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Article ; Online: 3D Bioprinting of Methylcellulose/Gelatin-Methacryloyl (MC/GelMA) Bioink with High Shape Integrity.

Rastin, Hadi / Ormsby, Renee T / Atkins, Gerald J / Losic, Dusan

ACS applied bio materials

2020 Volume 3, Issue 3, Page(s) 1815–1826

Abstract: The advent of three-dimensional (3D) bioprinting offers a feasible approach to construct complex structures suitable for tissue regeneration, during which cell-laden materials are dispensed on a substrate according to a predesigned structure. However, ... ...

Abstract	The advent of three-dimensional (3D) bioprinting offers a feasible approach to construct complex structures suitable for tissue regeneration, during which cell-laden materials are dispensed on a substrate according to a predesigned structure. However, the lack of ideal printable bioinks with high shape fidelity and improved biological stability remains a major challenge. In this study, methylcellulose/gelatin-methacryloyl (MC/GelMA) bioink with high shape integrity is presented, which takes advantage of the printability of MC and the permanent photo-cross-linking of GelMA under UV irradiation. Although MC demonstrates good printability at room temperature, the lack of cross-linking ability causes distortion and finally dissociation of printed MC in biological media within a few days. However, UV-cross-linked MC/GelMA bioink remains stable in biological media over a period of several months. The shape integrity of MC/GelMA was systematically characterized in terms of yield stress and complex modulus. Unlike pure MC ink, the MC/GelMA ink demonstrated self-supporting behavior once printed due to the higher complex modulus and yield stress induced by GelMA in the system. Shape integrity of MC/GelMA ink resulted in higher resolution and printability which are evaluated by the successful printing of various 1D, 2D, and 3D constructs. Moreover, human primary osteoblasts encapsulated within the MC/GelMA hydrogel show cell viability of >95%. Overall, this work introduces MC/GelMA bioink with high shape integrity and improved biological stability and highlights the importance of rheological properties and post-cross-linking for fabrication of physiologically scaled tissue implants.
Language	English
Publishing date	2020-03-06
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.0c00169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tailoring Additively Manufactured Titanium Implants for Short-Time Pediatric Implantations with Enhanced Bactericidal Activity.

Maher, Shaheer / Linklater, Denver / Rastin, Hadi / Le Yap, Pei / Ivanova, Elena P / Losic, Dusan

ChemMedChem

2021 Volume 17, Issue 2, Page(s) e202100580

Abstract: Paediatric titanium (Ti) implants are used for the short-term fixation of fractures, after which they are removed. However, bone overgrowth on the implant surface can complicate their removal. The current Ti implants research focuses on improving their ... ...

Abstract	Paediatric titanium (Ti) implants are used for the short-term fixation of fractures, after which they are removed. However, bone overgrowth on the implant surface can complicate their removal. The current Ti implants research focuses on improving their osseointegration and antibacterial properties for long-term use while overlooking the requirements of temporary implants. This paper presents the engineering of additively manufactured Ti implants with antibacterial properties and prevention of bone cell overgrowth. 3D-printed implants were fabricated followed by electrochemical anodization to generate vertically aligned titania nanotubes (TNTs) on the surface with specific diameters (∼100 nm) to reduce cell attachment and proliferation. To achieve enhanced antibacterial performance, TNTs were coated with gallium nitrate as antibacterial agent. The physicochemical characteristics of these implants assessed by the attachment, growth and viability of osteoblastic MG-63 cells showed significantly reduced cell attachment and proliferation, confirming the ability of TNTs surface to avoid cell overgrowth. Gallium coated TNTs showed strong antibacterial activity against S. aureus and P. aeruginosa with reduced bacterial attachment and high rates of bacterial death. Thus a new approach for the engineering of temporary Ti implants with enhanced bactericidal properties with reduced bone cell attachment is demonstrated as a new strategy toward a new generation of short-term implants in paediatrics.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cell Survival ; Dental Implants ; Dose-Response Relationship, Drug ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Nanotubes/chemistry ; Particle Size ; Printing, Three-Dimensional ; Prostheses and Implants ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Surface Properties ; Titanium/chemistry ; Titanium/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Anti-Bacterial Agents ; Dental Implants ; Titanium (D1JT611TNE)
Language	English
Publishing date	2021-11-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202100580
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Article: 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite

Rastin, Hadi / Ramezanpour, Mahnaz / Hassan, Kamrul / Mazinani, Arash / Tung, Tran Thanh / Vreugde, Sarah / Losic, Dusan

Carbohydrate polymers. 2021 July 15, v. 264

2021

Abstract: Bioink with inherent antibacterial activity is of particular interest for tissue engineering application due to the growing number of bacterial infections associated with impaired wound healing or bone implants. However, the development of cell-laden ... ...

Abstract	Bioink with inherent antibacterial activity is of particular interest for tissue engineering application due to the growing number of bacterial infections associated with impaired wound healing or bone implants. However, the development of cell-laden bioink with potent antibacterial activity while supporting tissue regeneration proved to be challenging. Here, we introduced a cell-laden antibacterial bioink based on Methylcellulose/Alginate (MC/Alg) hydrogel for skin tissue engineering via elimination of the risks associated with a bacterial infection. The key feature of the bioink is the use of gallium (Ga⁺³) in the design of bioink formulation with dual functions. First, Ga⁺³ stabilized the hydrogel bioink by the formation of ionic crosslinking with Alg chains. Second, the gallium-crosslinked bioink exhibited potent antibacterial activity toward both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria with a bactericidal rate of 99.99 %. In addition, it was found that the developed bioink supported encapsulated fibroblast cellular functions.
Keywords	Pseudomonas aeruginosa ; Staphylococcus aureus ; alginates ; antibacterial properties ; bacterial infections ; bioprinting ; crosslinking ; encapsulation ; fibroblasts ; gallium ; hydrogels ; methylcellulose ; tissue repair
Language	English
Dates of publication	2021-0715
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2021.117989
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Article ; Online: Characterization of human nasal organoids from chronic rhinosinusitis patients.

Ramezanpour, Mahnaz / Bolt, Harrison / Hon, Karen / Shaghayegh, Gohar / Rastin, Hadi / Fenix, Kevin Aaron / Psaltis Alkis, James / Wormald, Peter-John / Vreugde, Sarah

Biology open

2022 Volume 11, Issue 8

Abstract: Patient-derived organoids grown in three-dimensional cultures provide an excellent platform for phenotypic high-throughput screening and drug-response research. Organoid technology has been applied to study stem cell biology and various human pathologies. ...

Abstract	Patient-derived organoids grown in three-dimensional cultures provide an excellent platform for phenotypic high-throughput screening and drug-response research. Organoid technology has been applied to study stem cell biology and various human pathologies. This study investigates the characteristics and cellular morphology of organoids derived from primary human nasal epithelial cells (HNECs) of chronic rhinosinusitis (CRS) patients. Nasal organoids were cultured up to 20 days and morphological, cell composition and functional parameters were measured by immunofluorescence, RT-qPCR, western blot and FACS analysis. The results showed that nasal organoids expressed the stem cell marker leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and markers for apical junction genes, goblet cells and ciliated cells. Moreover, we were able to regrow and expand the nasal organoids well after freezing and thawing. This study provides an effective and feasible method for development of human nasal organoids, suitable for the phenotypic high-throughput screening and drug response research.
MeSH term(s)	Epithelial Cells ; Humans ; Organoids/pathology ; Stem Cells
Language	English
Publishing date	2022-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.059267
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Article ; Online: 3D printing of cell-laden electroconductive bioinks for tissue engineering applications.

Rastin, Hadi / Zhang, Bingyang / Bi, Jingxiu / Hassan, Kamrul / Tung, Tran Thanh / Losic, Dusan

Journal of materials chemistry. B

2020 Volume 8, Issue 27, Page(s) 5862–5876

Abstract: Bioprinting is an emerging powerful fabrication method, which enables the rapid assembly of 3D bioconstructs with dispensing cell-laden bioinks in pre-designed locations. However, to translate this technology into real applications, there are still a ... ...

Abstract	Bioprinting is an emerging powerful fabrication method, which enables the rapid assembly of 3D bioconstructs with dispensing cell-laden bioinks in pre-designed locations. However, to translate this technology into real applications, there are still a number of challenges that need to be addressed. First, the current inks are generally composed of polymeric materials with poor electrical conductivity that mismatches with the native tissue environment. The second challenge associated with the 3D bioprinting of hydrogel-based bioinks is the fabrication of anatomical-size constructs without any loss of shape fidelity and resolution. To address these challenges, in this work, we introduced a biocompatible bioink associated with current 3D bioprinting by combining methylcellulose and kappa-carrageenan (MC/κCA) hydrogels with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) conducting polymers. The prepared ink exhibited highly thixotropic behaviour, which could be tuned via changing the concentration of MC and κCA to obtain easy printing with high shape fidelity. The ink was able to fabricate physiological-scale constructs without requiring a secondary support bath. In addition, varying the concentration of PEDOT:PSS could control the electrical conductivity of the ink. Moreover, the encapsulated human embryonic kidney 293 (HEK-293) cells in bulk hydrogels and 3D bioprinted structures maintained high cell viability (>96%) over a week, confirming the in vitro biocompatibility of the ink. Overall, these findings indicate that the MC/κCA/PEDOT:PSS bioink can be promising in biomedical applications, which improved the electroconductivity of bioinks and can exploit the advantage of conductive polymers in the 3D bioprinting technology.
MeSH term(s)	Biocompatible Materials/chemistry ; Biocompatible Materials/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Carrageenan/chemistry ; Cells, Cultured ; Cross-Linking Reagents/chemistry ; Electric Conductivity ; HEK293 Cells ; Humans ; Hydrogels/chemistry ; Hydrogels/metabolism ; Methylcellulose/chemistry ; Polymers/chemistry ; Polystyrenes/chemistry ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Bridged Bicyclo Compounds, Heterocyclic ; Cross-Linking Reagents ; Hydrogels ; Polymers ; Polystyrenes ; poly(3,4-ethylene dioxythiophene) ; polystyrene sulfonic acid (70KO0R01RY) ; Carrageenan (9000-07-1) ; Methylcellulose (9004-67-5)
Language	English
Publishing date	2020-06-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d0tb00627k
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Article ; Online: Flame Retardancy of Bio-Based Polyurethanes: Opportunities and Challenges.

Vahabi, Henri / Rastin, Hadi / Movahedifar, Elnaz / Antoun, Karina / Brosse, Nicolas / Saeb, Mohammad Reza

Polymers

2020 Volume 12, Issue 6

Abstract: Sustainable polymers are emerging fast and have received much more attention in recent years compared to petro-sourced polymers. However, they inherently have low-quality properties, such as poor mechanical properties, and inadequate performance, such as ...

Abstract	Sustainable polymers are emerging fast and have received much more attention in recent years compared to petro-sourced polymers. However, they inherently have low-quality properties, such as poor mechanical properties, and inadequate performance, such as high flammability. In general, two methods have been considered to tackle such drawbacks: (i) reinforcement of sustainable polymers with additives; and (ii) modification of chemical structure by architectural manipulation so as to modify polymers for advanced applications. Development and management of bio-based polyurethanes with flame-retardant properties have been at the core of attention in recent years. Bio-based polyurethanes are currently prepared from renewable, bio-based sources such as vegetable oils. They are used in a wide range of applications including coatings and foams. However, they are highly flammable, and their further development is dependent on their flame retardancy. The aim of the present review is to investigate recent advances in the development of flame-retardant bio-based polyurethanes. Chemical structures of bio-based flame-retardant polyurethanes have been studied and explained from the point of view of flame retardancy. Moreover, various strategies for improving the flame retardancy of bio-based polyurethanes as well as reactive and additive flame-retardant solutions are discussed.
Language	English
Publishing date	2020-05-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym12061234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fractal Design for Advancing the Performance of Chemoresistive Sensors.

Hassan, Kamrul / Tung, Tran Thanh / Yap, Pei Lay / Rastin, Hadi / Stanley, Nathan / Nine, Md Julker / Losic, Dusan

ACS sensors

2021 Volume 6, Issue 10, Page(s) 3685–3695

Abstract: The rapid advancement of internet of things (IoT)-enabled applications along with connected automation in sensing technologies is the heart of future intelligent systems. The probable applications have significant implications, from chemical process ... ...

Abstract	The rapid advancement of internet of things (IoT)-enabled applications along with connected automation in sensing technologies is the heart of future intelligent systems. The probable applications have significant implications, from chemical process monitoring to agriculture, mining, space, wearable electronics, industrial manufacturing, smart cities, and point-of-care (PoC) diagnostics. Advancing sensor performance such as sensitivity to detect trace amounts (ppb-ppm) of analytes (gas/VOCs), selectivity, portability, and low cost is critical for many of these applications. These advancements are mainly achieved by selecting and optimizing sensing materials by their surface functionalization and/or structural optimization to achieve favorable transport characteristics or chemical binding/reaction sites. Surprisingly, the sensor geometry, shapes, and patterns were not considered as critical parameters, and most of these sensors were designed by following simple planar and interdigitated electrode geometry. In this study, we introduce a new bioinspired fractal approach to design chemoresistive sensors with fractal geometry, which grasp the architecture of fern leaves represented by the geometric group of space-filling curves of fractal patterns. These fractal sensors were printed by an extrusion process on a flexible substrate (PET) using specially formulated graphene ink as a sensing material, which provided significant enhancement of the active surface area to volume ratio and allowed high-resolution fractal patterning along with a reduced current transportation path. To demonstrate the advantages and influence of fractal geometry on sensor performance, here, three different kinds of sensors were fabricated based on different fractal geometrics (Sierpinski, Peano, and Hilbert), and the sensing performance was explored toward different VOC analytes (e.g., ethanol, methanol, and acetone). Among all these fractal-designed sensors including interdigitate sensors, the Hilbert-designed printed sensor shows enhanced sensing properties in terms of fast response time (6 s for 30 ppm), response value (14%), enhanced detection range (5-100 ppm), high selectivity, and low interference to humidity (up to RH 80%) for ethanol at room temperature (20 °C). Moreover, a significant improvement of this sensor performance was observed by applying the mechanical deformation (positive bending) technique. The practical application of this sensor was successfully demonstrated by monitoring food spoilage using a commercial box of strawberries as a model. Based on these presented results, this biofractal biomimetic VOC sensor is demonstrated for a prospective application in food monitoring.
MeSH term(s)	Electrodes ; Fractals ; Graphite ; Humidity ; Wearable Electronic Devices
Chemical Substances	Graphite (7782-42-5)
Language	English
Publishing date	2021-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.1c01449
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Graphene ink for 3D extrusion micro printing of chemo-resistive sensing devices for volatile organic compound detection.

Hassan, Kamrul / Tung, Tran Thanh / Stanley, Nathan / Yap, Pei Lay / Farivar, Farzaneh / Rastin, Hadi / Nine, Md Julker / Losic, Dusan

Nanoscale

2021 Volume 13, Issue 10, Page(s) 5356–5368

Abstract: Printed electronic sensors offer a breakthrough in the availability of low-cost sensor devices for improving the quality of human life. Conductive ink is the core of printing technology and also one of the fastest growing sector among all ink industries. ...

Abstract	Printed electronic sensors offer a breakthrough in the availability of low-cost sensor devices for improving the quality of human life. Conductive ink is the core of printing technology and also one of the fastest growing sector among all ink industries. Among many developed conductive inks, graphene-based inks are especially recognized as very promising for future fabrication of devices due to their low cost, unique properties, and compatibility with various platforms such as plastics, textiles, and paper. The development of graphene ink formulations for achieving high conductivity and high resolution printing is highly realized in 2D inkjet printing. Unfortunately, the ongoing development of graphene inks is possibly hampered by the non-uniform particle size and structures (e.g., different shapes and number of layers), which adversely affect printing resolution, conductivity, adhesion, and structural integrity. This study presents an environmentally sustainable route to produce graphene inks specifically designed for 3D extrusion-printing. The application of the prepared ink is demonstrated by mask-free automatic patterning of sensing devices for the detection of volatile organic compounds (VOCs). The sensing devices fabricated with this new ink display high-resolution patterning (average height/thickness of ∼12 μm) and a 10-fold improvement in the surface area/volume (SA/V) ratio compared to a conventional drop casting method. The extrusion printed sensors show enhanced sensing characteristics in terms of sensitivity and selectivity towards trace amount of VOC (e.g. 5 ppm ethanol) at room temperature (20 °C), which highlights that our method has highly promising potential in graphene printing technology for sensing applications.
Language	English
Publishing date	2021-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr00150g
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Article ; Online: 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite.

Rastin, Hadi / Ramezanpour, Mahnaz / Hassan, Kamrul / Mazinani, Arash / Tung, Tran Thanh / Vreugde, Sarah / Losic, Dusan

Carbohydrate polymers

2021 Volume 264, Page(s) 117989

Abstract	Bioink with inherent antibacterial activity is of particular interest for tissue engineering application due to the growing number of bacterial infections associated with impaired wound healing or bone implants. However, the development of cell-laden bioink with potent antibacterial activity while supporting tissue regeneration proved to be challenging. Here, we introduced a cell-laden antibacterial bioink based on Methylcellulose/Alginate (MC/Alg) hydrogel for skin tissue engineering via elimination of the risks associated with a bacterial infection. The key feature of the bioink is the use of gallium (Ga
Language	English
Publishing date	2021-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2021.117989
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Article: Comparative antibacterial activity of 2D materials coated on porous-titania

Mazinani, Arash / Rastin, Hadi / Nine, Md Julker / Lee, James / Tikhomirova, Alexandra / Tung, Tran Thanh / Ghomashchi, Reza / Kidd, Stephen / Vreugde, Sarah / Losic, Dusan

Journal of materials chemistry B. 2021 Aug. 18, v. 9, no. 32

2021

Abstract: Plasma electrolytic oxidation (PEO) is a well-established technique for the treatment of titanium-based materials. The formed titania-PEO surface can improve the osseointegration properties of titanium implants. Nevertheless, it can not address bacterial ...

Abstract	Plasma electrolytic oxidation (PEO) is a well-established technique for the treatment of titanium-based materials. The formed titania-PEO surface can improve the osseointegration properties of titanium implants. Nevertheless, it can not address bacterial infection problems associated with bone implants. Recently, 2-dimensional (2D) materials such as graphene oxide (GO), MXene, and hexagonal boron nitride (hBN) have received considerable attention for surface modifications showing their antibacterial properties. In this paper, a comparative study on the effect of partial deposition of these three materials over PEO titania substrates on the antibacterial efficiency and bioactivity is presented. Their partial deposition through drop-casting instead of continuous film coating is propsed to simultaneously address both antibacterial and osseointegration abilities. Our results demonstrate the dose-dependent nature of the deposited antibacterial agent on the PEO substrate. GO–PEO and MXene–PEO samples showed the highest antibacterial activity with 70 (±2) % and 97 (±0.5) % inactivation of S. aureus colonies in the low concentration group, respectively. Furthermore, only samples in the higher concentration group were effective against E. coli bacteria with 18 (±2) % and 17 (±4) % decrease in numbers of colonies for hBN–PEO and GO–PEO samples, respectively. Moreover, all antibacterial samples demonstrated acceptable bioactivity and good biocompatibility, making them a considerable candidates for the next generation of antibacterial titanium implants.
Keywords	Escherichia coli ; antibacterial properties ; antibiotics ; bacterial infections ; biocompatibility ; boron nitride ; comparative study ; dose response ; graphene oxide ; oxidation ; titanium ; titanium dioxide
Language	English
Dates of publication	2021-0818
Size	p. 6412-6424.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb01122g
Database	NAL-Catalogue (AGRICOLA)

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