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Article ; Online: Pioneering fully robotic donor hepatectomy and robotic recipient liver graft implantation - a new horizon in liver transplantation.

Broering, Dieter C / Raptis, Dimitri A / Elsheikh, Yasser

International journal of surgery (London, England)

2024 Volume 110, Issue 3, Page(s) 1333–1336

MeSH term(s)	Humans ; Liver Transplantation ; Hepatectomy ; Robotic Surgical Procedures ; Liver/surgery ; Tissue and Organ Harvesting ; Living Donors
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001031
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Article ; Online: Reply.

Oberkofler, Christian E / Raptis, Dimitri A / Petrowsky, Henrik

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2023 Volume 29, Issue 4, Page(s) E5

Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1097/LVT.0000000000000094
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Article: Navigating the Labyrinth: Intensive Care Challenges for Patients with Acute-on-Chronic Liver Failure.

Saner, Fuat H / Raptis, Dimitri A / Alghamdi, Saad A / Malagó, Massimo M / Broering, Dieter C / Bezinover, Dmitri

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short- ... ...

Abstract	Acute-on-chronic liver failure (ACLF) refers to the deterioration of liver function in individuals who already have chronic liver disease. In the setting of ACLF, liver damage leads to the failure of other organs and is associated with increased short-term mortality. Optimal medical management of patients with ACLF requires implementing complex treatment strategies, often in an intensive care unit (ICU). Failure of organs other than the liver distinguishes ACLF from other critical illnesses. Although there is growing evidence supporting the current approach to ACLF management, the mortality associated with this condition remains unacceptably high. In this review, we discuss considerations for ICU care of patients with ACLF and highlight areas for further research.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020506
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Article ; Online: Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation.

Staubli, Sebastian M / Ghani, Shahi / Walker, Harriet Louise / Fusai, Giuseppe K / Raptis, Dimitri A

Digestive diseases (Basel, Switzerland)

2023 Volume 42, Issue 1, Page(s) 70–77

Abstract: Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known.: ... ...

Abstract	Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known. Methods: A systematic review of the information about CP available online using the search term "chronic pancreatitis" in using the search engine Google has been conducted. The quality of the top 100 websites returned from this search term was analysed using the validated Ensuring Quality Information for Patients (EQIP) tool (maximum score 36). Additional items were included in the website analysis specific to CP. Results: In total, 45 websites were eligible for analysis. The median EQIP score of the websites was 16 (interquartile range 12-19.5). The majority of websites originated from the USA and the United Kingdom with 31 and 11 websites, respectively. Provision of additional information was inconsistent, with most websites covering information regarding aetiology and advocating alcohol and tobacco cessation, but only few reporting on more complex issues. Conclusion: Internet available information about CP is of limited quality. There is an immediate need for high quality, patient targeted, and informative literature accessible on the internet about this topic.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000535073
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Article ; Online: Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference.

Pollok, Joerg M / Tinguely, Pascale / Berenguer, Marina / Niemann, Claus U / Raptis, Dimitri A / Spiro, Michael

The lancet. Gastroenterology & hepatology

2022 Volume 8, Issue 1, Page(s) 81–94

Abstract: There is much controversy regarding enhanced recovery for recipients of liver transplants from deceased and living donors. The objectives of this Review were to summarise current knowledge on individual enhanced recovery elements on short-term outcomes, ... ...

Abstract	There is much controversy regarding enhanced recovery for recipients of liver transplants from deceased and living donors. The objectives of this Review were to summarise current knowledge on individual enhanced recovery elements on short-term outcomes, identify key components for comprehensive pathways, and create internationally accepted guidelines on enhanced recovery for liver-transplant recipients. The ERAS4OLT.org collaborative partnered by the International Liver Transplantation Society performed systematic literature reviews on the effect of 32 relevant enhanced perioperative recovery elements on short-term outcomes, and global specialists prepared expert statements on deceased and living donor liver transplantation. The Grading Recommendations, Assessment, Development and Evaluations approach was used for rating of quality of evidence and grading of recommendations. A virtual international consensus conference was held in January, 2022, in which results were presented, voted on by the audience, and discussed by an independent international jury of eight members, applying the Danish model of consensus. 273 liver transplantation specialists from 30 countries prepared expert statements on elements of enhanced recovery for liver transplantation based on the systematic literature reviews. The consensus conference yielded 80 final recommendations, covering aspects of enhanced recovery for preoperative assessment and optimisation, intraoperative surgical and anaesthetic conduct, and postoperative management for the recipients of liver transplants from both deceased and living donors, and for the living donor. The recommendations represent a comprehensive overview of the relevant elements and areas of enhanced recovery for liver transplantation. These internationally established guidelines could direct the development of enhanced recovery programmes worldwide, allowing adjustments according to local resources and practices.
MeSH term(s)	Humans ; Liver Transplantation/methods ; Living Donors ; Consensus
Language	English
Publishing date	2022-12-09
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(22)00268-0
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Article ; Online: Launch of the International Living Donor Liver Transplantation Outcomes Registry.

Staubli, Sebastian / Grover, Alexander Steen / Turner, Benedict R H / Raptis, Dimitri A / Spiro, Michael / Tinguely, Pascale / Berenguer, Marina / Rela, Mohamed

The lancet. Gastroenterology & hepatology

2023 Volume 8, Issue 8, Page(s) 698–699

MeSH term(s)	Humans ; Liver Transplantation ; Living Donors ; Registries
Language	English
Publishing date	2023-06-22
Publishing country	Netherlands
Document type	Letter
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(23)00185-1
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Article: The Value of Indocyanine Green Image-Guided Surgery in Patients with Primary Liver Tumors and Liver Metastases.

Weixler, Benjamin / Lobbes, Leonard A / Scheiner, Luis / Lauscher, Johannes C / Staubli, Sebastian M / Zuber, Markus / Raptis, Dimitri A

Life (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Introduction: Successful R0 resection is crucial for the survival of patients with primary liver cancer (PLC) or liver metastases. Up to date, surgical resection lacks a sensitive, real-time intraoperative imaging modality to determine R0 resection. ... ...

Abstract	Introduction: Successful R0 resection is crucial for the survival of patients with primary liver cancer (PLC) or liver metastases. Up to date, surgical resection lacks a sensitive, real-time intraoperative imaging modality to determine R0 resection. Real-time intraoperative visualization with near-infrared light fluorescence (NIRF) using indocyanine green (ICG) may have the potential to meet this demand. This study evaluates the value of ICG visualization in PLC and liver metastases surgery regarding R0 resection rates. Materials and methods: Patients with PLC or liver metastases were included in this prospective cohort study. ICG 10 mg was administered intravenously 24 h before surgery. Real-time intraoperative NIRF visualization was created with the Spectrum Results: Of the 66 included patients, median age was 65.5 years (IQR 58.7-73.9), 27 (40.9%) were female, and 18 (27.3%) were operated on laparoscopically. Additional ICG-positive lesions were detected in 23 (35.4%) patients, of which 9 (29%) were malignant. In patients with no fluorescent signal at the resection margin, R0 rate was 93.9%, R1 rate was 6.1%, and R2 rate was 0% compared to an ICG-positive resection margin with an R0 rate of 64.3%, R1 rate of 21.4%, and R2 rate of 14.3% ( Conclusion: The presented study provides significant evidence that ICG NIRF guidance helps to identify R0 resection intraoperatively. This offers true potential to verify radical resection and improve patient outcomes. Furthermore, implementation of NIRF-guided imaging in liver tumor surgery allows us to detect a considerable amount of additional malignant lesions.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13061290
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Article ; Online: Quality of Patient Information on Lipofilling in the Internet.

Spennato, Stefano / Zuk, Grzegorz / Ghamin, Wahid / Raptis, Dimitri A / Palma, Adrian F

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2021 Volume 47, Issue 3, Page(s) e86–e90

Abstract: Background: Patients interested in aesthetic surgery actively search the Internet, a source that contains important but biased information.: Objective: The aim of this study was to assess the quality of patient information on autologous fat grafting ... ...

Abstract	Background: Patients interested in aesthetic surgery actively search the Internet, a source that contains important but biased information. Objective: The aim of this study was to assess the quality of patient information on autologous fat grafting available on the Internet. Materials and methods: The quantitative and qualitative assessment of websites was based on a modified Ensuring Quality Information for Patients tool (EQIP-36 items). Websites were identified through the most popular search engines (Google, Yahoo, Bing, Ask, and AOL). Results: After duplicate and irrelevant sources were excluded, 608 remaining websites were assessed. Only 164 websites addressed >17 of the 36 items. Scores tended to be higher for academic centers and professional societies than for websites developed by private practitioners. The EQIP score achieved by websites ranged between 0 to 28, with a median value of 14 points. Conclusion: The quality of patient information on lipofilling available on the Internet is very poor, and research on existing websites reveals substantial shortcomings. There is an urgent need for sources offering superior quality and unbiased information on lipofilling for patients who intend to undergo this procedure.
MeSH term(s)	Adipose Tissue/transplantation ; Adult ; Consumer Health Information/standards ; Esthetics ; Humans ; Internet/standards ; Reconstructive Surgical Procedures ; Transplantation, Autologous ; Young Adult
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000002752
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Article ; Online: Liver transplant outcomes after ex vivo machine perfusion: a meta-analysis.

Liew, Belle / Nasralla, David / Iype, Satheesh / Pollok, Joerg-Matthias / Davidson, Brian / Raptis, Dimitri A

The British journal of surgery

2021 Volume 108, Issue 12, Page(s) 1409–1416

Abstract: Background: The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia-reperfusion injury in this setting. ... ...

Abstract	Background: The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia-reperfusion injury in this setting. Recipient outcomes with hypothermic or normothermic machine perfusion were assessed against SCS here. Methods: A search in MEDLINE, EMBASE and Scopus was conducted in February 2021. Primary studies investigating ex vivo machine perfusion were assessed for the following outcomes: morbidity, ICU and hospital stay, graft and patient survival rates and relative costs. Meta-analysis was performed to obtain pooled summary measures. Results: Thirty-four articles involving 1742 patients were included, of which 20 were used for quantitative synthesis. Odds ratios favoured hypothermic machine perfusion (over SCS) with less early allograft dysfunction, ischaemic cholangiopathy, non-anastomotic strictures and graft loss. Hypothermic machine perfusion was associated with a shorter hospital stay and normothermic machine perfusion with reduced graft injury. Two randomized clinical trials found normothermic machine perfusion reduced major complication risks. Conclusion: Machine perfusion assists some outcomes with potential cost savings.
MeSH term(s)	Cryopreservation ; Graft Survival ; Humans ; Length of Stay ; Liver Transplantation ; Organ Preservation/methods ; Perfusion ; Reperfusion Injury/prevention & control
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znab364
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Article ; Online: What is the optimal prophylaxis against postoperative deep vein thrombosis in the living donor to avoid complications and enhance recovery? - A systematic review of the literature and expert panel recommendations.

Ruffolo, Luis I / Levstik, Mark / Boehly, Jen / Spiro, Michael / Raptis, Dimitri A / Liu, Linda / Hernandez-Alejandro, Roberto

Clinical transplantation

2022 Volume 36, Issue 10, Page(s) e14688

Abstract: Background: Deep venous thrombosis (DVT) prophylaxis is often employed to prevent the potentially serious complication of pulmonary embolism (PE). However, little data exist regarding the optimal DVT prophylaxis strategy for living donors undergoing ... ...

Abstract	Background: Deep venous thrombosis (DVT) prophylaxis is often employed to prevent the potentially serious complication of pulmonary embolism (PE). However, little data exist regarding the optimal DVT prophylaxis strategy for living donors undergoing hepatectomy for living donor liver transplantation. Here we present our consensus statement on DVT prophylaxis for living donors undergoing hepatectomy. Objectives: To identify the optimal DVT prophylaxis strategy, which reduces, risk of complications in living liver donors, and enhances recovery. Methods: Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. Of interest was the impact of DVT prophylaxis or lack of prophylaxis on living donors undergoing hepatectomy and subsequent rates of DVT, PE, and hemorrhagic complications. Prospero id: CRD42021260720 RESULTS: The review of the literature identified three studies, which directly addressed thrombogenesis following living donor hepatectomy. All studies were observational in nature without randomization into treatments. The rate of DVT-PE in unscreened living donors with chemoprophylaxis was 5%. Furthermore, thromboelastography of living donors demonstrated sustained hypercoagulability for 50% of donors 10 days postoperatively. In line with CHEST (The American College of Chest Physicians) guidelines of chemoprophylaxis for surgical procedures with 3% or greater risk of DVT-PE, we conclude that a minimum of 10 days of postoperative chemoprophylaxis with unfractionated heparin or low-molecular weight heparin is recommended for patients undergoing living donor hepatectomy. The quality of evidence (QOE) for these recommendations based on the GRADE criteria is low, with a Grade of Recommendation of Strong. Conclusions: Chemoprophylaxis for DVT following living donor hepatectomy is associated with reduced adverse thrombotic events, (Quality of Evidence; Low \| Grade of Recommendation; Strong).
MeSH term(s)	Humans ; Heparin ; Liver Transplantation/adverse effects ; Living Donors ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control ; Heparin, Low-Molecular-Weight/therapeutic use ; Pulmonary Embolism/etiology ; Anticoagulants/therapeutic use ; Postoperative Complications/prevention & control ; Postoperative Complications/drug therapy
Chemical Substances	Heparin (9005-49-6) ; Heparin, Low-Molecular-Weight ; Anticoagulants
Language	English
Publishing date	2022-04-23
Publishing country	Denmark
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14688
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