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  1. Book ; Online: Handbook of research on competency-based education in university settings

    Colson, Robin / Northrup, Pamela Taylor / Rasmussen, Karen

    2017  

    Abstract: This book is a pivotal reference source for the latest academic research on the use of competency-based testing in higher education institutions, focusing on innovative practices, strategies, and real-world scenarios"--Provided by publisher ... Competency- ...

    Institution IGI Global
    Author's details Karen Rasmussen, Pamela Northrup, and Robin Colson, editors
    Abstract "This book is a pivotal reference source for the latest academic research on the use of competency-based testing in higher education institutions, focusing on innovative practices, strategies, and real-world scenarios"--Provided by publisher

    Competency-based education in higher education / Christine K. Sorensen Irvine, Jonathan M. Kevan -- Building competence: a historical perspective of competency-based education / Kristin A Jones, Steven G Olswang -- Challenges and opportunities in the currency of higher education / Deborah Everhart, Deborah M. Seymour -- People, processes, and philosophies: designing a CBE program within a traditional university / Tammi Cooper -- The challenge of CBE programs: administrative and technological considerations of non-semester-based programs / Julie Uranis, Tanja Bibbs -- Academic technology for competency-based education in higher education / Jonathan M. Kevan, Christine K. Sorensen Irvine -- The next-generation CBE architecture: a learning-centric standards-based approach / Jon Mott [and 4 others] -- Using communities of practice to identify competencies / Mambo G. Mupepi -- A framework for the design of online competency-based education to promote student engagement / Robin Colson, Atsusi Hirumi -- A return to doing: how authentic assessment changes higher education / Karen M. Mattison [and 3 others] -- Learning, adults, and competency-based education / Michelle Navarre Cleary [and 5 others] -- Designing and developing competency-based education courses using standards / Nancy B. Hastings, Karen L. Rasmussen -- A framework for the evaluation of competency-based curriculum / Devrim Ozdemir, Carla Stebbins --

    Measuring what matters: the UW flexible option's framework to measure success from the student vantage point / Aaron Brower [and 4 others] -- Child development associate (CDA) credential: a competency-based framework for workforce development / Valora Washington, Brandi N. King -- Polk State College's engineering technology OEEE associate's degree / Naomi Boyer [and 5 others] -- FLEX path: Capella University's innovative pathway to a degree / Kimberly Pearce, Brian Worden -- A systematic review of competency-based education effort in the health professions: seeking order out of chaos / Wenxia Wu, Brian C. Martin, Chen Ni -- Western Governors University: CBE innovator and national model / Robert Mendenhall
    Keywords Education, Higher ; Educational tests and measurements
    Language English
    Size 1 Online-Ressource (PDFs (453 pages)), illustrations
    Publisher IGI Global
    Publishing place Hershey, Pennsylvania (701 E. Chocolate Avenue, Hershey, PA 17033, USA)
    Document type Book ; Online
    Note Includes bibliographical references and index ; Restricted to subscribers or individual electronic text purchasers
    ISBN 1522509321 ; 9781522509325 ; 9781522509332 ; 152250933X
    Database ECONomics Information System

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  2. Article: Airborne Cladosporium and Alternaria spore concentrations through 26 years in Copenhagen, Denmark

    Olsen, Yulia / Skjøth, Carsten Ambelas / Hertel, Ole / Rasmussen, Karen / Sigsgaard, Torben / Gosewinkel, Ulrich

    Aerobiologia. 2020 June, v. 36, no. 2

    2020  

    Abstract: Cladosporium spp. and Alternaria spp. spores are dominating the airspora of Denmark. Currently, little is known about the influence of climate change on the fungal spore abundance in the air. The aim of this study was to examine temporal changes in ... ...

    Abstract Cladosporium spp. and Alternaria spp. spores are dominating the airspora of Denmark. Currently, little is known about the influence of climate change on the fungal spore abundance in the air. The aim of this study was to examine temporal changes in airborne Alternaria and Cladosporium spores over 26 years. This is the first report of long-term airborne Cladosporium spore occurrence in Denmark. Air spore concentrations were obtained with a Burkard volumetric spore sampler placed in Copenhagen, Denmark, during June–September, 1990–2015. The highest monthly Spore integrals (SIn) for Alternaria were measured in August, whereas for Cladosporium July SIn was nearly as high as August SIn. Average Alternaria seasonal spore integral (SSIn) was 8615 Spores day m⁻³, while average 3-month (July–September) Cladosporium SIn was 375,533 Spores day m⁻³. Despite increasing annual temperature and decreasing relative humidity, we found a decreasing trend for Alternaria seasonal SIn (Slope = − 277, R² = 0.38, p < 0.05), Alternaria (Slope = − 31, R² = 0.27, p < 0.05) and Cladosporium (Slope = − 440, R² = 0.23, p < 0.05) annual peak concentrations. We did not find any statistically significant trends for airborne Alternaria seasonal characteristics and duration, and likewise for Cladosporium 3-month SIn and peak concentration dates. Mean temperature was the main meteorological factor affecting daily spore concentrations. However, effect of meteorological parameters on daily spore concentrations was stronger for Cladosporium (R² = 0.41) than for Alternaria (R² = 0.21). Both genera had diurnal peaks during the day hours, earlier for Cladosporium (11:30–14:30) and later for Alternaria (15:00–19:00). Although Alternaria and Cladosporium daily concentrations were moderately correlated (Spearman’s correlation coefficient: rₛ = 0.55, p < 0.05), their overall annual indices were different, which indicates different sources and different factors determining spore release. We explain temporal decreasing trends in Alternaria SSIn by growing urbanisation around Copenhagen and by changes in agricultural practices.
    Keywords Alternaria ; Cladosporium ; air ; climate change ; fungal spores ; relative humidity ; temperature ; urbanization ; Denmark
    Language English
    Dates of publication 2020-06
    Size p. 141-157.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1499126-3
    ISSN 1573-3025 ; 0393-5965
    ISSN (online) 1573-3025
    ISSN 0393-5965
    DOI 10.1007/s10453-019-09618-7
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Climate-change-induced range shifts of three allergenic ragweeds (

    Rasmussen, Karen / Thyrring, Jakob / Muscarella, Robert / Borchsenius, Finn

    PeerJ

    2017  Volume 5, Page(s) e3104

    Abstract: Invasive allergenic plant species may have severe health-related impacts. In this study we aim to predict the effects of climate change on the distribution of three allergenic ragweed species ( ...

    Abstract Invasive allergenic plant species may have severe health-related impacts. In this study we aim to predict the effects of climate change on the distribution of three allergenic ragweed species (
    Language English
    Publishing date 2017-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.3104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association of patient navigation with care coordination in an Lynch syndrome screening program.

    Miesfeldt, Susan / Feero, W Gregory / Lucas, Frances L / Rasmussen, Karen

    Translational behavioral medicine

    2018  Volume 8, Issue 3, Page(s) 450–455

    Abstract: Lynch syndrome (LS) identification leads to improved health outcomes. Universal tumor screening (UTS) facilitates LS identification among colorectal cancer (CRC) and uterine cancer (UC) cases; institutional management affects screening program ... ...

    Abstract Lynch syndrome (LS) identification leads to improved health outcomes. Universal tumor screening (UTS) facilitates LS identification among colorectal cancer (CRC) and uterine cancer (UC) cases; institutional management affects screening program implementation and outcomes. There has been limited study of institutional UTS program care coordination needs, including patient navigation of genetic counseling referrals. We examined the influence of patient navigators on access to cancer genetic services among LS UTS screen-positive cases within a single institution. Electronic health record review of screen-positive CRC and UC cases for a 12-month period assessed the relationship between patient navigation and follow-through to genetic services. Among 451 newly diagnosed CRC (n = 175) and UC (n = 276) cases, 96 (21%; 28 CRC/68 UC cases) had abnormal UTS results. Among these, 66 (69%) showed MLH1 promoter hypermethylation (i.e., screen-negative). Of 30 screen-positive cases, 16 (53%) received navigation services. Among these, 14/16 (88%) and 13/14 (81%) underwent genetic counseling and testing, respectively; 7/13 (54%) had pathogenic or likely pathogenic variants detected. Among non-navigated screen-positive patients, 2/14 (14%) were excluded due to incomplete UTS results. Five of the remaining 12 cases (42%) sought genetic counseling, 4/12 (33%) underwent genetic testing; 1/4 (25%) tested positive for a pathogenic variant. The difference in navigated (88%) versus non-navigated cases (42%) undergoing genetic counseling was statistically significant (p = .02). Patient navigation was associated with follow-through to genetic counseling and testing services among LS screen-positive cases. This model deserves additional prospective investigation to confirm these findings and to assess their generalizability.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/therapy ; Early Detection of Cancer/methods ; Female ; Genetic Counseling ; Genetic Testing ; Humans ; Male ; Middle Aged ; Patient Navigation/methods ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/genetics ; Uterine Neoplasms/therapy
    Language English
    Publishing date 2018-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2586893-7
    ISSN 1613-9860 ; 1869-6716
    ISSN (online) 1613-9860
    ISSN 1869-6716
    DOI 10.1093/tbm/ibx078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Regional variation in airborne Alternaria spore concentrations in Denmark through 2012–2015 seasons: the influence of meteorology and grain harvesting

    Olsen, Yulia / Gosewinkel, Ulrich Bay / Hertel, Ole / Rasmussen, Karen / Sigsgaard, Torben / Skjøth, Carsten Ambelas

    Aerobiologia. 2019 Sept., v. 35, no. 3

    2019  

    Abstract: High airborne Alternaria spore concentrations measured in eastern Denmark have been associated with local agricultural sources. However, the density of agricultural areas is highest in western Denmark. This is the first report of airborne Alternaria ... ...

    Abstract High airborne Alternaria spore concentrations measured in eastern Denmark have been associated with local agricultural sources. However, the density of agricultural areas is highest in western Denmark. This is the first report of airborne Alternaria spore concentrations obtained with Burkard volumetric spore sampler in western Denmark, Viborg. We compared the concentrations of airborne Alternaria spores and the patterns of air mass transport using HYSPLIT model between Copenhagen and Viborg for the seasons 2012–2015, with the main focus on the days with daily average Alternaria spore concentrations ≥ 100 s m−3 (high concentration days). Except for 2012, Annual Spore Integrals (ASIns) were on average 3335 s day m−3 higher in Viborg than in Copenhagen. The high concentration days during 2012–2015 occurred more frequently and with higher values in Viborg (96 days; mean = 381 s m−3) than in Copenhagen (79 days; mean = 270 s m−3). We found increased shares of trajectories coming from South-East on the high concentration days and increased shares of trajectories coming from the West and North-West on the days with concentrations below 100 s m−3 for both stations. July and August had the highest spore integrals matching the periods of grain harvesting in Denmark. The absence of the concurrent grain harvesting in Denmark was associated with the lowest ASIns in 2012. The results of this study support the hypothesis that local sources cause the main load of airborne Alternaria spore concentrations in Denmark; however, the contribution from the remote source areas in northern Germany, Poland and southern Sweden remains unquantified.
    Keywords agricultural land ; air ; Alternaria ; mass transfer ; meteorology ; spores ; Denmark ; Germany ; Poland ; Sweden
    Language English
    Dates of publication 2019-09
    Size p. 533-551.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1499126-3
    ISSN 1573-3025 ; 0393-5965
    ISSN (online) 1573-3025
    ISSN 0393-5965
    DOI 10.1007/s10453-019-09587-x
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI).

    Anderson, Eric C / DiPalazzo, John / Lucas, F Lee / Hall, Michael J / Antov, Andrey / Helbig, Petra / Bourne, Jennifer / Graham, Leah / Gaitor, Lory / Lu-Emerson, Christine / Bradford, Leslie S / Inhorn, Roger / Sinclair, Sarah J / Brooks, Philip L / Thomas, Christian A / Rasmussen, Karen / Han, Paul K J / Liu, Edison T / Rueter, Jens

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 67

    Abstract: Genomic tumor testing (GTT) is an emerging technology aimed at identifying variants in tumors that can be targeted with genomically matched drugs. Due to limited resources, rural patients receiving care in community oncology settings may be less likely ... ...

    Abstract Genomic tumor testing (GTT) is an emerging technology aimed at identifying variants in tumors that can be targeted with genomically matched drugs. Due to limited resources, rural patients receiving care in community oncology settings may be less likely to benefit from GTT. We analyzed GTT results and observational clinical outcomes data from patients enrolled in the Maine Cancer Genomics Initiative (MCGI), which provided access to GTTs; clinician educational resources; and genomic tumor boards in community practices in a predominantly rural state. 1603 adult cancer patients completed enrollment; 1258 had at least one potentially actionable variant identified. 206 (16.4%) patients received a total of 240 genome matched treatments, of those treatments, 64% were FDA-approved in the tumor type, 27% FDA-approved in a different tumor type and 9% were given on a clinical trial. Using Inverse Probability of Treatment Weighting to adjust for baseline characteristics, a Cox proportional hazards model demonstrated that patients who received genome matched treatment were 31% less likely to die within 1 year compared to those who did not receive genome matched treatment (HR: 0.69; 95% CI: 0.52-0.90; p-value: 0.006). Overall, GTT through this initiative resulted in levels of genome matched treatment that were similar to other initiatives, however, clinical trials represented a smaller share of treatments than previously reported, and "off-label" treatments represented a greater share. Although this was an observational study, we found evidence for a potential 1-year survival benefit for patients who received genome matched treatments. These findings suggest that when disseminated and implemented with a supportive infrastructure, GTT may benefit cancer patients in rural community oncology settings, with further work remaining on providing genome-matched clinical trials.
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00547-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hunting for the elusive target antigen in gestational alloimmune liver disease (GALD).

    Rieneck, Klaus / Rasmussen, Karen Koefoed / Schoof, Erwin M / Clausen, Frederik Banch / Holze, Henrietta / Bergholt, Thomas / Jørgensen, Marianne Hørby / Christensen, Vibeke Brix / Almaas, Runar / Jordal, Peter Lüttge / Locard-Paulet, Marie / Runager, Kasper / Nielsen, Leif Kofoed / Schlotmann, Balthasar Clemens / Weischenfeldt, Joachim Lütken / Jensen, Lars Juhl / Dziegiel, Morten Hanefeld

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0286432

    Abstract: The prevailing concept is that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting a currently unknown antigen on the liver of the fetus. This leads to deposition of complement on the fetal hepatocytes and death of the ... ...

    Abstract The prevailing concept is that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting a currently unknown antigen on the liver of the fetus. This leads to deposition of complement on the fetal hepatocytes and death of the fetal hepatocytes and extensive liver injury. In many cases, the newborn dies. In subsequent pregnancies early treatment of the woman with intravenous immunoglobulin can be instituted, and the prognosis for the fetus will be excellent. Without treatment the prognosis can be severe. Crucial improvements of diagnosis require identification of the target antigen. For this identification, this work was based on two hypotheses: 1. The GALD antigen is exclusively expressed in the fetal liver during normal fetal life in all pregnancies; 2. The GALD antigen is an alloantigen expressed in the fetal liver with the woman being homozygous for the minor allele and the father being, most frequently, homozygous for the major allele. We used three different experimental approaches to identify the liver target antigen of maternal antibodies from women who had given birth to a baby with the clinical GALD diagnosis: 1. Immunoprecipitation of antigens from either a human liver cell line or human fetal livers by immunoprecipitation with maternal antibodies followed by mass spectrometry analysis of captured antigens; 2. Construction of a cDNA expression library from human fetal liver mRNA and screening about 1.3 million recombinants in Escherichia coli using antibodies from mothers of babies diagnosed with GALD; 3. Exome/genome sequencing of DNA from 26 presumably unrelated women who had previously given birth to a child with GALD with husband controls and supplementary HLA typing. In conclusion, using the three experimental approaches we did not identify the GALD target antigen and the exome/genome sequencing results did not support the hypothesis that the GALD antigen is an alloantigen, but the results do not yield basis for excluding that the antigen is exclusively expressed during fetal life., which is the hypothesis we favor.
    MeSH term(s) Child ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Digestive System Diseases ; Fetal Diseases ; Hemochromatosis/diagnosis ; Infant, Newborn, Diseases ; Isoantigens ; Liver Diseases/drug therapy ; Thrombocytopenia, Neonatal Alloimmune
    Chemical Substances Isoantigens
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sport concussion assessment in New Zealand high school rugby players: a collaborative approach to the challenges faced in primary care.

    Salmon, Danielle M / Chua, Jason / Sullivan, S John / Whatman, Chris / Brown, James / Register-Mihalik, Johna / Murphy, Ian / Walters, Simon / Clacy, Amanda / Sole, Gisela / Kerr, Zachary Y / Rasmussen, Karen / England, Mike

    Brain injury

    2022  Volume 36, Issue 2, Page(s) 258–270

    Abstract: Primary objective: To describe the collaborative development of a New Zealand Rugby Concussion Assessment (NZRCA) for primary care and to provide normative baseline data from a representative group of high school rugby players.: Methods: This study, ... ...

    Abstract Primary objective: To describe the collaborative development of a New Zealand Rugby Concussion Assessment (NZRCA) for primary care and to provide normative baseline data from a representative group of high school rugby players.
    Methods: This study, conducted over the 2018 and 2019 community rugby season where players were baseline tested during the pre- or start of season period.
    Results: Data were collected from 1428 players (males n = 1121, females n = 307) with a mean age of 15.9 ± 1.4 years. The mean ± SD symptom severity score was 11.3 ± 8.6, the mean number of endorsed symptoms was 8.5 ± 5.3 and the percentage feeling "normal" was 80.2 ± 15.3%. Only 5.3% of players reported no symptoms at baseline. The most common reported were: 'distracted easily' (72.5%), 'forgetful' (68.5%), and 'often tired' (62.6%). None of the participants achieved a perfect score for the SAC50. The majority of participants (89.7%) passed the tandem gait test with a time of 12.2 ± 1.7 seconds. Age, gender, and ethnicity were associated with NZRCA performance; albeit weakly.
    Conclusion: This study provides normative reference values for high-school rugby players. These data will aid healthcare providers in their identification of suspected concussion in the absence of individualized baselines.
    MeSH term(s) Adolescent ; Athletic Injuries/diagnosis ; Brain Concussion/diagnosis ; Female ; Football ; Humans ; Male ; Neuropsychological Tests ; New Zealand/epidemiology ; Primary Health Care ; Rugby ; Schools
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2022.2033839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Grain harvesting as a local source of Cladosporium spp. in Denmark

    Olsen, Yulia / Begovic, Tanja / Skjøth, Carsten Ambelas / Rasmussen, Karen / Gosewinkel, Ulrich / Hertel, Ole / Sigsgaard, Torben

    Aerobiologia. 2019 June, v. 35, no. 2

    2019  

    Abstract: Cladosporium spp. are omnipresent moulds that grow on multiple substrates. Their spores possess a high allergenic potential. Currently, little is known about the incidence and the sources of airborne Cladosporium spores in Denmark. Air samples were ... ...

    Abstract Cladosporium spp. are omnipresent moulds that grow on multiple substrates. Their spores possess a high allergenic potential. Currently, little is known about the incidence and the sources of airborne Cladosporium spores in Denmark. Air samples were collected between 31 May and 22 September 2015 in Viborg (Jutland, western Denmark). Eighteen out of 21 days with daily average concentrations exceeding the health-relevant threshold of 3000 Spores m−3, including the day with peak daily (13,553 Spores m−3) and 3-h concentrations (35,662 Spores m−3), occurred in August. The air masses that approached Viborg during the longest episode of elevated spore concentrations originated from northern Poland, the Baltics, passing over southern Sweden and the eastern Danish island of Zealand. The Cladosporium spore concentrations from Viborg were compared with the Cladosporium spore concentrations from the operational monitoring station in Copenhagen (Zealand, eastern Denmark). During the episode, concentrations in Viborg were on average 2268 spores m−3 higher than in Copenhagen. On the peak day between 8:00 and 15:00, concentrations in Viborg were 4–7 times higher than in Copenhagen, which we associated with grain crop harvesting in eastern Jutland. Elevated day time concentrations in Viborg on the days with daily average concentrations exceeding the threshold also indicate the local character of the sources.
    Keywords Cladosporium ; air ; allergenicity ; harvesting ; monitoring ; spores ; Baltic States ; Denmark ; Poland ; Sweden
    Language English
    Dates of publication 2019-06
    Size p. 373-378.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1499126-3
    ISSN 1573-3025 ; 0393-5965
    ISSN (online) 1573-3025
    ISSN 0393-5965
    DOI 10.1007/s10453-018-09556-w
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The Maine Cancer Genomics Initiative: Implementing a Community Cancer Genomics Program Across an Entire Rural State.

    Rueter, Jens / Anderson, Eric C / Graham, Leah C / Antov, Andrey / Helbig, Petra / Gaitor, Lory / Bourne, Jennifer / Edelman, Emily / Reed, E Kate / Reddi, Honey V / Mockus, Susan / DiPalazzo, John / Lu-Emerson, Christine / Inhorn, Roger / Sinclair, Sarah J / Thomas, Christian A / Brooks, Philip L / Rasmussen, Karen / Han, Paul /
    Liu, Edison T

    JCO precision oncology

    2023  Volume 7, Page(s) e2200619

    Abstract: Purpose: The Maine Cancer Genomics Initiative (MCGI) aimed to overcome patient- and provider-level barriers to using genomic tumor testing (GTT) in rural practices by providing genomic tumor boards (GTBs), clinician education, and access to ... ...

    Abstract Purpose: The Maine Cancer Genomics Initiative (MCGI) aimed to overcome patient- and provider-level barriers to using genomic tumor testing (GTT) in rural practices by providing genomic tumor boards (GTBs), clinician education, and access to comprehensive large-panel next-generation sequencing to all patients with cancer in Maine. This paper describes the successful implementation of the initiative and three key services made operative between 2016 and 2020.
    Methods: A community-inclusive, hub-and-spoke approach was taken to implement the three program components: (1) a centralized GTB program; (2) a modular online education program, designed using an iterative approach with broad clinical stakeholders; and (3) GTT free of charge to clinicians and patients. Implementation timelines, participation metrics, and survey data were used to describe the rollout.
    Results: The MCGI was launched over an 18-month period at all 19 oncology practices in the State. Seventy-nine physicians (66 medical oncologists, 5 gynecologic oncologists, 1 neuro-oncologist, and 7 pediatric oncologists) enrolled on the study, representing 100% of all practicing oncologists in Maine. Between July 2017 and September 2020, 1610 patients were enrolled. A total of 515 cases were discussed by 47 (73%) clinicians in 196 GTBs. Clinicians who participated in the GTBs enrolled significantly more patients on the study, stayed in Maine, and reported less time spent in clinical patient care.
    Conclusion: The MCGI was able to engage geographically and culturally disparate cancer care practices in a precision oncology program using a hub-and-spoke model. By facilitating access to GTT, structured education, and GTBs, we narrowed the gap in the implementation of precision oncology in one of the most rural states in the country.
    MeSH term(s) Child ; Humans ; Female ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Maine ; Precision Medicine ; Medical Oncology ; Genomics
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.22.00619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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