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Article ; Online: A comparison of ICG-NIR with blue dye and technetium for the detection of sentinel lymph nodes in vulvar cancer.

Rundle, Stuart / Korompelis, Porfyrios / Ralte, Angela / Bewick, Diane / Ratnavelu, Nithya

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2022 Volume 49, Issue 2, Page(s) 481–485

Abstract: Introduction: The sentinel lymph node (SLN) procedure for vulva cancer is a safe alternative to a radical inguino-femoral lymphadenectomy (IFLN) for small unifocal tumours. SLN evaluation through biopsy and ultra-staging has helped gynaecological ... ...

Abstract	Introduction: The sentinel lymph node (SLN) procedure for vulva cancer is a safe alternative to a radical inguino-femoral lymphadenectomy (IFLN) for small unifocal tumours. SLN evaluation through biopsy and ultra-staging has helped gynaecological oncology surgeons improve operative morbidity with no cost to oncologic safety. Established techniques for groin SLN detection and excision in vulvar cancer use Results: 92% of patients had a successful SLN procedure. The per-groin detection rate was 84%. All successfully mapped SLN were identified with the combination of ICG-NIR and Conclusions: Incorporation of ICG-NIR into standard SLN mapping protocols may allow for the abandonment of routine use of BD and its poor side effect profile.
MeSH term(s)	Female ; Humans ; Sentinel Lymph Node/pathology ; Indocyanine Green ; Vulvar Neoplasms/pathology ; Sentinel Lymph Node Biopsy/methods ; Technetium ; Technetium Tc 99m Aggregated Albumin ; Lymph Nodes/pathology ; Radiopharmaceuticals ; Coloring Agents
Chemical Substances	Indocyanine Green (IX6J1063HV) ; Technetium (7440-26-8) ; Technetium Tc 99m Aggregated Albumin ; Radiopharmaceuticals ; Coloring Agents
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2022.09.015
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Article ; Online: Conservative surgical approaches for small volume FIGO stage IB1 cervical cancer. Updated survival and obstetric outcomes of an expanded cohort.

Korompelis, Porfyrios / Rundle, Stuart / Cassar, Viktor / Ratnavelu, Nithya / Ralte, Angela / Biliatis, Ioannis / Kucukmetin, Ali

Gynecologic oncology

2023 Volume 176, Page(s) 155–161

Abstract: Objective: Standard surgical treatment of FIGO stage 1B1 cervical cancer is open radical surgery. However, there is increasing evidence that for small tumours a more conservative approach can minimise fertility consequences without impacting on long ... ...

Abstract	Objective: Standard surgical treatment of FIGO stage 1B1 cervical cancer is open radical surgery. However, there is increasing evidence that for small tumours a more conservative approach can minimise fertility consequences without impacting on long term oncologic outcomes. The objective of our study is to present survival and obstetric outcomes following extended follow-up for patients who underwent conservative management of small-volume stage 1B1 disease. Methods: All patients with FIGO stage 1B1 cancer and estimated tumour volume of <500 mm Results: 117 patients underwent conservative surgery for small volume stage 1B1 disease. 58 (49.5%) underwent fertility sparing conservative management with LLETZ while 59 (50.5%) underwent simple hysterectomy. Overall, 95% (111/117) of the patients underwent bilateral pelvic lymphadenectomy and 1 positive node was identified. There was no death related to cervical cancer and 1 recurrence identified during a median follow up of 8.5 years (1-20). 17 pregnancies have been recorded in patients underwent LLETZ and 17 live babies were born. No second trimester miscarriages were noted and there was one preterm delivery (36 weeks). Conclusion: Non-radical surgery with negative pelvic lymphadenectomy for smallvolume stage 1B1 cervical cancer ensures excellent survival without compromising obstetric outcomes. Should these results be verified by the ongoing prospective studies, radical surgery for these patients may be avoided.
MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Humans ; Uterine Cervical Neoplasms/pathology ; Prospective Studies ; Neoplasm Staging ; Hysterectomy/methods ; Trachelectomy ; Retrospective Studies
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.07.018
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Article ; Online: Finding the sentinel lymph node in early cervical cancer: When is unusual not uncommon?

Smits, Anke / Ten Eikelder, Mieke / Dhanis, Joelle / Moore, William / Blake, Dominic / Zusterzeel, Petra / Kucukmetin, Ali / Ratnavelu, Nithya / Rundle, Stuart

Gynecologic oncology

2023 Volume 170, Page(s) 84–92

Abstract: Objective: To report our institutional experience with sentinel lymph node (SLN) detection using indocyanine green for cervical cancer, in terms of detection rates, detection of SLN at unusual locations, and factors associated with unusual SLN locations. ...

Abstract	Objective: To report our institutional experience with sentinel lymph node (SLN) detection using indocyanine green for cervical cancer, in terms of detection rates, detection of SLN at unusual locations, and factors associated with unusual SLN locations. In addition, we performed a systematic review of the literature to identify factors associated with unusual SLN localizations. Methods: This is a retrospective cohort study of women with early-stage cervical cancer undergoing sentinel lymph node mapping between 2015 and 2019. Outcome measures were SLN detection rates, detection rates of unusual locations for SLN and risk factors for aberrant lymphatic drainage pathways. In addition, studies evaluating factors associated with unusual SLN locations in cervical cancer were assessed in a systematic review. Results: A total of 100 patients were included. The unilateral SLN detection rate was 88%, whereas the bilateral detection rate was 75%. In 37% of all patients, SLN were found in unusual locations, and in 10% of patients SLN were solely found in unusual locations. Body mass index (BMI) was associated with finding SLN in unusual locations, with unusual nodes detected in 52% of patients with BMI <25 kg/m Conclusion: Aberrant drainage sites represent a significant proportion of SLN detected in cervical cancer. Factors associated with increased rates of unusual nodal locations are a lower BMI, with a possible association with nulliparity and tumor size of >20 mm.
MeSH term(s)	Humans ; Female ; Sentinel Lymph Node/pathology ; Uterine Cervical Neoplasms/pathology ; Sentinel Lymph Node Biopsy ; Retrospective Studies ; Indocyanine Green ; Lymph Nodes/pathology ; Lymph Node Excision ; Neoplasm Staging
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2022.12.013
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Article ; Online: Predicting ovarian malignancy: the latest model looks promising as a triage tool for women with ovarian masses.

Biliatis, Ioannis / Ratnavelu, Nithya

BMJ (Clinical research ed.)

2014 Volume 349, Page(s) g6076

MeSH term(s)	Female ; Humans ; Models, Statistical ; Ovarian Neoplasms/diagnosis ; Predictive Value of Tests
Language	English
Publishing date	2014-10-16
Publishing country	England
Document type	Editorial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.g6076
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Article ; Online: An unusual cause of diarrhoea in a young female.

Ratnavelu, Nithya / Daly, Michael J

QJM : monthly journal of the Association of Physicians

2011 Volume 104, Issue 2, Page(s) 161–162

MeSH term(s)	Adult ; Diarrhea/etiology ; Female ; Humans ; Pregnancy ; Pregnancy, Ectopic/diagnosis ; Pregnancy, Ectopic/diagnostic imaging ; Pregnancy, Ectopic/surgery ; Salpingectomy ; Ultrasonography
Language	English
Publishing date	2011-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcq070
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Article ; Online: High-grade vaginal intraepithelial neoplasia: can we be selective about who we treat?

Ratnavelu, N / Patel, A / Fisher, A D / Galaal, K / Cross, P / Naik, R

BJOG : an international journal of obstetrics and gynaecology

2013 Volume 120, Issue 7, Page(s) 887–893

Abstract: Objective: To determine the role of conservative management in high-grade vaginal intraepithelial neoplasia (HG VaIN).: Design: Retrospective observational study.: Setting: Northern Gynaecological Oncology Centre, Gateshead, UK.: Population: A ... ...

Abstract	Objective: To determine the role of conservative management in high-grade vaginal intraepithelial neoplasia (HG VaIN). Design: Retrospective observational study. Setting: Northern Gynaecological Oncology Centre, Gateshead, UK. Population: A total of 100 women with histologically-proven HG VaIN. Methods: Review of patient records from 1995 to 2011. Main outcome measures: Rates of progression to cancer, treatment remission, and disease recurrence, particularly post-treatment when vaginoscopy is normal but cytology is abnormal. Results: Of 100 women referred, 69 underwent initial treatment of whom 47 (68%) went into remission: of these, seven developed a recurrence after a median follow-up of 29 months (range 15-214 months). Of the 31 women managed conservatively with cytological and vaginoscopic surveillance, no cancers developed after a median follow-up of 35 months (range 2-230 months). Rate of overall progression to cancer was 3% and all were detected among the initial treatment group after a median of 59 months (range 8-249 months). Post-treatment, when normal vaginoscopy was accompanied by abnormal cytology, two categories existed. Of 24 cases with low-grade cytological abnormality, recurrence of HG VaIN occurred in seven (29%) after a median follow-up of 12 months (range 2-110 months). Of 19 cases with HG cytological abnormality, 15 (79%) developed recurrence at a median follow-up of 7 months (range 2-21 months), giving a hazard ratio 5.6 (95% confidence interval 2.0-15.5, P = 0.001). Conclusions: It is possible to select women with HG VaIN for conservative surveillance with excellent results. The majority of women undergoing initial treatment will enter remission. Post-treatment, if cytological abnormality develops in the presence of normal vaginoscopy, the majority of women will develop histological HG VaIN recurrence.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma in Situ/pathology ; Carcinoma in Situ/therapy ; Colposcopy ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local ; Retrospective Studies ; Treatment Outcome ; Vagina/surgery ; Vaginal Neoplasms/pathology ; Vaginal Neoplasms/therapy ; Vaginal Smears ; Watchful Waiting
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.12223
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Article ; Online: Risk of ovarian recurrence after ovarian conservation in early-stage cervical cancer treated with radical surgery: A propensity match analysis.

Bizzarri, Nicolò / Pedone Anchora, Luigi / Kucukmetin, Ali / Ratnavelu, Nithya / Korompelis, Porfyrios / Fedele, Camilla / Bruno, Matteo / Di Fiore, Giacomo Lorenzo Maria / Fagotti, Anna / Fanfani, Francesco / Scambia, Giovanni / Ferrandina, Gabriella

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2021 Volume 47, Issue 8, Page(s) 2158–2165

Abstract: Introduction: The primary aim of the present study was to assess the incidence of ovarian metastasis/recurrence and the survival of patients undergoing radical hysterectomy with ovarian conservation (CONSERV) versus oophorectomy (OOPHOR). Secondary aim ... ...

Abstract	Introduction: The primary aim of the present study was to assess the incidence of ovarian metastasis/recurrence and the survival of patients undergoing radical hysterectomy with ovarian conservation (CONSERV) versus oophorectomy (OOPHOR). Secondary aim was to assess the incidence and the characteristics of menopausal symptoms in both groups. Materials and methods: Retrospective, multi-center, observational cohort study including patients <50 years with clinical FIGO 2009 stage IA1-IB1/IIA1 cervical carcinoma, treated by primary surgical treatment between 02/2007 and 07/2019. One-to-one case-control matching was used to adjust the baseline prognostic characteristics in survival analysis. Results: 419 patients were included. 264 in the OOPHOR (63.0%) and 155 (37.0%) in the CONSERV group. Ovarian transposition was performed in 28/155 (18.1%) patients. 1/264 (0.4%) patient had ovarian metastasis from endocervical adenocarcinoma. After propensity-matching, 310 patients were included in the survival analysis (155 per group). 5-year disease-free survival of patients undergoing CONSERV versus OOPHOR was 90.6% versus 82.2%, respectively (p = 0.028); 5-year overall survival was 94.3% versus 90.8%, respectively (p = 0.157). Two patients (1.3%) developed recurrence on the conserved ovary. CONSERV represented an independent protective factor of recurrence (HR:0.361, 95%CI 0.169-0.769; p = 0.008). 28 (20.6%) in the CONSERV group versus 116 (60.4%) in the OOPHOR group complained of menopausal symptoms during follow up (p < 0.001). HRT was prescribed to 12.0% of patients (median HRT time was 20 months). Conclusion: CONSERV was associated with reduced risk of recurrence and menopausal symptoms in early-stage cervical cancer. As the risk of ovarian metastasis and ovarian recurrence is relatively low, CONSERV in pre-menopausal women has to be considered.
MeSH term(s)	Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Adult ; Carcinoma, Squamous Cell/secondary ; Carcinoma, Squamous Cell/surgery ; Case-Control Studies ; Disease-Free Survival ; Female ; Humans ; Hysterectomy/methods ; Menopause ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Organ Sparing Treatments ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/secondary ; Postoperative Complications/epidemiology ; Retrospective Studies ; Salpingo-oophorectomy ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery ; Young Adult
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2021.04.009
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Article ; Online: Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?

O'Donnell, Rachel Louise / Verleye, Leen / Ratnavelu, Nithya / Galaal, Khadra / Fisher, Ann / Naik, Raj

Gynecologic oncology

2017 Volume 144, Issue 2, Page(s) 438–447

Abstract: Introduction: Treatment of locally advanced vulva cancer (LAVC) remains challenging. Due to the lack of randomised trials many questions regarding the indications for different treatment options and their efficacy remain unanswered.: Methods: In this ...

Abstract	Introduction: Treatment of locally advanced vulva cancer (LAVC) remains challenging. Due to the lack of randomised trials many questions regarding the indications for different treatment options and their efficacy remain unanswered. Methods: In this retrospective study we provide the largest published series of LAVC patients treated with anovulvectomy, reporting oncological outcomes and morbidity. Additionally, a systematic literature review was performed for all treatment options 1946-2015. Results: In our case series, 57/70 (81%) patients were treated in the primary setting with anovulvectomy and 13 patients underwent anovulvectomy for recurrent disease. The median overall survival (OS) was 69months (1-336) with disease specific survival of 159months (1-336). Following anovulvectomy for primary disease, time to progression and OS were significantly higher in node negative disease (10 vs. 96months; 19 vs. 121months, p<0.0001). Post-surgical complications were observed in 36 (51.4%), the majority of which were Grade I/II infections. There was one peri-operative death. Review of the literature showed that chemotherapy, radiotherapy or combination treatments are alternatives to surgery. Evidence relating to all of these consisted mostly of small retrospective series, which varied considerably in terms of patient characteristics and treatment schedules. Significant patient and treatment heterogeneity prevented meta-analysis with significant biases in these studies. It was unclear if survival or morbidity was better in any one group with a lack of data reporting complications, quality of life, and long term follow-up. However, results for chemoradiation are encouraging enough to warrant further investigation. Conclusions: There remains inadequate evidence to identify an optimal treatment for LAVC. However, there is sufficient evidence to support a trial of anovulvectomy versus chemoradiation. Discussions and consensus would be needed to determine trial criteria including the primary outcome measure. Neoadjuvant chemotherapy or radiotherapy alone may be best reserved for the palliative setting or metastatic disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy ; Female ; Humans ; Intersectoral Collaboration ; Middle Aged ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Vulva/surgery ; Vulvar Neoplasms/therapy
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2016.12.007
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Article ; Online: Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the transformation zone (LLETZ) of the cervix: Results of the DySIS colposcopy 1 study.

Founta, Christina / Papagiannakis, Emmanouil / Ratnavelu, Nithya / Feusi, Arlene / Natsis, Stavros / Bradbury, Melissa / Fisher, Ann / Naik, Raj

Medicine

2018 Volume 97, Issue 1, Page(s) e9560

Abstract: After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and ...

Abstract	After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to colposcopy. This pilot study assessed the incidence of residual/recurrent CIN and the diagnostic accuracy of colposcopy with dynamic spectral imaging (DSI) mapping in their detection.This was a prospective service evaluation carried out in a UK National Health Service (NHS) colposcopy clinic. All women, referred with negative cytology/HR-HPV positive result following treatment for CIN from March 2013 until November 2014, who were examined with the DSI digital colposcope were included. We excluded 3 cases because of poor-quality imaging from user errors. Everyday clinical practice was followed. Initial colposcopic impression, DSI map indication, and biopsy site selections were recorded. CIN2+ was considered the primary outcome and CIN of any grade a secondary outcome.A total of 105 women were included of which 5 (4.8%) had CIN2+ histology and 24 (22.9%) had CIN1. Pre-DSI map colposcopy suggested normal/low grade in all 5 of the CIN2+ cases and DSI suggested high-grade (HG) CIN in 4 of the 5 cases. Sensitivity of standard colposcopy for CIN2+ was 0%, improving to 80% with the incorporation of the DSI map.The CIN burden in this population is higher than previously expected. Colposcopic identification of HG CIN appears to improve significantly with DSI in this cohort leading to refinement in patient management. A larger, multicentric prospective study (DySIS colposcopy 2) is planned to confirm these initial findings.
MeSH term(s)	Adult ; Aged ; Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/surgery ; Cervical Intraepithelial Neoplasia/virology ; Colposcopy/methods ; Colposcopy/statistics & numerical data ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/virology ; Papillomaviridae ; Pilot Projects ; Prospective Studies ; Spectrum Analysis ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/virology
Language	English
Publishing date	2018-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000009560
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Article ; Online: Investigating the possible impact of peritoneal tumor exposure amongst women with early stage cervical cancer treated with minimally invasive approach.

Pedone Anchora, Luigi / Bizzarri, Nicolò / Kucukmetin, Ali / Turco, Luigi Carlo / Gallotta, Valerio / Carbone, Vittoria / Rundle, Stuart / Ratnavelu, Nithya / Cosentino, Francesco / Chiantera, Vito / Fagotti, Anna / Fedele, Camilla / Gomes, Nana / Ferrandina, Gabriella / Scambia, Giovanni

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2020 Volume 47, Issue 5, Page(s) 1090–1097

Abstract: Introduction: Recent findings show a detrimental impact of the minimally invasive approach on patients with early stage cervical cancer (ECC). Reasons beyond these results are unclear. The aim of the present article is to investigate the possible role ... ...

Abstract	Introduction: Recent findings show a detrimental impact of the minimally invasive approach on patients with early stage cervical cancer (ECC). Reasons beyond these results are unclear. The aim of the present article is to investigate the possible role of peritoneal contamination during intracorporeal colpotomy. Methods: patients with early stage cervical cancer were divided into 2 groups: no intraperitoneal exposure (N-IPE) intraperitoneal exposure (IPE) during minimally invasive surgery. Patients of the 2 groups were propensity-matched according to the major risk factors. Results: 226 cases of the IPE group had a significant worst prognosis than the 142 cases of the N-IPE group (4.5-years disease free survival: 86.6% vs 95.9% respectively, p = 0.005), while N-IPE had similar survival to open surgery (4.5-years disease free survival: 95.0% vs 90.5% respectively, p = 0.164). Distant recurrence was more frequent among IPE patients with a borderline significance (3.5% vs 0.4% among IPE and N-IPE respectively, p = 0.083). On multivariate analysis, intraperitoneal tumor exposure was an independent prognostic factors for worse survival; patients belonging to the N-IPE group had a risk of recurrence of about 3-fold lower compared to patients of the IPE group (hazard ratio: 0.37, 95% confidence interval: 0.15-0.88, p = 0.025). Conclusion: it would be advisable that further prospective studies investigating the efficacy of different surgical approach in ECC take into consideration of this issue. Moreover, all other measures that could potentially prevent peritoneal exposure of tumor should be adopted during minimally invasive surgery for early stage cervical cancer to provide higher survival outcomes.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Colpotomy/adverse effects ; Female ; Humans ; Italy ; Lymph Node Excision ; Lymphatic Metastasis ; Middle Aged ; Minimally Invasive Surgical Procedures/adverse effects ; Neoplasm Grading ; Neoplasm Staging ; Peritoneal Cavity/pathology ; Prognosis ; Propensity Score ; Retrospective Studies ; Risk Factors ; Survival Rate ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
Language	English
Publishing date	2020-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2020.09.038
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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito