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  1. Article ; Online: Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications

    Ali Afzal / Mohammed Jalalah / Abid Noor / Zubair Khaliq / Muhammad Bilal Qadir / Rashid Masood / Ahsan Nazir / Sheraz Ahmad / Faheem Ahmad / Muhammad Irfan / Munazza Afzal / Mohd Faisal / Saeed A. Alsareii / Farid A. Harraz

    Polymers, Vol 15, Iss 1355, p

    2023  Volume 1355

    Abstract: Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, ... ...

    Abstract Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.
    Keywords antimicrobial ; drug release ; medical ; polycaprolactone ; wound dressing ; Organic chemistry ; QD241-441
    Subject code 660
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Calvarial Reconstruction Following Massive Tissue Loss: A Feasible Treatment Strategy and Surgical Technique.

    Hofmann, Luzie / Rafizadeh Rashid, Masood / Ludtka, Christopher / Schwan, Stefan / Mendel, Thomas / Sanchin, Lhagva / Goehre, Felix

    Operative neurosurgery (Hagerstown, Md.)

    2020  Volume 20, Issue 3, Page(s) 317–322

    Abstract: Background: Severe cranial injuries require reconstructive surgeries to protect the underlying brain and to restore cranial contour and scalp integrity, as well as avoid complications such as neurocognitive decline. In cases of full-thickness cranial ... ...

    Abstract Background: Severe cranial injuries require reconstructive surgeries to protect the underlying brain and to restore cranial contour and scalp integrity, as well as avoid complications such as neurocognitive decline. In cases of full-thickness cranial tissue damage, adept surgical skill in both bone and soft tissue reconstruction is critical for a minimally invasive surgery and successful bone integration without endangering previous soft tissue efforts. Different surgical techniques and materials are beset with various problems.
    Objective: To present a surgical procedure intended for the reconstruction of complex calvarial and associated tissue defects with reduced invasiveness and improved soft tissue healing compared to the existing gold standard. Both soft tissue and bone reconstruction techniques are described in detail due to their intertwined importance for successful full thickness skull and scalp reconstruction.
    Methods: During initial medical care, aseptic wound treatment and temporary wound closure are performed. Two weeks postinjury, extensive necrotic tissue debridement and soft tissue reconstruction lay the foundation for well-vascularized tissue regeneration. Soft tissue healing is followed by minimally invasive cranioplasty using autologous split-rib transplants after approximately 6 mo.
    Results: With consideration of the established gold standards for treatment, soft tissue regenerated without complications. The minimally invasive insertion of autologous rib grafts underneath the healed soft tissue allowed for quick recovery without requiring further follow-up treatments.
    Conclusion: We optimized initial scalp wound healing and bone regeneration by making use of minimally invasive procedures and autologous materials, offering a viable treatment alternative to existing methods for treating large cranial bone injuries.
    MeSH term(s) Bone Diseases/surgery ; Craniocerebral Trauma/surgery ; Humans ; Reconstructive Surgical Procedures ; Scalp/surgery ; Skull/surgery
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opaa371
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424 -ON-: Show issues Location:
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  3. Article: Linear and crosslinked Polyurethanes based catalysts for reduction of methylene blue

    Sultan, Misbah / Asma Javeed / Maliha Uroos / Muhammad Imran / Farhat Jubeen / Shazia Nouren / Nazish Saleem / Ismat Bibi / Rashid Masood / Waqas Ahmed

    Journal of hazardous materials. 2018 Feb. 15, v. 344

    2018  

    Abstract: The large amount of synthetic dyes in effluents is a serious concern to be addressed. The chemical reduction is one of the potential way to resolve this problem. In this study, linear and crosslinked polyurethanes i.e. LPUR & CLPUR were synthesized from ... ...

    Abstract The large amount of synthetic dyes in effluents is a serious concern to be addressed. The chemical reduction is one of the potential way to resolve this problem. In this study, linear and crosslinked polyurethanes i.e. LPUR & CLPUR were synthesized from toluene diisocyanate (TDI), polyethylene glycol (PEG;1000g/mole) and tetraethylenepentamine (TEPA). The structure and morphology of synthesized materials were examined by FTIR, SEM and BET. The CLPUR was found stable in aqueous system with 0.80g/cm3 density and 16.4998m2g−1 surface area. These materials were applied for the reduction of methylene blue in presence of NaBH4. Both, polymers catalyzed the process and showed 100% reduction in 16 and 28mins., respectively, while, the reduction rate was significantly low in absence of these materials, even after 120mins. Furthermore, negligible adsorption was observed with only 7% removal of dye. The best reduction rates were observed at low concentration of dye, increasing concentration of NaBH4 and with more dosage of polymeric catalyst. The kinetic study of process followed zero order kinetics. It was hence concluded that both synthesized polymers played a catalytic role in reduction process. However, stability in aqueous system and better efficiency in reduction process endorsed CLPUR as an optimal choice for further studies.
    Keywords Fourier transform infrared spectroscopy ; adsorption ; artificial colors ; borohydrides ; catalysts ; chemical reduction ; crosslinking ; effluents ; methylene blue ; polyethylene glycol ; polyurethanes ; scanning electron microscopy ; surface area ; toluene
    Language English
    Dates of publication 2018-0215
    Size p. 210-219.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2017.10.019
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  4. Article: Production of rhamnolipid surfactant and its application in bioscouring of cotton fabric

    Raza, Zulfiqar Ali / Aisha Rehman / Amjed Javid / Anwar ul Haq / Muhammad Tahir Hussain / Muhammad Tahir Saddique / Niaz Ahmad / Rashid Masood

    Carbohydrate research. 2014 June 04, v. 391

    2014  

    Abstract: In the present study, a biosurfactant was synthesized by using a bacterial strain of Pseudomonas aeruginosa in minimal media provided with n-heptadecane as sole carbon source under shake-flask conditions. The biosurfactant was isolated (by acid ... ...

    Abstract In the present study, a biosurfactant was synthesized by using a bacterial strain of Pseudomonas aeruginosa in minimal media provided with n-heptadecane as sole carbon source under shake-flask conditions. The biosurfactant was isolated (by acid precipitation, solvent extraction, and rotary evaporation), purified (by column chromatography and TLC), identified (by FAB-MS, FTIR, and 1D-1H NMR), and chemo-physical characterized (by tensiometry). Two principal rhamnolipid congeners were identified as dirhamnolipid RRC10C10 and monorhamnolipid RC10C10 with a CMC of 50mg/L. The biosurfactant, hence produced, was applied in sole and in combination with pectinase in scouring of cotton fabric in contrast to conventional scouring agents of NaOH and anionic surfactant SDS. The scoured cotton fabric was investigated for its weight loss, residual oil and grease, wettability, whiteness, and tensile strength. The results were compared both for conventional and biological approaches. The scouring with biosurfactant plus pectinase was equivalent to or better in efficiency than conventional alkaline scouring. The former process is additionally environmentally friendly and bio-compatible. Scanning electron microscopy of cotton fabric showed that the alkaline scouring deteriorates the fabric texture whereas bioscouring with biosurfactant plus pectinase gently removes hydrophobic impurities from the cotton fabric.
    Keywords acid deposition ; anionic surfactants ; bioscouring ; biosurfactants ; carbon ; chromatography ; cotton fabric ; evaporation ; Fourier transform infrared spectroscopy ; hydrophobicity ; nuclear magnetic resonance spectroscopy ; oils ; polygalacturonase ; Pseudomonas aeruginosa ; rhamnolipids ; scanning electron microscopy ; sodium hydroxide ; solvents ; tensile strength ; texture ; weight loss ; wettability
    Language English
    Dates of publication 2014-0604
    Size p. 97-105.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2014.03.009
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    In stock of ZB MED Bonn / Germany

    Z 2002/704: Show issues
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  5. Article ; Online: The effects of low-level laser therapy on bone in diabetic and nondiabetic rats.

    Bayat, Mohammad / Abdi, Shabnam / Javadieh, Farshad / Mohsenifar, Zhaleh / Rashid, Masood Rafizadeh

    Photomedicine and laser surgery

    2009  Volume 27, Issue 5, Page(s) 703–708

    Abstract: Objective: The aim of the present study was to examine the effects of low-level laser therapy (LLLT) on the tibia of streptozotocin-induced diabetic (STZ-D) rats.: Background data: LLLT has been found to accelerate fracture healing in animals. ... ...

    Abstract Objective: The aim of the present study was to examine the effects of low-level laser therapy (LLLT) on the tibia of streptozotocin-induced diabetic (STZ-D) rats.
    Background data: LLLT has been found to accelerate fracture healing in animals. Diabetes mellitus decreases bone volume and its biomechanical parameters.
    Materials and methods: Twenty rats were divided randomly into four groups. Rats in the first two groups were administrated a single injection of STZ to induce diabetes, while animals in groups 3 and 4 were given a sham injection of distilled water. The right tibia in groups 1 and 2 was treated with a He-Ne laser (632.8 nm, 10 mW) of 28.6 and 382.2 J/cm(2), respectively. LLLT was performed daily for 14 consecutive days. The right tibia of rats in group 3 was treated with LLLT the same as group 2. The right tibia of rats in group 4 was used for based line studies. After 14 d, right tibiae and left tibiae (control bone) were extracted and subjected to the three-point bending test and histological study.
    Results: Maximum force (N) was significantly greater in laser-treated bones of groups 2 and 3 compared with their relevant control groups (paired Student t test, p = 0.05 and p = 0.007, respectively). Density of the bone lamella meshwork of compact bone in group 2 was significantly greater in comparison with its control group (paired Student t test, p = 0.005).
    Conclusion: LLLT on tibia of STZ-D rats increased the bone lamella meshwork density of compact bone and also increased its strength.
    MeSH term(s) Animals ; Bone Density/radiation effects ; Diabetes Mellitus, Experimental/complications ; Disease Models, Animal ; Fracture Healing/radiation effects ; Lasers, Gas ; Low-Level Light Therapy ; Male ; Rats ; Rats, Wistar ; Tibia/radiation effects ; Tibial Fractures/complications ; Tibial Fractures/radiotherapy
    Language English
    Publishing date 2009-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2158446-1
    ISSN 1557-8550 ; 1549-5418
    ISSN (online) 1557-8550
    ISSN 1549-5418
    DOI 10.1089/pho.2008.2351
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1908: Show issues Location:
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