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  1. Article ; Online: Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation.

    Rasmussen, Erik M K / Seier, Kristine L / Pedersen, Ingrid K / Kreibich, Claus / Amdam, Gro V / Münch, Daniel / Dahl, John Arne

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19156

    Abstract: Various bioactive food compounds may confer health and longevity benefits, possibly through altering or preserving the epigenome. While bioactive food compounds are widely being marketed for human consumption as 'improving health and longevity' by ... ...

    Abstract Various bioactive food compounds may confer health and longevity benefits, possibly through altering or preserving the epigenome. While bioactive food compounds are widely being marketed for human consumption as 'improving health and longevity' by counteracting harmful effects of poor nutrition and lifestyle, claimed effects are often not adequately documented. Using the honey bee (Apis mellifera) as a model species, we here employed a multi-step screening approach to investigate seven compounds for effects on lifespan and DNA methylation using ELISA and whole genome bisulfite sequencing (WGBS). A positive longevity effect was detected for valproic acid, isovaleric acid, and cyanocobalamin. For curcumin, we found that lifespan shortening caused by ethanol intake, was restored when curcumin and ethanol were co-administered. Furthermore, we identified region specific DNA methylation changes as a result of ethanol intake. Ethanol specific changes in DNA methylation were fully or partially blocked in honey bees receiving ethanol and curcumin together. Ethanol-affected and curcumin-blocked differentially methylated regions covered genes involved in fertility, temperature regulation and tubulin transport. Our results demonstrate fundamental negative effects of low dose ethanol consumption on lifespan and associated DNA methylation changes and present a proof-of-principle on how longevity and DNA methylation changes can be negated by the bioactive food component curcumin. Our findings provide a fundament for further studies of curcumin in invertebrates.
    MeSH term(s) Alcohol Drinking/adverse effects ; Animals ; Bees ; Curcumin/administration & dosage ; DNA Methylation/drug effects ; Disease Models, Animal ; Ethanol/toxicity ; Food Ingredients ; Humans ; Longevity/drug effects ; Proof of Concept Study
    Chemical Substances Food Ingredients ; Ethanol (3K9958V90M) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98614-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cytosine modifications in the honey bee (Apis mellifera) worker genome.

    Rasmussen, Erik M K / Amdam, Gro V

    Frontiers in genetics

    2015  Volume 6, Page(s) 8

    Abstract: Epigenetic changes enable genomes to respond to changes in the environment, such as altered nutrition, activity, or social setting. Epigenetic modifications, thereby, provide a source of phenotypic plasticity in many species. The honey bee (Apis ... ...

    Abstract Epigenetic changes enable genomes to respond to changes in the environment, such as altered nutrition, activity, or social setting. Epigenetic modifications, thereby, provide a source of phenotypic plasticity in many species. The honey bee (Apis mellifera) uses nutritionally sensitive epigenetic control mechanisms in the development of the royal caste (queens) and the workers. The workers are functionally sterile females that can take on a range of distinct physiological and/or behavioral phenotypes in response to environmental changes. Honey bees have a wide repertoire of epigenetic mechanisms which, as in mammals, include cytosine methylation, hydroxymethylated cytosines, together with the enzymatic machinery responsible for these cytosine modifications. Current data suggests that honey bees provide an excellent system for studying the "social repertoire" of the epigenome. In this review, we elucidate what is known so far about the honey bee epigenome and its mechanisms. Our discussion includes what may distinguish honey bees from other model animals, how the epigenome can influence worker behavioral task separation, and how future studies can answer central questions about the role of the epigenome in social behavior.
    Language English
    Publishing date 2015-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2015.00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Single-cell m

    Li, Yanjiao / Wang, Yunhao / Vera-Rodriguez, Maria / Lindeman, Leif Christopher / Skuggen, Linda Ellevog / Rasmussen, Erik M K / Jermstad, Ingunn / Khan, Shaista / Fosslie, Madeleine / Skuland, Trine / Indahl, Marie / Khodeer, Sherif / Klemsdal, Eva Kristine / Jin, Kang-Xuan / Dalen, Knut Tomas / Fedorcsak, Peter / Greggains, Gareth D / Lerdrup, Mads / Klungland, Arne /
    Au, Kin Fai / Dahl, John Arne

    Nature biotechnology

    2023  Volume 42, Issue 4, Page(s) 591–596

    Abstract: ... Current ... ...

    Abstract Current N
    MeSH term(s) Animals ; Mice ; Zebrafish/genetics ; Zebrafish/metabolism ; RNA/genetics ; RNA, Messenger/genetics ; Embryonic Stem Cells ; Cells, Cultured
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-01831-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  4. Article: DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.

    Rasmussen, Erik M K / Vågbø, Cathrine B / Münch, Daniel / Krokan, Hans E / Klungland, Arne / Amdam, Gro V / Dahl, John Arne

    Biochemistry and biophysics reports

    2016  Volume 6, Page(s) 9–15

    Abstract: Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, the abundance and the functional ...

    Abstract Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, the abundance and the functional implications of these modifications in invertebrate model organisms such as the honey bee (
    Language English
    Publishing date 2016-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2016.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Obtaining specimens with slowed, accelerated and reversed aging in the honey bee model.

    Münch, Daniel / Baker, Nicholas / Rasmussen, Erik M K / Shah, Ashish K / Kreibich, Claus D / Heidem, Lars E / Amdam, Gro V

    Journal of visualized experiments : JoVE

    2013  , Issue 78

    Abstract: Societies of highly social animals feature vast lifespan differences between closely related individuals. Among social insects, the honey bee is the best established model to study how plasticity in lifespan and aging is explained by social factors. The ... ...

    Abstract Societies of highly social animals feature vast lifespan differences between closely related individuals. Among social insects, the honey bee is the best established model to study how plasticity in lifespan and aging is explained by social factors. The worker caste of honey bees includes nurse bees, which tend the brood, and forager bees, which collect nectar and pollen. Previous work has shown that brain functions and flight performance senesce more rapidly in foragers than in nurses. However, brain functions can recover, when foragers revert back to nursing tasks. Such patterns of accelerated and reversed functional senescence are linked to changed metabolic resource levels, to alterations in protein abundance and to immune function. Vitellogenin, a yolk protein with adapted functions in hormonal control and cellular defense, may serve as a major regulatory element in a network that controls the different aging dynamics in workers. Here we describe how the emergence of nurses and foragers can be monitored, and manipulated, including the reversal from typically short-lived foragers into longer-lived nurses. Our representative results show how individuals with similar chronological age differentiate into foragers and nurse bees under experimental conditions. We exemplify how behavioral reversal from foragers back to nurses can be validated. Last, we show how different cellular senescence can be assessed by measuring the accumulation of lipofuscin, a universal biomarker of senescence. For studying mechanisms that may link social influences and aging plasticity, this protocol provides a standardized tool set to acquire relevant sample material, and to improve data comparability among future studies.
    MeSH term(s) Aging/physiology ; Animals ; Bees/cytology ; Bees/metabolism ; Bees/physiology ; Cellular Senescence/physiology ; Lipofuscin/metabolism ; Models, Animal ; Neuronal Plasticity ; Social Behavior
    Chemical Substances Lipofuscin
    Language English
    Publishing date 2013-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/50550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Obtaining specimens with slowed, accelerated and reversed aging in the honey bee model

    Münch, Daniel / Baker, Nicholas / Rasmussen, Erik M.K / Shah, Ashish K / Kreibich, Claus D / Heidem, Lars E / Amdam, Gro V

    Journal of visualized experiments. 2013 Aug. 29, , no. 78

    2013  

    Abstract: Societies of highly social animals feature vast lifespan differences between closely related individuals. Among social insects, the honey bee is the best established model to study how plasticity in lifespan and aging is explained by social factors. The ... ...

    Abstract Societies of highly social animals feature vast lifespan differences between closely related individuals. Among social insects, the honey bee is the best established model to study how plasticity in lifespan and aging is explained by social factors. The worker caste of honey bees includes nurse bees, which tend the brood, and forager bees, which collect nectar and pollen. Previous work has shown that brain functions and flight performance senesce more rapidly in foragers than in nurses. However, brain functions can recover, when foragers revert back to nursing tasks. Such patterns of accelerated and reversed functional senescence are linked to changed metabolic resource levels, to alterations in protein abundance and to immune function. Vitellogenin, a yolk protein with adapted functions in hormonal control and cellular defense, may serve as a major regulatory element in a network that controls the different aging dynamics in workers. Here we describe how the emergence of nurses and foragers can be monitored, and manipulated, including the reversal from typically short-lived foragers into longer-lived nurses. Our representative results show how individuals with similar chronological age differentiate into foragers and nurse bees under experimental conditions. We exemplify how behavioral reversal from foragers back to nurses can be validated. Last, we show how different cellular senescence can be assessed by measuring the accumulation of lipofuscin, a universal biomarker of senescence. For studying mechanisms that may link social influences and aging plasticity, this protocol provides a standardized tool set to acquire relevant sample material, and to improve data comparability among future studies.
    Keywords animals ; biomarkers ; brain ; cell senescence ; flight ; hormonal regulation ; immune response ; longevity ; models ; nectar ; nurses ; pollen ; social factors ; social insects ; vitellogenin ; worker honey bees
    Language English
    Dates of publication 2013-0829
    Size p. e50550.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/50550
    Database NAL-Catalogue (AGRICOLA)

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