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Article ; Online: The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis.

Abbas-Hashemi, Seyed Ali / Hosseininasab, Dorsa / Rastgoo, Samira / Shiraseb, Farideh / Asbaghi, Omid

Clinical nutrition ESPEN

2023 Volume 58, Page(s) 165–177

Abstract: Background and aims: Hypertension is a serious complication linked to a higher risk for organs. Caffeine is a natural component that affects the cardiovascular system, while the mechanisms of its effects are not fully established. Therefore, we aimed to ...

Abstract	Background and aims: Hypertension is a serious complication linked to a higher risk for organs. Caffeine is a natural component that affects the cardiovascular system, while the mechanisms of its effects are not fully established. Therefore, we aimed to examine the impact of caffeine supplementation on blood pressure (BP) by conducting a systematic review and dose-response meta-analysis of randomized controlled clinical trials (RCTs). Methods and results: We searched online databases using relevant keywords up to July 2022 to identify RCTs using caffeine on systolic (SBP) and diastolic BP (DBP) in adults. Inclusion criteria were adult participants ≥18 years old for subjects, examining the effect of caffeine supplementation on BP, and RCTs studies. A random-effects model was used to estimate the weighted mean difference (WMD) and 95% confidence (CI). The pooled of 11 effect sizes analysis of 8 studies demonstrated significant increases in SBP (WMD:1.94 mmHg; 95%CI:0.52, 3.35; p = 0.007) and DBP (WMD:1.66 mmHg; 95% CI:0.75, 2.57; p = 0.000) after caffeine supplementation. The subgroup analysis showed that caffeine supplementation more effectively increased SBP and DBP in males than females. Moreover, meta-regression analysis demonstrated a significant relationship between the dose of caffeine intake and changes in SBP (p = 0.000), DBP (p = 0.000), and duration of the trial in SBP (p = 0.005), and DBP (p = 0.001). The non-linear dose-response analysis detected the dosage of supplementation >400 mg/day is effective for increasing DBP (p = 0.034), and the duration of supplementation of more than nine weeks makes increasing in both SBP and DBP. Conclusion: This meta-analysis shows that caffeine supplementation significantly increased SBP and DBP in adults.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Blood Pressure ; Caffeine/pharmacology ; Dietary Supplements ; Hypertension/drug therapy
Chemical Substances	Caffeine (3G6A5W338E)
Language	English
Publishing date	2023-09-30
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.09.923
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Article: The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis.

Zamani, Mohammad / Pahlavani, Naseh / Nikbaf-Shandiz, Mahlagha / Rasaei, Niloufar / Ghaffarian-Ensaf, Rasool / Asbaghi, Omid / Shiraseb, Farideh / Rastgoo, Samira

Frontiers in nutrition

2023 Volume 9, Page(s) 1082097

Abstract: Background and aims: Hyperglycemia and insulin resistance are concerns today worldwide. Recently, L-carnitine supplementation has been suggested as an effective adjunctive therapy in glycemic control. Therefore, it seems important to investigate its ... ...

Abstract	Background and aims: Hyperglycemia and insulin resistance are concerns today worldwide. Recently, L-carnitine supplementation has been suggested as an effective adjunctive therapy in glycemic control. Therefore, it seems important to investigate its effect on glycemic markers. Methods: PubMed, Scopus, Web of Science, and the Cochrane databases were searched in October 2022 for prospective studies on the effects of L-carnitine supplementation on glycemic markers. Inclusion criteria included adult participants and taking oral L-carnitine supplements for at least seven days. The pooled weighted mean difference (WMD) was calculated using a random-effects model. Results: We included the 41 randomized controlled trials (RCTs) ( Conclusions: L-carnitine could reduce the levels of FBG, HbA1c, and HOMA-IR. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022358692.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1082097
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Article ; Online: The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials.

Yousefi, Mohsen / Fateh, Sahand Tehrani / Nikbaf-Shandiz, Mahlagha / Gholami, Fatemeh / Rastgoo, Samira / Bagher, Reza / Khadem, Alireza / Shiraseb, Farideh / Asbaghi, Omid

BMC pharmacology & toxicology

2023 Volume 24, Issue 1, Page(s) 65

Abstract: Purpose: Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for cardiovascular diseases (CVD). Several ...

Abstract	Purpose: Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for cardiovascular diseases (CVD). Several studies have shown the potential of acarbose in improving serum lipid markers. However, there have been conflicting results on the topic in adults. Therefore, a comprehensive systematic review and meta-analysis was conducted to assess the impact of acarbose on lipid profiles. Methods: The random-effects approach was used to combine the data, and the results were provided as weighted mean difference (WMD) with 95% confidence intervals (CI). Results: Our meta-analysis included a total of 74 studies with a combined sample size of 7046 participants. The results of the analysis showed that acarbose resulted in a reduction in levels of TG (WMD = - 13.43 mg/dl, 95% CI: - 19.20, - 7.67; P < 0.001) and TC (WMD = - 1.93 mg/dl, 95% CI: - 3.71, - 0.15; P = 0.033), but did not affect other lipid markers. When conducting a nonlinear dose-response analysis, we found that acarbose was associated with an increase in levels of HDL (coefficients = 0.50, P = 0.012), with the highest increase observed at a dosage of 400 mg/d. Furthermore, our findings suggested a non-linear relationship between the duration of the intervention and TC (coefficients = - 18.00, P = 0.032), with a decline observed after 50 weeks of treatment. Conclusion: The findings of this study suggest that acarbose can reduce serum levels of TG and TC. However, no significant effects were observed on LDL or HDL levels.
MeSH term(s)	Adult ; Humans ; Lipids ; Acarbose/pharmacology ; Acarbose/therapeutic use ; Randomized Controlled Trials as Topic ; Triglycerides ; Dyslipidemias ; Biomarkers ; Lipoproteins, HDL
Chemical Substances	Lipids ; Acarbose (T58MSI464G) ; Triglycerides ; Biomarkers ; Lipoproteins, HDL
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-023-00706-6
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Article ; Online: The effects of conjugated linoleic acid supplementation on inflammatory cytokines and adipokines in adults: A GRADE-assessed systematic review and dose-response meta-analysis.

Rastgoo, Samira / Shimi, Ghazaleh / Shiraseb, Farideh / Karbasi, Ashkan / Ashtary-Larky, Damoon / Yousefi, Mohsen / Golalipour, Elnaz / Asbaghi, Omid / Zamani, Mohammad

Frontiers in immunology

2023 Volume 14, Page(s) 1092077

Abstract: Background and aims: Many studies have investigated the effect of conjugated linoleic acid (CLA) supplementation on inflammatory cytokines and adipokines. However, the results of these studies are not consistent. Therefore, this systematic review and ... ...

Abstract	Background and aims: Many studies have investigated the effect of conjugated linoleic acid (CLA) supplementation on inflammatory cytokines and adipokines. However, the results of these studies are not consistent. Therefore, this systematic review and meta-analysis were designed to comprehensively evaluate the effect of CLA supplementation on inflammatory cytokines and adipokines. Methods: Randomized controlled trials (RCTs) examining the effects of CLA supplementation on C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin, published up to March 2022, were identified through PubMed, SCOPUS, and ISI Web of Science databases. A random-effects model was used to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI) for 42 studies that included 1,109 participants. Results: Findings from 42 studies with 58 arms indicated that CLA supplementation significantly decreased IL-6 and TNF-α levels and also slightly increased CRP levels. However, adiponectin and leptin levels did not change after CLA supplementation. A subgroup analysis found that CLA supplementation reduced adiponectin and leptin in women. Conclusion: Our results demonstrated that CLA supplementation increased CRP levels and decreased TNF-α and IL-6 levels. Therefore, it seems that CLA can have both proinflammatory and anti-inflammatory roles. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier (CRD42022331110).
MeSH term(s)	Female ; Humans ; Adult ; Cytokines ; Adipokines ; Leptin/metabolism ; Interleukin-6 ; Linoleic Acids, Conjugated/pharmacology ; Tumor Necrosis Factor-alpha ; Adiponectin/metabolism ; Dietary Supplements
Chemical Substances	Cytokines ; Adipokines ; Leptin ; Interleukin-6 ; Linoleic Acids, Conjugated ; Tumor Necrosis Factor-alpha ; Adiponectin
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1092077
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Article ; Online: The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis.

Rastgoo, Samira / Fateh, Sahand Tehrani / Nikbaf-Shandiz, Mahlagha / Rasaei, Niloufar / Aali, Yasaman / Zamani, Mohammad / Shiraseb, Farideh / Asbaghi, Omid

Inflammopharmacology

2023 Volume 31, Issue 5, Page(s) 2173–2199

Abstract: L-carnitine supplementation may be beneficial in improving inflammatory conditions and reducing the level of inflammatory cytokines. Therefore, according to the finding of randomized controlled trials (RCTs), the systematic review and meta-analysis aimed ...

Abstract	L-carnitine supplementation may be beneficial in improving inflammatory conditions and reducing the level of inflammatory cytokines. Therefore, according to the finding of randomized controlled trials (RCTs), the systematic review and meta-analysis aimed to investigate the effect of L-carnitine supplementation on inflammation in adults. To obtain acceptable articles up to October 2022, a thorough search was conducted in databases including PubMed, ISI Web of Science, the Cochrane Library, and Scopus. A random-effects model was used to estimate the weighted mean difference (WMD). We included the 48 RCTs (n = 3255) with 51 effect sizes in this study. L-carnitine supplementation had a significant effect on C-reactive protein (CRP) (p < 0.001), interleukin-6 (IL-6) (p = 0.001), tumor necrosis factor-α (TNF-α) (p = 0.002), malondialdehyde (MDA) (p = 0.001), total antioxidant capacity (TAC) (p = 0.029), alanine transaminase (ALT) (p < 0.001), and aspartate transaminase (AST) (p < 0.001) in intervention, compared to the placebo group. Subgroup analyses showed that L-carnitine supplementation had a lowering effect on CRP and TNF-α in trial duration ≥ 12 weeks in type 2 diabetes and BMI ≥ 25 kg/m
MeSH term(s)	Adult ; Humans ; Carnitine/pharmacology ; Carnitine/therapeutic use ; Dietary Supplements ; Interleukin-6/metabolism ; Tumor Necrosis Factor-alpha ; Overweight/drug therapy ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; C-Reactive Protein/analysis ; Antioxidants ; Biomarkers
Chemical Substances	Carnitine (S7UI8SM58A) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; C-Reactive Protein (9007-41-4) ; Antioxidants ; Biomarkers
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01323-9
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Article ; Online: The effects of folic acid supplementation on endothelial function in adults: a systematic review and dose-response meta-analysis of randomized controlled trials

Zamani, Mohammad / Rezaiian, Fatemeh / Saadati, Saeede / Naseri, Kaveh / Ashtary-Larky, Damoon / Yousefi, Mohsen / Golalipour, Elnaz / Clark, Cain C. T. / Rastgoo, Samira / Asbaghi, Omid

Nutr J. 2023 Dec., v. 22, no. 1 p.12-12

2023

Abstract: BACKGROUND: Endothelial dysfunction serves as an early marker for the risk of cardiovascular disease (CVD); therefore, it is an attractive site of therapeutic interventions to reduce the risk of CVD. This study was conducted to investigate the effect of ... ...

Abstract	BACKGROUND: Endothelial dysfunction serves as an early marker for the risk of cardiovascular disease (CVD); therefore, it is an attractive site of therapeutic interventions to reduce the risk of CVD. This study was conducted to investigate the effect of folic acid supplementation on endothelial function markers in randomized controlled trials (RCTs). METHODS: PubMed, ISI web of science, and Scopus databases were searched up to July 2022 for detecting eligible studies. A random-effects model was used for meta-analysis, and linear Meta-regression and non-linear dose-response analysis were performed to assess whether the effect of folic acid supplementation was affected by the dose and duration of intervention. Cochrane tools were also used to assess the risk of bias in the included studies. RESULTS: Twenty-one studies, including 2025 participants (1010 cases and 1015 controls), were included in the present meta-analysis. Folic acid supplementation significantly affected the percentage of flow-mediated dilation (FMD%) (WMD: 2.59%; 95% CI: 1.51, 3.67; P < 0.001) and flow-mediated dilation (FMD) (WMD: 24.38 μm; 95% CI: 3.08, 45.68; P = 0.025), but not end-diastolic diameter (EDD) (WMD: 0.21 mm; 95% CI: − 0.09, 0.52; P = 0.176), and intercellular adhesion molecule (ICAM) (WMD: 0.18 ng/ml; 95% CI: − 10.02, 13.81; P = 0.755). CONCLUSIONS: These findings suggest that folic acid supplementation may improve endothelial function by increasing FMD and FMD% levels. TRIAL REGISTRATION: PROSPERO registration cod: CRD42021289744.
Keywords	cardiovascular diseases ; cell adhesion molecules ; dose response ; folic acid ; meta-analysis ; risk ; risk assessment ; risk reduction ; statistical models ; systematic review ; therapeutics
Language	English
Dates of publication	2023-12
Size	p. 12.
Publishing place	BioMed Central
Document type	Article ; Online
Note	Review
ZDB-ID	2091602-4
ISSN	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-023-00843-y
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Article ; Online: The effect of acarbose on inflammatory cytokines and adipokines in adults: a systematic review and meta-analysis of randomized clinical trials.

Mohammadian, Ali / Fateh, Sahand Tehrani / Nikbaf-Shandiz, Mahlagha / Gholami, Fatemeh / Rasaei, Niloufar / Bahari, Hossein / Rastgoo, Samira / Bagheri, Reza / Shiraseb, Farideh / Asbaghi, Omid

Inflammopharmacology

2024 Volume 32, Issue 1, Page(s) 355–376

Abstract: Background: Although a large number of trials have observed an anti-inflammatory property of acarbose, the currently available research remains controversial regarding its beneficial health effects. Hence, the purpose of this study was to examine the ... ...

Abstract	Background: Although a large number of trials have observed an anti-inflammatory property of acarbose, the currently available research remains controversial regarding its beneficial health effects. Hence, the purpose of this study was to examine the effect of acarbose on inflammatory cytokines and adipokines in adults. Methods: PubMed, Web of Science, and Scopus were systematically searched until April 2023 using relevant keywords. The mean difference (MD) of any effect was calculated using a random-effects model. Weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated via the random-effects model. Results: The current meta-analysis of data comprised a total of 19 RCTs. Meta-analysis showed that acarbose significantly decreased tumor necrosis factor-alpha (TNF-α) (weighted mean difference [WMD]) = - 4.16 pg/ml, 95% confidence interval (CI) - 6.58, - 1.74; P = 0.001) while increasing adiponectin (WMD = 0.79 ng/ml, 95% CI 0.02, 1.55; P = 0.044). However, the effects of acarbose on TNF-α concentrations were observed in studies with intervention doses ≥ 300 mg/d (WMD = - 4.09; 95% CI - 7.00, - 1.18; P = 0.006), and the adiponectin concentrations were significantly higher (WMD = 1.03 ng/ml, 95%CI 0.19, 1.87; P = 0.016) in studies in which the duration of intervention was less than 24 weeks. No significant effect was seen for C-reactive protein (CRP; P = 0.134), interleukin-6 (IL-6; P = 0.204), and leptin (P = 0.576). Conclusion: Acarbose had beneficial effects on reducing inflammation and increasing adiponectin. In this way, it may prevent the development of chronic diseases related to inflammation. However, more studies are needed.
MeSH term(s)	Adult ; Humans ; Adipokines ; Cytokines ; Acarbose/pharmacology ; Acarbose/therapeutic use ; Adiponectin ; Tumor Necrosis Factor-alpha ; Randomized Controlled Trials as Topic ; Interleukin-6 ; Inflammation/drug therapy
Chemical Substances	Adipokines ; Cytokines ; Acarbose (T58MSI464G) ; Adiponectin ; Tumor Necrosis Factor-alpha ; Interleukin-6
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01401-y
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Article ; Online: The effect of L-arginine supplementation on maximal oxygen uptake: A systematic review and meta-analysis.

Rezaei, Shahla / Gholamalizadeh, Maryam / Tabrizi, Reza / Nowrouzi-Sohrabi, Peyman / Rastgoo, Samira / Doaei, Saeid

Physiological reports

2021 Volume 9, Issue 3, Page(s) e14739

Abstract: Background: The efficacy and safety of L-arginine supplements and their effect on maximal oxygen uptake (VO2 max) remained unclear. This systematic review aimed to investigate the effect of L-arginine supplementation (LAS) on VO2 max in healthy people.!# ...

Abstract	Background: The efficacy and safety of L-arginine supplements and their effect on maximal oxygen uptake (VO2 max) remained unclear. This systematic review aimed to investigate the effect of L-arginine supplementation (LAS) on VO2 max in healthy people. Methods: We searched PubMed, Scopus, Web of Science, Cochrane, Embase, ProQuest, and Ovid to identify all relevant literature investigating the effect of LAS on VO2 max. This meta-analysis was conducted via a random-effects model for the best estimation of desired outcomes and studies that meet the inclusion criteria were considered for the final analysis. Results: The results of 11 randomized clinical trials indicated that LAS increased VO2 max compared to the control group. There was no significant heterogeneity in this meta-analysis. Subgroup analysis detected that arginine in the form of LAS significantly increased VO2 max compared to the other forms (weighted mean difference = 0.11 L min Conclusions: This meta-analysis indicated that supplementation with L-arginine could increase VO2 max in healthy people. Further studies are warranted to confirm this finding and to identify the underlying mechanisms.
MeSH term(s)	Adult ; Arginine/administration & dosage ; Arginine/adverse effects ; Athletic Performance ; Dietary Supplements/adverse effects ; Female ; Healthy Volunteers ; Humans ; Male ; Muscle Contraction/drug effects ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Oxygen Consumption/drug effects ; Performance-Enhancing Substances/administration & dosage ; Performance-Enhancing Substances/adverse effects ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Young Adult
Chemical Substances	Performance-Enhancing Substances ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2021-03-28
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.14739
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Article ; Online: Growth and Nutritional Status of Phenylketonuric Children and Adolescents.

Ahmadzadeh, Mina / Sohrab, Golbon / Alaei, Mohammadreza / Eini-Zinab, Hassan / Mohammadpour-Ahranjani, Behzad / Rastgoo, Samira / Namkhah, Zahra

BMC pediatrics

2022 Volume 22, Issue 1, Page(s) 664

Abstract: Background: The goal of this study was to assess the anthropometric and biochemical parameters of children and adolescents with phenylketonuria (PKU).: Methods: The participants in this cross-sectional study ranged in age from four to 18 years old. ... ...

Abstract	Background: The goal of this study was to assess the anthropometric and biochemical parameters of children and adolescents with phenylketonuria (PKU). Methods: The participants in this cross-sectional study ranged in age from four to 18 years old. Biochemical markers such as vitamin B12, folic acid, iron, ferritin, calcium, 25-hydroxy vitamin D3, zinc, plasma phenylalanine (Phe) and tyrosine (Tyr) levels in blood were evaluated, as well as demographics and anthropometric measurements. A three-day dietary recall questionnaire was completed by all individuals. Results: 80% (64) of the 80 patients (42 females, 52.5%) had typical PKU. Consanguineous marriages were found in 57.5% (46) of the patients' parents. According to the height for age index, 17.5% of the study group (n = 14) were short or very short. According to age-related weight and body mass index (BMI), 37.5% (n = 30) and 43.8% (n = 35) of people are obese or overweight, respectively. Biochemical tests revealed increased vitamin B12 levels and 25-hydroxy vitamin D3 deficiency in 35% (n = 28) of the patients, insufficient folic acid in 12.5% (n = 10), and elevated phenylalanine levels in 70.3% (n = 45) of children under 12 years old, and adolescents 62.5% (n = 10). A high Phe intake (OR = 4.44, CI %95 = 1.27-15.57) is a risk factor for obesity and overweight. Conclusion: Patients with PKU had a high rate of overweight and obesity. PKU patients who are overweight or obese do not differ from normal-weight patients in terms of dietary intake or laboratory findings (except for serum iron levels). One-third of patients with phenylketonuria were vitamin D deficient and had a BMI/A index of overweight/obese. It is recommended to use special medical food to help solve energy and nutrient deficiencies.
MeSH term(s)	Child ; Female ; Humans ; Adolescent ; Child, Preschool ; Nutritional Status ; Overweight/epidemiology ; Cross-Sectional Studies ; Obesity ; Vitamin B 12 ; Phenylketonurias ; Vitamin D Deficiency/epidemiology ; Folic Acid ; Cholecalciferol ; Iron ; Phenylalanine
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; Folic Acid (935E97BOY8) ; Cholecalciferol (1C6V77QF41) ; Iron (E1UOL152H7) ; Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03715-2
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Article ; Online: FTO genotype was associated with breast cancer in HER2 negative patients

Montazeri, Fateme / Hatami, Hossein / Fathi, Soroor / Hasanpour Ardekanizadeh, Naeemeh / Bourbour, Fatemeh / Rastgoo, Samira / Shafiee, Fatemeh / Akbari, Mohammad Esmail / Gholamalizadeh, Maryam / Mosavi Jarrahi, Seyed Alireza / Doaei, Saeid

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2022 June, v. 49 p.495-498

2022

Abstract: The fat mass and obesity-associated (FTO) gene may influence the risk of breast cancer (BC). The single nucleotide polymorphisms (SNPs) of FTO gene may exert different impacts on different types of BC. In this study, we investigated the association ... ...

Abstract	The fat mass and obesity-associated (FTO) gene may influence the risk of breast cancer (BC). The single nucleotide polymorphisms (SNPs) of FTO gene may exert different impacts on different types of BC. In this study, we investigated the association between FTO SNP rs9939609 and the status of estrogen receptor (ER), progesterone receptor (PR), P53, and human epidermal growth factor receptor-2 (HER-2) in BC patients. Our case–control study was included 540 Iranian participants aged 35 to 70 (180 women with BC as the case group and 360 healthy controls). After genotyping for risk allele rs9939609 of the FTO gene, a logistic regression was applied to elucidate the association between FTO SNP rs9939609 and BC risk based on the receptor status. The number of HER-2 negative patients was significantly higher in FTO rs9939609 risk allele carrier group (61.5% vs. 41.4%, P < 0.05). A significant association was found between BC and rs9939609 FTO gene polymorphism only in HER2 negative BC patients (OR = 1.79, CI95%: 1.2–3.56, P = 0.03). No association was identified between FTO rs9939609 polymorphism and the status of ER, PR, and P53. We indicated that FTO SNP rs9939609 can be a potential therapeutic target particularly in HER-2 negative BC cases. The importance of this risk allele in BC pathogenesis needs to be further highlighted.
Keywords	alleles ; breast neoplasms ; case-control studies ; clinical nutrition ; erbB-2 receptor ; estrogen receptors ; genetic polymorphism ; genotype ; genotyping ; pathogenesis ; progesterone receptors ; regression analysis ; risk ; therapeutics ; FTO ; rs9939609 ; Breast cancer ; HER2 ; SNP ; BMI ; ER ; PR ; HER-2
Language	English
Dates of publication	2022-06
Size	p. 495-498.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2405-4577
DOI	10.1016/j.clnesp.2022.02.122
Database	NAL-Catalogue (AGRICOLA)

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