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  1. Article: Epigenetic Silencing of

    Rasmussen, Martin Q / Tindbæk, Gitte / Nielsen, Morten Muhlig / Merrild, Camilla / Steiniche, Torben / Pedersen, Jakob Skou / Moestrup, Søren K / Degn, Søren E / Madsen, Mette

    Cancers

    2023  Volume 15, Issue 6

    Abstract: More than 80% of human cancers originate in epithelial tissues. Loss of epithelial cell characteristics are hallmarks of tumor development. Receptor-mediated endocytosis is a key function of absorptive epithelial cells with importance for cellular and ... ...

    Abstract More than 80% of human cancers originate in epithelial tissues. Loss of epithelial cell characteristics are hallmarks of tumor development. Receptor-mediated endocytosis is a key function of absorptive epithelial cells with importance for cellular and organismal homeostasis. LRP2 (megalin) is the largest known endocytic membrane receptor and is essential for endocytosis of various ligands in specialized epithelia, including the proximal tubules of the kidney, the thyroid gland, and breast glandular epithelium. However, the role and regulation of LRP2 in cancers that arise from these tissues has not been delineated. Here, we examined the expression of
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.

    Revach, Or-Yam / Cicerchia, Angelina M / Shorer, Ofir / Petrova, Boryana / Anderson, Seth / Park, Joshua / Chen, Lee / Mehta, Arnav / Wright, Samuel J / McNamee, Niamh / Tal-Mason, Aya / Cattaneo, Giulia / Tiwari, Payal / Xie, Hongyan / Sweere, Johanna M / Cheng, Li-Chun / Sigal, Natalia / Enrico, Elizabeth / Miljkovic, Marisa /
    Evans, Shane A / Nguyen, Ngan / Whidden, Mark E / Srinivasan, Ramji / Spitzer, Matthew H / Sun, Yi / Sharova, Tatyana / Lawless, Aleigha R / Michaud, William A / Rasmussen, Martin Q / Fang, Jacy / Palin, Claire A / Chen, Feng / Wang, Xinhui / Ferrone, Cristina R / Lawrence, Donald P / Sullivan, Ryan J / Liu, David / Sachdeva, Uma M / Sen, Debattama R / Flaherty, Keith T / Manguso, Robert T / Bod, Lloyd / Kellis, Manolis / Boland, Genevieve M / Yizhak, Keren / Yang, Jiekun / Kanarek, Naama / Sade-Feldman, Moshe / Hacohen, Nir / Jenkins, Russell W

    bioRxiv : the preprint server for biology

    2024  

    Abstract: A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the development of resistance, which affects 50% of patients with metastatic ... ...

    Abstract A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the development of resistance, which affects 50% of patients with metastatic melanoma
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.12.579184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

    Takahashi, Mariko / Chong, Harrison B / Zhang, Siwen / Yang, Tzu-Yi / Lazarov, Matthew J / Harry, Stefan / Maynard, Michelle / Hilbert, Brendan / White, Ryan D / Murrey, Heather E / Tsou, Chih-Chiang / Vordermark, Kira / Assaad, Jonathan / Gohar, Magdy / Dürr, Benedikt R / Richter, Marianne / Patel, Himani / Kryukov, Gregory / Brooijmans, Natasja /
    Alghali, Aliyu Sidi Omar / Rubio, Karla / Villanueva, Antonio / Zhang, Junbing / Ge, Maolin / Makram, Farah / Griesshaber, Hanna / Harrison, Drew / Koglin, Ann-Sophie / Ojeda, Samuel / Karakyriakou, Barbara / Healy, Alexander / Popoola, George / Rachmin, Inbal / Khandelwal, Neha / Neil, Jason R / Tien, Pei-Chieh / Chen, Nicholas / Hosp, Tobias / van den Ouweland, Sanne / Hara, Toshiro / Bussema, Lillian / Dong, Rui / Shi, Lei / Rasmussen, Martin Q / Domingues, Ana Carolina / Lawless, Aleigha / Fang, Jacy / Yoda, Satoshi / Nguyen, Linh Phuong / Reeves, Sarah Marie / Wakefield, Farrah Nicole / Acker, Adam / Clark, Sarah Elizabeth / Dubash, Taronish / Kastanos, John / Oh, Eugene / Fisher, David E / Maheswaran, Shyamala / Haber, Daniel A / Boland, Genevieve M / Sade-Feldman, Moshe / Jenkins, Russell W / Hata, Aaron N / Bardeesy, Nabeel M / Suvà, Mario L / Martin, Brent R / Liau, Brian B / Ott, Christopher J / Rivera, Miguel N / Lawrence, Michael S / Bar-Peled, Liron

    Cell

    2024  

    Abstract: Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this ... ...

    Abstract Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed "DrugMap," an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability varies across cancer cell lines, and we attribute this to differences in cellular redox states, protein conformational changes, and genetic mutations. Leveraging these findings, we identify actionable cysteines in NF-κB1 and SOX10 and develop corresponding covalent ligands that block the activity of these transcription factors. We demonstrate that the NF-κB1 probe blocks DNA binding, whereas the SOX10 ligand increases SOX10-SOX10 interactions and disrupts melanoma transcriptional signaling. Our findings reveal heterogeneity in cysteine ligandability across cancers, pinpoint cell-intrinsic features driving cysteine targeting, and illustrate the use of covalent probes to disrupt oncogenic transcription-factor activity.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.03.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  4. Article ; Online: Targeting TBK1 to overcome resistance to cancer immunotherapy.

    Sun, Yi / Revach, Or-Yam / Anderson, Seth / Kessler, Emily A / Wolfe, Clara H / Jenney, Anne / Mills, Caitlin E / Robitschek, Emily J / Davis, Thomas G R / Kim, Sarah / Fu, Amina / Ma, Xiang / Gwee, Jia / Tiwari, Payal / Du, Peter P / Sindurakar, Princy / Tian, Jun / Mehta, Arnav / Schneider, Alexis M /
    Yizhak, Keren / Sade-Feldman, Moshe / LaSalle, Thomas / Sharova, Tatyana / Xie, Hongyan / Liu, Shuming / Michaud, William A / Saad-Beretta, Rodrigo / Yates, Kathleen B / Iracheta-Vellve, Arvin / Spetz, Johan K E / Qin, Xingping / Sarosiek, Kristopher A / Zhang, Gao / Kim, Jong Wook / Su, Mack Y / Cicerchia, Angelina M / Rasmussen, Martin Q / Klempner, Samuel J / Juric, Dejan / Pai, Sara I / Miller, David M / Giobbie-Hurder, Anita / Chen, Jonathan H / Pelka, Karin / Frederick, Dennie T / Stinson, Susanna / Ivanova, Elena / Aref, Amir R / Paweletz, Cloud P / Barbie, David A / Sen, Debattama R / Fisher, David E / Corcoran, Ryan B / Hacohen, Nir / Sorger, Peter K / Flaherty, Keith T / Boland, Genevieve M / Manguso, Robert T / Jenkins, Russell W

    Nature

    2023  Volume 615, Issue 7950, Page(s) 158–167

    Abstract: Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are ... ...

    Abstract Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking
    MeSH term(s) Humans ; Immune Evasion/genetics ; Immune Evasion/immunology ; Immunotherapy/methods ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/genetics ; Organoids ; Drug Resistance, Neoplasm ; Tumor Necrosis Factors/immunology ; Interferon-gamma/immunology ; Spheroids, Cellular ; Caspases ; Janus Kinases ; STAT Transcription Factors
    Chemical Substances Programmed Cell Death 1 Receptor ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; PDCD1 protein, human ; Tumor Necrosis Factors ; Interferon-gamma (82115-62-6) ; Caspases (EC 3.4.22.-) ; Janus Kinases (EC 2.7.10.2) ; STAT Transcription Factors
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05704-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

    Takahashi, Mariko / Chong, Harrison B / Zhang, Siwen / Lazarov, Matthew J / Harry, Stefan / Maynard, Michelle / White, Ryan / Murrey, Heather E / Hilbert, Brendan / Neil, Jason R / Gohar, Magdy / Ge, Maolin / Zhang, Junbing / Durr, Benedikt R / Kryukov, Gregory / Tsou, Chih-Chiang / Brooijmans, Natasja / Alghali, Aliyu Sidi Omar / Rubio, Karla /
    Vilanueva, Antonio / Harrison, Drew / Koglin, Ann-Sophie / Ojeda, Samuel / Karakyriakou, Barbara / Healy, Alexander / Assaad, Jonathan / Makram, Farah / Rachman, Inbal / Khandelwal, Neha / Tien, Pei-Chieh / Popoola, George / Chen, Nicholas / Vordermark, Kira / Richter, Marianne / Patel, Himani / Yang, Tzu-Yi / Griesshaber, Hanna / Hosp, Tobias / van den Ouweland, Sanne / Hara, Toshiro / Bussema, Lily / Dong, Rui / Shi, Lei / Rasmussen, Martin Q / Domingues, Ana Carolina / Lawless, Aleigha / Fang, Jacy / Yoda, Satoshi / Nguyen, Linh Phuong / Reeves, Sarah Marie / Wakefield, Farrah Nicole / Acker, Adam / Clark, Sarah Elizabeth / Dubash, Taronish / Fisher, David E / Maheswaran, Shyamala / Haber, Daniel A / Boland, Genevieve / Sade-Feldman, Moshe / Jenkins, Russel / Hata, Aaron / Bardeesy, Nabeel / Suva, Mario L / Martin, Brent / Liau, Brian / Ott, Christopher / Rivera, Miguel N / Lawrence, Michael S / Bar-Peled, Liron

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this ... ...

    Abstract Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.20.563287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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