These are first-order questions that require a collection of measurements and models to thoroughly understand and know the answers"--
Keywords	Hydrology
Subject code	551.48
Language	English
Size	1 online resource (594 pages)
Publisher	John Wiley & Sons, Inc
Publishing place	Hoboken, New Jersey
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-119-65699-0 ; 1-119-65700-8 ; 1-119-65698-2 ; 978-1-119-65699-9 ; 978-1-119-65700-2 ; 978-1-119-65698-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Biomedical applications of hydrogels handbook

Park, Kinam / Okano, Teruo / Ottenbrite, Raphael M.

2010

Author's details	ed.-in chief Raphael M. Ottenbrite. Ed. Kinam Park ; Teruo Okano
Language	English
Size	XIX, 432 S. : Ill., graph. Darst., 26 cm
Publisher	Springer
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT016567070
ISBN	978-1-4419-5918-8 ; 1-4419-5918-1 ; 9781441959195 ; 144195919X
Database	Catalogue ZB MED Medicine, Health

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2010 A 5440	order for loan	Magazin

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Article ; Online: Understanding Factors Influencing Decision Making by State Health Officials in a Public Health Emergency.

Barishansky, Raphael M / Fraser, Michael R

Journal of public health management and practice : JPHMP

2023 Volume 29, Issue 6, Page(s) 835–837

Abstract: State and territorial health officials (STHOs) play a critical role in leading public health emergency response in their respective states. Through an exploratory qualitative study with 21 current or former STHOs, we sought to understand the issues that ... ...

Abstract	State and territorial health officials (STHOs) play a critical role in leading public health emergency response in their respective states. Through an exploratory qualitative study with 21 current or former STHOs, we sought to understand the issues that impact STHO decision making in public health responses. Initial findings suggest the need for structured decision making tools for use by leaders responding to public health emergencies, including COVID-19. Such tools could lead to more systematic responses by STHOs during public health crises.
MeSH term(s)	Humans ; Public Health ; COVID-19/epidemiology ; Qualitative Research ; Decision Making ; Emergencies
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2027860-3
ISSN	1550-5022 ; 1078-4659
ISSN (online)	1550-5022
ISSN	1078-4659
DOI	10.1097/PHH.0000000000001761
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Article ; Online: Exploring intersections and integration of sexual reproductive health and mental health among adolescents and young adults: Areas of collaboration and lessons learned.

Abacan, Allyssa / Raphael, Meghna

Bulletin of the Menninger Clinic

2023 Volume 87, Issue 2, Page(s) 105–114

Abstract: This special issue of ... ...

Abstract	This special issue of the
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Mental Health ; Reproductive Health ; Sexual Behavior ; Reproduction ; Sex Education
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	390416-7
ISSN	1943-2828 ; 0025-9284
ISSN (online)	1943-2828
ISSN	0025-9284
DOI	10.1521/bumc.2023.87.2.105
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Article ; Online: Longitudinal Cognitive Decline in Alzheimer Disease Prevention Trials: A Test of Time

Castilhos, Raphael M / Snitz, Beth E

Neurology

2023 Volume 102, Issue 2, Page(s) e208067

Abstract: The landscape of clinical trials for Alzheimer disease (AD) has undergone significant evolution in the past decade, most notably by the inclusion of individuals at progressively earlier stages of the disease. Recent approvals by the Food and Drug ... ...

Abstract	The landscape of clinical trials for Alzheimer disease (AD) has undergone significant evolution in the past decade, most notably by the inclusion of individuals at progressively earlier stages of the disease. Recent approvals by the Food and Drug Administration have predominantly centered around individuals with prodromal and mild AD,
MeSH term(s)	United States ; Humans ; Alzheimer Disease/prevention & control ; Cognitive Dysfunction/prevention & control ; Neuropsychological Tests ; Research Design ; Signal Transduction
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Editorial
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000208067
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Article ; Online: Hs27 fibroblast response to contact guidance cues.

Kim, C / Robitaille, M / Christodoulides, J / Ng, Y / Raphael, M / Kang, W

Scientific reports

2023 Volume 13, Issue 1, Page(s) 21691

Abstract: Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge ... ...

Abstract	Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge and groove widths and groove depth ([Formula: see text], respectively). However, experimental studies that independently quantify the effect of the individual dimensions as well as their coupling on cellular function are still limited. In this work, we perform extensive parametric studies in the dimensional space-well beyond the previously studied range in the literature-to explore topographical effects on morphology and migration of Hs27 fibroblasts via static and dynamic analyses of live cell images. Our static analysis reveals that the [Formula: see text] is most significant, followed by the [Formula: see text]. The fibroblasts appear to be more elongated and aligned in the groove direction as the [Formula: see text] increases, but their trend changes after 725 nm. Interestingly, the cell shape and alignment show a very strong correlation regardless of [Formula: see text]. Our dynamic analysis confirms that directional cell migration is also strongly influenced by the [Formula: see text], while the effect of the [Formula: see text] and [Formula: see text] is statistically insignificant. Directional cell migration, as observed in the static cell behavior, shows the statistically significant transition when the [Formula: see text] is 725 nm, showing the intimate links between cell morphology and migration. We propose possible scenarios to offer mechanistic explanations of the observed cell behavior.
MeSH term(s)	Cues ; Fibroblasts ; Cell Membrane
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48913-9
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Article ; Online: Kinetics and mechanical work done to move the body centre of mass along a curve.

Mesquita, Raphael M / Willems, Patrick A / Dewolf, Arthur H / Catavitello, Giovanna

PloS one

2024 Volume 19, Issue 2, Page(s) e0298790

Abstract: When running on a curve, the lower limbs interact with the ground to redirect the trajectory of the centre of mass of the body (CoM). The goal of this paper is to understand how the trajectory of the CoM and the work done to maintain its movements ... ...

Abstract	When running on a curve, the lower limbs interact with the ground to redirect the trajectory of the centre of mass of the body (CoM). The goal of this paper is to understand how the trajectory of the CoM and the work done to maintain its movements relative to the surroundings (Wcom) are modified as a function of running speed and radius of curvature. Eleven participants ran at different speeds on a straight line and on circular curves with a 6 m and 18 m curvature. The trajectory of the CoM and Wcom were calculated using force-platforms measuring the ground reaction forces and infrared cameras recording the movements of the pelvis. To follow a circular path, runners overcompensate the rotation of their trajectory during contact phases. The deviation from the circular path increases when the radius of curvature decreases and speed increases. Interestingly, an asymmetry between the inner and outer lower limbs emerges as speed increases. The method to evaluate Wcom on a straight-line was adapted using a referential that rotates at heel strike and remains fixed during the whole step cycle. In an 18 m radius curve and at low speeds on a 6 m radius, Wcom changes little compared to a straight-line run. Whereas at 6 m s-1 on a 6 m radius, Wcom increases by ~25%, due to an augmentation in the work to move the CoM laterally. Understanding these adaptations provides valuable insight for sports sciences, aiding in optimizing training and performance in sports with multidirectional movements.
MeSH term(s)	Humans ; Biomechanical Phenomena ; Running ; Heel ; Kinetics ; Gravitation ; Gait
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298790
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Article ; Online: Colorectal cancer disparities in Latin America: Mortality trends 1990-2019 and a paradox association with human development.

Muzi, Camila D / Banegas, Matthew P / Guimarães, Raphael M

PloS one

2023 Volume 18, Issue 8, Page(s) e0289675

Abstract: Background: Colorectal cancer mortality is growing in Latin America. It is known for a marked income disparity between its countries, and there is a consistent association with development. Our purpose was to describe trends in colorectal cancer ... ...

Abstract	Background: Colorectal cancer mortality is growing in Latin America. It is known for a marked income disparity between its countries, and there is a consistent association with development. Our purpose was to describe trends in colorectal cancer mortality in Latin America between 1990 and 2019, identifying differences by human development categories. Methods: We extracted age-adjusted mortality rate from the Global Burden of Disease (GBD) Study from 22 Latin American countries, subregions, and country groups previously ranked by the GBD study due to Sociodemographic Index (SDI) between 1990 and 2019. We applied the segmented regression model to analyze the time trend. Also, we estimated the correlation between mortality rates and Human Development Index (HDI) categories for countries. Results: Between 1990 and 2019, colorectal cancer adjusted mortality rate increased by 20.56% in Latin America (95% CI 19.75% - 21.25%). Between 1990 and 2004, the average annual percentage change (APC) was 0.11% per year (95% CI 0.10-0.12), and between 2004 and 2019 there was a deceleration (APC = 0.04% per year, 95% CI 0.03%- 0.05%). There is great heterogeneity among the countries of the region. Correlation between these two variables was 0.52 for 1990 and 2019. When separated into HDI groups, the correlation varied in the direction of the association and its magnitude, typifying an effect modification known as Simpson's Paradox. Conclusions: Human development factors may be important for assessing variation in cancer mortality on a global scale. Studies that assess the social and -economic contexts of countries are necessary for robust evaluation and provision of preventive, diagnostic and curative services to reduce cancer mortality in Latin America.
MeSH term(s)	Humans ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/mortality ; Global Burden of Disease/ethnology ; Hispanic or Latino/statistics & numerical data ; Income/statistics & numerical data ; Latin America/epidemiology ; Socioeconomic Factors ; Mortality/trends ; Health Status Disparities
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289675
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship between mental health diagnoses and sexually transmitted infections.

Bretz, Lauren A / Keshwani, Najiba / Raphael, Meghna

Bulletin of the Menninger Clinic

2023 Volume 87, Issue 2, Page(s) 115–134

Abstract: Multiple studies have demonstrated a relationship between risk factors for sexually transmitted infections (STIs) and mental health needs. This "syndemic" phenomenon suggests that while many patients with mental health conditions are at higher risk for ... ...

Abstract	Multiple studies have demonstrated a relationship between risk factors for sexually transmitted infections (STIs) and mental health needs. This "syndemic" phenomenon suggests that while many patients with mental health conditions are at higher risk for STI acquisition, the relationship also works in the opposite direction: Patients diagnosed with STIs are more likely to have mental health issues. The purposes of this review article are to examine the overlap between mental health and STIs, to provide mental health providers the tools to identify individuals with behavioral health concerns who may be at increased risk for STI acquisition, to discuss how STI diagnosis can affect mental health, and to review interventions to mitigate these risks, such as cognitive-behavioral therapy and motivational interviewing-based behavioral interventions. Integrating primary health care and mental health care for sexual health needs may also help improve delivery of both of these services.
MeSH term(s)	Humans ; Mental Health ; Sexually Transmitted Diseases/diagnosis ; Sexual Behavior ; Sexual Health ; Risk Factors
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	390416-7
ISSN	1943-2828 ; 0025-9284
ISSN (online)	1943-2828
ISSN	0025-9284
DOI	10.1521/bumc.2023.87.2.115
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Article ; Online: Evaluation of the Topology Space of DNA-Encoded Libraries.

Weigel, William K / Montoya, Alba L / Franzini, Raphael M

Journal of chemical information and modeling

2023 Volume 63, Issue 15, Page(s) 4641–4653

Abstract: DNA-encoded libraries (DELs) are widely used in the discovery of drug candidates, and understanding their design principles is critical for accessing better libraries. Most DELs are combinatorial in nature and are synthesized by assembling sets of ... ...

Abstract	DNA-encoded libraries (DELs) are widely used in the discovery of drug candidates, and understanding their design principles is critical for accessing better libraries. Most DELs are combinatorial in nature and are synthesized by assembling sets of building blocks in specific topologies. In this study, different aspects of library topology were explored and their effect on DEL properties and chemical diversity was analyzed. We introduce a descriptor for DEL topological assignment (DELTA) and use it to examine the landscape of possible DEL topologies and their coverage in the literature. A generative topographic mapping analysis revealed that the impact of library topology on chemical space coverage is secondary to building block selection. Furthermore, it became apparent that the descriptor used to analyze chemical space dictates how structures cluster, with the effects of topology being apparent when using three-dimensional descriptors but not with common two-dimensional descriptors. This outcome points to potential challenges of attempts to predict DEL productivity based on chemical space analyses alone. While topology is rather inconsequential for defining the chemical space of encoded compounds, it greatly affects possible interactions with target proteins as illustrated in docking studies using NAD/NADP binding proteins as model receptors.
MeSH term(s)	Drug Discovery/methods ; DNA/chemistry ; Gene Library
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.3c01008
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