Article ; Online: Management of Monogenic and Syndromic Obesity.
Gastroenterology clinics of North America
2023 Volume 52, Issue 4, Page(s) 733–750
Abstract: Similar to the general population, lifestyle interventions focused on nutrition and physical activity form the foundation for treating obesity caused by rare genetic disorders. Additional therapies, including metreleptin and setmelanotide, that target ... ...
| Abstract | Similar to the general population, lifestyle interventions focused on nutrition and physical activity form the foundation for treating obesity caused by rare genetic disorders. Additional therapies, including metreleptin and setmelanotide, that target defects within the leptin signaling pathway can effectively synergize with lifestyle efforts to treat monogenic disorders of leptin, leptin receptor, proopiomelanocortin (POMC), and proprotein convertase subtilisin/kexin type 1 (PCSK1) and syndromic conditions, such as the ciliopathies Bardet-Biedl and Alström syndromes, whose pathophysiological mechanisms also converge on the leptin pathway. Investigational treatments for Prader-Willi syndrome target specific defects caused by reduced expression of paternally derived genes within the chromosome 15q region. |
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| MeSH term(s) | Humans ; Leptin/genetics ; Obesity/genetics ; Obesity/therapy ; Obesity/metabolism ; Prader-Willi Syndrome/genetics ; Prader-Willi Syndrome/therapy | |||||
| Chemical Substances | Leptin | |||||
| Language | English | |||||
| Publishing date | 2023-09-27 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 92114-2 | |||||
| ISSN | 1558-1942 ; 0889-8553 | |||||
| ISSN (online) | 1558-1942 | |||||
| ISSN | 0889-8553 | |||||
| DOI | 10.1016/j.gtc.2023.08.005 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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