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  1. Article ; Online: Toward a personalized medicine approach to trauma-related nightmares.

    Raskind, Murray A

    Sleep medicine reviews

    2020  Volume 50, Page(s) 101272

    MeSH term(s) Dreams ; Humans ; Military Personnel ; Prazosin ; Precision Medicine ; Stress Disorders, Post-Traumatic ; Veterans
    Chemical Substances Prazosin (XM03YJ541D)
    Language English
    Publishing date 2020-01-25
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1414211-9
    ISSN 1532-2955 ; 1087-0792
    ISSN (online) 1532-2955
    ISSN 1087-0792
    DOI 10.1016/j.smrv.2020.101272
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  2. Book ; Conference proceedings: Proceedings of a Symposium Alzheimer's Disease: Making Progress through a Multidisciplinary Approach

    Raskind, Murray

    based on a satellite symposium of the American Geriatric Society held on May 10, 1997, in Atlanta, Georgia

    (The American journal of medicine ; 104,4A)

    1998  

    Title variant Alzheimer's disease: making progress through a multidisciplinary approach
    Institution American Geriatrics Society
    Event/congress Symposium Alzheimer's Disease: Making Progress through a Multidisciplinary Approach (1997, AtlantaGa.)
    Author's details guest ed. Murray A. Raskind
    Series title The American journal of medicine ; 104,4A
    Collection
    Language English
    Size 42S S. : graph. Darst.
    Publisher Excerpta Medica
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT008741785
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Conference proceedings: Deliberations: an examination of the controversies in Alzheimer's disease

    Raskind, Murray

    proceedings of a round table meeting held in Sydney, Australia on 1 November 1995

    (Round table series / Royal Society of Medicine ; 44)

    1996  

    Author's details ed. by Murray Raskind
    Series title Round table series / Royal Society of Medicine ; 44
    Collection
    Keywords Alzheimer Disease / congresses
    Language English
    Size 25 S. : graph. Darst.
    Publisher Royal Soc. of Medicine Press
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT008592538
    ISBN 1-85315-273-0 ; 978-1-85315-273-3
    Database Catalogue ZB MED Medicine, Health

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    1998 A 4057 order for loan Magazin

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  4. Article ; Online: A case of prazosin in treatment of rapid eye movement sleep behavior disorder.

    Cho, Yeilim / Iliff, Jeffrey J / Lim, Miranda M / Raskind, Murray / Peskind, Elaine

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 20, Issue 2, Page(s) 319–321

    Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream-enactment behaviors that emerge during a loss of REM sleep atonia. Untreated RBD carries risks for physical injury from falls or other traumatic events during dream ... ...

    Abstract Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by dream-enactment behaviors that emerge during a loss of REM sleep atonia. Untreated RBD carries risks for physical injury from falls or other traumatic events during dream enactment as well as risk of injury to the bed partner. Currently, melatonin and clonazepam are the mainstay pharmacological therapies for RBD. However, therapeutic response to these medications is variable. While older adults are most vulnerable to RBD, they are also particularly vulnerable to the adverse effects of benzodiazepines, including increased risk of falls, cognitive impairment, and increased risk of Alzheimer disease. Prazosin is a centrally active alpha-1 adrenergic receptor antagonist often prescribed for trauma nightmares characterized by REM sleep without atonia in patients with posttraumatic stress disorder. We report a case of successful RBD management with prazosin in a patient in whom high-dose melatonin was ineffective. Although there was no observable reduction in dream-enactment behaviors with high-dose melatonin, the possibility of a synergistic effect of prazosin combined with melatonin cannot be ruled out. This case report supports further evaluation of prazosin as a potential therapeutic for RBD.
    Citation: Cho Y, Iliff JJ, Lim MM, Raskind M, Peskind E. A case of prazosin in treatment of rapid eye movement sleep behavior disorder.
    MeSH term(s) Humans ; Aged ; Melatonin/therapeutic use ; REM Sleep Behavior Disorder/complications ; REM Sleep Behavior Disorder/drug therapy ; Prazosin/therapeutic use ; Clonazepam/therapeutic use ; Stress Disorders, Post-Traumatic/complications
    Chemical Substances Melatonin (JL5DK93RCL) ; Prazosin (XM03YJ541D) ; Clonazepam (5PE9FDE8GB)
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10888
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  5. Article ; Online: Prazosin for Post-Traumatic Stress Disorder.

    Raskind, Murray A / Peskind, Elaine R

    The New England journal of medicine

    2018  Volume 378, Issue 17, Page(s) 1649–1650

    MeSH term(s) Dreams ; Humans ; Prazosin ; Stress Disorders, Post-Traumatic ; Veterans
    Chemical Substances Prazosin (XM03YJ541D)
    Language English
    Publishing date 2018--26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1803171
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  6. Article ; Online: Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury.

    Yamamoto, Erin A / Koike, Seiji / Luther, Madison / Dennis, Laura / Lim, Miranda M / Raskind, Murray / Pagulayan, Kathleen / Iliff, Jeffrey / Peskind, Elaine / Piantino, Juan A

    Journal of neurotrauma

    2024  

    Abstract: Blast-related mild traumatic brain injury (mTBI) is recognized as the "signature injury" of the Iraq and Afghanistan wars. Sleep disruption, mTBI, and neuroinflammation have been individually linked to cerebral perivascular space (PVS) dilatation. ... ...

    Abstract Blast-related mild traumatic brain injury (mTBI) is recognized as the "signature injury" of the Iraq and Afghanistan wars. Sleep disruption, mTBI, and neuroinflammation have been individually linked to cerebral perivascular space (PVS) dilatation. Dilated PVSs are putative markers of impaired cerebrospinal fluid (CSF) and interstitial fluid exchange, which plays an important role in removing cerebral waste. The aim of this cross-sectional, retrospective study was to define associations between biomarkers of inflammation and MRI-visible PVS (MV-PVS) burden in Veterans after blast-related mTBI (blast-mTBI) and controls. The CSF and plasma inflammatory biomarker concentrations were compared between blast-mTBI and control groups and correlated with MV-PVS volume and number per white matter cm
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0505
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  7. Article ; Online: Prazosin for Alcohol Use Disorder: Response to Kleinman and Ostacher.

    Simpson, Tracy L / Saxon, Andrew J / Raskind, Murray

    The American journal of psychiatry

    2019  Volume 176, Issue 2, Page(s) 165–166

    MeSH term(s) Alcohol Drinking ; Alcoholism ; Double-Blind Method ; Humans ; Prazosin
    Chemical Substances Prazosin (XM03YJ541D)
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2018.18101143r
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  8. Article ; Online: CSF β-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury.

    Li, Ge / Iliff, Jeffrey / Shofer, Jane / Mayer, Cynthia L / Meabon, James / Cook, David / Pagulayan, Kathleen F / Raskind, Murray A / Zetterberg, Henrik / Blennow, Kaj / Peskind, Elaine R

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209197

    Abstract: Background and objectives: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. This study ... ...

    Abstract Background and objectives: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. This study investigated early AD changes using CSF biomarkers in veterans with blast mTBI.
    Methods: This was a cross-sectional case-control study of veterans with mTBI and non-mTBI veterans and civilians from 2 study sources. Blast-mTBI veterans had at least 1 war zone blast or combined blast/impact mTBI meeting Veterans Affairs (VA) and Department of Defense (DoD) criteria for mTBI. Non-mTBI participants had no lifetime history of TBI. All participants underwent standardized clinical and neuropsychological assessments and lumbar puncture for collection of the CSF. CSF biomarkers were measured using MesoScale Discovery assays for Aβ40 and Aβ42 and INNOTEST ELISAs for phosphorylated tau181 (p-tau181) and total tau (t-tau).
    Results: Our sample comprised 51 participants with mTBI and 85 non-mTBI participants with mean (SD) ages 34.0 (10.1) and 33.5 years (8.9), respectively. All participants but 1 (99%) were male. Differences in CSF AD biomarkers between mTBI and non-mTBI groups were age dependent and most pronounced at older ages (omnibus test
    Discussion: CSF Aβ levels decreased in middle-aged veterans with blast-related mTBI. These data suggest that chronic neuropathologic processes associated with blast mTBI share properties in common with pathogenic processes known to portend AD onset, thus raising concern that veterans with blast-related mTBI may develop a dementing disorder later in life.
    MeSH term(s) Middle Aged ; Humans ; Male ; Aged ; Female ; Brain Concussion/complications ; Case-Control Studies ; Veterans ; Cross-Sectional Studies ; Amyloid beta-Peptides ; Alzheimer Disease/pathology ; tau Proteins ; Brain Injuries, Traumatic/complications ; Biomarkers ; Memory Disorders/complications
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Biomarkers
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209197
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  9. Article ; Online: Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings.

    Hendrickson, Rebecca C / Thomas, Ronald G / Schork, Nicholas J / Raskind, Murray A

    Frontiers in digital health

    2020  Volume 2, Page(s) 13

    Abstract: Background and Significance: ...

    Abstract Background and Significance:
    Language English
    Publishing date 2020-08-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-253X
    ISSN (online) 2673-253X
    DOI 10.3389/fdgth.2020.00013
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  10. Article ; Online: Posttraumatic Stress Disorder and Aging.

    Palmer, Barton W / Raskind, Murray A

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2016  Volume 24, Issue 3, Page(s) 177–180

    MeSH term(s) Aging/psychology ; Health Services Accessibility ; Humans ; Risk Factors ; Smoking/epidemiology ; Smoking/psychology ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Stress Disorders, Post-Traumatic/therapy ; Vascular Diseases/complications ; Vascular Diseases/epidemiology ; Veterans/psychology ; Veterans/statistics & numerical data
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2016.01.133
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