Article ; Online: Hospital Outcomes in Medical Patients With Alcohol-Related and Non-Alcohol-Related Wernicke Encephalopathy.
2023 Volume 99, Issue 5, Page(s) 740–753
Abstract: Objective: To conduct a nationwide retrospective cohort study to assess trends and hospitalization-associated outcomes in patients with Wernicke encephalopathy.: Patients and methods: In this nationwide retrospective cohort study, we used in-hospital ...
Abstract | Objective: To conduct a nationwide retrospective cohort study to assess trends and hospitalization-associated outcomes in patients with Wernicke encephalopathy. Patients and methods: In this nationwide retrospective cohort study, we used in-hospital claims data of patients hospitalized with Wernicke encephalopathy in Switzerland from January 1, 2012, to December 31, 2020. We estimated incidence rates per 100,000 person-years among the overall Swiss population stratified by alcohol and non-alcohol-induced Wernicke encephalopathy. The primary outcome was all-cause in-hospital mortality. Secondary outcomes included progression to Korsakoff syndrome and 1-year hospital readmission. We estimated odds ratios (ORs) for binary outcomes. Results: It was found that 4098 of 4393 hospitalizations (93.3%) for Wernicke encephalopathy during the 8-year study were alcohol-related. Incidence rates for hospitalizations were 14-fold higher in alcohol-related compared with non-alcohol-related Wernicke encephalopathy (5.43 vs 0.39 per 100,000 person-years). The risk for in-hospital mortality was significantly lower in patients with alcohol-related vs non-alcohol-related Wernicke encephalopathy (3.2% vs 8.5%; adjusted OR, 0.38; 95% CI, 0.23 to 0.62). Patients with alcohol-related Wernicke encephalopathy had higher risk for development of Korsakoff syndrome (16.9% vs 1.7%; adjusted OR, 10.64; 95% CI, 4.37 to 25.92) and 1-year hospital readmission (31.6% vs 18.7%; adjusted OR, 1.4; 95% CI, 1.04 to 1.88). Conclusion: In this Swiss nationwide cohort study, Wernicke encephalopathy was a rare but serious cause for hospitalization and mainly alcohol-related. Patients with alcohol-related Wernicke encephalopathy had lower risks of in-hospital mortality but were more likely to develop Korsakoff syndrome and be readmitted to the hospital. |
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MeSH term(s) | Humans ; Wernicke Encephalopathy/epidemiology ; Wernicke Encephalopathy/etiology ; Male ; Female ; Retrospective Studies ; Middle Aged ; Switzerland/epidemiology ; Hospital Mortality ; Aged ; Hospitalization/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Adult ; Incidence ; Korsakoff Syndrome/epidemiology ; Korsakoff Syndrome/etiology ; Alcoholism/complications ; Alcoholism/epidemiology |
Language | English |
Publishing date | 2023-12-08 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 124027-4 |
ISSN | 1942-5546 ; 0025-6196 |
ISSN (online) | 1942-5546 |
ISSN | 0025-6196 |
DOI | 10.1016/j.mayocp.2023.07.021 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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