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  1. Article ; Online: Recent Advances in Solid-State Modification for Thermoplastic Polymers: A Comprehensive Review.

    Perez Bravo, Jonas José / Gerbehaye, Carolane / Raquez, Jean-Marie / Mincheva, Rosica

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: This review introduces groundbreaking insights in polymer science, specifically spotlighting a novel review of the solid-state modification (SSM) approach of thermoplastic polymers, a method not extensively explored. Unlike traditional melt polymer ... ...

    Abstract This review introduces groundbreaking insights in polymer science, specifically spotlighting a novel review of the solid-state modification (SSM) approach of thermoplastic polymers, a method not extensively explored. Unlike traditional melt polymer modification, SSM stands out by incorporating monomers or oligomers into the amorphous phase of polymers through innovative exchange reactions. The background of the study places thermoplastics within the context of their increased use over the past century, highlighting their versatility in various applications and the associated environmental and health concerns due to certain additives. The results section outlines the unique aspects of SSM and its increasing recognition for its potential to enhance material performance in areas such as catalysts and composites. It also discusses the application of SSM in modifying different thermoplastic polymers, highlighting various studies demonstrating the method's effectiveness in altering polymer properties. Finally, this work emphasizes SSM's importance in environmental sustainability and its potential in the recycling and upcycling of plastic materials. It acknowledges the challenges and future perspectives in the field, particularly regarding the scalability of SSM techniques for industrial applications and their role in advancing a circular economy in the polymer industry.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Balancing the Strength-Impact Relationship and Other Key Properties in Polypropylene Copolymer-Natural CaSO

    Murariu, Marius / Laoutid, Fouad / Paint, Yoann / Murariu, Oltea / Raquez, Jean-Marie / Dubois, Philippe

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: To develop novel mineral-filled composites and assess their enhanced properties (stiffness, a good balance between mechanical strength and impact resistance, greater temperature stability), a high-impact polypropylene copolymer (PPc) matrix containing an ...

    Abstract To develop novel mineral-filled composites and assess their enhanced properties (stiffness, a good balance between mechanical strength and impact resistance, greater temperature stability), a high-impact polypropylene copolymer (PPc) matrix containing an elastomeric discrete phase was melt mixed with natural CaSO
    MeSH term(s) Polypropylenes ; Bone Screws ; Calcium Sulfate ; Cell-Derived Microparticles ; Crystallization ; Polymers
    Chemical Substances Polypropylenes ; Calcium Sulfate (WAT0DDB505) ; Polymers
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612659
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  3. Article ; Online: Nanocluster-Based Drug Delivery and Theranostic Systems: Towards Cancer Therapy.

    Villela Zumaya, Alma Lucia / Mincheva, Rosica / Raquez, Jean-Marie / Hassouna, Fatima

    Polymers

    2022  Volume 14, Issue 6

    Abstract: Over the last decades, the global life expectancy of the population has increased, and so, consequently, has the risk of cancer development. Despite the improvement in cancer therapies (e.g., drug delivery systems (DDS) and theranostics), in many cases ... ...

    Abstract Over the last decades, the global life expectancy of the population has increased, and so, consequently, has the risk of cancer development. Despite the improvement in cancer therapies (e.g., drug delivery systems (DDS) and theranostics), in many cases recurrence continues to be a challenging issue. In this matter, the development of nanotechnology has led to an array of possibilities for cancer treatment. One of the most promising therapies focuses on the assembly of hierarchical structures in the form of nanoclusters, as this approach involves preparing individual building blocks while avoiding handling toxic chemicals in the presence of biomolecules. This review aims at presenting an overview of the major advances made in developing nanoclusters based on polymeric nanoparticles (PNPs) and/or inorganic NPs. The preparation methods and the features of the NPs used in the construction of the nanoclusters were described. Afterwards, the design, fabrication and properties of the two main classes of nanoclusters, namely noble-metal nanoclusters and hybrid (i.e., hetero) nanoclusters and their mode of action in cancer therapy, were summarized.
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14061188
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  4. Article ; Online: Proof of concept of a predictive model of drug release from long-acting implants obtained by fused-deposition modeling.

    Manini, Giuseppe / Benali, Samira / Raquez, Jean-Marie / Goole, Jonathan

    International journal of pharmaceutics

    2022  Volume 618, Page(s) 121663

    Abstract: In the pharmaceutical field, there is a growing interest in manufacturing of drug delivery dosage forms adapted to the needs of a large variety of patients. 3D printing has proven to be a powerful tool allowing the adaptation of immediate drug delivery ... ...

    Abstract In the pharmaceutical field, there is a growing interest in manufacturing of drug delivery dosage forms adapted to the needs of a large variety of patients. 3D printing has proven to be a powerful tool allowing the adaptation of immediate drug delivery dosage forms. However, there are still few studies focusing on the adaptation of long-acting dosage forms for patient suffering of neurological diseases. In this study, paliperidone palmitate (PP) was chosen as a model drug in combination with different polymers adapted for fused-deposition modeling (FDM). The impact of different printing parameters on the release of PP were investigated. The layer thickness and the infill percentage were studied using a quality by design approach. Indeed, by defining the critical quality attributes (CQA), a proof of concept of a prediction system, and a quality control system were studied through designs of experiments (DoE). The first part of this study was dedicated to the release of PP from a fix geometry. In the second part, the prediction system was developed to require only surface and surface to volume ratio. From that point, it was possible to get rid of a fix geometry and predict the amount of PP released from complex architectures.
    MeSH term(s) Drug Liberation ; Humans ; Paliperidone Palmitate ; Pharmaceutical Preparations ; Polymers ; Printing, Three-Dimensional ; Tablets ; Technology, Pharmaceutical
    Chemical Substances Pharmaceutical Preparations ; Polymers ; Tablets ; Paliperidone Palmitate (R8P8USM8FR)
    Language English
    Publishing date 2022-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.121663
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Review on Liquid Crystal Polymers in Free-Standing Reversible Shape Memory Materials.

    Wen, Zhibin / Yang, Keke / Raquez, Jean-Marie

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 5

    Abstract: Liquid crystal polymers have attracted massive attention as stimuli-responsive shape memory materials due to their unique reversible large-scale and high-speed actuations. These materials can be utilized to fabricate artificial muscles, sensors, and ... ...

    Abstract Liquid crystal polymers have attracted massive attention as stimuli-responsive shape memory materials due to their unique reversible large-scale and high-speed actuations. These materials can be utilized to fabricate artificial muscles, sensors, and actuators driven by thermal order-disorder phase transition or
    MeSH term(s) Biocompatible Materials/chemistry ; Liquid Crystals/chemistry ; Macromolecular Substances/chemistry ; Polymers/chemistry ; Smart Materials/chemistry
    Chemical Substances Biocompatible Materials ; Macromolecular Substances ; Polymers ; Smart Materials ; liquid crystal polymer
    Language English
    Publishing date 2020-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25051241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Substantial Effect of Water on Radical Melt Crosslinking and Rheological Properties of Poly(ε-Caprolactone).

    Avella, Angelica / Mincheva, Rosica / Raquez, Jean-Marie / Lo Re, Giada

    Polymers

    2021  Volume 13, Issue 4

    Abstract: One-step reactive melt processing (REx) via radical reactions was evaluated with the aim of improving the rheological properties of poly(ε-caprolactone) (PCL). In particular, a water-assisted REx was designed under the hypothesis of increasing ... ...

    Abstract One-step reactive melt processing (REx) via radical reactions was evaluated with the aim of improving the rheological properties of poly(ε-caprolactone) (PCL). In particular, a water-assisted REx was designed under the hypothesis of increasing crosslinking efficiency with water as a low viscous medium in comparison with a slower PCL macroradicals diffusion in the melt state. To assess the effect of dry vs. water-assisted REx on PCL, its structural, thermo-mechanical and rheological properties were investigated. Water-assisted REx resulted in increased PCL gel fraction compared to dry REx (from 1-34%), proving the rationale under the formulated hypothesis. From dynamic mechanical analysis and tensile tests, the crosslink did not significantly affect the PCL mechanical performance. Dynamic rheological measurements showed that higher PCL viscosity was reached with increasing branching/crosslinking and the typical PCL Newtonian behavior was shifting towards a progressively more pronounced shear thinning. A complete transition from viscous- to solid-like PCL melt behavior was recorded, demonstrating that higher melt elasticity can be obtained as a function of gel content by controlled REx. Improvement in rheological properties offers the possibility of broadening PCL melt processability without hindering its recycling by melt processing.
    Language English
    Publishing date 2021-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13040491
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  7. Article ; Online: Design of Thermoplastic Polyurethanes with Conferred Antibacterial, Mechanical, and Cytotoxic Properties for Catheter Application.

    Al Nakib, Rana / Toncheva, Antoniya / Fontaine, Veronique / Vanheuverzwijn, Jérôme / Raquez, Jean-Marie / Meyer, Franck

    ACS applied bio materials

    2022  Volume 5, Issue 12, Page(s) 5532–5544

    Abstract: Thermoplastic polyurethanes ( ...

    Abstract Thermoplastic polyurethanes (
    MeSH term(s) Humans ; Polyurethanes/pharmacology ; Staphylococcus aureus ; Salts/pharmacology ; Anti-Bacterial Agents/pharmacology ; Quaternary Ammonium Compounds/pharmacology ; Polymers/pharmacology ; Pseudomonas aeruginosa ; Staphylococcal Infections ; Catheters
    Chemical Substances Polyurethanes ; Salts ; Anti-Bacterial Agents ; Quaternary Ammonium Compounds ; Polymers
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c00531
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  8. Article ; Online: A dynamic passive thermoregulation fabric using metallic microparticles.

    Abebe, Muluneh G / Rosolen, Gilles / Odent, Jeremy / Raquez, Jean-Marie / Maes, Bjorn

    Nanoscale

    2022  Volume 14, Issue 4, Page(s) 1421–1431

    Abstract: Maintaining comfort using photonic thermal management textiles has a large potential to decrease the energy cost for heating and cooling in residential and office buildings. We propose a thermoregulating fabric using metallic microparticles, which ... ...

    Abstract Maintaining comfort using photonic thermal management textiles has a large potential to decrease the energy cost for heating and cooling in residential and office buildings. We propose a thermoregulating fabric using metallic microparticles, which provides a dynamic and passive control of the infrared transmission, by adapting to the ambient temperature and humidity. The fabric is composed of tailored metal microparticles and a stimuli-responsive polymer actuator matrix, in order to benefit from strong scattering effects to control the wideband transmission of thermal radiation and to provide a sharp, dynamic response. The detailed numerical design demonstrates a wide dynamic ambient setpoint temperature window of ∼8 °C, with the wearer staying comfortable in the range between 18 and 26 °C. Its compatibility for large-scale manufacturing, with a safe and strong thermoregulating performance indicates a vital energy-saving potential and paves the way to a more sustainable society.
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d1nr07390g
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  9. Article ; Online: Paliperidone palmitate as model of heat-sensitive drug for long-acting 3D printing application.

    Manini, Giuseppe / Benali, Samira / Mathew, Allen / Napolitano, Simone / Raquez, Jean-Marie / Goole, Jonathan

    International journal of pharmaceutics

    2022  Volume 618, Page(s) 121662

    Abstract: In this work, two technologies were used to prepare long-acting implantable dosage forms in the treatment of schizophrenia. Hot-melt extrusion (HME) as well as fused deposition modelling (FDM) were used concomitantly to create personalized 3D printed ... ...

    Abstract In this work, two technologies were used to prepare long-acting implantable dosage forms in the treatment of schizophrenia. Hot-melt extrusion (HME) as well as fused deposition modelling (FDM) were used concomitantly to create personalized 3D printed implants. Different formulations were prepared using an amorphous PLA as matrix polymer and different solid-state plasticizers. Paliperidone palmitate (PP), a heat sensitive drug prescribed in the treatment of schizophrenia was chosen as model drug. After extrusion, different formulations were characterized using DSC and XRD. Then, an in vitro dissolution test was carried out to discriminate the formulation allowing a sustained drug release of PP. The formulation showing a sustained drug release of the drug was 3D printed as an implantable dosage form. By modulating the infill, the release profile was related to the proper design of tailored dosage form and not solely to the solubility of the drug. Indeed, different release profiles were achieved over 90 days using only one formulation. In addition, a stability test was performed on the 3D printed implants for 3 months. The results showed the stability of the amorphous state of PP, independently of the temperature as well as the integrity of the matrix and the drug.
    MeSH term(s) Drug Liberation ; Excipients ; Hot Temperature ; Paliperidone Palmitate ; Printing, Three-Dimensional ; Tablets ; Technology, Pharmaceutical/methods
    Chemical Substances Excipients ; Tablets ; Paliperidone Palmitate (R8P8USM8FR)
    Language English
    Publishing date 2022-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.121662
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Covalent Adaptable Networks through Dynamic

    Habets, Thomas / Seychal, Guillem / Caliari, Marco / Raquez, Jean-Marie / Sardon, Haritz / Grignard, Bruno / Detrembleur, Christophe

    Journal of the American Chemical Society

    2023  Volume 145, Issue 46, Page(s) 25450–25462

    Abstract: Finding new chemistry platforms for easily recyclable polymers has become a key challenge to face environmental concerns and the growing plastics demand. Here, we report a dynamic chemistry between ... ...

    Abstract Finding new chemistry platforms for easily recyclable polymers has become a key challenge to face environmental concerns and the growing plastics demand. Here, we report a dynamic chemistry between CO
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c10080
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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